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JYMS : Journal of Yeungnam Medical Science

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Volume 7(1); June 1990
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Reviews
Immunodeficiency and Infection.
Sung Kwang Kim
Yeungnam Univ J Med. 1990;7(1):1-10.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.1
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AbstractAbstract PDF
No abstract available.
Pulmonary atresia with intact ventricular septum.
Sung Sae Han
Yeungnam Univ J Med. 1990;7(1):11-18.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.11
  • 1,371 View
  • 1 Download
AbstractAbstract PDF
No abstract available.
Original Articles
Glucose incorporation into glycogen molecules of hypertrophied slow and fast twitch muscles in vitro.
Yong Woon Kim, Jong Yeon Kim, Suck Kang Lee
Yeungnam Univ J Med. 1990;7(1):19-27.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.19
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AbstractAbstract PDF
This investigation was undertaken to clarify the in vitro effect of the various stimulations, such as exercise (E), insulin (I) direct electrical stimulation (EST) and the combinations of the above, on the glucose incorporation intro glycogen molecules (glycogen synthesis) of the normal slow (soleus) and fast twitch (plantaris) muscles, and the different responses of slow and fast twitch muscles to persistent overloads causing compensatory muscle hypertrophy. In resting state, slow twitch muscle has greater capacity for glycogen synthesis than fast twitch muscle, and responses of different muscle to various stimuli were differ as follows: In slow twitch muscle, the glycogen synthesis was increased by insulin, and electrical stimulation but not increased by exercise; exercise increased insulin sensitivity and the effect of electrical stimulation. Whereas the glycogen synthesis in fast twitch muscle was increased only by the stimuli combined with E and EST, and E, I, and EST. As the result of removal of synergistic muscle, both muscles were hypertrophied, and the degree of hypertrophy in response to persistent overload was higher in fast twitch muscle (182%) than slow twitch muscle (151%). In hypertrophied muscles, glycogen synthesis of soleus in any groups was lower than that of the control, but similar in plantaris. In conclusions, there were marked heterogeneity in different muscle fiber in the effects of exercise and insulin addition and electrical stimulation on muscle glycogen synthesis, and fast twitch muscle may be adapted more easily to that kind of persistent overload than slow twitch muscle.
Effects of insulin and exercise on glucose uptake of skeletal muscle in diabetic rats.
Jin Hyun Park, Young Woon Kim, Jong Yeon Kim, Suck Kang Lee
Yeungnam Univ J Med. 1990;7(1):29-37.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.29
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AbstractAbstract PDF
The effects of insulin and exercise on glucose uptake of skeletal muscle were investigated in soleus muscle isolated from low dose streptozotocin induced diabetic rat in vitro. Glucose uptake was assessed by measuring ³H-methylglucose uptake in vitro. Basal glucose uptake in diabetes was reduced by approximately one-third of the control value (5.6±0.73µMol/g/20min. in diabetes versus 8.4±0.77 in control, P<0.01). There was also a significant decrease (P<0.01) in glucose uptake of diabetes at physiologic insulin concentration (200 µIU/ml) by 40% (6.1±1.20 versus 10.0±0.81). Furthermore, maximal insulin (20000 µIU/ml)-stimulated glucose uptake was 36% lower in diabetes as compared with control (7.3±1.29 versus 11.4±1.29, P<0.01). In contrast, exercise (1.0 km/hr, treadmill running for 45 min.) effect on glucose uptake was so dramatic in diabetes that glucose uptake at basal state was 8.+1.09 and insulin stimulated-glucose uptake were 10.2±1.47 and 11.9±1.64, in 200 and 20000 µIU/ml added insulin, respectively. These results suggest that insulin insensitivity develops in skeletal muscle after 2 weeks of streptozotocin-induced diabetes, but these insensitivity was recovered significantly by single session of running exercise.
The Affinity of Calmodulin-Affigel for Inositol Triphosphate Kinase From Bovine Brain.
Sung Woo Lim, Jung Hye Kim
Yeungnam Univ J Med. 1990;7(1):39-50.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.39
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AbstractAbstract PDF
The one event on signaling mechanism is the cleavage by adenyl cyclase of ATP into second messenger, cyclic AMP. The other transfer system of inositol metabolism, it is widely recognized that hydrolysis of the minor membrane lipid phosphoinositide bisphosphate (PIP₂) initiated by occupation of certain receptors and catalyzed by phospholipase C, lead to toe generation of the two intracellular messengers, inositol triphosphate (IP₃) and diacylglycerol (DG). IP₃ is converted to inositol tetrakisphosphate (IP₄) by IP₃ kinase. In the present study, it is that purification of calmodulin is used by phenyl-Sepharose CL-4B chromatography, it's molecular weigh, 17,000 in SDS-polyacrylamide gel electrophoresis. In order to observe the affinity between calmodulin (CaM)-Affigel 15 and IP₃ kinase, and isolated IP₃ kinase, was applied in CaM-Affigel with Ca²⁺ equilibrium buffer and EGTA equilibrium buffer. We compared with binding and elution effect of IP₃ kinase in several condition of buffer. In affinity of binding, Ca²⁺ equilibrium buffer was in the most proper condition, and elution, CaM/Ca²⁺buffer (CE 1 10.36, CE2 12.76pM/min/mg of protein) was effected much more than EGTA buffer (E2 1.48, E 2.43pM/min/mg of protein), but CaM/Ca²⁺stimulate the activity of IP₃ kinase. And then, several detergents such as sodium deoxycholate, tween 20, cholic acid, polyethylene glycol, chaps were applied. The 0.2% chaps buffer (E2 23.19, E3 8.05pnM/min/mg of protein) was the most effective in elution of IP3 kinase.
A study on physical growth of primary school student in the rural area.
Jun Sakong, Seok Beom Kim, Pock Soo Kang, Jong Hak Chung
Yeungnam Univ J Med. 1990;7(1):51-60.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.51
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AbstractAbstract PDF
In order to assess the physical growth of primary school student in the rural area, body height, weight, chest circumference and sitting height of 923 students (469 males, 454 females) in the town of Angang, Kyungpook province, Korea, were measured from April to May, 1988. The most growth age of boy height was 10-11 years old in both sex and the growth curves were crossed at 9-11 years old. The most rapid growth age of body weight was 10-11 years old and growth curves were crossed at 9-11 years old. The most rapid growth age of chest circumference was 10-11 years old in female, whereupon female outgrows male by contrast with male's slow and linear growth. The most rapid growth age of sitting height was 10-11 years old and the growth curves were crossed at 9-10 years old. The Rother index was 1.17-1.30 in male, 1.16-1.29 in female, and male's index was in general superior to female's.
Ventricular premature complexes and associated factors in the early postinfarction period.
Jong Hoa Choi, Myung Soo Hyun, Young Jo Kim, Bong Sup Shim, Hyun Woo Lee
Yeungnam Univ J Med. 1990;7(1):61-68.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.61
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AbstractAbstract PDF
To assess the role of multiple factors in influencing occurrence of ventricular premature complexes after acute myocardial infarction twenty-four hour Holter electrocardiographic tape recording were made in 40 survivors of an acute myocardial infarction 10 to 20days after attack. Ventricular premature complexes in the early post infarction period were not correlated with left ventricular function, age, sex, smoking, diabetes mellitus, previous angina, and previous myocardial infarction. The occurrence of ventricular premature complexes showed a positive correlation with the occurrence of ST-T change. The occurrence of ventricular premature complexes during sleep hours was compared to the awake state. In 22 patients, the incidence of ventricular premature complexes are excluded from analysis, the 22 of patients, or in 76 percent, sleep was associated with a lowered occurrence of ventricular extrasystoles.
A Clinical Study of Femur Neck Fractures.
Hwan Mo Koo, Myun Whan Ahn, Joo Choul Ihin
Yeungnam Univ J Med. 1990;7(1):69-80.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.69
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AbstractAbstract PDF
A clinical analysis was done on 23 patients (24 hips) with fracture of the femoral neck, who had been admitted and treated at our Orthopedic department during the period of 4 years, from Jan. 1984 to May 1988. The results were as follows 1. 23 patients were comprised of 4 males and 19 females, and 11 patients were over 65 years old. 2. 18 cases of 24 cases were due to minor traumas such as slipping down, and for over 65 years old, all cases were due to simple minor traumas, 8 cases were showed a severe osteoporosis, below grade 3 of the Singh's index. 3. 14 cases of 24 cases were displaced subcapital fractures, and 6 cases displaced transcervical fractures. Only 4 cases were the undisplaced transcervical fractures. 4. In treatment of fractures internal fixations after manipulation were performed in 14 cases and primary arthroplasties in 10 cases. Secondary arthroplasties were done in complicated 4 cases of 14 cases treated with internal fixations. 5. Complications after internal fixation were developed in 7 cases out of 14 cases, avascular necrosis in 6, nonunions in 2, pin migrations in 3, and metal failure in 1 case. 6. In 14 arthroplasty immediate surgical fitness of femoral stem were related to late loosening of femoral stem (correlation coefficient γ=–0.68, p<0.01).
A study of the cause of metal failure in treatment of femur shaft fracture: Fractographical and clinical analysis of metal failure.
Chun Bae Jeon, Jae Sung Seo, Jong Chul Ahn, Myun Whan Ahn, Joo Chyl Ihn
Yeungnam Univ J Med. 1990;7(1):81-93.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.81
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AbstractAbstract PDF
The author fractographically analyzed the cause of metal failure (the first time this procedure has been used for this metal failure) and also analyzed in clinically. In this study, I selected eight cases which have been analyzed fractographically. In all these cases, the analysis was done after treatment of metal failure of implants internally fixed to femur shaft fractures at the Department of Orthopedic Surgery, Yeung-Nam University Hospital during the six year period from May 1983 to September 1989. 1. Metal failure occurred in five dynamic-compression plates, one Jewett nail, one screw in Rowe plate, and one interlocking nail. 2. The clinical cause of metal failure was deficiency of medial buttes in five cases, incorrect position of implant in one case, and incorrect selection of implant in two cases. 3. The time interval between internal fixation and metal failure was four months in one case, between five months to twelve months in six cases, three years in one case. 4. The fractographically analytical cause of metal failure was ; first, impact failure, one case, second, fatigue failure, six cases, machining mark (stress riser), four case type: low consistent cyclic fatigue failure irregular cyclic fatigue failure third, stress corrosion crack, one case. 5. 316 L Stainless Steel has good resistance to corrosion. However, when its peculiar surface film is destroyed by fretting, it shows pitting corrosion. This is, perhaps, the main cause of metal failure. 6. It is possible that mechanical injury occurred in implants during the manufacturing of implants or that making a screw hole in the main cause of metal failure.
Autologous Transfusion in Pregnant Women with Significant Risk for Hemorrhage.
Gee Deuk Kim, Chul Suong Bae, Yoon Kee Park, Jong Wook Kim, Min Whan Koh, Sung Ho Lee
Yeungnam Univ J Med. 1990;7(1):95-103.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.95
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AbstractAbstract PDF
Autologous Transfusion, storage of one's own blood for subsequent infusion if needed, is safe and effective in a variety of scheduled operative procedures. Obstetric involvement in such programs in very limited, however, because of concern over the possibility of inducing premature labor or causing fetal distress by blood volume change or vasovagal reactions. We describe our experience with pregnant women in this program. The incidence of vagovagal reactions of autologous donation was 9.5% (2.21). After entry into this program, 17pastients received a total 37pints, which consist of 19 Autologous and 18 Homologous. Homologous transfusion was avoided in 30% of patients receiving blood. The values of the mean hematocrits before and after hpebotomy were 34.1% and 31.8% respectively. It was stastically significant (p<0.01). We recommended that autologous blood donation by pregnant women in third trimester is safe for mothers or infants and it should be strongly encouraged for patient with placenta previa and repeated cesarean section.
Clincal Effect of Ketotifen in Allergic Rhinitis.
Sun Jin Eun, Yong Dae Kim, Mun Heum Park, Jang Su Suh, Kei Won Song
Yeungnam Univ J Med. 1990;7(1):105-112.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.105
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AbstractAbstract PDF
Ketotifen, a benzocycloheptathiophene, has an orally effective antiallergic as well as antihistaminic properties. In pervious studies, Ketotifen has shown encouraging results on patient with allergic rhinitis, either perennial or seasonal. 39 patients with allergic rhinitis had been treated with Ketotifen 1 mg twice daily for 8 weeks. And we obtained following results. 1) The efficacy rate in sneezing attack was 73.5%, in nasal discharge 71%, in nasal obstruction 58%. 2) Some improvements in at least one of three-major symptoms were noted within 1 week in 30.7%, within 2 weeks in 55.8%, within 3 weeks in 66.7%, within 8 weeks in 87.2%. 3) Physical findings such as colour, swelling of turbinate, character of rhinorrhea were not improved significantly. 4) Side effect was observed only in one patient with abdominal pain and diarrhea, which was subsided after interruption of administration. These results suggested that Ketotifen was effective in treatment of allergic rhinitis.
The Dosimetry of Radiosurgery using of Rando Phantom.
Sung Kyu Kim, Sei One Shin, Myung Se Kim
Yeungnam Univ J Med. 1990;7(1):113-119.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.113
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AbstractAbstract PDF
The stereotactic radiosurgery using ionizing radiation of high energy is a technique for exadicating intracranial small tumors, which are inaccessible or unsuitable for open surgical technique. For such a small field radiosurgery, TLD or film dosimetry is essential. The three dimensional dose planning of radiosurgery was performed with dose planning computer system (Therac 2300). The target dose distribution and its error according to patient position were discussed. And were measured of circular cone which specially designed in our Hospital. The position error of Rando Phantom compared with CT were 0.4 mm in the AP-LAT section and in the AP-VERT section, 1.0 mm in the AP-VERT 45°section. The ratio of accuracy of the gantry and couch rotation were 1.5 mm diameter for central axis of 18MeV linear accelerator. Our study suggested that radiosurgery of small field in out department will be appropriate for clinical application.
The Effect of Enflurane Anesthesia on The Liver in patient with positive HBsAg and increased SGOT, SGPT.
Ill Sook Suh, Dae Pal Park
Yeungnam Univ J Med. 1990;7(1):121-126.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.121
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AbstractAbstract PDF
Halothane is usually a safe and effective inhalation anesthetic agent but it rarely has damaged liver. The authors selected 11 patients who had HBsAg positive and increased SGOT, SGPT at Yeungnam university hospital. Their physical status was ASA class 1 and 2. They had no previous history of operation or liver disease. The liver function tests were performed before surgery, and on 3rd, 7th and 10th postoperative days. The result were as follows: 1) The values of SGOT and SGPT were gradually increased on 3rd postoperative day and markedly increased on the 7th and 10th postoperative day. 2) Alkaline phosphatase, total protein, albumin, total bilirubin and direct bilirubin were not significantly changed.
Caudal Anesthesia for pediatric Inguinal Region Surgery.
Kyeung Sook Lee, Dae Pal Park
Yeungnam Univ J Med. 1990;7(1):127-131.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.127
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AbstractAbstract PDF
Pediatric caudal anesthesia was done in 50 infants and children under 10 years of age, who were to undergo surgery of inguinal region. All cases were given 10mg/kg body weigh t of 1% lidocaine solution with epinephrine 1:200,000. The results were as follows: 1) Pediatric caudal anesthesia was simple, easy and reliable in technique. 2) Additional intravenous administration of Ketamine or pentothal sodium was needed. i.e., to provide a more cooperative state. 3) Anesthetic effect was judged very Excellent. 4) Cardiovascular and respiratory changes were minimal. Author's came to conclusion that caudal anesthesia for pediatric inguinal region surgery in reliable, simple in technique, favorable to surgeon, and is considered to be a good technique for pediatric anesthesia.
Analysis of Surgical Blood Use in Operation at YUMC.
Chung Sook Kim, Kyung Dong Kim, Dae Chul Kim
Yeungnam Univ J Med. 1990;7(1):133-144.   Published online June 30, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.1.133
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AbstractAbstract PDF
This study was performed to guide the effective utilization of blood and optimal blood ordering schedule for various elective surgeries, based on the analysis of 1,462 transfused surgical procedures and 5,933 blood units transfused during operation in the period of two years through January, 197 to December, 1988 at Yeungnam University Hospital. The frequency of transfusion, and mean transfused units were evaluated and recommended blood unit for each surgical procedure was proposed. We assure that the successful establishment of this guideline can lead to substantial monetary saving, reduced blood outdating, and a decreased blood bank workload with a more appropriate allocation of the technician's time and effort.

JYMS : Journal of Yeungnam Medical Science