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JYMS : Journal of Yeungnam Medical Science

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Hyun Sook Ko 2 Articles
Effects of early clinical and basic laboratory exposure program on premedical students: a questionnaire survey
Kyu Hyang Cho, Hyun Sook Ko, Kyung Hee Lee, Tae-Yoon Hwang, Keun-Mi Lee, Sae Yoon Kim, Min Cheol Chang
J Yeungnam Med Sci. 2022;39(4):309-313.   Published online July 20, 2022
DOI: https://doi.org/10.12701/jyms.2022.00318
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AbstractAbstract PDF
Background
Because premed students do not take courses related to medicine during their first 2 years, they cannot establish their identity as students at medical schools, making it difficult for them to set goals as future doctors. We conducted an early clinical and basic laboratory exposure program for premed students and studied the effects of the program and student satisfaction levels.
Methods
We performed an early clinical and basic laboratory exposure program for premed students for 2 days and evaluated the effects of the program and student satisfaction with it. The program consisted of two types: type 1, where two to four students formed a group, which was assigned to a particular department to participate and make observations during ward rounds, outpatient clinics, examinations, procedures, and surgeries (in the case of basic laboratory work, the students partook in experimental observations); and type 2, where one student followed a medical school professor to observe the professor’s day. After the program ended, an online survey was conducted to investigate the effects on students, their thoughts, and satisfaction levels.
Results
In total, 114 students (91.2%) responded to the survey. Approximately 94% of them were satisfied with the program. They found that the program would be useful for deciding on future career paths, gaining knowledge about a department of interest, studying for a medical program after premedical studies, and befriending residents and professors in certain departments.
Conclusion
Early clinical and basic laboratory exposure programs are recommended for premedical students.
Anticancer Effects of Gleditsin in Human Mammary Cancer Cells
Hyun Sook Ko, Kyung Won Kang, Jung Hye Kim
Yeungnam Univ J Med. 2007;24(2 Suppl):S580-590.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S580
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AbstractAbstract PDF
Background
:Gleditsin is a herb medicine from extracted by Gleditschia spina. In oder to investigate anticancer effects of gleditsin in human various breast cancer cells, we tested with gleditsin on cytotoxicity of materials, observed to cell survival and cell cycle progression, and analyzed in starvation condition. Materials and Methods:The cytoxicity and cell cycle progression were analyzed in human breast cells, MCF-10A and human breast cancer cell lines, MDA-MB-231, MDA-MB-361, and MDA-MB-435. IC50s of breast cancer cell lines were measured by MTT assay. The cell cycle were showed by flow cytometric analysis in cells treated with gleditsin. We analyzed DNA content of sub-Go/G1 phase, it was detected apoptosis.
Results
:Cell survivals were decreased in a dose-dependent manner by the treatment of cells with gleditsin. IC50s were 4.11-fold higher in MDA-MB-435, 2.53-fold higher in MDAMB- 231, and 2.55-fold higher in MDA-MB-361 than in normal breast cells. Flow cytometric analysis showed that sub-G0/G1 fractions in cancer cells treated with gleditsin were higher than that normal cells, suggesting that increases in cytotoxicity of cancer cells by gleditsin were resulted from apoptosis. Cell cycle progression was also changed by the treatment of gleditsin. The treatments of gleditsin resulted in a decrease in G1 phase and an increase in G2/M phase in normal breast cells as well as cancer cell lines. Apoptotic cell death was synergistically increased by cell starvation and gleditsin treatments in cancer cells. MDAMB- 435 cells were more sensitive to apoptotic cell death by gleditsin than other cells.
Conclusion
:An anti-tumor effect of gleditsin was selectively higher in hman breast cancer cells than in normal human breast cells, and was mediated by apoptotic cell death.

JYMS : Journal of Yeungnam Medical Science