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JYMS : Journal of Yeungnam Medical Science

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HOME > J Yeungnam Med Sci > Volume 9(2); 1992 > Article
Original Article A study of cisplatin nephrotoxicity.
Young Hee Hwang, Kyoung A Lee, Son Moon Shin, Young Hoon Park, Jeong Ok Hah, Chun Dong Kim, Young Hwan Lee
Journal of Yeungnam Medical Science 1992;9(2):327-333
Published online: December 31, 1992
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To evaluate the nephrotoxicity of cisplatin, serum levels of sodium, potassium, chloride, calcium, phosphorous, magnesium, BUN, creatinine and creatinine clearance were measured before and after administration of cisplatin in 18 cases of patients with malignant neoplasm. The results were as follows: 1) Serum calcium, magnesium, potassium and BUN levels were changed after cisplatin administration, but those changes were not statistically significant. 2) The mean value of creatinine clearance was not decreased significantly after treatment with cisplatin. 3) Acute renal failure was developed in one case, and four cases of hypocalcemia, hypomagnesemia were also detected after administration of cisplatin.

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