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JYMS : Journal of Yeungnam Medical Science

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Young Woon Kim 2 Articles
A Case of Intracranial Involvement in Plasma Cell Myeloma.
Su Hyun Lee, Yoon Yung Chung, Ye Jee Lim, Sun Young Ko, Yoo A Choi, Young Woon Kim, Sung Eun Lee, Chong Won Park
Yeungnam Univ J Med. 2012;29(1):42-44.   Published online June 30, 2012
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AbstractAbstract PDF
Plasma cell myelomas generally manifest as bone or soft-tissue tumors with variable mass effects, pain, and infiltrative behavior. Extramedullary involvement occurs most commonly in the spleen, liver, lymph nodes, and kidneys, but intracranial involvement in plasma cell myeloma is a rare extramedullary manifestation. These authors recently encountered a case of intracranial involvement of plasma cell myeloma. A 69-year-old man was hospitalized for headache and mental changes. Brain CT showed subdural hemorrhage caused by plasma cell myeloma. Plasma cell myeloma with intracranial involvement has poor prognosis, and the patient in this case died from acute complications, such as subdural hemorrhage. Based on this case report, it is suggested that more effective treatment regimens of plasma cell myeloma with intracranial involvement be developed. Moreover, a screening method and decision on the appropriate time for intracranial involvement are needed for plasma cell myeloma patients.


Citations to this article as recorded by  
  • Relapsed plasmacytoma in central nervous system after complete remission of extramedullary plasmacytoma
    Sun Mi Kang, Seong Gyu Kim, Ji Ho Seo, Ji Yoon Kim, Woo Jung Sung, Sung Hwa Bae, Hun Mo Ryoo
    Yeungnam University Journal of Medicine.2014; 31(1): 43.     CrossRef
Effects of insulin and exercise on glucose uptake of skeletal muscle in diabetic rats.
Jin Hyun Park, Young Woon Kim, Jong Yeon Kim, Suck Kang Lee
Yeungnam Univ J Med. 1990;7(1):29-37.   Published online June 30, 1990
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AbstractAbstract PDF
The effects of insulin and exercise on glucose uptake of skeletal muscle were investigated in soleus muscle isolated from low dose streptozotocin induced diabetic rat in vitro. Glucose uptake was assessed by measuring ³H-methylglucose uptake in vitro. Basal glucose uptake in diabetes was reduced by approximately one-third of the control value (5.6±0.73µMol/g/20min. in diabetes versus 8.4±0.77 in control, P<0.01). There was also a significant decrease (P<0.01) in glucose uptake of diabetes at physiologic insulin concentration (200 µIU/ml) by 40% (6.1±1.20 versus 10.0±0.81). Furthermore, maximal insulin (20000 µIU/ml)-stimulated glucose uptake was 36% lower in diabetes as compared with control (7.3±1.29 versus 11.4±1.29, P<0.01). In contrast, exercise (1.0 km/hr, treadmill running for 45 min.) effect on glucose uptake was so dramatic in diabetes that glucose uptake at basal state was 8.+1.09 and insulin stimulated-glucose uptake were 10.2±1.47 and 11.9±1.64, in 200 and 20000 µIU/ml added insulin, respectively. These results suggest that insulin insensitivity develops in skeletal muscle after 2 weeks of streptozotocin-induced diabetes, but these insensitivity was recovered significantly by single session of running exercise.

JYMS : Journal of Yeungnam Medical Science