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From articles published in Journal of Yeungnam Medical Science during the past 2 years (2022 ~ ).

Focused Review article
The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review
Donghwi Park, Min Cheol Chang
J Yeungnam Med Sci. 2022;39(3):200-205.   Published online April 7, 2022
DOI: https://doi.org/10.12701/jyms.2022.00101
  • 5,940 View
  • 155 Download
  • 17 Web of Science
  • 21 Crossref
AbstractAbstract PDF
Pain from nervous or musculoskeletal disorders is one of the most common complaints in clinical practice. Corticosteroids have a high pain-reducing effect, and their injection is generally used to control various types of pain. However, they have various adverse effects including flushing, hyperglycemia, allergic reactions, menstrual changes, immunosuppression, and adrenal suppression. Pulsed radiofrequency (PRF) is known to have a pain-reducing effect similar to that of corticosteroid injection, with nearly no major side effects. Therefore, it has been widely used to treat various types of pain, such as neuropathic, joint, discogenic, and muscle pain. In the current review, we outlined the pain-reducing mechanisms of PRF by reviewing previous studies. When PRF was first introduced, it was supposed to reduce pain by long-term depression of pain signaling from the peripheral nerve to the central nervous system. In addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of C-afferent fibers, and microscopic damage of nociceptive C- and A-delta fibers have been found to contribute to pain reduction after PRF application. However, the pain-reducing mechanism of PRF has not been clearly and definitely elucidated. Further studies are warranted to clarify the pain-reducing mechanism of PRF.

Citations

Citations to this article as recorded by  
  • A narrative review of pulsed radiofrequency for the treatment of carpal tunnel syndrome
    Himanshu Gupta, Colm Vance, Vishal Bansal, Ahilraj Siva
    Pain Practice.2024; 24(2): 374.     CrossRef
  • Pulsed Radiofrequency for Auriculotemporal Neuralgia: A Case Report
    Yan Tereshko, Enrico Belgrado, Christian Lettieri, Simone Dal Bello, Giovanni Merlino, Gian Luigi Gigli, Mariarosaria Valente
    Neurology International.2024; 16(2): 349.     CrossRef
  • Transforaminal pulsed radiofrequency and epidural steroid injection on chronic lumbar radiculopathy: A prospective observational study from a tertiary care hospital in Vietnam
    Viet-Thang Le, Phuoc Trong Do, Vu Duc Nguyen, Luan Trung Nguyen Dao, Ipek Saadet Edipoglu
    PLOS ONE.2024; 19(4): e0292042.     CrossRef
  • Pulsed Radiofrequency Ablation for Refractory Cancer-Related Leg Pain: A Case Report
    Praveen Reddy Elmati, Tyler J Wilkinson, Alexander Bautista
    Cureus.2024;[Epub]     CrossRef
  • Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain
    Giusy Guzzi, Attilio Della Torre, Andrea Bruni, Angelo Lavano, Vincenzo Bosco, Eugenio Garofalo, Domenico La Torre, Federico Longhini
    Journal of Anesthesia, Analgesia and Critical Care.2024;[Epub]     CrossRef
  • Radiofrecuencia del nervio supraescapular como estrategia analgésica para el dolor crónico de hombro. Revisión sistemática y metaanálisis
    J. Sebastián Infante, N. Blackburn, J. Felipe Vargas
    Revista Española de Anestesiología y Reanimación.2024; 71(9): 678.     CrossRef
  • Effect of pulsed radiofrequency to the suprascapular nerve (SSN) in treating frozen shoulder pain: A randomised controlled trial
    Ghada Mohammad Abo Elfadl, Ayman Mamdouh Osman, Yasmeen Alaa-Eldeen Elmasry, Sherif Sayed Abdelraheem, Manal Hassanien
    Journal of Perioperative Practice.2024;[Epub]     CrossRef
  • Radiofrequency of suprascapular nerve as an analgesic strategy for chronic pain management. Systematic review and meta-analysis
    J. Sebastián Infante, N. Blackburn, J. Felipe Vargas
    Revista Española de Anestesiología y Reanimación (English Edition).2024;[Epub]     CrossRef
  • Transforaminal Steroid Injection After Dorsal Root Ganglion Pulsed Radiofrequency (DRG-PRF): Impact on Pain Intensity and Disability
    Matteo Luigi Giuseppe Leoni, Fabrizio Micheli, David Michael Abbott, Marco Cascella, Giustino Varrassi, Pasquale Sansone, Roberto Gazzeri, Monica Rocco, Marco Mercieri
    Pain and Therapy.2024; 13(5): 1271.     CrossRef
  • Efficacy and Safety of Pulsed Radiofrequency of Dorsal Root Ganglion in Elderly Patient Population With Acute and Subacute Zoster‐Related Pain
    Gözde Dağıstan, Serdar Erdine, Massimiliano Valeriani
    Pain Research and Management.2024;[Epub]     CrossRef
  • Effectiveness of combining greater occipital nerve block and pulsed radiofrequency treatment in patients with chronic migraine: a double-blind, randomized controlled trial
    Tuba Tanyel Saraçoğlu, Ayten Bılır, Mehmet Sacit Güleç
    Head & Face Medicine.2024;[Epub]     CrossRef
  • Two-Centre Retrospective Analysis on Selective Sensory Denervation of Shoulder Joint by Means of Cooled Radiofrequency in Chronic Shoulder Pain
    Carola Santi, Thomas Haag, Christian Cooke, Michael Schatman, Andrea Tinnirello
    Journal of Pain Research.2024; Volume 17: 3139.     CrossRef
  • A central and peripheral dual neuromodulation strategy in pain management of zoster-associated pain
    Xuelian Li, Huaxiang Zhang, Xu Zhang, Ke Ma, Yan Lv, Tao Song, Gangwen Guo, Dong Huang
    Scientific Reports.2024;[Epub]     CrossRef
  • Pulsed Radiofrequency on Sphenopalatine Ganglion as the Interventional Pain Management in Cluster Headache Secondary to Sphenoid Meningioma
    Naomi Rahmasena, Mirza Koeshardiandi, Fajar Tri Mudianto
    Indonesian Journal of Anesthesiology and Reanimation.2024; 6(1): 32.     CrossRef
  • Comparison of two distinct needle tip positions in pulsed radiofrequency for herpes zoster‐related pain
    Shao‐jun Li, Dan Feng
    CNS Neuroscience & Therapeutics.2023; 29(7): 1881.     CrossRef
  • Previous Lumbar Spine Surgery Decreases the Therapeutic Efficacy of Dorsal Root Ganglion Pulsed Radiofrequency in Patients with Chronic Lumbosacral Radicular Pain
    Jiri Jandura, Milan Vajda, Roman Kostysyn, Jiri Vanasek, Eva Cermakova, Jan Zizka, Pavel Ryska
    Journal of Personalized Medicine.2023; 13(7): 1054.     CrossRef
  • Spinal Injections: A Narrative Review from a Surgeon’s Perspective
    Dong Ah Shin, Yoo Jin Choo, Min Cheol Chang
    Healthcare.2023; 11(16): 2355.     CrossRef
  • Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological Ca2+ Influx, Cytosolic ATP Level, Δψm, and pERK Compared to 4 Hz: An Insight on the Safety of Pulsed Radiofrequency in Pain Management
    Ristiawan Muji Laksono, Taufiq Agus Siswagama, Fa'urinda Riam Prabu Nery, Walter van der Weegen, Willy Halim
    Journal of Pain Research.2023; Volume 16: 3643.     CrossRef
  • Summary of the 48th KORSIS Symposium in 2023
    Min Cheol Chang
    International journal of Pain.2023; 14(2): 96.     CrossRef
  • The blind spot and challenges in pain management
    Min Cheol Chang
    Journal of Yeungnam Medical Science.2022; 39(3): 179.     CrossRef
  • Use of QR Codes for Promoting a Home-Based Therapeutic Exercise in Patients with Lumbar Disc Herniation and Lumbar Spinal Stenosis: A Prospective Randomized Study
    Min Cheol Chang, Donghwi Park, Yoo Jin Choo
    Journal of Pain Research.2022; Volume 15: 4065.     CrossRef
Review articles
Beneficial effects of intermittent fasting: a narrative review
Dae-Kyu Song, Yong-Woon Kim
J Yeungnam Med Sci. 2023;40(1):4-11.   Published online April 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00010
  • 9,241 View
  • 426 Download
  • 12 Web of Science
  • 20 Crossref
AbstractAbstract PDF
Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction. Moreover, intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects. In this review, the beneficial effects of intermittent fasting are discussed.

Citations

Citations to this article as recorded by  
  • Intermittent fasting and longevity: From animal models to implication for humans
    Olha Strilbytska, Svitlana Klishch, Kenneth B. Storey, Alexander Koliada, Oleh Lushchak
    Ageing Research Reviews.2024; 96: 102274.     CrossRef
  • Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females
    Purwo Sri Rejeki, Adi Pranoto, Deandra Maharani Widiatmaja, Dita Mega Utami, Nabilah Izzatunnisa, Sugiharto, Ronny Lesmana, Shariff Halim
    Sports.2024; 12(5): 116.     CrossRef
  • Effect of Intermittent Fasting Interventions for Treatment of Overweight and Obesity in Adults – A Systematic Review
    Teena Lal, S. J. Ajeet Arulkumar, S. Roopa
    Acta Medica International.2024; 11(1): 7.     CrossRef
  • Intermittent fasting influences immunity and metabolism
    Daniel M. Marko, Meghan O. Conn, Jonathan D. Schertzer
    Trends in Endocrinology & Metabolism.2024; 35(9): 821.     CrossRef
  • Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus
    Martín García-Juárez, Adamary García-Rodríguez, Gabriela Cruz-Carrillo, Orlando Flores-Maldonado, Miguel Becerril-Garcia, Lourdes Garza-Ocañas, Ivan Torre-Villalvazo, Alberto Camacho-Morales
    Molecular Neurobiology.2024;[Epub]     CrossRef
  • Impact of Intermittent Fasting and Dietary Restriction on Redox State, Energetic Metabolism, and Liver Injury in Common Bile Duct Ligation Model
    Dmitry S. Semenovich, Ljubava D. Zorova, Polina A. Abramicheva, Nadezda V. Andrianova, Andrey V. Elchaninov, Aleksandra S. Petrukhina, Irina B. Pevzner, Vasily N. Manskikh, Dmitry B. Zorov, Egor Y. Plotnikov
    Antioxidants.2024; 13(7): 835.     CrossRef
  • DOSE: a lifestyle philosophy for dementia prevention informed by drug development and epidemiology
    Timothy Daly
    Dementia & Neuropsychologia.2024;[Epub]     CrossRef
  • The effects of time‐restricted eating alone or in combination with probiotic supplementation in comparison with a calorie‐restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial
    Sepide Talebi, Sakineh Shab‐Bidar, Ashraf Moini, Hamed Mohammadi, Kurosh Djafarian
    Diabetes, Obesity and Metabolism.2024; 26(10): 4468.     CrossRef
  • The Combined Effect of Diets with Different Time Restriction and Low-intensity Aerobic Exercise on Metabolic Factors and Anthropometry in Overweight Middle-aged Men
    Hamid Vasfi, Hamid Mohebbi, Marefat Siahkouhian, Lotfollah Rezagholizadeh, Abouzar jorbonian
    Journal of Ardabil University of Medical Sciences.2024; 24(1): 58.     CrossRef
  • Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence
    Carla Pezzuoli, Giuseppe Biagini, Riccardo Magistroni
    Nutrients.2024; 16(16): 2676.     CrossRef
  • Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
    Rungroj Krittayaphong, Witcha Treesuwan, Pornpoj Pramyothin, Thammarak Songsangjinda, Yodying Kaolawanich, Weerachai Srivanichakorn, Preechaya Jangtawee, Ahthit Yindeengam, Prajak Tanapibunpon, Apichart Vanavichit
    Scientific Reports.2024;[Epub]     CrossRef
  • Exploring the Impact of Fasting and Fasting-Mimicking Diets on Type 2 Diabetes Management in Adults: A Systematic Review
    José Amilcar Rivera Regalado, Juan García, Isabella Ramirez, Plinio Hermosilla, Jose Rascon, Sergio José Fausto Girón
    Cureus.2024;[Epub]     CrossRef
  • As a phenomenon: Ramadan fasting improves olfactory performance
    Doğan Çakan, Hüseyin Baki Yılmaz, Harun Cansız, Haluk Çevik, Michael C. F. Tong, Begüm Bahar Yılmaz, Zeliha Kübra Çakan
    Laryngoscope Investigative Otolaryngology.2024;[Epub]     CrossRef
  • Artificial intelligence driven definition of food preference endotypes in UK Biobank volunteers is associated with distinctive health outcomes and blood based metabolomic and proteomic profiles
    Hana F. Navratilova, Anthony D. Whetton, Nophar Geifman
    Journal of Translational Medicine.2024;[Epub]     CrossRef
  • Fasting for clearer skin: Review article investigating the impact of intermittent fasting on dermatological conditions
    Hiba Fathimathul Harshiba, Nabeel Muhammed Rafi
    Cosmoderma.2024; 4: 124.     CrossRef
  • External factors affecting weight loss during intermittent fasting. Author's reply
    M. Khalil, H. Abdallah, G. Garruti, A.Di Ciaula, P. Portincasa
    European Journal of Internal Medicine.2024;[Epub]     CrossRef
  • The distinct mechanism regulating taurine homeostasis in mice: Nutrient availability affects taurine levels in the liver and energy restriction influences it in the intestine
    András Gregor, Arturo Auñon-Lopez, Marc Pignitter, Kalina Duszka
    Life Sciences.2024; 359: 123213.     CrossRef
  • Socio-demographic determinants of dietary choices and their impact on health in Spanish adults
    Elena Sandri, Eva Cantín Larumbe, Michela Capoferri, Germán Cerdá Olmedo, Lisa Ursula Werner, M. Jesús Vega-Bello
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling
    Wenzhen Yin, Lijun Sun, Yuan Liang, Chao Luo, Tiange Feng, Yunhua Zhang, Weizhen Zhang, Yue Yin
    The FASEB Journal.2023;[Epub]     CrossRef
  • Time-Restricted Feeding and Intermittent Fasting as Preventive Therapeutics: A Systematic Review of the Literature
    Arturo P Jaramillo, Javier Castells, Sabina Ibrahimli, Luisa Jaramillo, Rebeca R Briones Andriuoli, Denisse Moncada, Jhoanny C Revilla
    Cureus.2023;[Epub]     CrossRef
Current diagnosis and treatment of vestibular neuritis: a narrative review
Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi
J Yeungnam Med Sci. 2022;39(2):81-88.   Published online August 9, 2021
DOI: https://doi.org/10.12701/yujm.2021.01228
  • 65,535 View
  • 546 Download
  • 10 Web of Science
  • 15 Crossref
AbstractAbstract PDF
Vertigo is the sensation of self-motion of the head or body when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement. Representative peripheral vertigo disorders include benign paroxysmal positional vertigo, Ménière disease, and vestibular neuritis. Vestibular neuritis, also known as vestibular neuronitis, is the third most common peripheral vestibular disorder after benign paroxysmal positional vertigo and Ménière disease. The cause of vestibular neuritis remains unclear. However, a viral infection of the vestibular nerve or ischemia of the anterior vestibular artery is known to cause vestibular neuritis. In addition, recent studies on immune-mediated mechanisms as the cause of vestibular neuritis have been reported. The characteristic clinical features of vestibular neuritis are abrupt true-whirling vertigo lasting for more than 24 hours, and no presence of cochlear symptoms and other neurological symptoms and signs. To accurately diagnose vestibular neuritis, various diagnostic tests such as the head impulse test, bithermal caloric test, and vestibular-evoked myogenic potential test are conducted. Various treatments for vestibular neuritis have been reported, which are largely divided into symptomatic therapy, specific drug therapy, and vestibular rehabilitation therapy. Symptomatic therapies include generalized supportive care and administration of vestibular suppressants and antiemetics. Specific drug therapies include steroid therapy, antiviral therapy, and vasodilator therapy. Vestibular rehabilitation therapies include generalized vestibular and customized vestibular exercises.

Citations

Citations to this article as recorded by  
  • Vestibular function is associated with immune inflammatory response
    Zhaohui Song, Yuchuan Ding, Nathan Sim, Ho Jun Yun, Jing Feng, Pan Gu, Xiaokun Geng
    Reviews in the Neurosciences.2024; 35(3): 293.     CrossRef
  • Prevalence of Scarpa’s ganglion enhancement on high-resolution MRI imaging
    Clayton Siminski, John C Benson, Matthew L Carlson, John I Lane
    The Neuroradiology Journal.2024; 37(3): 332.     CrossRef
  • Vestibular rehabilitation for peripheral vestibular hypofunction: an interdisciplinary consensus
    N.L. Kunelskay, G.E. Ivanova, E.V. Baybakova, A.L. Guseva, V.A. Parfenov, M.V. Zamergrad, O.V. Zaitseva, O.A. Melnikov, A.A. Shmonin, M.N. Maltseva
    Vestnik otorinolaringologii.2024; 89(1): 52.     CrossRef
  • A Review of Calcitonin Gene-Related Peptide and Its Implications for Vestibular Disorders
    Richard Baron, Kristen K. Steenerson
    Current Treatment Options in Neurology.2024; 26(6): 203.     CrossRef
  • Evolution of Hyperventilation-Induced Nystagmus in Acute Unilateral Vestibulopathy—Interpretative Model and Etiopathogenetic Hypotheses
    Francesco Frati, Alessandra D’Orazio, Valeria Gambacorta, Giacomo Ciacca, Giampietro Ricci, Mario Faralli
    Audiology Research.2024; 14(3): 442.     CrossRef
  • Evaluating the impact of COVID-19 on vertigo and hearing impairment: A post-recovery analysis
    Sarah Alshehri, Khalid A. Alahmari
    Medicine.2024; 103(27): e38819.     CrossRef
  • Does dimenhydrinate delay recovery of vestibular ocular reflex in acute unilateral vestibulopathy? A retrospective comparative study
    Minah Shin, Chae-Young Kim, Ji Eun Choi, Jae Yun Jung, Min Young Lee
    Research in Vestibular Science.2024; 23(3): 89.     CrossRef
  • Vestibular Dysfunction in Patients With Sickle Cell Disease: A Systematic Review
    Jonathan Laredo, Sofia Torres-Small, Lin Wu, Tomoko Makishima, Celine Richard
    Otology & Neurotology.2024;[Epub]     CrossRef
  • Vertigo in the Setting of COVID-19 Infection: A Case Report
    Sanjana Devaragudi, Mohit Gupta
    Cureus.2023;[Epub]     CrossRef
  • Hospital Admission Profile Related to Inner Ear Diseases in England and Wales
    Esra’ O. Taybeh, Abdallah Y. Naser
    Healthcare.2023; 11(10): 1457.     CrossRef
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    E. V. Isakova
    Russian neurological journal.2023; 28(4): 5.     CrossRef
  • VESTIBULAR NEURONITIS: A CLINICAL EXAMPLE OF THE COURSE OF THE DISEASE USING BIOFEEDBACK (BOS)
    Geraskina M.M., Razzhivina K.S., Ustinov S.A.
    "Medical & pharmaceutical journal "Pulse".2023; : 30.     CrossRef
  • Acute vestibular neuritis: A rare complication after the adenoviral vector-based COVID-19 vaccine
    Hamze Shahali, Ramin Hamidi Farahani, Parham Hazrati, Ebrahim Hazrati
    Journal of NeuroVirology.2022; 28(4-6): 609.     CrossRef
  • A Holistic Approach to a Dizzy Patient: A Practical Update
    Ioannis Koukoulithras, Gianna Drousia, Spyridon Kolokotsios, Minas Plexousakis, Alexandra Stamouli, Charis Roussos, Eleana Xanthi
    Cureus.2022;[Epub]     CrossRef
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    Yajing Cheng, Jianrong Zheng, Ying Zhan, Cong Liu, Bihua Lu, Jun Hu
    Frontiers in Neurology.2022;[Epub]     CrossRef
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Eun Kyung Choi, Dong Gun Lim
J Yeungnam Med Sci. 2023;40(2):115-122.   Published online March 21, 2022
DOI: https://doi.org/10.12701/jyms.2022.00017
  • 4,134 View
  • 146 Download
  • 13 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

Citations

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    Badr Bahloul, Roua Chaabani, Yosri Zahra, Nesrine Kalboussi, Jamil Kraiem, Souad Sfar, Nathalie Mignet, Hassen ben Abdennebi
    Drug Delivery and Translational Research.2024; 14(1): 223.     CrossRef
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    Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
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    International Immunopharmacology.2022; 113: 109185.     CrossRef
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Focused Review article
The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review
Aung Chan Thu
J Yeungnam Med Sci. 2022;39(3):206-215.   Published online June 8, 2022
DOI: https://doi.org/10.12701/jyms.2022.00290
  • 5,519 View
  • 160 Download
  • 8 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Musculoskeletal pain is the most common pain reported by patients. Platelet-rich plasma (PRP) is widely used to treat musculoskeletal pain. However, the efficacy of PRP to treat this pain remains controversial. This review highlights the application of PRP in the treatment of musculoskeletal pain. PRP treatment appears to reduce pain and improve function in patients with musculoskeletal pain. However, there are limitations to the currently published studies. These limitations include the PRP preparation methods, type of activators, types of pathology to be treated, methods and times of administration, and association of PRP with other treatments.

Citations

Citations to this article as recorded by  
  • Injections of Platelet-Rich Plasma: An Emerging Novel Biological Cure for Low Back Pain?
    Adarsh Jayasoorya , Nitin Samal, Gajanan Pisulkar, Kaustav Datta, Kevin Kawde
    Cureus.2024;[Epub]     CrossRef
  • Platelet-Rich Plasma in the Management of Temporomandibular Joint Pain in Young Adults With Temporomandibular Disorder
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    Cureus.2024;[Epub]     CrossRef
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    V. H. Dzhyvak, I. M. Klishch, O. I. Khlibovska, S. S. Levenets
    Biopolymers and Cell.2024; 40(1): 3.     CrossRef
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    Vijay Sharma, Ulka Sakhalkar, Pratiksha Nadkarni, Rashmi Mishal, Dinesh Parandhaman, Kirti Vichare, Anjalina Francis, Mudit Khanna, Mohit Kukreja, Anuka Sharma
    Cureus.2024;[Epub]     CrossRef
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    Gordon Slater
    Journal of Clinical Medical Research.2024; : 1.     CrossRef
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Original article
Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study
Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon
J Yeungnam Med Sci. 2022;39(1):46-52.   Published online August 26, 2021
DOI: https://doi.org/10.12701/yujm.2021.01221
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AbstractAbstract PDF
Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.

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    Pattharaporn Sinthuprasith, Karn Wejaphikul, Dolrutai Puttawong, Hataitip Tang-Ngam, Naphatsorn Sanrattana, Kevalee Unachak, Prapai Dejkhamron
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  • The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
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Focused Review article
Pain in amyotrophic lateral sclerosis: a narrative review
Soyoung Kwak
J Yeungnam Med Sci. 2022;39(3):181-189.   Published online June 8, 2022
DOI: https://doi.org/10.12701/jyms.2022.00332
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AbstractAbstract PDF
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

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    Katie Stenson, T. E. Fecteau, L. O’Callaghan, P. Bryden, J. Mellor, J. Wright, L. Earl, O. Thomas, H. Iqbal, S. Barlow, S. Parvanta
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Review articles
Home mechanical ventilation in children with chronic respiratory failure: a narrative review
Soyoung Kwak
J Yeungnam Med Sci. 2023;40(2):123-135.   Published online May 27, 2022
DOI: https://doi.org/10.12701/jyms.2022.00227
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AbstractAbstract PDF
Advances in perinatal and pediatric intensive care and recent advances in mechanical ventilation during the last two decades have resulted in an exponential increase in the number of children undergoing home mechanical ventilation (HMV) treatment. Although its efficacy in chronic respiratory failure is well established, HMV in children is more complex than that in adults, and there are more considerations. This review outlines clinical considerations for HMV in children. The goal of HMV in children is not only to correct alveolar hypoventilation but also to maximize development as much as possible. The modes of ventilation and ventilator settings, including ventilation masks, tubing, circuits, humidification, and ventilator parameters, should be tailored to the patient’s individual characteristics. To ensure effective HMV, education for the parent and caregiver is important. HMV continues to change the scope of treatment for chronic respiratory failure in children in that it decreases respiratory morbidity and prolongs life spans. Further studies on this topic with larger scale and systemic approach are required to ensure the better outcomes in this population.

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  • The follow‐up of children on home invasive mechanical ventilation after hospital discharge
    Halime Nayır Büyükşahin, Ebru Yalcın
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    Gizem Özcan, Nazan Çobanoğlu
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    Secahattin Bayav, Nazan Çobanoğlu
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    Aysun Genç, Birkan Sonel Tur
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    Jennifer Henningfeld, Annie B. Friedrich, Grace Flanagan, Cynthia Griffith, Anna Hughes, Lisa Molkentine, Rebecca Steuart, Stuart Wilkinson, Christopher D. Baker
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    Sonia Khirani, Vivian Ducrot
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    Majid Keivanfar, Mahnaz Kheiri, Sharareh Babaie, Mohsen Reisi
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The use of animal models in rheumatoid arthritis research
Jin-Sun Kong, Gi Heon Jeong, Seung-Ah Yoo
J Yeungnam Med Sci. 2023;40(1):23-29.   Published online November 22, 2022
DOI: https://doi.org/10.12701/jyms.2022.00773
  • 4,958 View
  • 304 Download
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AbstractAbstract PDF
The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells.

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Original article
Impact of an emergency department resident strike during the coronavirus disease 2019 (COVID-19) pandemic in Daegu, South Korea: a retrospective cross-sectional study
Yo Han Cho, Jae Wan Cho, Hyun Wook Ryoo, Sungbae Moon, Jung Ho Kim, Sang-Hun Lee, Tae Chang Jang, Dong Eun Lee
J Yeungnam Med Sci. 2022;39(1):31-38.   Published online August 10, 2021
DOI: https://doi.org/10.12701/yujm.2021.01130
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AbstractAbstract PDF
Background
To prepare for future work stoppages in the medical industry, this study aimed to identify the effects of healthcare worker strikes on the mortality rate of patients visiting the emergency department (ED) at six training hospitals in Daegu, Korea.
Methods
We used a retrospective, cross-sectional, multicenter design to analyze the medical records of patients who visited six training hospitals in Daegu (August 21–September 8, 2020). For comparison, control period 1 was set as the same period in the previous year (August 21–September 8, 2019) and control period 2 was set as July 1–19, 2020. Patient characteristics including age, sex, and time of ED visit were investigated along with mode of arrival, length of ED stay, and in-hospital mortality. The experimental and control groups were compared using t-tests, and Mann-Whitney U-test, chi-square test, and Fisher exact tests, as appropriate. Univariate logistic regression was performed to identify significant factors, followed by multivariate logistic regression analysis.
Results
During the study period, 31,357 patients visited the ED, of which 7,749 belonged to the experimental group. Control periods 1 and 2 included 13,100 and 10,243 patients, respectively. No significant in-hospital mortality differences were found between study periods; however, the results showed statistically significant differences in the length of ED stay.
Conclusion
The ED resident strike did not influence the mortality rate of patients who visited the EDs of six training hospitals in Daegu. Furthermore, the number of patients admitted and the length of ED stay decreased during the strike period.

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Focused Review article
The pathophysiology of diabetic foot: a narrative review
Jiyoun Kim
J Yeungnam Med Sci. 2023;40(4):328-334.   Published online October 5, 2023
DOI: https://doi.org/10.12701/jyms.2023.00731
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AbstractAbstract PDF
An aging population and changes in dietary habits have increased the incidence of diabetes, resulting in complications such as diabetic foot ulcers (DFUs). DFUs can lead to serious disabilities, substantial reductions in patient quality of life, and high financial costs for society. By understanding the etiology and pathophysiology of DFUs, their occurrence can be prevented and managed more effectively. The pathophysiology of DFUs involves metabolic dysfunction, diabetic immunopathy, diabetic neuropathy, and angiopathy. The processes by which hyperglycemia causes peripheral nerve damage are related to adenosine triphosphate deficiency, the polyol pathway, oxidative stress, protein kinase C activity, and proinflammatory processes. In the context of hyperglycemia, the suppression of endothelial nitric oxide production leads to microcirculation atherosclerosis, heightened inflammation, and abnormal intimal growth. Diabetic neuropathy involves sensory, motor, and autonomic neuropathies. The interaction between these neuropathies forms a callus that leads to subcutaneous hemorrhage and skin ulcers. Hyperglycemia causes peripheral vascular changes that result in endothelial cell dysfunction and decreased vasodilator secretion, leading to ischemia. The interplay among these four preceding pathophysiological factors fosters the development and progression of infections in individuals with diabetes. Charcot neuroarthropathy is a chronic and progressive degenerative arthropathy characterized by heightened blood flow, increased calcium dissolution, and repeated minor trauma to insensate joints. Directly and comprehensively addressing the pathogenesis of DFUs could pave the way for the development of innovative treatment approaches with the potential to avoid the most serious complications, including major amputations.

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Original article
Classification of dental implant systems using cloud-based deep learning algorithm: an experimental study
Hyun Jun Kong
J Yeungnam Med Sci. 2023;40(Suppl):S29-S36.   Published online July 26, 2023
DOI: https://doi.org/10.12701/jyms.2023.00465
  • 3,056 View
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AbstractAbstract PDF
Background
This study aimed to evaluate the accuracy and clinical usability of implant system classification using automated machine learning on a Google Cloud platform.
Methods
Four dental implant systems were selected: Osstem TSIII, Osstem USII, Biomet 3i Os-seotite External, and Dentsply Sirona Xive. A total of 4,800 periapical radiographs (1,200 for each implant system) were collected and labeled based on electronic medical records. Regions of interest were manually cropped to 400×800 pixels, and all images were uploaded to Google Cloud storage. Approximately 80% of the images were used for training, 10% for validation, and 10% for testing. Google automated machine learning (AutoML) Vision automatically executed a neural architecture search technology to apply an appropriate algorithm to the uploaded data. A single-label image classification model was trained using AutoML. The performance of the mod-el was evaluated in terms of accuracy, precision, recall, specificity, and F1 score.
Results
The accuracy, precision, recall, specificity, and F1 score of the AutoML Vision model were 0.981, 0.963, 0.961, 0.985, and 0.962, respectively. Osstem TSIII had an accuracy of 100%. Osstem USII and 3i Osseotite External were most often confused in the confusion matrix.
Conclusion
Deep learning-based AutoML on a cloud platform showed high accuracy in the classification of dental implant systems as a fine-tuned convolutional neural network. Higher-quality images from various implant systems will be required to improve the performance and clinical usability of the model.

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DOI: https://doi.org/10.12701/jyms.2022.00689
  • 6,219 View
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AbstractAbstract PDF
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AbstractAbstract PDF
Headache is one of the most common neurological disorders in children and adults and can cause significant distress and disability in children and their families. The spectrum of pediatric headaches is broad, and the underlying etiology is variable. The symptoms and phenotypes of headaches in children may differ slightly from those in adults. It is important to have a good understanding of headaches in children and to distinguish between primary and secondary headaches through appropriate history assessment and neurological examination. Accurate diagnosis and appropriate drug selection are helpful for effective treatment. This article reviews headaches in children and adolescents, focusing on approaches for diagnosis and management.

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DOI: https://doi.org/10.12701/jyms.2021.01683
  • 8,238 View
  • 133 Download
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AbstractAbstract PDF
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