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JYMS : Journal of Yeungnam Medical Science

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Dong Gun Lim 2 Articles
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Eun Kyung Choi, Dong Gun Lim
J Yeungnam Med Sci. 2023;40(2):115-122.   Published online March 21, 2022
DOI: https://doi.org/10.12701/jyms.2022.00017
  • 2,683 View
  • 121 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

Citations

Citations to this article as recorded by  
  • Thymoquinone-loaded self-nano-emulsifying drug delivery system against ischemia/reperfusion injury
    Badr Bahloul, Roua Chaabani, Yosri Zahra, Nesrine Kalboussi, Jamil Kraiem, Souad Sfar, Nathalie Mignet, Hassen ben Abdennebi
    Drug Delivery and Translational Research.2024; 14(1): 223.     CrossRef
  • An update on the molecular mechanism and pharmacological interventions for Ischemia-reperfusion injury by regulating AMPK/mTOR signaling pathway in autophagy
    Bin Tang, Zhijian Luo, Rong Zhang, Dongmei Zhang, Guojun Nie, Mingxing Li, Yan Dai
    Cellular Signalling.2023; : 110665.     CrossRef
  • Unveiling the Crucial Roles of O2•–and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging
    Jihong Liu, Wen Zhang, Xin Wang, Qi Ding, Chuanchen Wu, Wei Zhang, Luling Wu, Tony D. James, Ping Li, Bo Tang
    Journal of the American Chemical Society.2023; 145(36): 19662.     CrossRef
  • New insights into ischemia-reperfusion injury signaling pathways in organ transplantation
    Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
    Current Opinion in Organ Transplantation.2022; 27(5): 424.     CrossRef
  • Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress
    Jinjin Li, Jie Li, Hongbo Fang, Hang Yang, Tianchun Wu, Xiaoyi Shi, Chun Pang
    International Immunopharmacology.2022; 113: 109185.     CrossRef
  • Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance
    Nihan Aydoğan, Gülgün Aylaz, Monireh Bakhshpour, Tugba Tugsuz, Müge Andaç
    Biomimetics.2022; 7(4): 191.     CrossRef
Effect of preoperative pregabalin on postoperative pain after gastrectomy
Chan Yoon Park, Sol Hee Park, Dong Gun Lim, Eun Kyung Choi
Yeungnam Univ J Med. 2018;35(1):40-44.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.40
  • 5,133 View
  • 81 Download
  • 2 Crossref
AbstractAbstract PDF
Background
Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain.
Methods
Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period.
Results
The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth.
Conclusion
A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.

Citations

Citations to this article as recorded by  
  • Treatment of acute postoperative pain in patients undergoing open abdominal aortic repair (current state of the problem)
    Anzhelika V. Kozhanova, Georgy P. Plotnikov
    Regional Anesthesia and Acute Pain Management.2022; 16(1): 45.     CrossRef
  • Comparison of premedication with 75 mg and 150 mg pregabalin for postoperative analgesia in total hysterectomy patients - A randomised control trial
    Ajish Varghese Cheruvathur, Dilshad Thondi Parambil, Saurabh Vig, Salman Mohammed Kutty Chenath, Priyadharshini Nagaraj, Krupa Mulgaonkar, S Jeevithan
    Indian Journal of Clinical Anaesthesia.2022; 9(4): 467.     CrossRef

JYMS : Journal of Yeungnam Medical Science