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Most-read articles are from the articles published in 2021 during the last 3 months.

Review articles
Long-term management of Graves disease: a narrative review
Hyo-Jeong Kim
J Yeungnam Med Sci. 2023;40(1):12-22.   Published online November 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00444
  • 3,456 View
  • 210 Download
  • 2 Citations
AbstractAbstract PDF
Graves disease (GD) is the most common cause of hyperthyroidism, accounting for more than 90% of cases in Korea. Patients with GD are treated with any of the following: antithyroid drugs (ATDs), radioactive iodine (RAI) therapy, or thyroidectomy. Most patients begin treatment with ATDs, and clinical guidelines suggest that the appropriate treatment period is 12 to 18 months. While RAI treatment and surgery manage thyrotoxicosis by destroying or removing thyroid tissue, ATDs control thyrotoxicosis by inhibiting thyroid hormone synthesis and preserving the thyroid gland. Although ATDs efficiently control thyrotoxicosis symptoms, they do not correct the main etiology of GD; therefore, frequent relapses can follow. Recently, a large amount of data has been collected on long-term ATDs for GD, and low-dose methimazole (MMZ) is expected to be a good option for remission. For the long-term management of recurrent GD, it is important to induce remission by evaluating the patient’s drug response, stopping ATDs at an appropriate time, and actively switching to surgery or RAI therapy, if indicated. Continuing drug treatment for an extended time is now encouraged in patients with a high possibility of remission with low-dose MMZ. It is also important to pay attention to the quality of life of the patients. This review aimed to summarize the appropriate treatment methods and timing of treatment transition in patients who relapsed several times while receiving treatment for GD.

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  • Total Thyroidectomy – A Cost-effective Alternative to Anti-Thyroid Drugs in the Management of Grave's Disease
    Erivelto Volpi, Leonardo M. Volpi
    Clinical Thyroidology.2023; 35(5): 183.     CrossRef
  • Evaluation of the Abbott Alinity i Thyroid-Stimulating Hormone Receptor Antibody (TRAb) Chemiluminescent Microparticle Immunoassay (CMIA)
    Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
    Diagnostics.2023; 13(16): 2707.     CrossRef
Current diagnosis and treatment of vestibular neuritis: a narrative review
Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi
J Yeungnam Med Sci. 2022;39(2):81-88.   Published online August 9, 2021
DOI: https://doi.org/10.12701/yujm.2021.01228
  • 8,070 View
  • 333 Download
  • 5 Citations
AbstractAbstract PDF
Vertigo is the sensation of self-motion of the head or body when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement. Representative peripheral vertigo disorders include benign paroxysmal positional vertigo, Ménière disease, and vestibular neuritis. Vestibular neuritis, also known as vestibular neuronitis, is the third most common peripheral vestibular disorder after benign paroxysmal positional vertigo and Ménière disease. The cause of vestibular neuritis remains unclear. However, a viral infection of the vestibular nerve or ischemia of the anterior vestibular artery is known to cause vestibular neuritis. In addition, recent studies on immune-mediated mechanisms as the cause of vestibular neuritis have been reported. The characteristic clinical features of vestibular neuritis are abrupt true-whirling vertigo lasting for more than 24 hours, and no presence of cochlear symptoms and other neurological symptoms and signs. To accurately diagnose vestibular neuritis, various diagnostic tests such as the head impulse test, bithermal caloric test, and vestibular-evoked myogenic potential test are conducted. Various treatments for vestibular neuritis have been reported, which are largely divided into symptomatic therapy, specific drug therapy, and vestibular rehabilitation therapy. Symptomatic therapies include generalized supportive care and administration of vestibular suppressants and antiemetics. Specific drug therapies include steroid therapy, antiviral therapy, and vasodilator therapy. Vestibular rehabilitation therapies include generalized vestibular and customized vestibular exercises.

Citations

Citations to this article as recorded by  
  • Vertigo in the Setting of COVID-19 Infection: A Case Report
    Sanjana Devaragudi, Mohit Gupta
    Cureus.2023;[Epub]     CrossRef
  • Hospital Admission Profile Related to Inner Ear Diseases in England and Wales
    Esra’ O. Taybeh, Abdallah Y. Naser
    Healthcare.2023; 11(10): 1457.     CrossRef
  • Acute vestibular neuritis: A rare complication after the adenoviral vector-based COVID-19 vaccine
    Hamze Shahali, Ramin Hamidi Farahani, Parham Hazrati, Ebrahim Hazrati
    Journal of NeuroVirology.2022; 28(4-6): 609.     CrossRef
  • A Holistic Approach to a Dizzy Patient: A Practical Update
    Ioannis Koukoulithras, Gianna Drousia, Spyridon Kolokotsios, Minas Plexousakis, Alexandra Stamouli, Charis Roussos, Eleana Xanthi
    Cureus.2022;[Epub]     CrossRef
  • Identification of hub genes and pathophysiological mechanism related to acute unilateral vestibulopathy by integrated bioinformatics analysis
    Yajing Cheng, Jianrong Zheng, Ying Zhan, Cong Liu, Bihua Lu, Jun Hu
    Frontiers in Neurology.2022;[Epub]     CrossRef
Lactate: a multifunctional signaling molecule
Tae-Yoon Lee
Yeungnam Univ J Med. 2021;38(3):183-193.   Published online February 18, 2021
DOI: https://doi.org/10.12701/yujm.2020.00892
  • 17,076 View
  • 439 Download
  • 24 Citations
AbstractAbstract PDF
Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.

Citations

Citations to this article as recorded by  
  • B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
    Kevin Li, Maria Romero, Macarena Cañardo, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg, Daniela Frasca
    Mechanisms of Ageing and Development.2023; 209: 111742.     CrossRef
  • The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
    Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
    Genes & Diseases.2023; 10(5): 2029.     CrossRef
  • Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
    Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang
    Cell Biology International.2023; 47(2): 295.     CrossRef
  • Insights on the role of l-lactate as a signaling molecule in skin aging
    Salvatore Chirumbolo, Dario Bertossi, Pierre Magistretti
    Biogerontology.2023; 24(5): 709.     CrossRef
  • Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions
    Maria Szrejder, Marlena Typiak, Piotr Pikul, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska
    European Journal of Cell Biology.2023; 102(2): 151298.     CrossRef
  • Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus
    Andreas Hoffmann, Alexander Franz, Thomas Walther, Christian Löser
    Applied Microbiology and Biotechnology.2023; 107(5-6): 1635.     CrossRef
  • Lactate, histone lactylation and cancer hallmarks
    Xinyu Lv, Yingying Lv, Xiaofeng Dai
    Expert Reviews in Molecular Medicine.2023;[Epub]     CrossRef
  • Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
    Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
    Aging.2023;[Epub]     CrossRef
  • Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
    Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni, Veera Venkata Satyanarayana Reddy Karri
    Biomedicine & Pharmacotherapy.2023; 161: 114540.     CrossRef
  • Immunomodulatory Properties of Probiotics and Their Derived Bioactive Compounds
    Christina Thoda, Maria Touraki
    Applied Sciences.2023; 13(8): 4726.     CrossRef
  • Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer
    Ting Wang, Zeng Ye, Zheng Li, De‐sheng Jing, Gui‐xiong Fan, Meng‐qi Liu, Qi‐feng Zhuo, Shun‐rong Ji, Xian‐jun Yu, Xiao‐wu Xu, Yi Qin
    Cell Proliferation.2023;[Epub]     CrossRef
  • Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets
    Zisis Kozlakidis, Patricia Shi, Ganna Abarbanel, Carolina Klein, Adonis Sfera
    BioTech.2023; 12(2): 38.     CrossRef
  • High-concentrate diet elevates histone lactylation mediated by p300/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows
    Lairong Wang, Yan Wang, Meijuan Meng, Nana Ma, Guozhen Wei, Ran Huo, Guangjun Chang, Xiangzhen Shen
    Microbial Pathogenesis.2023; 180: 106135.     CrossRef
  • ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation
    Seung-Hwa Woo, Yun Jeong Mo, Yun-Il Lee, Ji Hwan Park, Daehee Hwang, Tae Jun Park, Hee Young Kang, Sang Chul Park, Young-Sam Lee
    Journal of Investigative Dermatology.2023;[Epub]     CrossRef
  • Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia
    Qianting Deng, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
    Experimental Neurology.2023; 367: 114450.     CrossRef
  • Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
    Chuan Cheng, Zhiqiang Xu, Cao Yang, Xinghuo Wu
    Medical Hypotheses.2022; 159: 110758.     CrossRef
  • A bioorthogonal chemical reporter for the detection and identification of protein lactylation
    Yanan Sun, Yanchi Chen, Tao Peng
    Chemical Science.2022; 13(20): 6019.     CrossRef
  • Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
    Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
    Pharmacological Research.2022; 181: 106270.     CrossRef
  • Understanding lactate sensing and signalling
    Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro
    Trends in Endocrinology & Metabolism.2022; 33(10): 722.     CrossRef
  • Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
    Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Alvarez-Mon, Ana M. Gomez-Lahoz, Jorge Monserrat, Maria Llavero-Valero, Fernando Ruiz-Grande, Santiago Coca, Melchor Alvarez-Mon, Julia Buján, Natalio García-Honduvilla, Jose V. Saz, Miguel A. Orte
    Journal of Personalized Medicine.2022; 12(10): 1642.     CrossRef
  • Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
    Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna
    EMBO reports.2022;[Epub]     CrossRef
  • Crosstalk between glucose metabolism, lactate production and immune response modulation
    Lei Ye, Yi Jiang, Mingming Zhang
    Cytokine & Growth Factor Reviews.2022; 68: 81.     CrossRef
  • Metabolic orchestration of the wound healing response
    Sabine A. Eming, Peter J. Murray, Edward J. Pearce
    Cell Metabolism.2021; 33(9): 1726.     CrossRef
  • Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer
    Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Kelly McCann, Leonie Voorwerk, Javier I. J. Orozco, Miquel Ensenyat-Mendez, Borja Sesé, Maggie L. DiNome, Diego M. Marzese
    Cancers.2021; 13(16): 4139.     CrossRef
Classification of endometriosis
Soo-Young Lee, Yu-Jin Koo, Dae-Hyung Lee
Yeungnam Univ J Med. 2021;38(1):10-18.   Published online August 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00444
  • 19,787 View
  • 636 Download
  • 37 Citations
AbstractAbstract PDF
Endometriosis is a chronic disease associated with pelvic pain and infertility. Several classification systems for the severity of endometriosis have been proposed. Of these, the revised American Society for Reproductive Medicine classification is the most well-known. The ENZIAN classification was developed to classify deep infiltrating endometriosis and focused on the retroperitoneal structures. The endometriosis fertility index was developed to predict the fertility outcomes in patients who underwent surgery for endometriosis. Finally, the American Association of Gynecological Laparoscopists classification is currently being developed, for which 30 endometriosis experts are analyzing and researching data by assigning scores to categories considered important; however, it has not yet been fully validated and published. Currently, none of the classification systems are considered the gold standard. In this article, we review the classification systems, identify their pros and cons, and discuss what improvements need to be made to each system in the future.

Citations

Citations to this article as recorded by  
  • Ultrasound Characteristics and Scanning Techniques of Uterosacral Ligaments for the Diagnosis of Endometriosis
    Shae Maple, K Jane Chalmers, Eva Bezak, Katelyn Henry, Nayana Parange
    Journal of Ultrasound in Medicine.2023; 42(6): 1193.     CrossRef
  • The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis
    Ewa Skarżyńska, Monika Wróbel, Hanna Zborowska, Mateusz Franciszek Kołek, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski,
    International Journal of Molecular Sciences.2023; 24(2): 1619.     CrossRef
  • Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study
    Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Beata Smolarz
    Genes.2023; 14(1): 152.     CrossRef
  • Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis
    Brunella Zizolfi, Virginia Foreste, Simona Bonavita, Valentina Rubino, Giuseppina Ruggiero, Vincenzo Brescia Morra, Roberta Lanzillo, Antonio Carotenuto, Francesca Boscia, Maurizio Taglialatela, Maurizio Guida
    Journal of Clinical Medicine.2023; 12(5): 2043.     CrossRef
  • Rectal endometriosis imaging: A case based pictorial essay
    Garvit D. Khatri, Deepashri Basavalingu, Nitin Chaubal, Manjiri Dighe
    WFUMB Ultrasound Open.2023; 1(1): 100002.     CrossRef
  • KRAS mutations and endometriosis burden of disease
    Natasha L Orr, Arianne Albert, Yang Doris Liu, Amy Lum, JooYoon Hong, Catalina L Ionescu, Janine Senz, Tayyebeh M Nazeran, Anna F Lee, Heather Noga, Kate Lawrenson, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Michael S Anglesio, Paul J Yong
    The Journal of Pathology: Clinical Research.2023; 9(4): 302.     CrossRef
  • The Clinical Presentation of Endometriosis and Its Association to Current Surgical Staging
    Matilda Shaked Ashkenazi, Ole Linvåg Huseby, Gard Kroken, Marcela Trocha, Aurora Henriksson, Hanna Jasiak, Karen Cuartas, Alessandra Loschiavo, Isabella Kuhn, Dina Støve, Hanna Grindahl, Emilia Latour, Mathias Melbø, Katrine Holstad, Sebastian Kwiatkowski
    Journal of Clinical Medicine.2023; 12(7): 2688.     CrossRef
  • Evaluation and management of endometriosis
    T. Yoldemir
    Climacteric.2023; 26(3): 248.     CrossRef
  • COX isozymes and non-uniform neoangiogenesis: What is their role in endometriosis?
    Andrea Caruana, Charles Savona-Ventura, Jean Calleja-Agius
    Prostaglandins & Other Lipid Mediators.2023; 167: 106734.     CrossRef
  • Time to move beyond surgical classification systems for endometriosis
    María Isabel Hernández Cardona, Christana Ajewole, Hannah Lewis, Jorge F. Carrillo, Mario E. Castellanos, Stefanie Barish, Juan Diego Villegas Echeverri, Georgine Lamvu
    International Journal of Gynecology & Obstetrics.2023; 163(1): 58.     CrossRef
  • Antimüllerian hormone (AMH) and age as predictors of preimplantation genetic testing for aneuploidies (PGT-A) cycle outcomes and blastocyst quality on day 5 in women undergoing in vitro fertilization (IVF)
    A. Arnanz, A. Bayram, I. Elkhatib, A. Abdala, A. El-Damen, R. Patel, B. Lawrenz, L. Melado, H. Fatemi, N. De Munck
    Journal of Assisted Reproduction and Genetics.2023; 40(6): 1467.     CrossRef
  • Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis
    Shulin Zhong, Yuzhen Liang, Zhixi Wu, Li Wei
    Journal of Reproductive Immunology.2023; 158: 103969.     CrossRef
  • Psychological hallmarks of endometriosis with emphasis on sexual dysfunction, stress, anxiety and depressive symptoms
    Ludek Fiala, Jiri Lenz, Zdenek Adamik, Rachel Sajdlova, Daniela Kestlerova, Vaclav Vetvicka
    International Clinical Pathology Journal.2023; 10(1): 45.     CrossRef
  • Detection of Endometriosis Lesions Using Gd-Based Collagen I Targeting Probe in Murine Models of Endometriosis
    Nazanin Talebloo, Maria Ariadna Ochoa Bernal, Elizabeth Kenyon, Christiane L. Mallett, Asgerally Fazleabas, Anna Moore
    Molecular Imaging and Biology.2023;[Epub]     CrossRef
  • Exosomal microRNAs and long noncoding RNAs: as novel biomarkers for endometriosis
    Elahe Soltani-Fard, Marzieh Asadi, Sina Taghvimi, Asma Vafadar, Parisa Vosough, Amir Tajbakhsh, Amir Savardashtaki
    Cell and Tissue Research.2023;[Epub]     CrossRef
  • Use of the Free Endometriosis Risk Advisor App as a Non-Invasive Screening Test for Endometriosis in Patients with Chronic Pelvic Pain and/or Unexplained Infertility
    Camran Nezhat, Ellie Armani, Hsuan-Chih Carolina Chen, Zahra Najmi, Steven R. Lindheim, Ceana Nezhat
    Journal of Clinical Medicine.2023; 12(16): 5234.     CrossRef
  • Comparison of Clinical and Reproductive Outcomes between Adenomyomectomy and Myomectomy
    Kristyna Hlinecka, Michal Mara, Barbora Boudova, Zdenka Lisa, Adela Richtarova, David Kuzel
    Journal of Minimally Invasive Gynecology.2022; 29(3): 392.     CrossRef
  • Evaluating Surgical Complexity of Endoscopic Hysterectomy: An Inter-rater and Intra-rater Agreement Study of Novel Scoring Tool
    Meenal Misal, Marlene Girardo, Sadikah Behbehani, Vimee Bindra, Mark R. Hoffman, Wei How Lim, Courtney Martin, Sukrant K. Mehta, Alysha Nensi, Thiers Soares, Deborah Taylor, Steve Wagner, Kelly N. Wright, Megan N. Wasson
    Journal of Minimally Invasive Gynecology.2022; 29(5): 683.     CrossRef
  • MRI in the Diagnosis of Endometriosis and Related Diseases
    Aki Kido, Yuki Himoto, Yusaku Moribata, Yasuhisa Kurata, Yuji Nakamoto
    Korean Journal of Radiology.2022; 23(4): 426.     CrossRef
  • Role of Robotic Surgery in Benign Gynecology
    Mireille D. Truong, Lauren N. Tholemeier
    Obstetrics and Gynecology Clinics of North America.2022; 49(2): 273.     CrossRef
  • NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis
    Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang, Yongdong Dai
    Journal of Reproductive Immunology.2022; 152: 103649.     CrossRef
  • Endometriosis: A Disease with Few Direct Treatment Options
    Patricia Ribeiro de Carvalho França, Anna Carolina Pereira Lontra, Patricia Dias Fernandes
    Molecules.2022; 27(13): 4034.     CrossRef
  • The Role of the Immune System in the Development of Endometriosis
    Monika Abramiuk, Ewelina Grywalska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz, Paulina Niedźwiedzka-Rystwej
    Cells.2022; 11(13): 2028.     CrossRef
  • Transvaginal Ultrasound vs. Magnetic Resonance Imaging (MRI) Value in Endometriosis Diagnosis
    Alexandra Baușic, Ciprian Coroleucă, Cătălin Coroleucă, Diana Comandașu, Roxana Matasariu, Andrei Manu, Francesca Frîncu, Claudia Mehedințu, Elvira Brătilă
    Diagnostics.2022; 12(7): 1767.     CrossRef
  • History of Endometriosis Is Independently Associated with an Increased Risk of Ovarian Cancer
    Antonio Sarría-Santamera, Zaukiya Khamitova, Arnur Gusmanov, Milan Terzic, Mar Polo-Santos, Miguel A. Ortega, Angel Asúnsolo
    Journal of Personalized Medicine.2022; 12(8): 1337.     CrossRef
  • Surgical Classification of Endometriosis
    João Nogueira Neto, Mauricio Simões Abrão, Eduardo Schor, Julio Cesar Rosa-e-Silva
    Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics.2022; 44(08): 737.     CrossRef
  • Analysis of Long Non-Coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 Expression in Endometriosis
    Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Radosław Kołaciński, Magdalena M. Michalska, Dariusz Samulak, Beata Smolarz
    International Journal of Molecular Sciences.2022; 23(19): 11583.     CrossRef
  • Colorectal infiltrating deep endometriosis: Laparoscopic treatment. A case report
    Giuseppe Di Buono, Matilde Micheli, Gaia Russo, Roberta Vella, Giuseppe Amato, Girolamo Geraci, Antonino Agrusa
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden
    Emily Redwood, Virginie Lam, Ryusuke Takechi, Deborah Anne Kerr, Connie Jackaman, Arazu Sharif, John Charles Louis Mamo
    Frontiers in Pain Research.2022;[Epub]     CrossRef
  • Histotyping and grading of endometriosis and its association with clinico-pathological parameters
    Jyothika Litson, Rini Agnes, Gayatri Ravikumar
    Journal of Obstetrics and Gynaecology.2022; 42(8): 3628.     CrossRef
  • Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis
    Damian Warzecha, Julia Załęcka, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Sz
    International Journal of Molecular Sciences.2022; 23(24): 15669.     CrossRef
  • Progestins in the symptomatic management of endometriosis: a meta-analysis on their effectiveness and safety
    Jon-Benay Mitchell, Sarentha Chetty, Fatima Kathrada
    BMC Women's Health.2022;[Epub]     CrossRef
  • Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis
    Sixue Wang, Mingyu Yi, Xinyue Zhang, Tingting Zhang, Li Jiang, Le Cao, Yuxin Zhou, Xiaoling Fang
    Reproductive BioMedicine Online.2021; 42(6): 1057.     CrossRef
  • Structured report for dynamic ultrasonography in patients with suspected or known endometriosis: Recommendations of the International Society for Gynecologic Endoscopy (ISGE)
    Dusan Djokovic, Patrícia Pinto, Bruno J. van Herendael, Antonio Simone Laganà, Viju Thomas, Jörg Keckstein
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2021; 263: 252.     CrossRef
  • Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay
    Omar T. Sims, Jhumka Gupta, Stacey A. Missmer, Irene O. Aninye
    International Journal of Environmental Research and Public Health.2021; 18(15): 8210.     CrossRef
  • AAGL 2021 Endometriosis Classification: An Anatomy-based Surgical Complexity Score
    Mauricio S. Abrao, Marina Paula Andres, Charles E. Miller, Julian A. Gingold, Mariona Rius, Joao Siufi Neto, Francisco Carmona
    Journal of Minimally Invasive Gynecology.2021; 28(11): 1941.     CrossRef
  • Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis
    Xin Meng, Ying Li, Qingxue Li, Jian Yang, Mingli An, Xinping Fu, Shuancheng Zhang, Jingwei Chen
    Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
Avulsion injuries: an update on radiologic findings
Changwon Choi, Sun Joo Lee, Hye Jung Choo, In Sook Lee, Sung Kwan Kim
Yeungnam Univ J Med. 2021;38(4):289-307.   Published online August 13, 2021
DOI: https://doi.org/10.12701/yujm.2021.01102
  • 6,811 View
  • 145 Download
  • 1 Citations
AbstractAbstract PDF
Avulsion injuries result from the application of a tensile force to a musculoskeletal unit or ligament. Although injuries tend to occur more commonly in skeletally immature populations due to the weakness of their apophysis, adults may also be subject to avulsion fractures, particularly those with osteoporotic bones. The most common sites of avulsion injuries in adolescents and children are apophyses of the pelvis and knee. In adults, avulsion injuries commonly occur within the tendon due to underlying degeneration or tendinosis. However, any location can be involved in avulsion injuries. Radiography is the first imaging modality to diagnose avulsion injury, although advanced imaging modalities are occasionally required to identify subtle lesions or to fully delineate the extent of the injury. Ultrasonography has a high spatial resolution with a dynamic assessment potential and allows the comparison of a bone avulsion with the opposite side. Computed tomography is more sensitive for depicting a tiny osseous fragment located adjacent to the expected attachment site of a ligament, tendon, or capsule. Moreover, magnetic resonance imaging is the best imaging modality for the evaluation of soft tissue abnormalities, especially the affected muscles, tendons, and ligaments. Acute avulsion injuries usually manifest as avulsed bone fragments. In contrast, chronic injuries can easily mimic other disease processes, such as infections or neoplasms. Therefore, recognizing the vulnerable sites and characteristic imaging features of avulsion fractures would be helpful in ensuring accurate diagnosis and appropriate patient management. To this end, familiarity with musculoskeletal anatomy and mechanism of injury is necessary.

Citations

Citations to this article as recorded by  
  • Isolated fracture of the lesser tuberosity of the humerus – a rare injury that requires surgical treatment
    Miodrag Glisic, Vladan Stevanovic, Aleksandar Jevtic, Uros Jovicevic, Ivan Jankovic
    Vojnosanitetski pregled.2023; 80(3): 279.     CrossRef
Hepatic encephalopathy on magnetic resonance imaging and its uncertain differential diagnoses: a narrative review
Chun Geun Lim, Myong Hun Hahm, Hui Joong Lee
J Yeungnam Med Sci. 2023;40(2):136-145.   Published online January 10, 2023
DOI: https://doi.org/10.12701/jyms.2022.00689
  • 2,364 View
  • 153 Download
  • 1 Citations
AbstractAbstract PDF
Hepatic encephalopathy (HE) is a severe neuropsychiatric abnormality in patients with either acute or chronic liver failure. Typical brain magnetic resonance imaging findings of HE are bilateral basal ganglia high signal intensities due to manganese deposition in chronic liver disease and hyperintensity in T2, fluid-attenuated inversion recovery, or diffusion-weighted imaging (DWI) with hemispheric white matter changes including the corticospinal tract. Low values on apparent diffusion coefficient mapping of the affected area on DWI, indicating cytotoxic edema, can be observed in acute HE. However, neuropsychological impairment in HE ranges from mild deficits in psychomotor abilities affecting quality of life to stupor or coma with higher grades of hepatic dysfunction. In particular, the long-lasting compensatory mechanisms for the altered metabolism in chronic liver disease make HE imaging results variable. Therefore, the clinical relevance of imaging findings is uncertain and differentiating HE from other metabolic diseases can be difficult. The recent introduction of concepts such as “acute-on-chronic liver failure (ACLF),” a new clinical entity, has led to a change in the clinical view of HE. Accordingly, there is a need to establish a corresponding concept in the field of neuroimaging diagnosis. Herein, we review HE from a historical and etiological perspective to increase understanding of brain imaging and help establish an imaging approach for advanced new concepts such as ACLF. The purpose of this manuscript is to provide an understanding of HE by reviewing neuroimaging findings based on pathological and clinical concepts of HE, thereby assisting in neuroimaging interpretation.

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  • Rule out all differential causes before attributing cerebral bleeding to 5-aminolevulinic acid
    Josef Finsterer, Sounira Mehri
    Child's Nervous System.2023; 39(4): 847.     CrossRef
Can antioxidants be effective therapeutics for type 2 diabetes?
Soyoung Park, So-Young Park
Yeungnam Univ J Med. 2021;38(2):83-94.   Published online October 8, 2020
DOI: https://doi.org/10.12701/yujm.2020.00563
  • 8,695 View
  • 195 Download
  • 10 Citations
AbstractAbstract PDF
The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

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    Jiwan S. Sidhu, Tasleem Zafar, Abdulwahab Almusallam, Muslim Ali, Amani Al-Othman
    Arab Gulf Journal of Scientific Research.2023;[Epub]     CrossRef
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    M.Q. Al-Mssallem
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    Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
    Biogerontology.2023; 24(5): 609.     CrossRef
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    Tyler Touchet, Samuel Briggs, Lance Graul, Duncan J. Maitland
    ACS Applied Bio Materials.2022; 5(6): 2633.     CrossRef
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    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome
    Sahar Mazloomi, Nasrin Sheikh, Marzieh Sanoee Farimani, Shamim Pilehvari, Raffaele Pezzani
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
    Mayadah Bashir Shehadeh, Ghadeer A. R. Y. Suaifan, Ala’ Mustafa Abu-Odeh
    Molecules.2021; 26(14): 4333.     CrossRef
  • An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults
    Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis
    Applied Sciences.2021; 11(17): 7818.     CrossRef
  • Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
    Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
    Journal of Inflammation Research.2021; Volume 14: 6749.     CrossRef
  • Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice
    Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
    Redox Biology.2020; : 101823.     CrossRef
Psychiatric understanding and treatment of patients with amputations
So-Hye Jo, Suk-Hun Kang, Wan-Seok Seo, Bon-Hoon Koo, Hye-Geum Kim, Seok-Ho Yun
Yeungnam Univ J Med. 2021;38(3):194-201.   Published online May 11, 2021
DOI: https://doi.org/10.12701/yujm.2021.00990
  • 6,873 View
  • 204 Download
  • 2 Citations
AbstractAbstract PDF
Amputation changes the lives of patients and their families. Consequently, the patient must adapt to altered body function and image. During this adaptation process, psychological problems, such as depression, anxiety, and posttraumatic stress disorder, can occur. The psychological difficulties of patients with amputation are often accepted as normal responses that are often poorly recognized by patients, family members, and their primary physicians. Psychological problems can interfere with rehabilitation and cause additional psychosocial problems. Therefore, their early detection and treatment are important. A multidisciplinary team approach, including mental health professionals, is ideal for comprehensive and biopsychosocial management. Mental health professionals could help patients set realistic goals and use adaptive coping styles. Psychiatric approaches should consider the physical, cognitive, psychological, social, and spiritual functions and social support systems before and after amputation. The abilities and limitations of physical, cognitive, psychological, and social functions should also be considered. To improve the patient’s adaptation, psychological interventions such as short-term psychotherapy, cognitive behavioral therapy, mindfulness meditation, biofeedback, and group psychotherapy can be helpful.

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  • Effect of Increasing Assistance From a Powered Prosthesis on Weight-Bearing Symmetry, Effort, and Speed During Stand-Up in Individuals With Above-Knee Amputation
    Grace R. Hunt, Sarah Hood, Lukas Gabert, Tommaso Lenzi
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 11.     CrossRef
  • The Effect of Motivational Interview-Based Counseling in Individuals With Amputation: A Randomized Controlled Trial in Turkey
    Gülhan Küçük Öztürk, Nuray Şimşek
    Rehabilitation Nursing.2023; 48(5): 160.     CrossRef
Gallbladder polyps: evolving approach to the diagnosis and management
Kook Hyun Kim
Yeungnam Univ J Med. 2021;38(1):1-9.   Published online May 15, 2020
DOI: https://doi.org/10.12701/yujm.2020.00213
  • 20,741 View
  • 425 Download
  • 6 Citations
AbstractAbstract PDF
Gallbladder (GB) polyp is a mucosal projection into the GB lumen. With increasing health awareness, GB polyps are frequently found using ultrasonography during health screening. The prevalence of GB polyps ranges between 1.3% and 9.5%. Most patients are asymptomatic and have benign characteristics. Of the nonneoplastic polyps, cholesterol polyps are most common, accounting for 60%–70% of lesions. However, a few polyps have malignant potential. Currently, the guidelines recommend laparoscopic cholecystectomy for polyps larger than 1 cm in diameter due to their malignan potential. The treatment algorithm can be influenced by the size, shape, and numbers of polyps, old age (>50 years), the presence of primary sclerosing cholangitis, and gallstones. This review summarizes the commonly recognized concepts on GB polyps from diagnosis to an algorithm of treatment.

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    Huifang Pang, Quan Man, Li Min, Zheng Zhang, Shengtao Zhu, Shuyue Yang, Yao Xu, Haijun Hou, Shutian Zhang, Peng Li
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    Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G. Shelat
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    Rachel Runde, Edward D. Auyang, Raye Ng, Kaysey Llorente, Hina Arif Tiwari, Shana Elman, William M. Thompson
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    S. N. Perekhodov, D. V. Nikolaev, S. S. Saidov
    Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2021; 11(4): 88.     CrossRef
  • Is there a role for growth status in distinguishing gallbladder adenomas from cholesterol polyps? – A retrospective study based on 520 cholecystectomy patients
    Wenqing Bao, Anan Xu, Shubin Ni, Bo Wang, Humaira Urmi, Bin Zhao, Yongmei You, Hai Hu
    Scandinavian Journal of Gastroenterology.2021; 56(12): 1450.     CrossRef
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    G. V. Shavkuta
    South Russian Journal of Therapeutic Practice.2020; 1(2): 78.     CrossRef
Beneficial effects of intermittent fasting: a narrative review
Dae-Kyu Song, Yong-Woon Kim
J Yeungnam Med Sci. 2023;40(1):4-11.   Published online April 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00010
  • 3,954 View
  • 228 Download
  • 2 Citations
AbstractAbstract PDF
Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction. Moreover, intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects. In this review, the beneficial effects of intermittent fasting are discussed.

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  • Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling
    Wenzhen Yin, Lijun Sun, Yuan Liang, Chao Luo, Tiange Feng, Yunhua Zhang, Weizhen Zhang, Yue Yin
    The FASEB Journal.2023;[Epub]     CrossRef
  • Time-Restricted Feeding and Intermittent Fasting as Preventive Therapeutics: A Systematic Review of the Literature
    Arturo P Jaramillo, Javier Castells, Sabina Ibrahimli, Luisa Jaramillo, Rebeca R Briones Andriuoli, Denisse Moncada, Jhoanny C Revilla
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Hypertension and cognitive dysfunction: a narrative review
Eun-Jin Cheon
J Yeungnam Med Sci. 2023;40(3):225-232.   Published online November 29, 2022
DOI: https://doi.org/10.12701/jyms.2022.00605
  • 1,742 View
  • 119 Download
  • 2 Citations
AbstractAbstract PDF
Cognitive dysfunction is relatively less considered a complication of hypertension. However, there is sufficient evidence to show that high blood pressure in middle age increases the risk of cognitive decline and dementia in old age. The greatest impact on cognitive function in those with hypertension is on executive or frontal lobe function, similar to the area most damaged in vascular dementia. Possible cognitive disorders associated with hypertension are vascular dementia, Alzheimer disease, and Lewy body dementia, listed in decreasing strength of association. The pathophysiology of cognitive dysfunction in individuals with hypertension includes brain atrophy, microinfarcts, microbleeds, neuronal loss, white matter lesions, network disruption, neurovascular unit damage, reduced cerebral blood flow, blood-brain barrier damage, enlarged perivascular damage, and proteinopathy. Antihypertensive drugs may reduce the risk of cognitive decline and dementia. Given the high prevalence of dementia and its impact on quality of life, treatment of hypertension to reduce cognitive decline may be a clinically relevant intervention.

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  • Chronic Neuroinflammation and Cognitive Decline in Patients with Cardiac Disease: Evidence, Relevance, and Therapeutic Implications
    Jan Traub, Anna Frey, Stefan Störk
    Life.2023; 13(2): 329.     CrossRef
  • The A-to-Z factors associated with cognitive impairment. Results of the DeCo study
    María Gil-Peinado, Mónica Alacreu, Hernán Ramos, José Sendra-Lillo, Cristina García, Gemma García-Lluch, Teresa Lopez de Coca, Marta Sala, Lucrecia Moreno
    Frontiers in Psychology.2023;[Epub]     CrossRef
Original article
Clinical investigation on acute pyelonephritis without pyuria: a retrospective observational study
Hyung Keun Song, Dong Hyuk Shin, Ji Ung Na, Sang Kuk Han, Pil Cho Choi, Jang Hee Lee
J Yeungnam Med Sci. 2022;39(1):39-45.   Published online August 11, 2021
DOI: https://doi.org/10.12701/yujm.2021.01207
  • 4,581 View
  • 134 Download
AbstractAbstract PDF
Background
The current guidelines for the diagnosis of acute pyelonephritis (APN) recommend that APN be diagnosed based on the clinical features and the presence of pyuria. However, we observed that some of the patients who are diagnosed with APN do not have characteristic clinical features or pyuria at the initial examination. We performed this study to investigate the characteristics of APN without pyuria.
Methods
A retrospective, cross-sectional study was conducted on 391 patients diagnosed with APN based on clinical and radiologic findings, between 2015 and 2019. The clinical features, laboratory results, and computed tomography (CT) findings were compared between patients with normal white blood cell (WBC) counts and those with abnormal WBC counts (WBC of 0–5/high power field [HPF] vs. >5/HPF) in urine.
Results
More than 50% of patients with APN had no typical urinary tract symptoms and one-third of them had no costovertebral angle (CVA) tenderness. Eighty-eight patients (22.5%) had normal WBC counts (0–5/HPF) on urine microscopy. There was a negative correlation between pyuria (WBC of >5/HPF) and previous antibiotic use (odds ratio, 0.249; 95% confidence interval, 0.140–0.441; p<0.001), and the probability of pyuria was reduced by 75.1% in patients who took antibiotics before visiting the emergency room.
Conclusion
The diagnosis of APN should not be overlooked even if there are no typical clinical features, or urine microscopic examination is normal. If a patient has already taken antibiotics at the time of diagnosis, imaging studies such as CT should be performed more actively, regardless of the urinalysis results.
Review articles
The role of microRNAs in cell death pathways
Ji Hoon Jang, Tae-Jin Lee
Yeungnam Univ J Med. 2021;38(2):107-117.   Published online January 13, 2021
DOI: https://doi.org/10.12701/yujm.2020.00836
  • 8,820 View
  • 196 Download
  • 7 Citations
AbstractAbstract PDF
MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

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    Hendrik Setia Budi, Laith A. Younus, Methaq Hadi Lafta, Sameena Parveen, Hawraa Jabbar Mohammad, Zahraa Haleem Al-qaim, Mohammed Abed Jawad, Rosario Mireya Romero Parra, Yasser Fakri Mustafa, Firas Rahi Alhachami, Sajad Karampoor, Rasoul Mirzaei
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review
    Marianna Makowska, Beata Smolarz, Hanna Romanowicz
    International Journal of Molecular Sciences.2023; 24(4): 3521.     CrossRef
  • The regulatory role of microRNAs in common eye diseases: A brief review
    Javier A. Benavides-Aguilar, Jonathan I. Morales-Rodríguez, Héctor Ambriz-González, Luis M. Ruiz-Manriquez, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy, Sujay Paul
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay
    Csaba Horvath, Izabela Jarabicova, Branislav Kura, Barbora Kalocayova, Eva Faurobert, Sean M. Davidson, Adriana Adameova
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119534.     CrossRef
  • The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury
    Leonid N. Maslov, Sergey V. Popov, Natalia V. Naryzhnaya, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Ivan A. Derkachev, Alla A. Boshchenko, Igor Khaliulin, N. Rajendra Prasad, Nirmal Singh, Alexei Degterev, Evgenia A. Tomilova, Ekaterina V. Sapozhenko
    Apoptosis.2022; 27(9-10): 697.     CrossRef
  • Interleukin-10 Protects against Ureteral Obstruction-Induced Kidney Fibrosis by Suppressing Endoplasmic Reticulum Stress and Apoptosis
    Kyongjin Jung, Taejin Lee, Jooyoung Kim, Eongi Sung, Inhwan Song
    International Journal of Molecular Sciences.2022; 23(18): 10702.     CrossRef
  • Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke
    Sima Abbasi-Habashi, Glen C. Jickling, Ian R. Winship
    Frontiers in Neurology.2021;[Epub]     CrossRef
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review
Haneol Ko, Sang-Pil Yoon
J Yeungnam Med Sci. 2022;39(4):269-277.   Published online February 14, 2022
DOI: https://doi.org/10.12701/jyms.2021.01683
  • 2,972 View
  • 99 Download
  • 2 Citations
AbstractAbstract PDF
The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

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    Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
    Scientific Reports.2023;[Epub]     CrossRef
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    Carlo Matera, Piotr Bregestovski
    International Journal of Molecular Sciences.2022; 23(21): 12921.     CrossRef
Advances in management of pediatric chronic immune thrombocytopenia: a narrative review
Jae Min Lee
J Yeungnam Med Sci. 2023;40(3):241-246.   Published online January 9, 2023
DOI: https://doi.org/10.12701/jyms.2022.00745
  • 2,104 View
  • 134 Download
  • 1 Citations
AbstractAbstract PDF
Immune thrombocytopenia (ITP) is a disease in which thrombocytopenia occurs because of immune-mediated platelet destruction and decreased platelet production. Although many pediatric patients with ITP experience spontaneous remission or reach remission within 12 months of first-line therapy, approximately 20% progress to chronic ITP. Patients who do not respond to first-line treatment or experience frequent relapses are of great concern to physicians. This review summarizes recent treatments for second-line treatment of pediatric chronic ITP.

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    Hyun Sik Kang
    Clinical Pediatric Hematology-Oncology.2023; 30(1): 42.     CrossRef

JYMS : Journal of Yeungnam Medical Science