1Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Center for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, The Catholic University of Korea, Seoul, Korea
Copyright © 2023 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Conflicts of interest
No potential conflict of interest relevant to this article was reported.
Funding
This work was supported by grants from the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (2019R1A2C2010897).
Author contributions
Conceptualization, Data curation, Resources, Software: all authors; Formal analysis: SAY, GHJ; Funding acquisition, Validation: SAY, JSK; Methodology, Investigation, Project administration, Visualization, Supervision: SAY; Writing-original draft: SAY; Writing-review & editing: SAY, JSK.
Model | Immune cell | Cytokine |
---|---|---|
Collagen-induced arthritis | Monocytes/macrophages, dendritic cells, granulocytes, synoviocytes, T cells, B cells | TNF-α, IL-1β, IL-6, IL-17, IL-23, IL-32, MCP-1, MIP1 |
Antigen-induced arthritis | Monocytes/macrophages, dendritic cells, granulocytes, synoviocytes, T cells, B cells | TNF-α, IL-1β, IL-6, IL-17, IFN-γ |
Proteoglycan-induced arthritis | Monocytes/macrophages, | TNF-α, IL-1β, IL-6, IL-12, MCP-1, MIP1α, MIP-2 |
granulocytes, synoviocytes, | ||
T cells, B cells | ||
Collagen antibody-induced arthritis | Monocytes/macrophages, synoviocytes | IL-1β, IL-6, TNF |
HuTNF transgenic mice | Monocytes/macrophages, granulocytes | TNF-α, IL-1β, |
IL-1 receptor antagonist knockout mice | Monocytes/macrophages, synoviocytes | IL-1, IL-17 |
Variable | CIA | CAIA |
---|---|---|
Induction method | Type II collagen/CFA | Type II collagen monoclonal antibodies |
Period | 7–8 weeks | 1–2 weeks |
Mouse strains | Restricted to select mouse strains | Many mouse strains |
Feature of arthritis | Polyarthritis | Polyarthritis |
RF and ACPA | Positive | Negative |
TNF, tumor necrosis factor; IL, interleukin; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; IFN, interferon; HuTNF, human tumor necrosis factor.
CIA, collagen-induced arthritis; CAIA, collagen antibody-induced arthritis; CFA, complete Freund’s adjuvant; RF, rheumatoid factor; ACPA, anticitrullinated protein/peptide antibodies.