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JYMS : Journal of Yeungnam Medical Science

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Volume 15(2); December 1998
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Reviews
Stargardt`s Macular Dystrophy.
D K Hahn
Yeungnam Univ J Med. 1998;15(2):183-193.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.183
  • 1,272 View
  • 3 Download
AbstractAbstract PDF
No abstract available.
Early Detection of Lung Cancer.
H W Lee, K H Lee
Yeungnam Univ J Med. 1998;15(2):195-207.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.195
  • 1,184 View
  • 3 Download
AbstractAbstract PDF
No abstract available.
Mollecular Diagnosis of Mycotic Infection.
J S Choi
Yeungnam Univ J Med. 1998;15(2):208-223.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.208
  • 1,334 View
  • 2 Download
AbstractAbstract PDF
No abstract available.
Original Articles
Blood Lead and ZPP Concentrations of Underground Parking Lot Workers.
Tae Heum Jung, Chang Yoon Kim, Jong Hak Chung
Yeungnam Univ J Med. 1998;15(2):224-236.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.224
  • 1,342 View
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AbstractAbstract PDF
A study was conducted to investigate the blood lead and zinc protoporphyrin(ZPP) concentrations of the underground parking lot workers who exposed to vehicular exhaust aerosols which contained lead. The blood samples were collected from 25 study subjects of underground parking lot and from 33 controls in Taegu, from July to October, 1997. And also the related factors to the blood lead and ZPP concentrations were investigated. Blood lead concentration and ZPP concentration were measured by flameless furnace atomic absorption spectrophotometer (IL.551) and hemetofluorometer, respectively. The mean blood lead concentrations of study subjects and controls were 23.10+/-20.77microgram/dl and 12.99+/-12.71microgram/dl, respectively(p<0.05), and the mean blood ZPP concentrations of study subjects and controls were 40.72+/-9.46microgram/dl and 38.21+/-10.97microgram/dl, respectively. No significant correlations were observed between the blood lead concentration of the study subjects and their job duration and between blood ZPP concentration of the study subjects and their job duration. There were no statistically significant differences in the blood lead concentration and the blood ZPP concentration of smokers and nonsmokers. In multiple regression analysis on blood lead concentration of the study subjects and controls, occupation was a only significant dependent variable. In case of bood ZPP concentration, age was a only significant dependent variable in the study subjects and controls.
Effect of alpha-Interferon 2b on Chronic Hepatitis B Patients with High Serum ALT.
Heon Ju Lee, Young Doo Song
Yeungnam Univ J Med. 1998;15(2):237-245.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.237
  • 1,528 View
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AbstractAbstract PDF
No abstract available.
The Clinical Effect of Sparfloxacin for the Treatment of Acute Respiratory Infection.
Hak Jun Lee, Hye Jung Park, Chang Jin Shin, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee, Hyun Woo Lee
Yeungnam Univ J Med. 1998;15(2):246-253.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.246
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AbstractAbstract PDF
Sparfloxacin is a new synthetic quinolone antimicrobial developed at the Research Laboratories of Dainippon Pharmaceutical Co, Ltd. To evaluate the efficacy and safty of sparfloxacin in acute pulmonary infection, we administered sparfloxacina(100mg) twice in a day to 30 patients who had sign and symptoms of acute pulmonary infectious diseases regardless of their underlying lung disease for 7 days. The results were : 1) A total 30 patients were enrolled in the trial. Among them 24 cases(80%) had underlying lung problems such as chronic obstructive pulmonary disease(36.4%), bronchiectasis(36.4%), bronchial asthma(3.3%), lung cancer(3.3%). 2) In 26 cases(86.6%), we observed effective improvement, and 4 cases(13.4%) show mildly effective improvement of symptoms and signs of respiratory infection. 3) In 23 cases(73.4%), we observed bacteriological eradication in culture or decreased the number of bacteria in Gram stain which found dominantly in previous Gram stain. 4) The significant side effect was not noted. The above results suggest that sparfloxacin was effective as a first line therapy in patients with acute respiratory infection.
Vertebral compression fractures: distinction between benign and malignant causes with Tc-99m labeled antigranulocyte antibody immunoscintigraphy.
Ihn Ho Cho, Hyong Woo Lee, Sang Ho An, Kyu Chang Won, Jang Ho Bae, Soo Ho Cho
Yeungnam Univ J Med. 1998;15(2):254-262.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.254
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AbstractAbstract PDF
We evaluated the effectiveness of Tc-99m labeled antigranulocyte antibody immunoscintigraphy in differentiating the causes of vertebral compression fracture. This study involved 16 patients with vertebral compression fracture; 8 were due to trauma or osteoporosis, 3 were due to metastasis and 5 were due to tuberculous spondylitis. We retrospectively analyzed the location and the extent of decreased tracer uptake in tomographic images of Tc-99m labeled antigranulocyte antibody immunoscintigraphy. Eight patients had a 16 vertebral compression fractures due to trauma or osteoporosis , three patients had a 3 vertebral compression fractures due to metastasis and 5 patients had a 6 vertebral compression fractures due to tuberculous spondylitis. Sixteen vertebral compression fractures by trauma or osteoporosis showed a normal tracer uptake in pedicle, laminar and spinous process, but there was noted with 6 decreased uptake, 8 absence of tracer uptake and 2 normal tracer uptake in the vertebral body. Two vertebral compression fractures by metastasis showed the absence of uptake in vertebral body, pedicle, laminar and spinous process, and one showed an absence of vertebral body and spinous process. Six vertebral compression fractures by tuberculous spondylitis showed the absence of uptake in six compression fractures, the absence of pedicle in five compression fractures. We concluded Tc-99m labeled antigranulocyte antibody immunoscintigraphy may be helpful to differentiate the causes of vertebral compression fractures.
Arthrographic Evaluation in Developmental Dislocation of the Hip: Comparison Between Hip Arthrogram and Operative Findings.
Se Dong Kim, Yun Seok Lee
Yeungnam Univ J Med. 1998;15(2):263-274.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.263
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AbstractAbstract PDF
One of the main purposes in the treatment of developmental dislocation of the hip is to achieve and maintain concentric, congruent, and stable reduction. The arthrogram perform an important role in the diagnosis and treatment of developmental dislocation of the hip. The arthrogram provides much information about the soft tissue status of the hip joint. Limbus and ligamentum teres is exactly evaluated so we can plan the reduction and treatment before operation. 18 preoperative hip arthrograms of 17 children treated for developmental dislocation of the hip from 1992 to 1998 were reviewed. The limbus, ligamentum teres and transverse acetabular ligament were compared with the pathoanatomy seen at the time of open reduction. Arthrography proved reliable in identifying the limbus and ligamentum teres. So we recommend that arthrography must be performed before closed or open reduction. Also, we recorded the radiographic parameters: acetabular index, acetabular floor thickness, center edge(CE) angle of Wiberg, and Y-coordinate. The center edge(CE) angle of Wiberg obtained from arthrography was measured more accurately than from simple roentgenograms because the ossification of the femoral head was frequently located eccentrically in the developmental dislocation of the hip.
A Clinical Study of 20 Uterine Sarcomas.
Young Gi Lee, Yoon Kee Park, Doo Jin Lee
Yeungnam Univ J Med. 1998;15(2):275-285.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.275
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AbstractAbstract PDF
Sarcoma of the uterus is very rare malignant tumor originating from uterine muscle or connective tissue. We have experienced 20 cases of uterine sarcoma from January 1991 to June 1998. The results were as follows: 1. The pathologic types were 13 cases(65.0%) of leiomyosarcoma, 5 cases(25.0%) of malignant mixed Mullerian tumor, 1 case of rhabdomyosarcoma, and 1 case of angiosarcoma. 2. The average age and parity was 50.2 and 3.7. The chief complaints were irregular vaginal bleeding(35.0%), lower abdominal pain(25.0%), and abdominal mass(25.0%). 3. Nine cases(45.0%) were FIGO stage I, 1 case(5.0%) was stage II, 6 cases(30.0%) were stage III, and 4 cases(20.0%) were stage IV. 4. The survival was from 1.5 months to over 130 months(median 16.5 months), and there was no correlation between survival and FIGO stage or pathologic type. The correlation between survival and number of mitotic figure was incalcurable. 5. CA 125 levels were serially measured as a tumor marker in monitoring patients and the positive rate was 40%. Further study was needed to make a conclusion for usefulness of CA 125 as a tumor marker.
In Vitro Culture of Human Nasal Epithelial Cells by Monolayer Culture of Dissociated Cells.
Yong Dae Kim, Si Youn Song, Myung Ki Min, Jang Su Suh, Kei Won Song, Ho Sun Park
Yeungnam Univ J Med. 1998;15(2):286-296.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.286
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AbstractAbstract PDF
Different techniques for culturing respiratory epithelial cells have been developed to overcome the limitations of studies on in vivo and on bioptic material. Traditionally, culture systems are divided into organ cultures, explant cultures and dissociated cell cultures. The first two contain both epithelial and non-epithelial cells. However, in monolayer cultures of dissociated cells only epithelial cells are present, the effects observed are caused by a pure epithelial responses. The purpose of this study is to establish primary culture method of human nasal epithelium (HNEC) by monolayer culture of dissociated cells to evaluate the role of the epithelial cells in the allergic and non-allergic nasal inflammatory reactions. HNEC was prepared by primary culture method of monolayer culture of dissociated cells from human inferior nasal turbinate mucosa of septal deviation patients. Primary cultured cells were characterized by indirect immunofluorescence assay and transmission electron microscopy. The immunoreactivities of cytokeratin-pan and cytokeratin No. 8 were observed in cultured HNEC. However, the immnoreactivities of vimentin and von Willebrand factor were not observed in cultured HNEC. The tonofilaments and desmosome were observed in cultured HNEC. The cultured epithelial cells were identified to be pure nasal epithelial cells. The monolayer culture of dissociated cells could successfully be employed for further study to investigate the role of the epithelial cells in allergic or non-allergic nasal inflammatory diseases.
Early Clinical Experience with Transurethral Electrovaporization of the Prostate for Benign Prostatic Hyperplasia: Comparison with Transurethral Resection of the Prostate and Visual Laser Ablation of the Prostate.
Jung Hyun Kim, Ki Hak Moon, Hee Chang Jung, Tong Choon Park
Yeungnam Univ J Med. 1998;15(2):297-305.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.297
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AbstractAbstract PDF
Recently, several alternatives have been attempted in the management of benign prostatic hyperplasia (BPH) to reduce morbidity of traditional transurethral resection of the prostate (TURP). Among new modalities, transurethral electrovaporization (TEVP) is considered as a promising alternative. To evaluate the safety and initial efficacy of TEVP using the roller loop electrode (ProSurg Inc. USA) on BPH patients, we compared the results of TEVP with those of TURP and visual laser ablation of the prostate (VLAP). In this study, a total of 115 patients with symptomatic BPH were underwent TEVP (n=17), TURP (n=59) or VLAP (n=39) since 1995. Before treatment, patients were evaluated with an International Prostate Symptom Score (IPSS) and the measurement of maximal uroflow rate (MFR) and postvoid residual urine (PVR). After treatment, the operative and hospital records were reviewed. The uroflowmetry and IPSS were re-evaluated 3-10 months after treatment. In clinical outcome of re-evaluation compared to the preoperative parameters, there was a clinically significant improvement in three procedures. TEVP resulted in 62% reduction in IPSS (TURP, 73% : VLAP, 69%), 84% improvement in MFR (TURP, 113% : VLAP, 91%), and 74% reduction in PVR (TURP, 88% : VLAP, 78%). TEVP had shorter duration of hospitalization and catheterization than the others. TEVP was associated with lower rates of treatment-related complication than TURP. In conclusions, TEVP is considered as a useful procedure to treat symptomatic BPH. And, the advantages of TEVP over TURP include excellent intraoperative hemostasis, lower morbidity, shorter hospital stay and simple technique. In addition to this, the advantages over VLAP include lower cost, shorter duration of catheterization and early symptom improvement.
MRI Findings of Neuro-Behcet' Disease.
Han Won Jang, Woo Mok Byun, Kil Ho Cho, Mi Soo Hwang
Yeungnam Univ J Med. 1998;15(2):306-315.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.306
  • 1,539 View
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AbstractAbstract PDF
MR findings in nine patients(three female, six male) with neuroBehcet's disease were retrospectively analyzed. NeuroBehcet's disease was diagnosed on the basis of typical clinical symptoms. Involved site, pattern, signal intensity, and contrast enhancement pattern on MRI were evaluated. In addition, follow up MR imaging was performed in four patients. The midbrain(7/9), internal capsule(7/9), pons(6/9), thalamus(6/9), basal ganglia(5/9), middle cerebella peduncle(4/9), medulla oblongata(2/9), and subcortical white matter(2/9) are involved on MRI. The size of lesions were 1cm to 3cm and their margin was ill-defined and patchy. Inhomogeneous high signal intensity on the T2-weighted images and low signal intensity on T1-weighted images was seen respectvely. In four of nine cases, there was focal enhancement. On follow up MR imaging, improvement or recurrance of the lesions was found. Also in two cases of follow up cases there was artophy in brainstem and/or middle cerebellar peduncles. In conclusion, MR imaging with systemic clinical symptoms is useful for diagnosing neuro-Behcet's disease.
Clinical Features of the Temporomandibular Disorder Patients with Occlusal Splint Therapy.
Jae Chul Song, Byung Rho Chin
Yeungnam Univ J Med. 1998;15(2):316-324.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.316
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AbstractAbstract PDF
This study was performed to evaluate the clinical features and treatment results on 55 temporomandibular disorder patients who had treated by conservative treatment using occlusal splint. The results were as follows; 1. The ratio of men to women was about 1:2.2 and most of the patients were second and third decades. 2. Pain was the most frequent symptom, followed by clicking and mouth opening limitation. 3. The number of acute and chronic groups on the basis of 6 months duration of symptoms were similar. 4. Most of patients had Angle's Class 1 molar relationships(78.2%), followed by Class 3 and Class 2. 5. Centric Relation splints were used alone for treatment of 34 patients and 21 patients were treated with Centric Relation splints and Anterior Repositioning splints. The treatment duration of the patients who had complained pain was average 9.8 weeks and 6 patients of them had slight pain continuously during follow-up. 6. Eleven patient's maximum mouth opening who had mouth opening limitation was improved from 30.7mm to 43.0mm during procedures.
Sick building syndrome in 130 underground workers.
Ree Joo, Joon Sakong, Jong Hak Chung, Sang Whan Park, Dong Hee Kim, Dong Min Kim, Eun Kyong Choi, Hyun Geon Cho
Yeungnam Univ J Med. 1998;15(2):325-339.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.325
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AbstractAbstract PDF
A cross-sectional study was conducted to evaluate the relationship between sick building syndrome(SBS) and the environmental factors affecting SBS on 130 underground workers and 60 controls. The study consisted of 1) a review of environmental condition 2) measurement of temperature, O2, CO2, CO, and formaldehyde and 3) a questionnaire survey of symptom prevalence and perception of environmental conditions using Indoor Air Quality questionnaire by National Institute for Occupational Safety and Health Bronchitis and dust allergy were more prevalent in underground workers significantly(p<0.05). Among the 18 symptoms related to the indoor air pollution, the experience rate of dry, itching or irritated eyes, sore or dry throat, chest tightness, tired or strained eyes and dry or itchy skin symptom is significantly different between the underground workers and controls. The diagnostic criteria of SBS was defined as at least one symptom is experienced 1-3 times a week during the last 1 month among 18 indoor air pollution related symptoms which can be relieved by moving out of the underground. Applying the criteria, the mean symptom score was significant higher in underground workers than controls significantly(p<0.05). These results indicated that underground workers are under inappropriate ergonomic and physical condition and inadequate ventilation. Their experience rate of symptoms related to indoor air pollution and prevalence of SBS was significantly higher than controls. To reduce the prevalence of SBS in underground workers, the surveillance system of indoor air quality, restriction of using fuel in underground and legislative regulations for the environment are needed to establish a better indoor air quality. Early detection, treatment and prevention of SBS through medical attention is also needed.

Citations

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Effects of Regular Treadmill Running on GLUT4 Protein of Skeletal Muscle in STZ-diabetic Rats.
Jong yeon Kim, Hyung il Bae, So young Park, Yong woon Kim, Suck kang Lee
Yeungnam Univ J Med. 1998;15(2):341-349.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.341
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AbstractAbstract PDF
The purpose of this study was to investigate the effects of regular treadmill running on GLUT4 protein of skeletal muscle in STZ-diabetic rats. I used 19 male Sprague-Dawley rats weighing 140 to 160 grams. Rats were randomly assigned into normal, diabetes(DM) and DE(DE) groups. The exercise was loaded with treadmill running for 5 days per week during 4 weeks. All experimental procedures were carried out following overnight fasting 48 hours after last exercise. Gain(gm) in body weight in DM rats(82+/-2.4) was lowered compared to normal rats(109+/-2.8), and decreased by exercise. Plasma glucose concentration(mg/dl) in DM rats was 143+/-3.1 which is higher than that of normal group of 103+/-6.4. The concentration of DE group was lower than that of DM rats. Plasma insulin concentration(micronU/ml) of DM and DE rats was significantly lowerd compared to normal rats. There was no difference of plasma concentrations of FFA and HDL cholesterol among noraml, DM and DE groups. Plasma triglyceride concentration(mg/dl) was significantly highered in DM group compared to those of DM group, the concentration of DE group was lower. Glycogen concentration(mg/gm wet weight) of the plantaris muscle in DM and DE groups was significantly reduced compared to normal group. Glucose transporter 4(GLUT4) protein of soleus was analyzed by Western blot. In DM group, the GLUT4 protein level was markdly decreased compared to normal group, but the level was recovered to the level of normal group by 4 weeks treadmill running. In conclusion, the insulin resistance induced by STZ administration was partially improved by 4 weeks physical training in rats.

JYMS : Journal of Yeungnam Medical Science