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J Yeungnam Med Sci > Volume 24(2); 2007 > Article
Yeungnam University Journal of Medicine 2007;24(2):252-261.
DOI:    Published online December 31, 2007.
Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean.
Hong Soo Jung, Joo Hyun Lee, Jun Sakong, Sung Wook Bae, Jung Hye Kim, Jae Ryong Kim
1Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Preventive Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
3Health Promotion Center, Yeungnam University Hospital, Daegu, Korea.
BACKGROUND: Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. MATERIALS AND METHODS: In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. RESULTS: The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. CONCLUSION: These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.
Key Words: Obesity, Beta-3 adrenergic receptor, Uncoupling protein 2, Polymorphism, Body Mass Index
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