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HOME > J Yeungnam Med Sci > Volume 39(3); 2022 > Article
The blind spot and challenges in pain management
Min Cheol Changorcid
Journal of Yeungnam Medical Science 2022;39(3):179-180.
Published online: June 9, 2022

Department of Rehabilitation Medicine, Yeungnam University College of Medicine, Daegu, Korea

Corresponding author: Min Cheol Chang, MD Department of Physical Medicine and Rehabilitation, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea Tel: +82-53-620-4682 • Fax: +0504-231-8694 • E-mail:
• Received: May 11, 2022   • Revised: May 13, 2022   • Accepted: May 27, 2022

Copyright © 2022 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Although pain is not a matter of life and death, it is a common cause of poor quality of life for people [1,2]. It is also the primary reason why patients visit hospitals. Therefore, clinicians should pay particular attention to the presence of a patient's pain and effectively control it.
Pain occurs primarily because of degeneration or damage to musculoskeletal structures. A herniated disc, spinal stenosis, rotator cuff disease, adhesive capsulitis, myofascial pain syndrome on the cervical or lumbar areas, knee and hip osteoarthritis, and musculoskeletal or nervous system injuries are common causes of pain, and clinicians are familiar with diagnosing and treating these diseases. However, clinicians are often unaware of pain in patients suffering from diseases of relatively low incidence. In this special issue, Kwak [3] reviews the pain patterns and pain management in patients with amyotrophic lateral sclerosis (motor neuron disease). In addition, Park and Chang [4] describe the methodology of ultrasound-guided intervention to treat thoracic spine and chest wall pain. Motor neuron disease is uncommon; furthermore, pain in patients with motor neuron disease is often overlooked because clinicians focus on and treat the patient's main symptoms, including muscle weakness. In addition, the incidence of thoracic spine and chest wall pain is relatively low compared to that of the abovementioned common diseases causing musculoskeletal pain, and thoracic spine and chest wall pain are often not actively treated by clinicians because of the risk of developing lung puncture during pain control interventions. This special issue allows clinicians to improve their understanding of pain in patients with motor neuron disease and implement interventions safely and confidently in patients with thoracic spine and chest wall pain.
In clinical practice, corticosteroid injections are mainly used to control musculoskeletal pain [5]. Although corticosteroid injections can effectively control various musculoskeletal disease-associated pain, several side effects, such as allergic reaction, flushing, hyperglycemia, immunosuppression, menstrual changes, and adrenal suppression may occur [6]. Thus, several methods have been assessed as corticosteroid injection replacements. Among these methods, PRF stimulation and PRP injections are known to have some pain control effects that are equivalent to those of corticosteroid injections [6,7]. Moreover, this special issue deals with pain treatment using pulsed radiofrequency (PRF) stimulation and platelet-rich plasma (PRP) injection. Park and Chang [8] review studies on mechanisms of PRP stimulation for controlling pain, and Thu [9] reviews studies related to PRP injection in the management of musculoskeletal pain. With the help of these review papers, we hope that clinicians can effectively use PRF stimulation and PRP injections to control pain in patients, thereby enhancing the therapeutic effectiveness of pain control.
We also expect that this special issue will serve as a bridge to advanced research on neglected pain-causing diseases, PRF stimulation, and PRP injections.

Conflicts of interest

No potential conflict of interest relevant to this article was reported.



  • 1. Chang MC. Conservative treatments frequently used for chronic pain patients in clinical practice: a literature review. Cureus 2020;12:e9934.ArticlePubMedPMC
  • 2. Yang S, Chang MC. Chronic pain: structural and functional changes in brain structures and associated negative affective states. Int J Mol Sci 2019;20:3130.ArticlePubMedPMC
  • 3. Kwak S. Pain in amyotrophic lateral sclerosis: a narrative review. J Yeungnam Med Sci 2022;39:181–9.Article
  • 4. Park D, Chang MC. Ultrasound-guided interventions for controlling the thoracic spine and chest wall pain: a narrative review. J Yeungnam Med Sci 2022;39:190–9.Article
  • 5. Kwak S, Jang SH, Chang MC. Long-term outcomes of transforaminal epidural steroid injection in patients with lumbosacral radicular pain according to the location, type, and size of herniated lumbar disc. Pain Pract 2021;21:836–42.ArticlePubMedPDF
  • 6. Lim JW, Cho YW, Lee DG, Chang MC. Comparison of intraarticular pulsed radiofrequency and intraarticular corticosteroid injection for management of cervical facet joint pain. Pain Physician 2017;20:E961–67.ArticlePubMed
  • 7. Barman A, Mishra A, Maiti R, Sahoo J, Thakur KB, Sasidharan SK. Can platelet-rich plasma injections provide better pain relief and functional outcomes in persons with common shoulder diseases: a meta-analysis of randomized controlled trials. Clin Shoulder Elb 2022;25:73–89.ArticlePubMedPMCPDF
  • 8. Park D, Chang MC. The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review. J Yeungnam Med Sci 2022;39:200–5.Article
  • 9. Thu AC. The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review. J Yeungnam Med Sci 2022;39:206–15.Article

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    Citations to this article as recorded by  
    • Deep-Learning Algorithms for Prescribing Insoles to Patients with Foot Pain
      Jeoung Kun Kim, Yoo Jin Choo, In Sik Park, Jin-Woo Choi, Donghwi Park, Min Cheol Chang
      Applied Sciences.2023; 13(4): 2208.     CrossRef
    • Effectiveness of transcranial alternating current stimulation for controlling chronic pain: a systematic review
      Min Cheol Chang, Marie-Michèle Briand, Mathieu Boudier-Revéret, Seoyon Yang
      Frontiers in Neurology.2023;[Epub]     CrossRef
    • Use of QR Codes for Promoting a Home-Based Therapeutic Exercise in Patients with Lumbar Disc Herniation and Lumbar Spinal Stenosis: A Prospective Randomized Study
      Min Cheol Chang, Donghwi Park, Yoo Jin Choo
      Journal of Pain Research.2022; Volume 15: 4065.     CrossRef

    JYMS : Journal of Yeungnam Medical Science