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JYMS : Journal of Yeungnam Medical Science

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Choong-ki Lee 2 Articles
Epidemiology, Risk Factors, and Pathophysiology of Osteoarthritis
Choong-ki Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S132-141.   Published online December 31, 2007
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  • 10 Download
  • 1 Crossref
AbstractAbstract PDF
Osteoarthritis (OA) is the most prevalent form of arthritis and a major cause of disability in people aged 65 and older. OA is not a single disease; rather, it is a group of overlapping yet distinct diseases with different etiologies but similar pathologic, morphologic, and clinical outcomes. OA occurs when the dynammic equilibrium between the breakdown and reapir of joint tissues is overwhelmed. Systemic and local biomechanical factors contribute to the development of the disease, with systemic factors also making the joint vulnerable and resulting in a greater impact of local joint factors. Systemic risk factors include ethnicity, gender, age, genetic factors, hormonal status, bone density, and nutritional factors. Local biomechanical factors include altered joint biomechanics, prior injuries, the effects of physical activities, sports participation, occupation, developmental abnormalities, and obesity. The normal joint is protected by biomechanical factors such as alignment and muscle strength, the lubrication provided by the synovial fluid, and the shock-absorbing function of bone and cartilage. When these functions are altered, changes occur at both the macroscopic and cellular levels, with derangements in any structure contributing to further joint destruction. 1) Further studies of both risk factor modification and cellular changes in OA will hopefully continue to enhance our understanding of this complex disease and lead to improved outcomes.


Citations to this article as recorded by  
  • Prevalence of Osteoarthritis and Its Affecting Factors among a Korean Population Aged 50 and Over
    Hye-Ryoung Kim, Eun-Jung Kim
    Journal of Korean Public Health Nursing.2013; 27(1): 27.     CrossRef
A Case of Gout with Nodular Pigmented Villonodular Synovitis
Yong-Wook Jung, Myung-Jin Oh, Dae-Young Yun, Young-Hoon Hong, Choong-Ki Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S775-780.   Published online December 31, 2007
  • 1,246 View
  • 15 Download
AbstractAbstract PDF
Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of uncertain etiology that affect synovial lined joints. This disesse is an uncommon that usually afflicts the knee joint. Two types of villi are present in this disease, localized form is called ‘nodular PVNS’ and non localized form is ‘diffuse PVNS’. On microscopy, PVNS is characterized by the presence of hemosiderin-laden, multinucleated, giant cells. But plain radiograph in PVNS shows normal finding exclude effusion, so cannot help diagnosis of PVNS. We experienced a case of a 59-years-old male patient who complained multiple arthralgia, swelling, limit of motion of Lt knee. We gave diagonsis of gout with PVNS by MRI and arthroscopic procedure. So we report this case with review of literature.

JYMS : Journal of Yeungnam Medical Science