Journal of Yeungnam Medical Science

Original article

Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count: Hyun-Hwa Cha, Jong Mi Kim, Hyun Mi Kim, Mi Ju Kim, Gun Oh Chong, Won Joon Seong; Yeungnam Univ J Med. 2021;38(1):34-38. Published online June 18, 2020; DOI: https://doi.org/10.12701/yujm.2020.00234

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Background
We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes.
Methods
We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test.
Results
The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r=−0.126, p=0.016).
Conclusion
We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes.

Citations

Citations to this article as recorded by

Correlation of maternal platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, C- reactive protein with gestational age at delivery and fetal outcome - A prospective observational study from tertiary care centre
Mrinalini Kannan, Sajeetha Kumari R, Vinodhini Shanmugham
Clinical Epidemiology and Global Health.2024; 28: 101687. CrossRef
The predictive value of thromboelastography, routine blood indices, ultrasound parameters, and placental thickness in determining fetal outcome
Liang Guo
American Journal of Translational Research.2024; 16(7): 3014. CrossRef
Relationship between Platelet-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Spontaneous Preterm Birth: A Systematic Review and Meta-analysis
Liang Peng, Baodi Cao, Fangpeng Hou, Baolin Xu, Hong Zhou, Luyi Liang, Yu Jiang, Xiaohui Wang, Jingjian Zhou, Lingzhang Meng
Journal of Immunology Research.2023; 2023: 1. CrossRef
High Apoptotic Index in Amniotic Membrane of Pregnant Women is A Risk Factor for Preterm Labor
Anak Agung Gede Putra Wiradnyana, Anak Agung Ngurah Jaya Kusuma, Anak Agung Ngurah Anantasika, I Made Darmayasa, Ryan Saktika Mulyana, Gde Bagus Rizky Kornia
European Journal of Medical and Health Sciences.2023; 5(3): 79. CrossRef
Evaluation of Complete Blood Cell Count Parameters in the Diagnosis of Threatened Preterm Labor and Premature Rupture of Membranes
Jule Eriç Horasanlı, Elifsena Canan Alp, Ramazan Bülbül
Dubai Medical Journal.2022; 5(3): 157. CrossRef
The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis
Sina Vakili, Parham Torabinavid, Reza Tabrizi, Alireza Shojazadeh, Nasrin Asadi, Kamran Hessami, Oleh Andrukhov
Mediators of Inflammation.2021; 2021: 1. CrossRef

Original Article

Clinical Significance of Interleukin-6 Concentration of Cervical Discharge in Pregnant Women with Preterm Labor and Preterm Rupture of Membrane: Seong Woong Kim, Sung Chul Park, Sung Ho Lee, Doo Jin Lee; Yeungnam Univ J Med. 2007;24(2 Suppl):S505-518. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S505

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Abstract PDF: Background
：This study is conducted to determine the clinical efficacy of measurement of IL-6 concentration in cervical discharge as a biochemical predictor of preterm labor and PROM. Materials and Methods：Twenty-two pregnant women with preterm labor and 28 women with preterm rupture of membrane(PROM) between 20-36 gestational weeks were selected as study group, and 26 normal pregnant women were selected as control group. In both groups, following routine antenatal laboratory tests, concentration of interleukin-6(IL-6) in cervical discharge and amniotic fluid(in case of preterm labor and PROM) were estimated, and maternal C-reactive protein(CRP) level and WBC count were checked also. To compare the microbiological environment of both groups, Gram stain and culture of cervical smear were undertaken.
Results
：There were no significant differences in maternal age, gravity, parity, gestational age at sampling, and prior preterm delivery, but there were significant differences in initial cervical dilation, effacement, cervicovaginal pH, and preterm delivery in each groups. The average IL-6 level of cervical discharge in women with preterm labor and PROM were significantly higher than control group (p＜0.01). The distribution of women with preterm labor and PROM were significantly different from control group, when 186.7 pg/mL was selected as cutoff value(p＜0.01). There was strong positive correlation between IL-6 concentration in cervical discharge and amniotic fluid IL-6 concentration (r=0.865, p＜0.05). There was no significant difference in CRP in each groups. Maternal WBC count of PROM group at admission was higher than that of preterm labor and control group, but was not statistically significant (p=0.062). Gram (-) rods was detected frequently in women with preterm labor and PROM than control group (p＜0.05). The distribution of microorganisms in cervical discharge in women with preterm labor and PROM were different from control group. Conlusion：The results of this study suggested that cervical IL-6 concentration could be used as an indicator detecting the high risk pregnant women who might develop preterm labor and PROM, and could be accepted as a noninvasive diagnostic marker of intrauterine infection.

Review

Management of Preterm Labor.: Woon Ki Park; Yeungnam Univ J Med. 1999;16(2):141-154. Published online December 31, 1999; DOI: https://doi.org/10.12701/yujm.1999.16.2.141

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Abstract PDF: Premature birth is the single largest cause of perinatal mortality and morbidity in nonanomalous infants in developing countries. Advances in neonatal care have lead to increased survival and reduced short and long term morbidity for preterm infants. but the rate of preterm birth has actually increased. This review provides recent multifactorial approaches to treatment and prevention of preterm birth.

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