Introduction

Although recent advances in solid tumor treatment have dramatically improved patients’ survival, the prognosis of pancreatic cancer remains dismal, with a 5-year survival rate of 9% in all stages [1]. Considering that surgical resection is possible only in 15%–20% of patients at diagnosis and most patients relapse after surgery, palliative chemotherapy is the mainstay of treatment for irresectable or recurrent diseases. Over the last decade, in two randomized phase 3 trials (the PRODIGE and MPACT trials), intensive combination chemotherapies, such as 5-fluorouracil (FU) plus leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine/nab-paclitaxel, have shown a more improvement in overall survival (OS) as the initial palliative chemotherapy than gemcitabine monotherapy, which was the standard treatment until then [2,3]. In a phase 3 trial (NCIC CTG PA.3 trial]), the addition of erlotinib to gemcitabine demonstrated statistically significant improvement in OS compared with gemcitabine monotherapy. However, small survival gain (median OS, 6.2 months vs. 5.9 months; hazard ratio [HR], 0.82; 95% confidence interval [CI], 0.69–0.99; p=0.038), increased toxicity risk, and high cost have limited the efficacy of the addition of erlotinib to gemcitabine [4]. Thus, FOLFRINOX and gemcitabine/nab-paclitaxel are the most widely used front-line chemotherapy regimens in patients with excellent performance status (PS), and gemcitabine monotherapy remains an option for the treatment of patients with poor OS. However, no subsequent treatment after failure of the initial chemotherapy has been established.

Three randomized phase 3 clinical trials have been conducted for second-line chemotherapy for advanced pancreatic cancer. The CONKO-003 trial showed that the combination of oxaliplatin and 5-FU/leucovorin (FOLFOX) was better in extending OS as second-line chemotherapy than 5-FU/leucovorin in patients with gemcitabine-refractory advanced pancreatic cancer (5.9 months vs. 2.3 months; HR, 0.66; 95% CI, 0.48–0.91; p=0.010) [5]. Conversely, the PANCREOX trial showed that FOLFOX did not improve OS, compared with infusional 5-FU/leucovorin (6.1 months vs. 9.9 months; HR, 1.78; 95% CI, 1.08–2.93; p=0.024) after gemcitabine failure [6]. This difference seems to be explained by the PS imbalance between the study groups and a possible crossover after disease progression in the PANCREOX trial. Recently, the NAPOLI-1 trial assessed the effects of nanoliposomal irinotecan, a new irinotecan formulation, alone or in combination with 5-FU/leucovorin, in patients with advanced pancreatic cancer after the failure of gemcitabine-based chemotherapy. In this trial, the group receiving nanoliposomal irinotecan combined with 5-FU/leucovorin had a longer OS than the group receiving 5-FU/leucovorin (6.1 months vs. 4.2 months; 95% CI, 0.49–0.92; p=0.012); hence, the combination of nanoliposomal irinotecan and 5-FU/leucovorin was approved as subsequent chemotherapy after failure of gemcitabine-based chemotherapy [7].

However, these studies on second-line chemotherapy were conducted in patients who previously underwent gemcitabine, and no randomized trials focusing on treatment after the failure of a more intensive chemotherapy, such as FOLFIRINOX or gemcitabine/nab-paclitaxel have been conducted. Moreover, given that patients with advanced pancreatic cancer have different clinical characteristics and situations in a real clinical setting, their second-line treatment should be individualized. In this retrospective study, we aimed to report the clinical characteristics and results of second-line chemotherapy for patients with advanced pancreatic cancer who failed initial chemotherapy in actual clinical practice.

Methods

Ethical statements: We obtained the patients’ clinical features, treatment information, and outcomes from the medical records. The Institutional Review Board (IRB) of Kosin University Gospel Hospital approved this study (IRB No: KUGH 2021-07-018). The requirement for informed consent was waived because of the retrospective nature of the study.

1. Patients

This retrospective study reviewed the clinical data of patients with advanced pancreatic cancer who had received palliative chemotherapy at Kosin University Gospel Hospital (Busan, Korea) between January 2013 and October 2020.

We included patients who had pathologically confirmed pancreatic adenocarcinoma with locally advanced or metastatic disease and underwent at least one cycle of second-line chemotherapy. If chemotherapy was performed after the disease had progressed within 6 months of the completion of adjuvant chemotherapy, it was considered second-line chemotherapy. Histological findings other than adenocarcinoma were excluded.

2. Statistical analysis

Progression-free survival (PFS) was calculated from the date of starting second-line chemotherapy to the date of disease progression, and OS was calculated from the date of starting second-line chemotherapy to the date of death. The duration of clinical benefit was defined as the time interval from the time of response, including complete response (CR), partial response (PR), and stable disease (SD), to the date of disease progression. The median PFS and OS were estimated using the Kaplan-Meier method. The Cox proportional hazard model was used for univariate and multivariate analyses of prognostic factors associated with PFS and OS. Statistical analysis was performed using IBM SPSS version 23.0 (IBM Corp., Armonk, NY, USA), and statistical significance was set at p<0.05.

Results

1. Patient characteristics

This study included 366 patients diagnosed with advanced pancreatic cancer who had received palliative chemotherapy between the abovementioned periods. Among them, 104 (28.4%) underwent at least one cycle of second-line chemotherapy. Table 1 summarizes the patient characteristics. The median age of the patients at the beginning of second-line treatment was 62 years (interquartile range [IQR], 57–62 years), and 89% of the patients had an excellent Eastern Cooperative Oncology Group (ECOG) PS (0 or 1). At the time of initiating the second-line chemotherapy, 82 patients (78.8%) had metastatic disease. As first-line chemotherapy, 38 (36.5%), 26 (25.0%), and 34 patients (32.7%) received gemcitabine (with or without erlotinib), gemcitabine/nab-paclitaxel, and FOLFIRINOX, respectively. Tumor response to first-line chemotherapy was assessable in 82 patients, and response rate according to the Response Evaluation Criteria in Solid Tumor (RECIST) version 1.1 was 20.7 % (none of the patients had a CR and 17 patients achieved a PR).

2. Treatment of second-line chemotherapy

Tables 2 and 3 list the treatment patterns and regimens used for second-line chemotherapy according to first-line regimens. For second-line chemotherapy, FOLFIRINOX, gemcitabine/nab-paclitaxel, gemcitabine±erlotinib, and FOLFOX were administered to 33 (31.7%), 29 (27.9%), 13 (12.5%), and 12 patients (11.5%), respectively. Of the 38 patients who received gemcitabine±erlotinib as a first-line regimen, 12 (31.6%), 8 (21.1%), and 7 (18.4%) received FOLFIRINOX, FOLFOX, and gemcitabine/nab-paclitaxel as their subsequent chemotherapy regimens, respectively. Of the 26 patients whose gemcitabine/nab-paclitaxel therapy failed, 20 (76.9%) received oxaliplatin-based chemotherapy as a second-line regimen (FOLFOX and FOLFIRINOX in 3 and 17 patients, respectively). The majority of the 34 patients (97.1%) who underwent first-line FOLFIRINOX received gemcitabine-based chemotherapy (gemcitabine±erlotinib and gemcitabine/nab-paclitaxel in 12 and 21 patients, respectively).

A median of three cycles of second-line chemotherapy (IQR, 2–6 cycles) was administered. Eighty-six of the 104 patients had a measurable disease based on the RECIST version 1.1, and tumor responses were assessed in these patients. None of the patients achieved a CR. Two patients had PR, and 33 patients had SD. The clinical benefit rate, including CR, PR, and SD, was 40.7% (35 patients), and the median duration of clinical benefit was 4.5 months (IQR, 2.1–7.0 months). Among the 17 patients who had a PR in first-line chemotherapy, none achieved a PR, but 9 patients (52.9%) attained an SD. Second-line chemotherapy was discontinued in 21 (20.2%) patients before the first planned follow-up point due to disease progression or PS deterioration. At the first response evaluation, disease progression was observed in 31 patients (29.8%). Furthermore, 47 patients (45.2%) discontinued treatment because of chemotherapy toxicity or PS deterioration. Two patients died of septic shock due to chemotherapy-induced neutropenia; one had been administered gemcitabine/nab-paclitaxel and the other had been administered FOLFIRINOX.

3. Survivals and prognostic factors

For a median follow-up of 16.8 months, the median PFS was 4.5 months (95% CI, 2.7–6.3 months) (Fig. 1A). Additionally, the median OS was 6.4 months (95% CI, 4.5–8.6 months), and the 1-year survival rate was 25.3% (Fig. 1B).

Tables 4 and 5 present the univariate and multivariate analyses of potential prognostic factors associated with survival in patients with advanced pancreatic cancer who underwent second-line chemotherapy. Univariate analysis revealed that the absence of diabetes mellitus, the presence of metastatic disease, liver metastasis, and bone metastases at the time of initiating second-line treatment were associated with lower PFS. In the multivariate analysis, metastatic disease (HR, 2.728; 95% CI, 1.205–6.178; p=0.016) and bone metastasis (HR, 3.143; 95% CI, 1.150–8.592; p=0.026) at the time of initiating second-line were statistically significant (Table 4). In the univariate analysis of OS, poor ECOS PS (≥2), metastatic disease, liver metastasis, bone metastasis, and elevated serum carcinoembryonic antigen (CEA) levels at the time of initiating the second-line treatment were associated with lower OS. Among these factors, poor ECOG PS (≥2) (HR, 2.247; 95% CI, 1.129–4.474; p=0.021), metastatic disease (HR, 2.745; 95% CI, 1.260–5.983; p=0.011), and elevated serum CEA level (HR, 1.939; 95% CI, 1.065–3.530; p=0.030) at the time of initiating the second-line treatment were statistically significant in the multivariate analysis (Table 5).

Discussion

Recently, intensive initial chemotherapy using FOLFIRINOX or gemcitabine/nab-paclitaxel has improved the survival of patients with advanced pancreatic cancer [2,3]. However, the prognosis of advanced pancreatic cancer remains poor, with no standard treatment after the failure of initial chemotherapy. Hence, the present study retrospectively analyzed the clinical characteristics and outcomes of subsequent chemotherapy in patients with advanced pancreatic cancer after the failure of initial chemotherapy in clinical practice. The median OS after the start of second-line chemotherapy was 6.4 months (95% CI, 4.5–8.6 months), similar to the recent retrospective reports of second-line chemotherapy for advanced pancreatic cancer in the real-world setting (5.2–8.1 months) [8-10]. Excellent PS, locally advanced disease, and normal CEA level at the time of second-line treatment initiation were associated with better OS.

Advanced pancreatic cancer progresses quickly, and once it begins to progress after the initial treatment, the patient’s PS deteriorates rapidly; hence, the decision to perform subsequent treatment is challenging. Nagrial et al. [11] systematically reviewed 24 prospective clinical trials of subsequent chemotherapy in patients with advanced pancreatic cancer who previously received gemcitabine-based chemotherapy between 1988 and 2012. They reported that 43% of the patients underwent subsequent chemotherapy and that the utilization rate significantly increased from studies published pre-2007 to those published post-2007 (35%–48%; p=0.0015). The MPACT and PRODIGE trials reported that the rates of utilizing second-line chemotherapy were 38% and 47%, respectively [2,3]. In our study, it was 28.4%, which was slightly lower than in these prospective studies, possibly because the prospective clinical trials generally included patients with a better PS than in actual clinical practice.

After the failure of initial chemotherapy in patients with advanced pancreatic cancer, those who only received supportive care showed dismal survival (approximately 2 months) compared with those who underwent second-line treatment [12]. The CONKO phase 3 trial demonstrated that OS was longer when administering FOLFOX as a second-line treatment than providing the best supportive care in patients with advanced pancreatic cancer (4.8 months vs. 2.3 months; 95% CI, 0.24–0.83 months; p=0.008); however, this trial was stopped prematurely because of insufficient recruitment (best supportive care was not accepted by patients and physicians) [13]. Although the clinical benefit of second-line chemotherapy is marginal, survival can be improved by providing appropriate subsequent treatment in selected patients. Therefore, patients who will benefit from subsequent chemotherapy after failure of the initial treatment must be identified.

Several studies have reported factors that can predict the survival outcomes of patients who undergo second-line chemotherapy [9,10,14-18]. Among several clinical and biochemical variables, PS is one of the most common and important prognostic factors in patients receiving second-line chemotherapy [9,14-17]. Consistent with these studies, patients with an excellent ECOG PS score (0 or 1) in our study had longer survival than those with poor PS. Patients with an excellent PS could be offered aggressive treatment to prolong their survival and manage their symptoms. Therefore, PS should be regarded as an important prognostic factor in patients receiving not only second-line but also first-line chemotherapy. A meta-analysis of 12 phase 3 randomized studies for the first-line chemotherapy of metastatic pancreatic cancer demonstrated that patients with a poor ECOG PS had a worse prognosis than those with an excellent ECOG PS (HR for OS, 1.45; 95% CI, 1.21–1.74; p<0.001) [19]. PS was also considered in selecting the initial chemotherapy regimen. Intensive chemotherapy regimens, such as FOLFIRINOX or gemcitabine/nab-paclitaxel, are recommended for patients with an excellent ECOG PS (0 or 1), whereas gemcitabine monotherapy is an option for the treatment of patients with an ECOG PS 2 [20,21].

Apart from excellent PS, locally advanced disease and normal CEA level at the time of initiating the second-line chemotherapy were associated with prolonged OS in our study. Our study revealed that locally advanced disease was associated with better survival, which is consistent with other retrospective studies [9,17]. In several studies, serum CA 19-9 levels at the beginning of second-line chemotherapy were reported as a prognostic factor, but in our study, this factor showed no significance [10,15,17]. Meanwhile, CEA level was associated with OS in our study, but other studies showed no such association; thus, it remains unclear whether CEA level is a significant prognostic factor. Considering the heterogeneity of patients who underwent second-line treatment, the prognostic factors of survival outcomes have been reported differently and, have not been established. Vienot et al. [16] analyzed a large cohort of 395 patients with advanced pancreatic cancer and developed a prognostic nomogram to predict patient survival for second-line chemotherapy. They identified nine independent prognostic factors: age, smoking status, liver metastasis, PS, pain, jaundice, ascites, duration of first-line chemotherapy, and second-line chemotherapy type. Given the lack of unified prognostic factors to predict patient survival for second-line chemotherapy, further prospective clinical studies are needed to validate these variables.

Randomized trials on subsequent chemotherapy for patients with advanced pancreatic cancer who failed in the initial chemotherapy are limited, and no acceptable standard regimen for subsequent chemotherapy has been established. The only second-line chemotherapy regimen that showed a survival benefit in a phase 3 trial is the combination of nanoliposomal irinotecan and 5-FU/leucovorin (the NAPOLRI trial) [7]. However, the NAPOLRI trial did not include patients who underwent first-line FOLFIRINOX, and the value of using such combined regimen after FOLFIRINOX remains vague. In our study, only one patient received a second-line regimen containing nanoliposomal irinotecan, probably because nanoliposomal irinotecan is not covered by public insurance in Korea.

The optimal sequence of palliative chemotherapy for advanced pancreatic cancer remains unclear. Generally, first-line chemotherapy regimens and PS are considered when selecting second-line regimens. For patients who were administered prior gemcitabine-based regimens, 5-FU-based regimens are acceptable subsequent treatment options. Gemcitabine-based regimens can be administered to patients previously treated with 5-FU-based chemotherapy. Intensive chemotherapy regimens, such as FOLFIRINOX and gemcitabine/nab-paclitaxel, can be considered after failure of gemcitabine-based regimens and FOLFIRINOX, respectively, but no randomized trials have been conducted. In a single-arm phase 2 trial, administering FOLFIRINOX after gemcitabine failure showed a promising outcome, with a median OS of 8.5 months (95% CI, 5.6–11.4 months), but 41.0% of the patients developed grade 3 or 4 neutropenia despite using an attenuated regimen [22].

Administering gemcitabine/nab-paclitaxel after first-line FOLFIRINOX failure showed a better median OS of 8.8 months (95% CI, 6.2–9.7 months) in the AGEO trial than gemcitabine monotherapy (3.6–5.7 months) in several retrospective trials [23-26]. However, grade 3 or 4 adverse events occurred in 40% of the patients [23]. Second-line FOLFIRINOX and gemcitabine/nab-paclitaxel have shown promising OS, but with high toxicities; thus, they should be administered to patients with an excellent PS and a favorable comorbidity profile. In our study, FOLFIRINOX was administered to 45.3% of the patients who previously underwent gemcitabine-based chemotherapy (29 of 64 patients), and gemcitabine/nab-paclitaxel was administered to 61.8% of the patients who failed FOLFIRINOX (21 of 34 patients).

This study has several limitations. First, it has a retrospective design; thus, all data were only acquired by reviewing the medical records. Therefore, the results of prognostic factors to predict survival outcomes should be interpreted with caution. Second, the patients received various chemotherapy regimens; hence, defining the benefit of a certain regimen for second-line chemotherapy is inappropriate. Further clinical studies are needed to determine the appropriate sequences for chemotherapy. In addition, the characteristics of the patients included in this retrospective analysis were heterogeneous, and the duration of second-line chemotherapy was short (median, 1.9 months). Because of these limitations, our analysis is insufficient to verify the actual effects of second-line chemotherapy for advanced pancreatic cancer, and caution is needed to interpret these outcomes.

In conclusion, our findings revealed that the clinical outcome of second-line chemotherapy for advanced pancreatic cancer is still poor, with a median OS of 6.4 months (95% CI, 4.5–8.6 months), which is consistent with other retrospective studies. Nonetheless, some factors such as PS, disease extent (locally advanced or metastatic), and CEA level at the beginning of second-line treatment could help identify patients who may benefit from second-line chemotherapy. However, because this was a small retrospective study including patients with heterogeneous characteristics, the results of this analysis should be cautiously interpreted, and further prospective clinical trials are needed to evaluate the effect of second-line chemotherapy on advanced pancreatic cancer.

Notes

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Funding

None.

Author contributions

Conceptualization, Data curation, EML; Writing-original draft: EML, HyJ; Writing-review & editing: EML, HyJ.

Fig. 1.

Kaplan-Meier survival after second-line chemotherapy initiation. (A) Progression-free survival (PFS) after second-line chemotherapy initiation in patients with advanced pancreatic cancer. (B) Overall survival (OS) after second-line chemotherapy initiation in patients with advanced pancreatic cancer. CI, confidence interval.

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Figure & Data

References

Citations

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