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JYMS : Journal of Yeungnam Medical Science

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Dong Hyup Lee 15 Articles
Surgical Treatment of Renal Cell Carcinoma with Acute Pulmonary Embolism Using Deep Hypothermic Circulatory Arrest -A Case Report-
Dong Hyup Lee, Dong Chun Park
Yeungnam Univ J Med. 2007;24(2 Suppl):S731-736.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S731
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Renal cell carcinoma occasionally invades the inferior vena cava and rarely extends to the right atrium and occurred massive pulmonary embolism. A healthy 54-year-old man presented to the emergency room with anterior chest pain, dyspnea and hypotension from which he had been suffering for several hours. We diagnosed him as left renal cell carcinoma with acute both pulmonary arteries embolism. The patient underwent a complex surgical procedure in which left radical nephrectomy, inferior vena cava thrombectomy and both pulmonary arteries thromboembolectomy under deep hypothermic circulatory arrest. Total circulatory arrest time was 44 minutes. We should use many inotropic agents for weaning of cardiopulmonary bypass. The patient had many postoperative complications including of acute renal failure, respiratory distress and sepsis. He died from septic shock and multi organ failure at 36th postoperative day.
Myocardial Protective Effect of Histidine-Tryptophan-Ketoglutarate Solution and Cold Blood Cardioplegic Solution in Pediatric Cardiac Surgery.
Tae Eun Jung, Dong Hyup Lee, Sung Sae Han
Yeungnam Univ J Med. 2006;23(1):19-25.   Published online June 30, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.1.19
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BACKGROUND
There is limited data on comparisons between the effect of histidine-tryptophan-ketoglutarate (HTK) solution and cold blood cardioplegic (CBC) solution in pediatric cardiac surgery. The purpose of this study was to compare the myocardial protective effect of HTK solution and CBC solution in patients undergoing pediatric cardiac surgery. MATERILAS AND METHODS: We selected 49 patients with ventricular septal defect and atrial septal defect. HTK solution was used in 21 patients and CBC solution was used in 28 patents. HTK solution was given as a single dose, whereas CBC solution was used in the usual multi-dose method. The incidence of EKG change and concentration of Troponin T and CK-MB were compared for the evaluation of myocardial damage. RESULTS: There were no significant differences in the incidence of ST, T segment change by EKG and serial cardiac enzyme levels between two groups. CONCLUSION: These results suggested that the myocardial protective effect of HTK solution was similar to CBC solution in simple pediatric cardiac surgery.
Recent Advances in Surgery for Atrial Fibrillation.
Dong Hyup Lee, Tae Eun Jung
Yeungnam Univ J Med. 2005;22(1):13-26.   Published online June 30, 2005
DOI: https://doi.org/10.12701/yujm.2005.22.1.13
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Atrial fibrillation (AF) is the most common cardiac rhythm disturbance, which carries significant cardiovascular morbidity and mortality. The medical treatment for AF is cumbersome and unsatisfactory, which has highlighted the need to develop alternative treatments for AF. The recent discovery that AF is often initiated by atrial ectopic beats has resulted in treatments designed to target the ectopic sources, particularly those within the pulmonary veins. Building on the pioneering work of Cox et al., a recent reported series demonstrated the feasibility of treating patients undergoing cardiac surgery for other structural heart diseases with limited, left-atrial ablation lesion sets using alternative energy sources. As less complex modifications of the Maze procedure have been developed, a number of energy sources have been introduced to create of electrically isolating lesions within the atria. These sources have been used both endocardially in arrest heart procedures as well as epicardially in a beating heart setting. This review summarizes the recent advances in surgery for AF that will aid in the development of an effective, minimally invasive surgical procedure to cure patients with AF.
Clinical Analysis of Patch Repair of Ventricular Septal Defect in Infant.
Tae Eun Jung, Jang Hoon Lee, Dong Hyup Lee, Jung Cheul Lee, Sung Sae Han, Sae Yeun Kim, Dae Lim Ji
Yeungnam Univ J Med. 2002;19(2):99-106.   Published online December 31, 2002
DOI: https://doi.org/10.12701/yujm.2002.19.2.99
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BACKGROUND
Simple ventricular septal defect(VSD) is the most common congenital heart disease. Although closure of VSD is currently associated with a relatively low risk, experience with younger and smaller infants has been variably less satisfactory. We assessed the results of surgical closure of VSD in infant. MATERIALS AND METHODS: Between 1996 and 2000, 45 non-restrictive VSD patients underwent patch repair and retrospective analysis was done. Patients were divided into two groups based on weight: group I infants weighed 5kg or less(n=16), and group II infants weighed more than 5kg(n=29). Both groups had similar variation in sex, VSD location, aortic cross clamp time and total bypass time. But combined diseases (ASD, PDA, MR) were more in group I. We closed VSD with patch and used simple continuous suture method in all patients. RESULTS: There were no operative mortality, no reoperation for hemodynamically significant residual shunt and no surgically induced complete heart block. As a complication, pneumonia(group I: 2 cases, group II: 2 cases), transient seizure(group II: 2), wound infection(group I: 1, group II: 1), urinary tract infection(group I: 1) and chylopericardium(group I: 1) developed, and there was no significant difference between two groups(p>0.05). CONCLUSION: Early primary closure with simple continuous suture method was applicable in all patients with non-restrictive VSD without any serious complications.
Localization of Sensory Neurons Innervating the Rat Intestine Using the Cholera Toxin B Subunit(CTB) and Wheat Germ Agglutinin-Horseradish Peroxidase(WGA-HRP).
Dong Hyup Lee, Chang Hyun Lee, Moo Sam Lee
Yeungnam Univ J Med. 1998;15(1):75-96.   Published online June 30, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.1.75
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AbstractAbstract PDF
The local arrangement of sensory nerve cell bodies and nerve fibers in the brain stem, spinal ganglia and nodose ganglia were observed following injection of cholera toxin B subunit(CTB) and wheat germ agglutinin-horseradish peroxidase(WGA-HRP) into the rat intestine. The tracers were injected in the stomach(anterior and posterior portion), duodenum, jejunum, ileum, cecum, ascending colon or descending colon. After survival times of 48-96 hours, the rats were perfused and their brain, spinal and nodose ganglia were frozen sectioned(40microM). These sectiones were stained by CTB immunohistochemical and HRP histochemical staining methods and observed by dark and light microscopy. The results were as follows: 1. WGA-HRP labeled afferent terminal fields in the brain stem were seen in the stomach and cecum, and CTB labeled afferent terminal fields in the brain stem were seen in all parts of the intestine. 2. Afferent terminal fields innervating the intestine were heavily labeled bilaterally gelalinous part of nucleus of tractus solitarius(gelNTS), dorsomedial part of gelNTS, commissural part of NTS(comNTS), medial part of NTS(medNTS), wall of the fourth ventricle, ventral border of area postrema and comNTS in midline dorsal to the central canal. 3. WGA-HRP labeled sensory neurons were observed bilaterally within the spinal ganglia, and labeled sensory neurons innervating the stomach were observed in spinal ganglia T2-L1 and the most numerous in spinal ganglia T8-9. 4. Labeled sensory neurons innervating the duodenum were observed in spinal ganglia T6-L2 and labeled cell number were fewer than the other parts of the intestines. 5. Labeled sensory neurons innervating the jejunum were observed in spinal ganglia T6-L2 and the most numerous area in the spinal ganglia were T12 in left and T13 in right. 6. Labeled sensory neurons innervating the ileum were observed in spinal ganglia T6-L2 and the most numerous area in the spinal ganglia were T11 in left and L1 in right. 7. Labeled sensory neurons innervating the cecum were observed in spinal ganglia T7-L2 and the most numerous area in the spinal ganglia were T11 in left and T11-12 in right. 8. Labeled sensory neurons innervating the ascending colon were observed in spinal ganglia T7-L2 in left, and T9-L4 in right. The most numerous area in the spinal ganglia were T9 in left and T11 in right. 9. Labeled sensory neurons innervating the descending colon were observed in spinal ganglia T9-L2 in left, and T6-L2 in right. The most numerous area in the spinal ganglia were T13 in left and L1 in right. 10. WGA-HRP labeled sensory neurons were observed bilaterally within the nodose ganglia, and the most numerous labeled sensory neurons innervating the abdominal organs were observed in the stomach. 11. The number of labeled sensory neurons within the nodose ganglia innervating small and large intestines were fewer than that of labeled sensory neurons innervating stomach These results indicated that area of sensory neurons innervated all parts of intestines were bilaterally gelatinous part of nucleus tractus solitarius(gelNTS), dorsomedial part of gelNTS, commissural part of NTS(comNTS), medial part of NTS, wall of the fourth ventricle, ventral border of area postrema and com NTS in midline dorsal to the central canal within brain stem, spinal ganglia T2-L4, and nodose ganglia. Labeled sensory neurons innervating the intestines except the stomach were observed in spinal ganglia T6-L4. The most labeled sensory neurons from the small intestine to large intestine came from middle thoracic spinal ganglia to upper lumbar spinal ganglia.
Two cases report of bronchial carcinoid tumors.
Kyo Won Choi, Jeong Ill Suh, Sung Suk Kim, Jin Hong Chung, Kwan Ho Lee, Hyun Woo Lee, Dong Hyup Lee, Jung Cheul Lee, Sung Sae Han
Yeungnam Univ J Med. 1993;10(2):525-536.   Published online December 31, 1993
DOI: https://doi.org/10.12701/yujm.1993.10.2.525
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Bronchial carcinoid tumor was a low grade malignant and it was regarded as predictable clinical course and good survivality after surgical resection. But despite of its low grade malignant potentiality, bronchial carcinoid tumor was clearly capable of metastasizing and causing death. We present 2 cases of bronchial carcinoid tumors. One of them was typical carcinoid tumor in 44 year-old female and another was atypical carcinoid tumor in 53 year-old male patient. Currative therapeutic procedure was performed by lobectomy and wedge resection.
An aortic dissection in pregnant woman - a case report -.
Hyeong Min Lee, Eun Pyo Hong, Dong Hyup Lee, Jung Cheul Lee, Sung Sae Han, Dong Gu Sin, Young Jo Kim, Bong Sup Shim
Yeungnam Univ J Med. 1993;10(1):253-259.   Published online June 30, 1993
DOI: https://doi.org/10.12701/yujm.1993.10.1.253
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AbstractAbstract PDF
We have experienced a case of aortic dissecting aneurysm in pregnant woman. She felt initially severe chest pain which was radiated to the neck on the 3days before delivery. Thereafter dyspnea and generalized edema were developed for 1 month after delivery. She was diagnosed as aortic dissectLn, Debakey type-II. During cardiopulmonary bypass, the selective cerebral perfusion was done through the right and left commom carotid arteries. Aortic replacement with Hemashield vascular graft and reimplantation of innominate artery, resuspension of aortic valve, repair of intimal tear were performed. The postoperative course was uneventful.

Citations

Citations to this article as recorded by  
  • A Case of Ascending Aortic Dissection with Severe Aortic Regurgitation Diagnosed by Echocardiography
    Sung-Hee Kim, Ok-Kyoung Lee
    The Korean Journal of Clinical Laboratory Science.2020; 52(4): 425.     CrossRef
Surgical treatment of atrial septal defect in adult patients.
Dong Hyup Lee, Jung Cheul Lee, Sung Sae Han
Yeungnam Univ J Med. 1992;9(2):321-326.   Published online December 31, 1992
DOI: https://doi.org/10.12701/yujm.1992.9.2.321
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The study consisted of all patients over 35yerars old undergoing surgical repair of atrial septal defect for the period from June 1985, to August 1992. The following results were observed. 1. ASD was closed with patch in 11 (73%) patients. 2. The relationship of pulmonary artery systolic pressure to Qp/Qs ratio was not significant. 3. Before operation 6 patients were in NYHA functional class II. 8 were in class III, After operation 8 patients were in class I, 6 were in class II. 4. Atrial fibrillation has persisted in 3 patients and returned regular rhythm in 1 patient after surgery. 5. There was no operative mortality and we had good surgical results regardless of patient's age.
Effects of Dimethyl Sulfoxide on the Differentiation of Myocardial and Endothelial Cells.
Dong Hyup Lee, Yee Tae Park, Sung Sae Han, Yung Chang Lee
Yeungnam Univ J Med. 1988;5(2):111-119.   Published online December 31, 1988
DOI: https://doi.org/10.12701/yujm.1988.5.2.111
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To elucidate the effects of dimethyl sulfoxide on of myocardial and endothelial cells in culture, the cells were exposed to 10% dimethyl sulfoxide in culture medium for 1 hour at 48 hours after cell isolation. The general morphology and the cytochemical reaction of marker enzymes for mitochondria and Golgi complexes were investigated. The results were summarized as follows 1. DMSO induced elongation and narrowing of the cells and increase of mitochondrial reaction in myocardial cells. 2. DMSO induced destruction and disruption of myofibrils in myocardial cells resulting in increase of contractile activities. 3. In the endothelial cells, DMSO suppressed proliferative activities but thiamine pyrophosphatase reactions were enhanced indicating increase of Golgi complex activity. 4. DMSO seemed to hamper with the adhesiveness and motility of the endothelial cells causing the decrease of the number of cells in vitro.
A Case Report of Primary Pericardial Malignant Epitheloid Mesothelioma.
Moon Ho Chung, Myung Soo Hyun, Young Jo Kim, Bong Sup Shim, Chong Suhi Kim, Dong Hyup Lee, Cheol Joo Lee, Myeun Shik Kang
Yeungnam Univ J Med. 1986;3(1):301-306.   Published online December 31, 1986
DOI: https://doi.org/10.12701/yujm.1986.3.1.301
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Primary pericardial mesothelioma is a rare tumor of mesodermal origin that is infrequently diagnosed antemortem and survival is short. A 60 year old male case of pericardial mesothelioma (epitheloid type) is reported. He was admitted to Yeungnam University Hospital because of chest pain, dyspnea, orthopnea and nonproductive cough. Chest x-ray suggested pericardial effusion. 2-D echocardiography showed echo free spaces of massive pericardial effusion and areas of thick hyperrefractile echoes arising from the pericardium. Pericardiocentesis was attempted and aspirated fluid was bloody exudates. Pericardial window operation with biopsy was done. Swan-Ganz catheterization showed equalization between right atrial pressure and pulmonary capillary wedge pressure. The pathologic diagnosis was established by histologic finding at pericardial biopsy.
The Clinical Analysis of Patient with Patent Ductus Arteriosus.
Myeun Shik Kang, Dong Hyup Lee, Cheol Joo Lee, Tae Eun Jung
Yeungnam Univ J Med. 1986;3(1):287-292.   Published online December 31, 1986
DOI: https://doi.org/10.12701/yujm.1986.3.1.287
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AbstractAbstract PDF
A clinical analysis was performed on 61 cases of patent ductus arteriosus experienced at Yeungnam University Hospital during 3 years period from April, 1984 to December, 1986. Of the 61 patient of PDA, 13 patients were male and 48 patient were female and age ranged 2 months to 26 years old with the average age of 9.4 years. The chief complaints on admission were frequent URI and dyspnea on exertion. diagnostic procedure were Doppler echocardiogram (in 53 among 61). Three postoperative complication were developed, but there was no operative mortality.
Anatomic Classification of Ventricular Septal Defects and Clinical Review of 99 Cases.
Cheol Joo Lee, Tae Eun Jung, Dong Hyup Lee, Myeun Shik Kang
Yeungnam Univ J Med. 1986;3(1):221-227.   Published online December 31, 1986
DOI: https://doi.org/10.12701/yujm.1986.3.1.221
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AbstractAbstract PDF
Ventricular septal defects is most common congenital cardiac anomaly in Korea and worldwide. And its clinical spectrum is well known. The anatomic classification had been undertaken by several authors, but recently Dr. Soto and Anderson's classification is widely used instead of Dr. Kirklin's it. From April, 1984 to December 1986, 99 cases of ventricular septal defects had been taken surgical repair under direct vision using conventional cardiopulmonary bypass technique at Yeungnam university hospital. The clinical spectrum was similar to other hospital, and postoperative mortality was 2%, the most common associated anomaly was patent foramen ovale, and the most common postoperative complication was incomplete or complete right bundle branch block. The rank of defects was as followings: 45 perimembranous inlet type, 21 doubly committed subarterial type, 17, perimembranous trabecular type, and 16 perimembranous outlet type. There was no muscular and mixed type.
Clinical Analysis of Open Heart Surgery: A report of 111 cases.
Cheol Joo Lee, Tae Eun Jung, Dong Hyup Lee, Myeun Shik Kang
Yeungnam Univ J Med. 1986;3(1):215-219.   Published online December 31, 1986
DOI: https://doi.org/10.12701/yujm.1986.3.1.215
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AbstractAbstract PDF
During 1986, 111 cases of open heart surgery were performed at Yeungnam University Hospital consisting 88 cases of congenital heart disease and 23 cases of acquired heart disease. Among 88 congenital heart disease, 72 were acyanotic group and 16 were cyanotic. Common congenital heart diseases were ventricular septal defect (51%), atrial septal defect (18%) and Tetralogy of Fallot (16%). Among 23 acquired heart disease, 22 cases were valvular heart disease and one was dissecting aortic aneurysm. Three cases of the postoperative death were present resulting 2.7% of surgical mortality rate.
Congenital Tracheoesophageal Fistula without Atresia of the Esophagus.
Dong Hyup Lee, Cheol Joo Lee, Hyun Sik Min
Yeungnam Univ J Med. 1985;2(1):253-258.   Published online December 31, 1985
DOI: https://doi.org/10.12701/yujm.1985.2.1.253
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AbstractAbstract PDF
The congenital tracheoesophageal fistula without atresia of the esophagus is considered a rare variant, and the literature concerned to the tracheoesophageal fistula fistula without atresia is little in adult especially. The 22-year-old male was admitted to Yeungnam University Hospital with his chief complaints of weight loss (6 kg/6 months), abdominal discomfort, and intermittent coughing. The diagnosis was made by the endoscopy and esophagography. The fistula was 1.5 cm in diameter, 0.5 cm in length. The level was around second thoracic vertebra. The operation was performed transpleurally through the right third intercostals space and the fistula was secured with interrupted silk suture after division. The fibrotic adhesion was seen around the tracheoesophageal fistula. The postoperative course was uneventful, and postoperative esophagogram revealed no extraluminal leakage. Herewith we report this unusual case of isolated tracheo-esophageal fistula with review of literatures.
A Case Report of Ventricular Septal Defect with Bacterial Endocarditis and Pulmonic Valve Vegetation.
Wha Chong Park, Young Jo Kim, Bong Sup Sim, Chong Suhl Kim, Dong Hyup Lee, Cheol Joo Lee, Bum Koo Cho
Yeungnam Univ J Med. 1985;2(1):241-247.   Published online December 31, 1985
DOI: https://doi.org/10.12701/yujm.1985.2.1.241
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AbstractAbstract PDF
Bacterial endocarditis has been well recognized as an important complication of congenital heart disease, such as ventricular septal defect, patent ductus arteriosus or pulmonary stenosis. The incidence of right sided bacterial endocarditis is lesser than left sided bacterial endocarditis. Also, pulmonic valve vegetation has been thought to be relatively uncommon. So in a patient with fever and evidence of recurrent pulmonary infarction, changing heart murmurs and scattered pneumonic infiltrates, one should direct attention to the heart as a possible source of the infection. Echocardiography with M-mode, 2-D and Doppler mode represents the only noninvasive technic available for detecting vegetations in bacterial endocarditis. In fact, the technic is more sensitive in identifying these lesions than angiography. We experienced a case of ventricular septal defect with bacterial endocarditis, pulmonic valve vegetation and multiple pulmonary embolism diagnosed with Echocardiogram and lung scan, and confirmed by operation. Patch repair of ventricular septal defect, resection of pulmonic valve and vegetation and artificial valve formation with pericardium were done.

JYMS : Journal of Yeungnam Medical Science