Journal of Yeungnam Medical Science

Original Articles

Chemotherapy adherence is a favorable prognostic factor for elderly patients with multiple myeloma who are treated with a frontline bortezomib-containing regimen: Hee-Jeong Cho, Sang-Kyung Seo, Dong Won Baek, Sung-Woo Park, Yoo-Jin Lee, Sang-Kyun Sohn, Ho-Sup Lee, Won Sik Lee, Ji Hyun Lee, Sung Hyun Kim, Joon-Ho Moon; Yeungnam Univ J Med. 2018;35(1):76-83. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.76

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Background
Elderly patients with multiple myeloma (MM) are vulnerable to adverse events (AEs). This study evaluated adherence to chemotherapy and treatment outcomes in elderly patients treated with a frontline bortezomib (BTZ), melphalan, and prednisone (VMP) regimen and regimens without BTZ.
Methods
One-hundred and forty elderly patients who were diagnosed with MM from March 2007 to March 2015 were included in this retrospective study. To evaluate regimen adherence, patients who were treated with more than 4 cycles were assigned to the good adherence group.
Results
Among the 140 patients, 71 were treated with a frontline VMP and 69 with non-BTZ regimens. The median age was 71 years (range, 65-90 years). The VMP group showed a higher complete response rate than the non-BTZ group: 26.8% vs. 7.2%. More patients in the VMP group achieved ≥very good partial response (VGPR) and ≥PR. In the VMP group, 27 patients (38.0%) received less than 4 cycles. The VMP good adherence group showed a higher 3-year overall survival (OS) rate (70.9%) than the poor adherence group (60.2%, p=0.059). In the multivariate analysis, treatment with ≥4 cycles of VMP was a favorable factor for OS.
Conclusion
A good adherence to a frontline VMP regimen resulted in favorable long-term survival. Adequate management of AEs will be needed to achieve favorable outcomes in elderly patients with MM.

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Solomon Islands Oncology Unit: Sustainability in Terms of Outcomes
Dylan Bush, Mark Love, Hugo Bugoro, Nixon Panda
JCO Global Oncology.2024;[Epub] CrossRef
Real World Adherence to and Persistence With Oral Oncolytics in Multiple Myeloma: A Systematic Review and Meta-analysis
Abdallah Y. Naser, Richard Ofori-Asenso, Safaa Al Awawdeh, Sami Qadus, Hassan Alwafi, Danny Liew
Clinical Lymphoma Myeloma and Leukemia.2022; 22(10): 760. CrossRef
Oral therapy adherence and satisfaction in patients with multiple myeloma
Marine Solano, Etienne Daguindau, Cyril Faure, Pierre Loriod, Coline Pain, Anne-Cécile Maes, Pauline Marguet, Marie Kroemer, Anne Rumpler, Jean Fontan, Eric Deconinck, Samuel Limat, Anne-Laure Clairet
Annals of Hematology.2021; 100(7): 1803. CrossRef

The Relationship between Chewing Ability and Health Status in the Urban Elderly who Resides in the House.: Yoon Ho Bae, Hee Kyung Lee; Yeungnam Univ J Med. 2004;21(1):51-59. Published online June 30, 2004; DOI: https://doi.org/10.12701/yujm.2004.21.1.51

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Abstract PDF

BACKGROUND
The objective of this study is to evaluate the relationship between chewing ability and health status in order to provide basic information for the development of program which may lead to an improvement of a the elderly health status in urban areas. MATERIALS AND METHODS: The subjects of this study were 128 elderly urban female over the age of 65 who reside at house. The data were collected from May 21 to August 20, 2001, through questionnaires about nutrient intake status, direct measurement of anthropometrics, and oral examinations. RESULTS: In terms of remaining teeth, there was significant negative relationship between age and number of remained teeth. The average number of remained teeth our subjects was 13.1 10.6. About sixty five percent of the subjects were denture users (partial or full dentures) and there was positive relationship between age and the percentage of denture user. There was a significant negative correlation between age and chewing ability. The group that was able to chew had more remained teeth than the other group. CONCLUSION: This study suggests that there is strong positive relationship between chewing ability (remaining teeth) and elderly health status in urban areas, and the importance of preserving original teeth to improve the elderly health status in the public health program.

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The analysis of dental treatments among the disabled in a charity dental clinic, Cheongju city
Jae-In Ryu, Hye-Ri Jeong
Journal of Korean Academy of Oral Health.2022; 46(2): 78. CrossRef
Difference in food and nutrient intakes in Korean elderly people according to chewing difficulty: using data from the Korea National Health and Nutrition Examination Survey 2013 (6th)
Song Hee Kwon, Hae Ryun Park, Young Mi Lee, Soo Youn Kwon, Ok Sun Kim, Hee Young Kim, Young Suk Lim
Nutrition Research and Practice.2017; 11(2): 139. CrossRef
The Relationships between Stress and ADL in Elderly Living Alone
Eun-Joo Seo, Nam-Hyun Cha
Journal of Digital Convergence.2016; 14(7): 251. CrossRef
Oral health status and care needs of elderly patients in long-term care hospital
Ju-Hyun Lee, Tae-Yoon Hwang
Journal of Korean society of Dental Hygiene.2015; 15(3): 411. CrossRef
Influencing factors on anxiety and depression before and after dental prosthetic treatment in the patients
Sun-Hwa Kwon, Han-Gon Kim
Journal of Korean society of Dental Hygiene.2015; 15(5): 777. CrossRef
Oral health of the elderly people receiving nursing care and home care serivces in Chungnam
Hee-kyung Jang, Eun Mi Choi, Boo-Soon Son
Journal of Korean society of Dental Hygiene.2015; 15(4): 565. CrossRef
Characteristics of the dietary intake of Korean elderly by chewing ability using data from the Korea National Health and Nutrition Examination Survey 2007-2010
Ji Eun Park, Hee Jung An, Sung Ug Jung, Yoonna Lee, Cho-il Kim, Young Ai Jang
Journal of Nutrition and Health.2013; 46(3): 285. CrossRef

The Relationship Between Chewing Ability and Health Status in the Long-lived Elderly of Kyungpook Area.: Hee Kyung Lee, Young Kwon Lee; Yeungnam Univ J Med. 1999;16(2):200-207. Published online December 31, 1999; DOI: https://doi.org/10.12701/yujm.1999.16.2.200

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Abstract PDF

BACKGROUND
The objective of this study is to evaluate the effect of the dental and general health in relation to the state of dentition and chewing ability by survering oral condition and anthropometric measure in order to provide primary statistics for the development of a program which may lead to an improvement in the long-lived elderly health status in a rural community. MATERIALS AND METHODS: The subjects of this study were 97 rural long-lived elderly(27 males and 70 females) who were over 85 years-old (average age of subjects are 88.14+/-3.20 year old) in Sungju-Gun. Kyungpook Province. Data were collected by using questionnaires and direct measurement of anthropometrics, and oral examination from all 97 subjects on July, 1999. RESULTS: The following results were obtained: 1. 53.6% of all subjects believe that they are healthy. The average values of height, weight, BMI, body fat, lean body fat and total water were 148.8+/-11.2cm, 46.9+/-10.5kg, 21.2+/-3.5kg/m2, 26.7+/-6.9%, 73.0+/-7.1%, and 53.4+/-5.2%, respectively. 2. The average number of teeth remaining in the subjects were 3.50+/-571: the number of maxillary teeth remaining were 1.08+/-2.88; and the number of mandibular teeth remaining were 2.41+/-3.76. The maximum number of teeth remaining among subjects were 22 teeth, and the fully edentulous(no natural teeth) people were 76.3%. The oral conditions of the subjects were 52.6% using denture, 23.7% using natural teeth and 23.7% masticating edentulous ridge without denture. 3. In terms of oral condition in self-assessment of health, digestive ability, and chewing ability : On self-assessment of health, 47.1% of those wearing denture group responded as feeling food, 56.5% of those of edentulous without denture, and 65.2% in group of matural teeth only. On self-assessment of digestive ability, 82.4% of those in group of denture responded as feeling food, 65.2% of those in group of no teeth and no denture, and 73.9% of those in group of natural teeth only. On self-assessment of chewing ability, 90.2% of those in the group wearing a denture, 60.9% of those in the group of no teeth and no denture, and 65.2% of those in the group of natural teeth only. 4. In terms of oral condition in anthropometric measurements; The height. weight, body fat, lean body mass, and total water according to oral conditions were 150.0+/-10.7cm, 49.0+/-10.9kg, 26.9+/-6.6%, 72,7+/-7.0%, 53.2+/-5.1%, respectively, in group wearing a denture, 142.7+/-6.0cm, 43.2+/-5.5kg, 29.5+/-7.2%, 70.8+/-6.9%, 51.8+/-5.0%, respectively, in the group of no teeth and no denture, and 152.3+/-14.1cm, 45.9+/-12.6kg, 23.4+/-6.0%, 75.9+/-6.9%, 55.6+/-5.1%, respectively, in the group of natural teeth only. CONCLUSION: The subjective measurements of good health were higher denture user, and natural teeth.

Citations

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Difference in food and nutrient intakes in Korean elderly people according to chewing difficulty: using data from the Korea National Health and Nutrition Examination Survey 2013 (6th)
Song Hee Kwon, Hae Ryun Park, Young Mi Lee, Soo Youn Kwon, Ok Sun Kim, Hee Young Kim, Young Suk Lim
Nutrition Research and Practice.2017; 11(2): 139. CrossRef
Correlation with subjective oral health status and food preference in elderly people
Chung-Soon Park, In-Ja Kim, So-Young Park
Journal of Korean society of Dental Hygiene.2015; 15(6): 973. CrossRef
Demand for Elderly Food Development: Relation to Oral and Overall Health -Focused on the Elderly Who Are Using Senior Welfare Centers in Seoul-
Geum-Yong Lee, Jung-Ah Han
Journal of the Korean Society of Food Science and Nutrition.2015; 44(3): 370. CrossRef
A study of chewing ability According to malocclusion and orthodontic treatment
Hong-Sik Kim, Soo-Chul Park, Nam-Joong Kim
Journal of Korean Acedemy of Dental Technology.2013; 35(1): 67. CrossRef
Characteristics of the dietary intake of Korean elderly by chewing ability using data from the Korea National Health and Nutrition Examination Survey 2007-2010
Ji Eun Park, Hee Jung An, Sung Ug Jung, Yoonna Lee, Cho-il Kim, Young Ai Jang
Journal of Nutrition and Health.2013; 46(3): 285. CrossRef
The effects of dental prostheses to the quality of life among the elderly
Ik-Gang Hur, Tae-Yong Lee, Jin-Keun Dong, Song-Hee Hong
The Journal of Korean Academy of Prosthodontics.2010; 48(2): 101. CrossRef

Differences in Clinical Laboratory Data between the Elderly and the Young Adults.: Kun A Lee, Keun Mi Lee, Seung Pil Jung, Seong Wook Bae; Yeungnam Univ J Med. 1997;14(2):430-442. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.430

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Abstract PDF: Due to the lowering of biological functions resulted from old age, the elderly is known to have many different clinical laboratory data compared with the young adults. But, in korea, such study is lacking. This research is to find the differences between the elderly and the young adults, and also to know the sexual differences, by comparing the outcomes of the clinical laboratory data. Along with that, it is to help clinical usage of the data in the future. The age of the elderly was between 60 and 83(average age 63.8), and that of the young controls was between 20 and 35. In both sexes, MCV, MCH, ESR, CRP,AST, ALT, gamma GTP, ALP, BUN, total cholesterol were significantly higher in the elderly than in the controls. And lymphocyte count(%), total bilirubin, direct bilirubin, total protein, albumin, T3 were significantly lower in the elderly than in the controls(P<0.05). Hemoglobin, Hct, platelet count, T4 were significantly lower only in the male elderly, and eosinophil count(%), creatinine were significantly higher only in the female elderly(P<0.05). HDLcholesterol was significantly higher only in the male elderly(P<0.01). There were no significant difference between two groups regarding WBCcount, segment neutrophil count(%), monocyte count(%), TSH. Many clinical laboratory data are different between the elderly and the young adults, and some clinical laboratory data also have sexual differences.

A Study of Depression Observed Among The Eledrly Residing in Home For The Aged In Korea.: Byung Tak Park, Jong Bum Lee, Jung Hoon Lee, Seung Douk Cheung; Yeungnam Univ J Med. 1990;7(2):79-87. Published online December 31, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.2.79

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Abstract PDF: Using Zung's self-rating depression scale, the authors studied depression in 310 elderlies residing in the 9 home for the aged (HFA) in Kyungbuk area, and 234 elderlies living in Taegu city and 107 elderlies attending a Life-long education program in Taegu, which serve as a control group, Community resident elderlies (CRE). The research had been administered during the period from June to August, 1986. The results were as follows: 1. The mean scores of male, female, and the total of the elderlies in HFA were 38.95±11.55, 44.18±14.15, and 42.8±13.7 respectively while CRE marked 40.8±11.3 for male, 45.2±12.0 for female, and 43.4±11.9 for the total. Therefore there were significant differences between male and female in both groups (<0.01, p<0.001), though no significant difference between the two groups. However, the depression score of elderlies in HFA might be much higher than that of CRE if 81 elderlies (14.2%) in HFA who had been left out of the statistical evaluation due to their having severe depression, organic brain syndrome, or pseudoementia, etc had been included. 2. The score distribution by items for the elderlies in HFA were from highest scores hopelessness, worthlessness, emptiness, decreased appetite, confusion, while for CRE, hopelessness, decreased appetite, psychomotor retardation, indecisiveness, and worthlessness, Elderlies in HFA showed significantly high scores in depressed mood, weight loss, suicidal rumination (ideation) and psychomotor excitement, while CRE showed significantly high scores in decreased appetite, psychomotor retardation, indecisiveness, and dissatisfaction. 3. Elderlies who scored over 50 numbered 10 males (16%), 57 females (34%), and total of 67 (29%) in HFA and 28 male (21%), 77 females (37%), and total of 105 (31%) in CRE: female showed higher seores in both groups. 4. Psychococial factors such as getting older (respectively p<0.01, p<0.01), being Buddhist (respectively p<0.01, p<0.01), and monthly pocket money less than ₩30,000 (respectively p<0.001, p<0.001) were found to have a noticeable impact on the depression level of the elderlies in both groups. Factors such as illiteracy (p<0.001), monthly pocket money less than ₩10,000 (p<0.05), and having no family (p<0.01) recorded significantly higher scores among CRE than the elderlies in HFA.

Effect of the Early Traumatic Experience on the Mental Health of the Elderly.: Kwang Hun Lee, Jung Hoon Lee, Jong Bum Lee, Byung Tak Park, Seung Douk Cheung; Yeungnam Univ J Med. 1990;7(2):67-77. Published online December 31, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.2.67

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Abstract PDF: This study was intended to analyze the relation between the psychic traumatic experience and the psychological health of the aged. The authors carried out this study by means of the combined anxiety-depression scale (CADS) and the preadolescence traumatic experience scale (PTES) with 278 aged men and women residing in Taegu from September to October 1988. The results were as follows: 1. Based on the scores evaluated by CADS, the scores of the both groups showed that comparative group was accounted for 40.15±6.19, while the experimental group for 57.75±6.37, which showed significantly higher score in the experimental group (p<0.001). 2. The experimental group showed significantly higher early experience score than the comparative group in the dietary difficulty, alcoholism among family members, disunion between husband and wife, trouble between mother and children, early mother loss, parent's indifference and unwanted birth (p<0.001). 3. The experimental group showed higher early experience score than the comparative group by sex, age, marital status and grown location (p<0.001). 4. When the subjects were included in the unemployed and in the middle or low classes and their parents were engaged in agriculture and commercial business and believing in buddhism or no-religion, showed higher experience score (p<0.001).

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