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JYMS : Journal of Yeungnam Medical Science

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You Jeong 1 Article
Estrogen-secreting adrenocortical carcinoma
You Jeong, Sung Chul Cho, Hee Joon Cho, Ji Soo Song, Joon Seog Kong, Jong Wook Park, Yun Hyi Ku
Yeungnam Univ J Med. 2019;36(1):54-58.   Published online December 20, 2018
DOI: https://doi.org/10.12701/yujm.2019.00017
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AbstractAbstract PDF
Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete aldosterone or androgen. Estrogen-secreting adrenocortical carcinomas are extremely rare, irrespective of the secretion status of other adrenocortical hormones. Here, we report the case of a 53-year-old man with a cortisol and estrogen-secreting adrenocortical carcinoma. The patient presented with gynecomastia and abdominal discomfort. Radiological assessment revealed a tumor measuring 21×15.3×12 cm localized to the retroperitoneum. A hormonal evaluation revealed increased levels of estradiol, dehydroepiandrosterone sulfate, and cortisol. The patient underwent a right adrenalectomy, and the pathological examination revealed an adrenocortical carcinoma with a Weiss’ score of 6. After surgery, he was treated with adjuvant radiotherapy. Twenty-one months after treatment, the patient remains alive with no evidence of recurrence.

Citations

Citations to this article as recorded by  
  • Gynecomastia in a Man With Adrenal Mass
    Jasmine Saini, Patrick Navin, Michael Rivera, Irina Bancos
    JCEM Case Reports.2023;[Epub]     CrossRef
  • Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging
    Alfred King-yin Lam
    Biomedicines.2021; 9(2): 175.     CrossRef

JYMS : Journal of Yeungnam Medical Science