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J Yeungnam Med Sci > Volume 9(2); 1992 > Article
Yeungnam University Journal of Medicine 1992;9(2):342-350.
DOI: https://doi.org/10.12701/yujm.1992.9.2.342    Published online December 31, 1992.
Gastric mucosal damage by bile acid.
Hyun Hong Cho, Jeong Ill Suh, Keyong Hee Lee, Tae Nyeun Kim, Moon Kwan Chung, Hyun Woo Lee, Won Hee Choi, Chang Heon Yang
Abstract
To investigate the effect of bile acid on gastric mucosa, we performed biologic test using Sprague-Dawley rat. Mixture solution of TDCA 15mM and Hcl of pH 3 was given into stomach to one group and HCl of pH 3 was given into stomach to another group. The significant gastric mucosal change was vasodilation and edema, that was disappeared progressively. These findings suggest the bile acid and damage gastric mucosa.
Key Words: Stomach, Bile acid, Infalammation
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