Journal of Yeungnam Medical Science

Original article

Usefulness of presepsin in predicting the prognosis of patients with sepsis or septic shock: a retrospective cohort study: Jeong Suk Koh, Yoon Joo Kim, Da Hyun Kang, Jeong Eun Lee, Song-I Lee; Yeungnam Univ J Med. 2021;38(4):318-325. Published online June 15, 2021; DOI: https://doi.org/10.12701/yujm.2021.01018

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Background
The diagnosis and prediction of prognosis are important in patients with sepsis, and presepsin is helpful. In this study, we aimed to examine the usefulness of presepsin in predicting the prognosis of sepsis in Korea.
Methods
Patients diagnosed with sepsis according to the sepsis-3 criteria were recruited into the study and classified into surviving and non-surviving groups based on in-hospital mortality. A total of 153 patients (33 and 121 patients with sepsis and septic shock, respectively) were included from July 2019 to August 2020.
Results
Among the 153 patients with sepsis, 91 and 62 were in the survivor and non-survivor groups, respectively. Presepsin (p=0.004) and lactate (p=0.003) levels and the sequential organ failure assessment (SOFA) scores (p<0.001) were higher in the non-survivor group. Receiver operating characteristic curve analysis revealed poor performances of presepsin and lactate in predicting the prognosis of sepsis (presepsin: area under the curve [AUC]=0.656, p=0.001; lactate: AUC=0.646, p=0.003). The SOFA score showed the best performance, with the highest AUC value (AUC=0.751, p<0.001). The prognostic cutoff point for presepsin was 1,176 pg/mL. Presepsin levels of >1,176 pg/mL (odds ratio [OR], 3.352; p<0.001), lactate levels (OR, 1.203; p=0.003), and SOFA score (OR, 1.249; p<0.001) were risk factors for in-hospital mortality.
Conclusion
Presepsin levels were higher in non-survivors than in survivors. Thus, presepsin may be a valuable biomarker in predicting the prognosis of sepsis.

Citations

Citations to this article as recorded by

Diagnostic and Prognostic Roles of C-Reactive Protein, Procalcitonin, and Presepsin in Acute Kidney Injury Patients Initiating Continuous Renal Replacement Therapy
Suyeon Han, Moo-Jun Kim, Ho-Joon Ko, Eu-Jin Lee, Hae-Ri Kim, Jae-Wan Jeon, Young-Rok Ham, Ki-Ryang Na, Kang-Wook Lee, Song-I. Lee, Dae-Eun Choi, Heyrim Park
Diagnostics.2023; 13(4): 777. CrossRef
Existe Relação entre Miocardite Aguda e a Permeabilidade Intestinal? Dois Biomarcadores nos Ajudam a Responder a esta Pergunta
Fernando Arturo Effio Solis, Adriana Brentegani, Marcelo Luiz Campos Vieira
Arquivos Brasileiros de Cardiologia.2023;[Epub] CrossRef
Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!
Neelmani Ahuja, Anjali Mishra, Ruchi Gupta, Sumit Ray
World Journal of Critical Care Medicine.2023; 12(4): 188. CrossRef
Presepsin as a Novel Biomarker in predicting In‐hospital Mortality in Patients With COVID‐19 Pneumonia
Hebatallah Hany Assal, Safaa Mohamed Abdelrahman, Maha AlyAlden Abdelbasset, Mai Abdelaziz, Irene Mohamed Sabry, Marwa Moawad Shaban
International Journal of Infectious Diseases.2022; 118: 155. CrossRef

Case Report

A successful management after preterm delivery in a patient with severe sepsis during third-trimester pregnancy: Moni Ra, Myungkyu Kim, Mincheol Kim, Sangwoo Shim, Seong Yeon Hong; Yeungnam Univ J Med. 2018;35(1):84-88. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.84

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Abstract PDF: A 33-year-old woman visited the emergency department presenting with fever and dyspnea. She was pregnant with gestational age of 31 weeks and 6 days. She had dysuria for 7 days, and fever and dyspnea for 1 day. The vital signs were as follows: blood pressure 110/70 mmHg, heart rate 118 beats/minute, respiratory rate 28/minute, body temperature 38.7℃, and oxygen saturation by pulse oximetry 84% during inhalation of 5 liters of oxygen by nasal prongs. Crackles were heard over both lung fields. There were no signs of uterine contractions. Chest X-ray and chest computed tomography scan showed multiple consolidations and air bronchograms in both lungs. According to urinalysis, there was pyuria and microscopic hematuria. She was diagnosed with community-acquired pneumonia and urinary tract infection (UTI) that progressed to severe sepsis and acute respiratory failure. We found extended-spectrum beta-lactamase producing Escherichia coli in the blood culture and methicillin-resistant Staphylococcus aureus in the sputum culture. The patient was transferred to the intensive care unit with administration of antibiotics and supplementation of high-flow oxygen. On hospital day 2, hypoxemia was aggravated. She underwent endotracheal intubation and mechanical ventilation. After 3 hours, fetal distress was suspected. Under 100% fraction of inspired oxygen, her oxygen partial pressure was 87 mmHg in the arterial blood. She developed acute kidney injury and thrombocytopenia. We diagnosed her with multi-organ failure due to severe sepsis. After an emergent cesarean section, pneumonia, UTI, and other organ failures gradually recovered. The patient and baby were discharged soon thereafter.

Original Article

Causative organisms of neonatal sepsis.: Kyung Ah Kim, Son Moon Shin, Han Gu Moon, Young Hoon Park; Yeungnam Univ J Med. 1999;16(1):60-68. Published online June 30, 1999; DOI: https://doi.org/10.12701/yujm.1999.16.1.60

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Abstract PDF

A nationwide survey was conducted to investigate the annual occurrence rate of neonatal sepsis, maternal risk factor in neonatal sepsis, localized infection in neonate, causative organism in nosocomial infection and the most common causative organism in neonatal sepsis in Korea. Clinical and bacteriological data were collected from thirty seven neonatal units through retrospective review of the medical records of the newborn infants who were confirmed as neonatal sepsis by isolating organisms from blood culture during one year study period from January to December in 1997. 78,463 neonates were born at 37 hospital in 1997 and 20,869 neonates were admitted to the neonatal units. During this period, 772 episodes of neonatal sepsis were recorded in 517 neonates. The occurrence rate of neonatal sepsis was 0.73%(0~2.95%). Male to female ratio was 1.15:1 and 303 cases(42.1%) were born prematurely. The main pathogens of early onset sepsis were S. aureus(20%), S. epidermidis(14.4%) and coagulase negative Staphylococcus( 14.4%). Gram negative bacilli including Enterobacter spp (7.2%), E.coli(5.1%), Klepsiella(4.5%), Pseudomonas(3.7%) Enterobacter faecium(3.6%) constitute 24.1%. Only two cases of group B beta-hemolytic Streptococcus were isolated. Common obstetric factors were PROM(21.1%), difficulty delivery(18.7%), fetal tachycardia(5.3%), chorioamnionitis(4.9%), maternal fever(4.7%). The main pathogens of late-onset sepsis were S. aureus(22.3%), S. epidermidis(20.4%) and CONS(9.9%). There were 6 cases (1.0%) of Candida sepsis. Frequent focal infections accompanying sepsis were pneumonia(26.1%), urinary tract infection(10.5%), meningitis(8.2%), and arthritis(3.6%). S. epidermidis(22.0%) and S. aureus(21.7%) were also the most common pathogens in 373 nosocomial infection.

Citations

Citations to this article as recorded by

Characteristics of Microorganisms Isolated from Blood Cultures at a University Hospital Located in an Island Region During 2003~2007
Sung Ha Kang, Young Ree Kim
Korean Journal of Clinical Microbiology.2008; 11(1): 11. CrossRef
Microorganisms Isolated from Blood Cultures and Their Antimicrobial Susceptibility Patterns At a University Hospital During 1994-2003
Eun-Mi Koh, Sang-Guk Lee, Chang Ki Kim, Myungsook Kim, Dongeun Yong, Kyungwon Lee, June Myung Kim, Dong Soo Kim, Yunsop Chong
Annals of Laboratory Medicine.2007; 27(4): 265. CrossRef

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