Journal of Yeungnam Medical Science

From articles published in Journal of Yeungnam Medical Science during the past 2 years (2021 ~ ).

Review articles

Classification of endometriosis: Soo-Young Lee, Yu-Jin Koo, Dae-Hyung Lee; Yeungnam Univ J Med. 2021;38(1):10-18. Published online August 7, 2020; DOI: https://doi.org/10.12701/yujm.2020.00444

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37 Citations

Endometriosis is a chronic disease associated with pelvic pain and infertility. Several classification systems for the severity of endometriosis have been proposed. Of these, the revised American Society for Reproductive Medicine classification is the most well-known. The ENZIAN classification was developed to classify deep infiltrating endometriosis and focused on the retroperitoneal structures. The endometriosis fertility index was developed to predict the fertility outcomes in patients who underwent surgery for endometriosis. Finally, the American Association of Gynecological Laparoscopists classification is currently being developed, for which 30 endometriosis experts are analyzing and researching data by assigning scores to categories considered important; however, it has not yet been fully validated and published. Currently, none of the classification systems are considered the gold standard. In this article, we review the classification systems, identify their pros and cons, and discuss what improvements need to be made to each system in the future.

Citations

Citations to this article as recorded by

Ultrasound Characteristics and Scanning Techniques of Uterosacral Ligaments for the Diagnosis of Endometriosis
Shae Maple, K Jane Chalmers, Eva Bezak, Katelyn Henry, Nayana Parange
Journal of Ultrasound in Medicine.2023; 42(6): 1193. CrossRef
The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis
Ewa Skarżyńska, Monika Wróbel, Hanna Zborowska, Mateusz Franciszek Kołek, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski,
International Journal of Molecular Sciences.2023; 24(2): 1619. CrossRef
Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study
Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Beata Smolarz
Genes.2023; 14(1): 152. CrossRef
Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis
Brunella Zizolfi, Virginia Foreste, Simona Bonavita, Valentina Rubino, Giuseppina Ruggiero, Vincenzo Brescia Morra, Roberta Lanzillo, Antonio Carotenuto, Francesca Boscia, Maurizio Taglialatela, Maurizio Guida
Journal of Clinical Medicine.2023; 12(5): 2043. CrossRef
Rectal endometriosis imaging: A case based pictorial essay
Garvit D. Khatri, Deepashri Basavalingu, Nitin Chaubal, Manjiri Dighe
WFUMB Ultrasound Open.2023; 1(1): 100002. CrossRef
KRAS mutations and endometriosis burden of disease
Natasha L Orr, Arianne Albert, Yang Doris Liu, Amy Lum, JooYoon Hong, Catalina L Ionescu, Janine Senz, Tayyebeh M Nazeran, Anna F Lee, Heather Noga, Kate Lawrenson, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Michael S Anglesio, Paul J Yong
The Journal of Pathology: Clinical Research.2023; 9(4): 302. CrossRef
The Clinical Presentation of Endometriosis and Its Association to Current Surgical Staging
Matilda Shaked Ashkenazi, Ole Linvåg Huseby, Gard Kroken, Marcela Trocha, Aurora Henriksson, Hanna Jasiak, Karen Cuartas, Alessandra Loschiavo, Isabella Kuhn, Dina Støve, Hanna Grindahl, Emilia Latour, Mathias Melbø, Katrine Holstad, Sebastian Kwiatkowski
Journal of Clinical Medicine.2023; 12(7): 2688. CrossRef
Evaluation and management of endometriosis
T. Yoldemir
Climacteric.2023; 26(3): 248. CrossRef
COX isozymes and non-uniform neoangiogenesis: What is their role in endometriosis?
Andrea Caruana, Charles Savona-Ventura, Jean Calleja-Agius
Prostaglandins & Other Lipid Mediators.2023; 167: 106734. CrossRef
Time to move beyond surgical classification systems for endometriosis
María Isabel Hernández Cardona, Christana Ajewole, Hannah Lewis, Jorge F. Carrillo, Mario E. Castellanos, Stefanie Barish, Juan Diego Villegas Echeverri, Georgine Lamvu
International Journal of Gynecology & Obstetrics.2023; 163(1): 58. CrossRef
Antimüllerian hormone (AMH) and age as predictors of preimplantation genetic testing for aneuploidies (PGT-A) cycle outcomes and blastocyst quality on day 5 in women undergoing in vitro fertilization (IVF)
A. Arnanz, A. Bayram, I. Elkhatib, A. Abdala, A. El-Damen, R. Patel, B. Lawrenz, L. Melado, H. Fatemi, N. De Munck
Journal of Assisted Reproduction and Genetics.2023; 40(6): 1467. CrossRef
Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis
Shulin Zhong, Yuzhen Liang, Zhixi Wu, Li Wei
Journal of Reproductive Immunology.2023; 158: 103969. CrossRef
Psychological hallmarks of endometriosis with emphasis on sexual dysfunction, stress, anxiety and depressive symptoms
Ludek Fiala, Jiri Lenz, Zdenek Adamik, Rachel Sajdlova, Daniela Kestlerova, Vaclav Vetvicka
International Clinical Pathology Journal.2023; 10(1): 45. CrossRef
Detection of Endometriosis Lesions Using Gd-Based Collagen I Targeting Probe in Murine Models of Endometriosis
Nazanin Talebloo, Maria Ariadna Ochoa Bernal, Elizabeth Kenyon, Christiane L. Mallett, Asgerally Fazleabas, Anna Moore
Molecular Imaging and Biology.2023;[Epub] CrossRef
Exosomal microRNAs and long noncoding RNAs: as novel biomarkers for endometriosis
Elahe Soltani-Fard, Marzieh Asadi, Sina Taghvimi, Asma Vafadar, Parisa Vosough, Amir Tajbakhsh, Amir Savardashtaki
Cell and Tissue Research.2023;[Epub] CrossRef
Use of the Free Endometriosis Risk Advisor App as a Non-Invasive Screening Test for Endometriosis in Patients with Chronic Pelvic Pain and/or Unexplained Infertility
Camran Nezhat, Ellie Armani, Hsuan-Chih Carolina Chen, Zahra Najmi, Steven R. Lindheim, Ceana Nezhat
Journal of Clinical Medicine.2023; 12(16): 5234. CrossRef
Comparison of Clinical and Reproductive Outcomes between Adenomyomectomy and Myomectomy
Kristyna Hlinecka, Michal Mara, Barbora Boudova, Zdenka Lisa, Adela Richtarova, David Kuzel
Journal of Minimally Invasive Gynecology.2022; 29(3): 392. CrossRef
Evaluating Surgical Complexity of Endoscopic Hysterectomy: An Inter-rater and Intra-rater Agreement Study of Novel Scoring Tool
Meenal Misal, Marlene Girardo, Sadikah Behbehani, Vimee Bindra, Mark R. Hoffman, Wei How Lim, Courtney Martin, Sukrant K. Mehta, Alysha Nensi, Thiers Soares, Deborah Taylor, Steve Wagner, Kelly N. Wright, Megan N. Wasson
Journal of Minimally Invasive Gynecology.2022; 29(5): 683. CrossRef
MRI in the Diagnosis of Endometriosis and Related Diseases
Aki Kido, Yuki Himoto, Yusaku Moribata, Yasuhisa Kurata, Yuji Nakamoto
Korean Journal of Radiology.2022; 23(4): 426. CrossRef
Role of Robotic Surgery in Benign Gynecology
Mireille D. Truong, Lauren N. Tholemeier
Obstetrics and Gynecology Clinics of North America.2022; 49(2): 273. CrossRef
NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis
Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang, Yongdong Dai
Journal of Reproductive Immunology.2022; 152: 103649. CrossRef
Endometriosis: A Disease with Few Direct Treatment Options
Patricia Ribeiro de Carvalho França, Anna Carolina Pereira Lontra, Patricia Dias Fernandes
Molecules.2022; 27(13): 4034. CrossRef
The Role of the Immune System in the Development of Endometriosis
Monika Abramiuk, Ewelina Grywalska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz, Paulina Niedźwiedzka-Rystwej
Cells.2022; 11(13): 2028. CrossRef
Transvaginal Ultrasound vs. Magnetic Resonance Imaging (MRI) Value in Endometriosis Diagnosis
Alexandra Baușic, Ciprian Coroleucă, Cătălin Coroleucă, Diana Comandașu, Roxana Matasariu, Andrei Manu, Francesca Frîncu, Claudia Mehedințu, Elvira Brătilă
Diagnostics.2022; 12(7): 1767. CrossRef
History of Endometriosis Is Independently Associated with an Increased Risk of Ovarian Cancer
Antonio Sarría-Santamera, Zaukiya Khamitova, Arnur Gusmanov, Milan Terzic, Mar Polo-Santos, Miguel A. Ortega, Angel Asúnsolo
Journal of Personalized Medicine.2022; 12(8): 1337. CrossRef
Surgical Classification of Endometriosis
João Nogueira Neto, Mauricio Simões Abrão, Eduardo Schor, Julio Cesar Rosa-e-Silva
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics.2022; 44(08): 737. CrossRef
Analysis of Long Non-Coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 Expression in Endometriosis
Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Radosław Kołaciński, Magdalena M. Michalska, Dariusz Samulak, Beata Smolarz
International Journal of Molecular Sciences.2022; 23(19): 11583. CrossRef
Colorectal infiltrating deep endometriosis: Laparoscopic treatment. A case report
Giuseppe Di Buono, Matilde Micheli, Gaia Russo, Roberta Vella, Giuseppe Amato, Girolamo Geraci, Antonino Agrusa
Frontiers in Surgery.2022;[Epub] CrossRef
Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden
Emily Redwood, Virginie Lam, Ryusuke Takechi, Deborah Anne Kerr, Connie Jackaman, Arazu Sharif, John Charles Louis Mamo
Frontiers in Pain Research.2022;[Epub] CrossRef
Histotyping and grading of endometriosis and its association with clinico-pathological parameters
Jyothika Litson, Rini Agnes, Gayatri Ravikumar
Journal of Obstetrics and Gynaecology.2022; 42(8): 3628. CrossRef
Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis
Damian Warzecha, Julia Załęcka, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Sz
International Journal of Molecular Sciences.2022; 23(24): 15669. CrossRef
Progestins in the symptomatic management of endometriosis: a meta-analysis on their effectiveness and safety
Jon-Benay Mitchell, Sarentha Chetty, Fatima Kathrada
BMC Women's Health.2022;[Epub] CrossRef
Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis
Sixue Wang, Mingyu Yi, Xinyue Zhang, Tingting Zhang, Li Jiang, Le Cao, Yuxin Zhou, Xiaoling Fang
Reproductive BioMedicine Online.2021; 42(6): 1057. CrossRef
Structured report for dynamic ultrasonography in patients with suspected or known endometriosis: Recommendations of the International Society for Gynecologic Endoscopy (ISGE)
Dusan Djokovic, Patrícia Pinto, Bruno J. van Herendael, Antonio Simone Laganà, Viju Thomas, Jörg Keckstein
European Journal of Obstetrics & Gynecology and Reproductive Biology.2021; 263: 252. CrossRef
Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay
Omar T. Sims, Jhumka Gupta, Stacey A. Missmer, Irene O. Aninye
International Journal of Environmental Research and Public Health.2021; 18(15): 8210. CrossRef
AAGL 2021 Endometriosis Classification: An Anatomy-based Surgical Complexity Score
Mauricio S. Abrao, Marina Paula Andres, Charles E. Miller, Julian A. Gingold, Mariona Rius, Joao Siufi Neto, Francisco Carmona
Journal of Minimally Invasive Gynecology.2021; 28(11): 1941. CrossRef
Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis
Xin Meng, Ying Li, Qingxue Li, Jian Yang, Mingli An, Xinping Fu, Shuancheng Zhang, Jingwei Chen
Experimental and Therapeutic Medicine.2021;[Epub] CrossRef

Lactate: a multifunctional signaling molecule: Tae-Yoon Lee; Yeungnam Univ J Med. 2021;38(3):183-193. Published online February 18, 2021; DOI: https://doi.org/10.12701/yujm.2020.00892

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436 Download
24 Citations

Abstract PDF

Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.

Citations

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B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
Kevin Li, Maria Romero, Macarena Cañardo, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg, Daniela Frasca
Mechanisms of Ageing and Development.2023; 209: 111742. CrossRef
The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
Genes & Diseases.2023; 10(5): 2029. CrossRef
Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang
Cell Biology International.2023; 47(2): 295. CrossRef
Insights on the role of l-lactate as a signaling molecule in skin aging
Salvatore Chirumbolo, Dario Bertossi, Pierre Magistretti
Biogerontology.2023; 24(5): 709. CrossRef
Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions
Maria Szrejder, Marlena Typiak, Piotr Pikul, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska
European Journal of Cell Biology.2023; 102(2): 151298. CrossRef
Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus
Andreas Hoffmann, Alexander Franz, Thomas Walther, Christian Löser
Applied Microbiology and Biotechnology.2023; 107(5-6): 1635. CrossRef
Lactate, histone lactylation and cancer hallmarks
Xinyu Lv, Yingying Lv, Xiaofeng Dai
Expert Reviews in Molecular Medicine.2023;[Epub] CrossRef
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
Aging.2023;[Epub] CrossRef
Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni, Veera Venkata Satyanarayana Reddy Karri
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Christina Thoda, Maria Touraki
Applied Sciences.2023; 13(8): 4726. CrossRef
Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer
Ting Wang, Zeng Ye, Zheng Li, De‐sheng Jing, Gui‐xiong Fan, Meng‐qi Liu, Qi‐feng Zhuo, Shun‐rong Ji, Xian‐jun Yu, Xiao‐wu Xu, Yi Qin
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High-concentrate diet elevates histone lactylation mediated by p300/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows
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ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation
Seung-Hwa Woo, Yun Jeong Mo, Yun-Il Lee, Ji Hwan Park, Daehee Hwang, Tae Jun Park, Hee Young Kang, Sang Chul Park, Young-Sam Lee
Journal of Investigative Dermatology.2023;[Epub] CrossRef
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Yanan Sun, Yanchi Chen, Tao Peng
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Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro
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Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Alvarez-Mon, Ana M. Gomez-Lahoz, Jorge Monserrat, Maria Llavero-Valero, Fernando Ruiz-Grande, Santiago Coca, Melchor Alvarez-Mon, Julia Buján, Natalio García-Honduvilla, Jose V. Saz, Miguel A. Orte
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Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
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Original article

Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study: Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon; J Yeungnam Med Sci. 2022;39(1):46-52. Published online August 26, 2021; DOI: https://doi.org/10.12701/yujm.2021.01221

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10 Citations

Abstract PDF

Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.

Citations

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Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
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Review articles

Can antioxidants be effective therapeutics for type 2 diabetes?: Soyoung Park, So-Young Park; Yeungnam Univ J Med. 2021;38(2):83-94. Published online October 8, 2020; DOI: https://doi.org/10.12701/yujm.2020.00563

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Abstract PDF

The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

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An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults
Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis
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Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
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Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice
Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
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An update on the cause and treatment of sleep disturbance in children and adolescents with autism spectrum disorder: Wan Seok Seo; Yeungnam Univ J Med. 2021;38(4):275-281. Published online September 13, 2021; DOI: https://doi.org/10.12701/yujm.2021.01410

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by abnormalities in social communication/interaction and restrictive, repetitive patterns of behavior. ASD is a relatively common psychiatric disorder, with a prevalence of approximately 1.7% in children. Although many children and adolescents with ASD visit the hospital for medical help for emotional and behavioral problems such as mood instability and self-harming behavior, there are also many visits for sleep disturbances such as insomnia and sleep resistance. Sleep disturbances are likely to increase fatigue and daytime sleepiness, impaired concentration, negatively impact on daytime functioning, and pose challenges in controlling anger and aggressive behavior. Sleep disturbance in children and adolescents with ASD negatively affects the quality of life, nothing to say the quality of life of their families and school members. In this review, sleep disturbances that are common in children and adolescents with ASD and adolescents are presented. The developmental and behavioral impacts of sleep disturbances in ASD were also considered. Finally, non-pharmacological and pharmacological treatments for sleep disturbances in children and adolescents with ASD and adolescents are reviewed.

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Deepa Burman, Karthikeyan Ramanujam, Dilshad Manzar, Vijay Kumar Chattu, David Warren Spence, Nevin F. W. Zaki, Haitham Jahrami, Seithikurippu R. Pandi-Perumal
Sleep and Vigilance.2023; 7(1): 9. CrossRef
Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis
Mei Xiong, Fang Li, Zhaohua Liu, Xin Xie, Hongli Shen, Weiteng Li, Liping Wei, Rongfang He
Neuropediatrics.2023; 54(03): 167. CrossRef
Sleep disturbances and emotional dysregulation in young children with autism spectrum, intellectual disability, or global developmental delay
Irene Favole, Chiara Davico, Daniele Marcotulli, Roberta Sodero, Barbara Svevi, Federico Amianto, Federica S. Ricci, G. Maurizio Arduino, Benedetto Vitiello
Sleep Medicine.2023; 105: 45. CrossRef
A novel case of prolonged Ifosfamide encephalopathy and long-term treatment with methylene blue: a case report and review of literature
Gabriel Chain, Mudit Kalia, Karen Kestenbaum, Lara Pappas, Anna Sechser-Perl, Gadi Abebe Campino, Nibal Zaghloul
BMC Pediatrics.2022;[Epub] CrossRef
Sleep Disturbances in Children Affected by Autism Spectrum Disorder
Jessica Galli, Erika Loi, Lucrezia Maria Visconti, Paola Mattei, Anna Eusebi, Stefano Calza, Elisa Fazzi
Frontiers in Psychiatry.2022;[Epub] CrossRef
Analysis of sleep problem in children aged 1–3 years with autism spectrum disorder in Zhejiang province, China
Dan Yao, Shasha Wang, Fangfang Li, Minjie Gao, Jie Shao
Frontiers in Psychiatry.2022;[Epub] CrossRef
Understanding sleep and sleep disturbances in autism spectrum disorder, and management of insomnia: an update
Hye-Geum Kim
Yeungnam University Journal of Medicine.2021; 38(4): 265. CrossRef

The role of microRNAs in cell death pathways: Ji Hoon Jang, Tae-Jin Lee; Yeungnam Univ J Med. 2021;38(2):107-117. Published online January 13, 2021; DOI: https://doi.org/10.12701/yujm.2020.00836

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7 Citations

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MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

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Csaba Horvath, Izabela Jarabicova, Branislav Kura, Barbora Kalocayova, Eva Faurobert, Sean M. Davidson, Adriana Adameova
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119534. CrossRef
The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury
Leonid N. Maslov, Sergey V. Popov, Natalia V. Naryzhnaya, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Ivan A. Derkachev, Alla A. Boshchenko, Igor Khaliulin, N. Rajendra Prasad, Nirmal Singh, Alexei Degterev, Evgenia A. Tomilova, Ekaterina V. Sapozhenko
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Interleukin-10 Protects against Ureteral Obstruction-Induced Kidney Fibrosis by Suppressing Endoplasmic Reticulum Stress and Apoptosis
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International Journal of Molecular Sciences.2022; 23(18): 10702. CrossRef
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Updates on the treatment of adhesive capsulitis with hydraulic distension: Jang Hyuk Cho; Yeungnam Univ J Med. 2021;38(1):19-26. Published online August 31, 2020; DOI: https://doi.org/10.12701/yujm.2020.00535

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Adhesive capsulitis of the shoulder joint is a common disease characterized by pain at the insertional area of the deltoid muscle and decreased range of motion. The pathophysiological process involves fibrous inflammation of the capsule and intraarticular adhesion of synovial folds leading to capsular thickening and contracture. Regarding the multidirectional limitation of motion, a limitation in external rotation is especially prominent, which is related to not only global fibrosis but also to a localized tightness of the anterior capsule. Ultrasound and magnetic resonance imaging studies can be applied to rule out other structural lesions in the diagnosis of adhesive capsulitis. Hydraulic distension of the shoulder joint capsule provides pain relief and an immediate improvement in range of motion by directly expanding the capsule along with the infusion of steroids. However, the optimal technique for hydraulic distension is still a matter of controversy, with regards to the infusion volume and rupture of the capsule. By monitoring the real-time pressure-volume profile during hydraulic distension, the largest possible fluid volume can be infused without rupturing the capsule. The improvement in clinical outcomes is shown to be greater in capsule-preserved hydraulic distension than in capsule-ruptured distension. Moreover, repeated distension is possible, which provides additional clinical improvement. Capsule-preserved hydraulic distension with maximal volume is suggested to be an efficacious treatment option for persistent adhesive capsulitis.

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Ultrasound-guided hydrodilatation of glenohumeral joint combined with acupotomy for treatment of frozen shoulder
Huajun Xu, Yingchun Zhang, Caishan Wang
Journal of Back and Musculoskeletal Rehabilitation.2022; 35(5): 1153. CrossRef
Impact of capsular preservation on patient-reported outcomes and complication rates in total hip arthroplasty using the direct anterior approach
Vincent A. Stadelmann, Hannes A. Rüdiger, Selina Nauer, Michael Leunig
The Bone & Joint Journal.2022; 104-B(7): 826. CrossRef
Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience
Yung-Chieh Chen, Shu-Huei Shen, Hong-Jen Chiou, Yung-Liang Wan
Life.2022; 12(9): 1293. CrossRef
Role of Platelet-Rich Plasma in the Treatment of Adhesive Capsulitis: A Prospective Cohort Study
Syed Imran Haider, Muhammad Zarak Awais, Muhammad Tahir Iqbal
Cureus.2022;[Epub] CrossRef
Musculoskeletal complications in patients with diabetes mellitus
Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
The Korean Journal of Internal Medicine.2022; 37(6): 1099. CrossRef
Comparison of the spread pattern of medial-to-lateral and lateral-to-medial rotator interval injections: A cadaveric study
Benjamin J. Kozlowski, John Tran, Philip W.H. Peng, Anne M.R. Agur, Nimish Mittal
Interventional Pain Medicine.2022; 1(4): 100164. CrossRef
Updates on Intra-articular Corticosteroid Injection for the Treatment of Adhesive Capsulitis
Ju Heon Oh, In Ho Jung, Eun Woo Park, Jang Hyuk Cho
Keimyung Medical Journal.2022; 41(2): 51. CrossRef

Gallbladder polyps: evolving approach to the diagnosis and management: Kook Hyun Kim; Yeungnam Univ J Med. 2021;38(1):1-9. Published online May 15, 2020; DOI: https://doi.org/10.12701/yujm.2020.00213

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Abstract PDF

Gallbladder (GB) polyp is a mucosal projection into the GB lumen. With increasing health awareness, GB polyps are frequently found using ultrasonography during health screening. The prevalence of GB polyps ranges between 1.3% and 9.5%. Most patients are asymptomatic and have benign characteristics. Of the nonneoplastic polyps, cholesterol polyps are most common, accounting for 60%–70% of lesions. However, a few polyps have malignant potential. Currently, the guidelines recommend laparoscopic cholecystectomy for polyps larger than 1 cm in diameter due to their malignan potential. The treatment algorithm can be influenced by the size, shape, and numbers of polyps, old age (>50 years), the presence of primary sclerosing cholangitis, and gallstones. This review summarizes the commonly recognized concepts on GB polyps from diagnosis to an algorithm of treatment.

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Endoscopic ultrasound-guided gallbladder endoscopic mucosal resection: a pilot porcine study
Huifang Pang, Quan Man, Li Min, Zheng Zhang, Shengtao Zhu, Shuyue Yang, Yao Xu, Haijun Hou, Shutian Zhang, Peng Li
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The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review
Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G. Shelat
Annals of Hepato-Biliary-Pancreatic Surgery.2023; 27(3): 241. CrossRef
The gallbladder: what’s new in 2022?
Rachel Runde, Edward D. Auyang, Raye Ng, Kaysey Llorente, Hina Arif Tiwari, Shana Elman, William M. Thompson
Abdominal Radiology.2022; 48(1): 2. CrossRef
Gallbladder polyps: diagnosis and treatment tactics (literature review)
S. N. Perekhodov, D. V. Nikolaev, S. S. Saidov
Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2021; 11(4): 88. CrossRef
Is there a role for growth status in distinguishing gallbladder adenomas from cholesterol polyps? – A retrospective study based on 520 cholecystectomy patients
Wenqing Bao, Anan Xu, Shubin Ni, Bo Wang, Humaira Urmi, Bin Zhao, Yongmei You, Hai Hu
Scandinavian Journal of Gastroenterology.2021; 56(12): 1450. CrossRef
Polyps and cancer of the biliary system (lecture for medical practitioners)
G. V. Shavkuta
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Pain in amyotrophic lateral sclerosis: a narrative review: Soyoung Kwak; J Yeungnam Med Sci. 2022;39(3):181-189. Published online June 8, 2022; DOI: https://doi.org/10.12701/jyms.2022.00332

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Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

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Likely Pathogenic Variants of Cav1.3 and Nav1.1 Encoding Genes in Amyotrophic Lateral Sclerosis Could Elucidate the Dysregulated Pain Pathways
Zsófia Flóra Nagy, Balázs Sonkodi, Margit Pál, Péter Klivényi, Márta Széll
Biomedicines.2023; 11(3): 933. CrossRef
Palliative Care in Amyotrophic Lateral Sclerosis
Sebastiano Mercadante, Lou'i Al-Husinat
Journal of Pain and Symptom Management.2023;[Epub] CrossRef
The blind spot and challenges in pain management
Min Cheol Chang
Journal of Yeungnam Medical Science.2022; 39(3): 179. CrossRef
Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?
Bradley Roberts, Frances Theunissen, Francis L. Mastaglia, P. Anthony Akkari, Loren L. Flynn
International Journal of Molecular Sciences.2022; 23(16): 9364. CrossRef
Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report
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The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review: Donghwi Park, Min Cheol Chang; J Yeungnam Med Sci. 2022;39(3):200-205. Published online April 7, 2022; DOI: https://doi.org/10.12701/jyms.2022.00101

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5 Citations

Abstract PDF

Pain from nervous or musculoskeletal disorders is one of the most common complaints in clinical practice. Corticosteroids have a high pain-reducing effect, and their injection is generally used to control various types of pain. However, they have various adverse effects including flushing, hyperglycemia, allergic reactions, menstrual changes, immunosuppression, and adrenal suppression. Pulsed radiofrequency (PRF) is known to have a pain-reducing effect similar to that of corticosteroid injection, with nearly no major side effects. Therefore, it has been widely used to treat various types of pain, such as neuropathic, joint, discogenic, and muscle pain. In the current review, we outlined the pain-reducing mechanisms of PRF by reviewing previous studies. When PRF was first introduced, it was supposed to reduce pain by long-term depression of pain signaling from the peripheral nerve to the central nervous system. In addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of C-afferent fibers, and microscopic damage of nociceptive C- and A-delta fibers have been found to contribute to pain reduction after PRF application. However, the pain-reducing mechanism of PRF has not been clearly and definitely elucidated. Further studies are warranted to clarify the pain-reducing mechanism of PRF.

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Comparison of two distinct needle tip positions in pulsed radiofrequency for herpes zoster‐related pain
Shao‐jun Li, Dan Feng
CNS Neuroscience & Therapeutics.2023; 29(7): 1881. CrossRef
Previous Lumbar Spine Surgery Decreases the Therapeutic Efficacy of Dorsal Root Ganglion Pulsed Radiofrequency in Patients with Chronic Lumbosacral Radicular Pain
Jiri Jandura, Milan Vajda, Roman Kostysyn, Jiri Vanasek, Eva Cermakova, Jan Zizka, Pavel Ryska
Journal of Personalized Medicine.2023; 13(7): 1054. CrossRef
Spinal Injections: A Narrative Review from a Surgeon’s Perspective
Dong Ah Shin, Yoo Jin Choo, Min Cheol Chang
Healthcare.2023; 11(16): 2355. CrossRef
The blind spot and challenges in pain management
Min Cheol Chang
Journal of Yeungnam Medical Science.2022; 39(3): 179. CrossRef
Use of QR Codes for Promoting a Home-Based Therapeutic Exercise in Patients with Lumbar Disc Herniation and Lumbar Spinal Stenosis: A Prospective Randomized Study
Min Cheol Chang, Donghwi Park, Yoo Jin Choo
Journal of Pain Research.2022; Volume 15: 4065. CrossRef

Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review: Eun Kyung Choi, Dong Gun Lim; J Yeungnam Med Sci. 2023;40(2):115-122. Published online March 21, 2022; DOI: https://doi.org/10.12701/jyms.2022.00017

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Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

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Bin Tang, Zhijian Luo, Rong Zhang, Dongmei Zhang, Guojun Nie, Mingxing Li, Yan Dai
Cellular Signalling.2023; : 110665. CrossRef
Thymoquinone-loaded self-nano-emulsifying drug delivery system against ischemia/reperfusion injury
Badr Bahloul, Roua Chaabani, Yosri Zahra, Nesrine Kalboussi, Jamil Kraiem, Souad Sfar, Nathalie Mignet, Hassen ben Abdennebi
Drug Delivery and Translational Research.2023;[Epub] CrossRef
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Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
Current Opinion in Organ Transplantation.2022; 27(5): 424. CrossRef
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Jinjin Li, Jie Li, Hongbo Fang, Hang Yang, Tianchun Wu, Xiaoyi Shi, Chun Pang
International Immunopharmacology.2022; 113: 109185. CrossRef
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Nihan Aydoğan, Gülgün Aylaz, Monireh Bakhshpour, Tugba Tugsuz, Müge Andaç
Biomimetics.2022; 7(4): 191. CrossRef

Current diagnosis and treatment of vestibular neuritis: a narrative review: Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi; J Yeungnam Med Sci. 2022;39(2):81-88. Published online August 9, 2021; DOI: https://doi.org/10.12701/yujm.2021.01228

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Abstract PDF

Vertigo is the sensation of self-motion of the head or body when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement. Representative peripheral vertigo disorders include benign paroxysmal positional vertigo, Ménière disease, and vestibular neuritis. Vestibular neuritis, also known as vestibular neuronitis, is the third most common peripheral vestibular disorder after benign paroxysmal positional vertigo and Ménière disease. The cause of vestibular neuritis remains unclear. However, a viral infection of the vestibular nerve or ischemia of the anterior vestibular artery is known to cause vestibular neuritis. In addition, recent studies on immune-mediated mechanisms as the cause of vestibular neuritis have been reported. The characteristic clinical features of vestibular neuritis are abrupt true-whirling vertigo lasting for more than 24 hours, and no presence of cochlear symptoms and other neurological symptoms and signs. To accurately diagnose vestibular neuritis, various diagnostic tests such as the head impulse test, bithermal caloric test, and vestibular-evoked myogenic potential test are conducted. Various treatments for vestibular neuritis have been reported, which are largely divided into symptomatic therapy, specific drug therapy, and vestibular rehabilitation therapy. Symptomatic therapies include generalized supportive care and administration of vestibular suppressants and antiemetics. Specific drug therapies include steroid therapy, antiviral therapy, and vasodilator therapy. Vestibular rehabilitation therapies include generalized vestibular and customized vestibular exercises.

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Sanjana Devaragudi, Mohit Gupta
Cureus.2023;[Epub] CrossRef
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Esra’ O. Taybeh, Abdallah Y. Naser
Healthcare.2023; 11(10): 1457. CrossRef
Acute vestibular neuritis: A rare complication after the adenoviral vector-based COVID-19 vaccine
Hamze Shahali, Ramin Hamidi Farahani, Parham Hazrati, Ebrahim Hazrati
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Case report

Pembrolizumab-related autoimmune hemolytic anemia in a patient with metastatic lung adenocarcinoma: a case report: Dong Won Baek, Yee Soo Chae; Yeungnam Univ J Med. 2021;38(4):366-370. Published online March 23, 2021; DOI: https://doi.org/10.12701/yujm.2021.00899

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Immune checkpoint inhibitors (ICIs) have become the main drugs for programmed cell death receptor-1 or ligand-1 expressing non-small cell lung cancer (NSCLC) combined with conventional chemotherapy. ICIs are generally more tolerable than cytotoxic chemotherapies in terms of toxicity, and ICI-related adverse events are mild and manageable. However, these drugs may lead to unexpected severe adverse events such as immune-related hematologic toxicities, which could be life-threatening. Here, a rare case of a pembrolizumab-related adverse event in a patient with NSCLC who showed early-onset hemolytic anemia and recovered by high-dose steroid and a series of plasma exchanges is reported.

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Hang-Yu Gu, Jing-Wen Zhao, Yin-Shuang Wang, Zhuo-Nan Meng, Xiu-Ming Zhu, Fu-Wei Wang, Ai-Hong Zheng, Guo-Qing Wu
Frontiers in Immunology.2023;[Epub] CrossRef
Immunotherapy-associated Autoimmune Hemolytic Anemia
Steven R. Hwang, Antoine N. Saliba, Alexandra P. Wolanskyj-Spinner
Hematology/Oncology Clinics of North America.2022; 36(2): 365. CrossRef
Therapeutic plasma exchange in the management of immune checkpoint inhibitor‐associated immune‐related adverse effects: A review
Oluwatoyosi A. Onwuemene, Chizoba I. Nnoruka, Christopher J. Patriquin, Laura S. Connelly‐Smith
Transfusion.2022; 62(11): 2370. CrossRef
Diagnosis and management of cold agglutinin disease associated with low-grade B-cell lymphoma in a patient receiving pembrolizumab for lung cancer
Nabin Raj Karki, Peyton McElhone, Natasha Savage, Nagla Abdel Karim
BMJ Case Reports.2021; 14(8): e243751. CrossRef
Red Blood Cell Autoantibodies in Patients Treated with Immune Checkpoint Inhibitors
Eungjun Yoon, Tae Yeul Kim, Sun Kyoung Mun, Duck Cho
The Korean Journal of Blood Transfusion.2021; 32(3): 201. CrossRef

Review article

Pathophysiology and protective approaches of gut injury in critical illness: Chang Yeon Jung, Jung Min Bae; Yeungnam Univ J Med. 2021;38(1):27-33. Published online September 23, 2020; DOI: https://doi.org/10.12701/yujm.2020.00703

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The gut is a complex organ that has played an important role in digestion, absorption, endocrine functions, and immunity. The gut mucosal barriers consist of the immunologic barrier and nonimmunologic barrier. During critical illnesses, the gut is susceptible to injury due to the induction of intestinal hyperpermeability. Gut hyperpermeability and barrier dysfunction may lead to systemic inflammatory response syndrome. Additionally, gut microbiota are altered during critical illnesses. The etiology of such microbiome alterations in critical illnesses is multifactorial. The interaction or systemic host defense modulation between distant organs and the gut microbiome is increasingly studied in disease research. No treatment modality exists to significantly enhance the gut epithelial integrity, permeability, or mucus layer in critically ill patients. However, multiple helpful approaches including clinical and preclinical strategies exist. Enteral nutrition is associated with an increased mucosal barrier in animal and human studies. The trophic effects of enteral nutrition might help to maintain the intestinal physiology, prevent atrophy of gut villi, reduce intestinal permeability, and protect against ischemia-reperfusion injury. The microbiome approach such as the use of probiotics, fecal microbial transplantation, and selective decontamination of the digestive tract has been suggested. However, its evidence does not have a high quality. To promote rapid hypertrophy of the small bowel, various factors have been reported, including the epidermal growth factor, membrane permeant inhibitor of myosin light chain kinase, mucus surrogate, pharmacologic vagus nerve agonist, immune-enhancing diet, and glucagon-like peptide-2 as preclinical strategies. However, the evidence remains unclear.

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Original article

A comparative study of the psychological impacts of tasks related and unrelated to COVID-19 on nurses: a cross-sectional study: Hyun Ji Kim, Geon Ho Lee; J Yeungnam Med Sci. 2022;39(3):216-222. Published online November 3, 2021; DOI: https://doi.org/10.12701/yujm.2021.01361

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Background
This study assessed the psychological impact of the outbreak of coronavirus disease 2019 (COVID-19) on university hospital nurses. It provides an assessment of mental health issues, including depression, anxiety, distress, and burnout of nurses dealing directly and indirectly with COVID-19.
Methods
In a web-based, cross-sectional study, 111 nurses from Daegu Catholic University Hospital in Korea were enrolled from August 4 to August 9, 2020. Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Impact of Event Scale-Revised, and Maslach Burnout Inventory were used to assess the psychological symptoms of depression, anxiety, psychological distress, and burnout among the study participants.
Results
Of 111 nurses, 35 (31.5%), nine (8.1%), 26 (23.4%), and 49 (44.1%) experienced depression, anxiety, distress, and burnout, respectively. Nurses who performed COVID-19–related tasks were more likely to have moderate depression (related vs. unrelated, 52.0% vs. 25.6%; p=0.037). There were no differences in anxiety, distress, and burnout between nurses with and without COVID-19–related tasks. More than 50% of the participants showed receptive and positive attitudes toward caring for COVID-19 patients.
Conclusion
Nurses who performed COVID-19–related tasks had a higher risk of depression. There were no significant differences in anxiety, distress, and burnout between the two groups. Since nurses who perform COVID-19–related tasks are more prone to psychological distress, continued psychiatric interventions are required for infectious disease outbreaks with a high mortality rate for healthcare workers who are emotionally vulnerable.

Citations

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Frontiers in Psychology.2023;[Epub] CrossRef
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Jingjun Wang, Xia Huang, Mengmeng Wang, Lei Huang, Ya Wang
BMC Psychiatry.2023;[Epub] CrossRef
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International Journal of Environmental Research and Public Health.2022; 19(21): 13775. CrossRef

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