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JYMS : Journal of Yeungnam Medical Science

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Focused Review article
Management of diabetic foot ulcers: a narrative review
Jahyung Kim, Otgonsaikhan Nomkhondorj, Chi Young An, Ye Chan Choi, Jaeho Cho
J Yeungnam Med Sci. 2023;40(4):335-342.   Published online September 22, 2023
DOI: https://doi.org/10.12701/jyms.2023.00682
  • 2,896 View
  • 221 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Diabetic foot ulcers (DFUs) are among the most serious complications of diabetes and are a source of reduced quality of life and financial burden for the people involved. For effective DFU management, an evidence-based treatment strategy that considers the patient's clinical context and wound condition is required. This treatment strategy should include conventional practices (surgical debridement, antibiotics, vascular assessment, offloading, and amputation) coordinated by interdisciplinary DFU experts. In addition, several adjuvant therapies can be considered for nonhealing wounds. In this narrative review, we aim to highlight the current trends in DFU management and review the up-to-date guidelines.

Citations

Citations to this article as recorded by  
  • Kick-Starting Wound Healing: A Review of Pro-Healing Drugs
    Bethany L. Patenall, Kristyn A. Carter, Matthew R. Ramsey
    International Journal of Molecular Sciences.2024; 25(2): 1304.     CrossRef
  • Unveiling the challenges of diabetic foot infections: diagnosis, pathogenesis, treatment, and rehabilitation
    Chul Hyun Park
    Journal of Yeungnam Medical Science.2023; 40(4): 319.     CrossRef
Original article
Risk factors affecting amputation in diabetic foot
Jun Ho Lee, Ji Sung Yoon, Hyoung Woo Lee, Kyu Chang Won, Jun Sung Moon, Seung Min Chung, Yin Young Lee
Yeungnam Univ J Med. 2020;37(4):314-320.   Published online May 6, 2020
DOI: https://doi.org/10.12701/yujm.2020.00129
  • 6,411 View
  • 205 Download
  • 10 Crossref
AbstractAbstract PDF
Background
A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU).
Methods
The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Their demographic characteristics, disease history, laboratory data, ankle-brachial index, Wagner classification, osteomyelitis, sarcopenia index, and ulcer sizes were considered as variables to predict outcome. A chi-square test and multivariate logistic regression analysis were performed to test the relationship of the data gathered. Additionally, the subjects were divided into two groups based on their amputation surgery.
Results
Out of the 351 subjects, 170 required LEA. The mean age of the subjects was 61 years and the mean duration of diabetes was 15 years; there was no significant difference between the two groups in terms of these averages. Osteomyelitis (hazard ratio [HR], 6.164; 95% confidence interval [CI], 3.561−10.671), lesion on percutaneous transluminal angioplasty (HR, 2.494; 95% CI, 1.087−5.721), estimated glomerular filtration rate (eGFR; HR, 0.99; 95% CI, 0.981−0.999), ulcer size (HR, 1.247; 95% CI, 1.107−1.405), and forefoot ulcer location (HR, 2.475; 95% CI, 0.224−0.73) were associated with risk of amputation.
Conclusion
Osteomyelitis, peripheral artery disease, chronic kidney disease, ulcer size, and forefoot ulcer location were risk factors for amputation in diabetic foot patients. Further investigation would contribute to the establishment of a diabetic foot risk stratification system for Koreans, allowing for optimal individualized treatment.

Citations

Citations to this article as recorded by  
  • Efficacy of Chinese and Western Medical Techniques in Treating Diabetic Foot Ulcers With Necrotizing Fasciitis of the Lower Leg
    Yongchong Chen, Yunzhu Wang, TaiAn Zhang, Chao Meng, Qing Li, Bohui Zhang, Kai Zhang, Chunfang Qin
    The International Journal of Lower Extremity Wounds.2024; 23(1): 70.     CrossRef
  • Classification of foot ulcers in people with diabetes: A systematic review
    Matilde Monteiro‐Soares, Emma J. Hamilton, David A. Russell, Gulapar Srisawasdi, Edward J. Boyko, Joseph L. Mills, William Jeffcoate, Fran Game
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • Renal function is highly associated with podiatric risk in diabetic patients
    Jean-Baptiste Bonnet, Ilan Szwarc, Antoine Avignon, Sébastien Jugant, Ariane Sultan
    Clinical Kidney Journal.2023; 16(11): 2156.     CrossRef
  • Risk factor analysis for diabetic foot ulcer‐related amputation including Controlling Nutritional Status score and neutrophil‐to‐lymphocyte ratio
    Yandan Zhu, Hongtao Xu, Yuzhen Wang, Xia Feng, Xinyu Liang, Liying Xu, Zhiqiang Liang, Zhongjia Xu, Yawen Li, Yi Le, Manchen Zhao, Jianfei Yang, Ji Li, Yemin Cao
    International Wound Journal.2023; 20(10): 4050.     CrossRef
  • The association between estimated glomerular filtration rate and prognosis in patients with diabetic foot osteomyelitis
    Jinghang Zhang, Dong Chen, Xuemei Li, Min Ding, Jun Xu, Meijun Wang, Bai Chang
    International Wound Journal.2022; 19(7): 1650.     CrossRef
  • Renal Function Status in Patients with Diabetes Mellitus Having Diabetic Foot Infection and Role of Antibiotics
    Shabab Hussain, . Arrham, Syeda Javeriya Saeed, Ahmad Murtaza Anwar, Asif Khan, Saifullah Brohi
    Pakistan Journal of Health Sciences.2022; : 189.     CrossRef
  • Re-understanding and focusing on normoalbuminuric diabetic kidney disease
    Na An, Bi-tao Wu, Yu-wei Yang, Zheng-hong Huang, Jia-fu Feng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial
    Mehrdad Mokhtari, Reza Razzaghi, Mansooreh Momen‐Heravi
    Phytotherapy Research.2021; 35(4): 2099.     CrossRef
  • Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study
    Michael Salim
    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef

JYMS : Journal of Yeungnam Medical Science