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JYMS : Journal of Yeungnam Medical Science

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Sung Bae Park 2 Articles
Impact of calcineurin inhibitors on rat glioma cells viability
Jeong Hun Seong, Woo Yeong Park, Jin Hyuk Paek, Sung Bae Park, Seungyeup Han, Kyo-Cheol Mun, Kyubok Jin
Yeungnam Univ J Med. 2019;36(2):105-108.   Published online January 21, 2019
DOI: https://doi.org/10.12701/yujm.2019.00108
  • 4,312 View
  • 73 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of CNIs by focusing on the viability of glioma cells.
Methods
Glioma cells were treated with several concentrations of CNIs for 24 hours at 37 ℃ and their cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Results
Exposure to 0, 0.25, 0.5, 2.5, 5.0, and 10.0 mM concentrations respectively showed 100%, 64.3%, 61.3%, 68.1%, 62.4%, and 68.6% cell viability for cyclosporine and 100%, 38.6%, 40.8%, 43.7%, 37.8%, and 43.0% for tacrolimus. The direct toxic effect of tacrolimus on glioma cell viability was stronger than that of cyclosporine at the same concentration.
Conclusion
CNIs can cause neurological side effects by directly exerting cytotoxic effects on brain cells. Therefore, we should carefully monitor the neurologic symptoms and level of CNIs in kidney transplant patients.

Citations

Citations to this article as recorded by  
  • Tacrolimus-Induced Neurotoxicity After Transplant: A Literature Review
    Paige Verona, Jocelyn Edwards, Kassidy Hubert, Federica Avorio, Vincenzina Lo Re, Roberta Di Stefano, Anna Carollo, Heather Johnson, Alessio Provenzani
    Drug Safety.2024;[Epub]     CrossRef
Ocular manifestations in a patient with de novo Fabry disease
You Hyun Lee, Kyu Young Shim, Sung Bae Park, Yu Cheol Kim
Yeungnam Univ J Med. 2018;35(2):232-235.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.232
  • 4,742 View
  • 85 Download
  • 1 Crossref
AbstractAbstract PDF
Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

Citations

Citations to this article as recorded by  
  • Implications of Corneal Refractive Surgery in Patients with Fabry Disease
    Majid Moshirfar, Nour Bundogji, Alyson N. Tukan, Yasmyne C. Ronquillo
    Ophthalmology and Therapy.2022; 11(3): 925.     CrossRef

JYMS : Journal of Yeungnam Medical Science