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JYMS : Journal of Yeungnam Medical Science

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HOME > J Yeungnam Med Sci > Volume 5(2); 1988 > Article
Original Article Effects of Dimethyl Sulfoxide on the Differentiation of Myocardial and Endothelial Cells.
Dong Hyup Lee, Yee Tae Park, Sung Sae Han, Yung Chang Lee
Journal of Yeungnam Medical Science 1988;5(2):111-119
DOI: https://doi.org/10.12701/yujm.1988.5.2.111
Published online: December 31, 1988
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To elucidate the effects of dimethyl sulfoxide on of myocardial and endothelial cells in culture, the cells were exposed to 10% dimethyl sulfoxide in culture medium for 1 hour at 48 hours after cell isolation. The general morphology and the cytochemical reaction of marker enzymes for mitochondria and Golgi complexes were investigated. The results were summarized as follows 1. DMSO induced elongation and narrowing of the cells and increase of mitochondrial reaction in myocardial cells. 2. DMSO induced destruction and disruption of myofibrils in myocardial cells resulting in increase of contractile activities. 3. In the endothelial cells, DMSO suppressed proliferative activities but thiamine pyrophosphatase reactions were enhanced indicating increase of Golgi complex activity. 4. DMSO seemed to hamper with the adhesiveness and motility of the endothelial cells causing the decrease of the number of cells in vitro.

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