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JYMS : Journal of Yeungnam Medical Science

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Soyoung Park 2 Articles
Can antioxidants be effective therapeutics for type 2 diabetes?
Soyoung Park, So-Young Park
Yeungnam Univ J Med. 2021;38(2):83-94.   Published online October 8, 2020
DOI: https://doi.org/10.12701/yujm.2020.00563
  • 10,537 View
  • 217 Download
  • 10 Crossref
AbstractAbstract PDF
The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

Citations

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  • Effect of substitution of wheat flour with chickpea flour on their physico-chemical characteristics
    Jiwan S. Sidhu, Tasleem Zafar, Abdulwahab Almusallam, Muslim Ali, Amani Al-Othman
    Arab Gulf Journal of Scientific Research.2023;[Epub]     CrossRef
  • The consumption of date palm fruits as a source of bioactive compounds in patients with type 2 diabetes: a cross sectional study
    M.Q. Al-Mssallem
    Acta Horticulturae.2023; (1371): 381.     CrossRef
  • Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
    Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
    Biogerontology.2023; 24(5): 609.     CrossRef
  • Development and Characterization of Oxidatively Responsive Thiol–Ene Networks for Bone Graft Applications
    Tyler Touchet, Samuel Briggs, Lance Graul, Duncan J. Maitland
    ACS Applied Bio Materials.2022; 5(6): 2633.     CrossRef
  • Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome
    Sahar Mazloomi, Nasrin Sheikh, Marzieh Sanoee Farimani, Shamim Pilehvari, Raffaele Pezzani
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
    Mayadah Bashir Shehadeh, Ghadeer A. R. Y. Suaifan, Ala’ Mustafa Abu-Odeh
    Molecules.2021; 26(14): 4333.     CrossRef
  • An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults
    Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis
    Applied Sciences.2021; 11(17): 7818.     CrossRef
  • Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment
    Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
    Journal of Inflammation Research.2021; Volume 14: 6749.     CrossRef
  • Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice
    Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
    Redox Biology.2020; : 101823.     CrossRef
Secondary amyloidosis complication of Crohn disease treated with infliximab.
Min Joo Song, Hyo Sang Kim, Soyoung Park, Jaekyung Cheon, Sojung Park, Ji Young Yang, Su Kil Park
Yeungnam Univ J Med. 2015;32(2):102-105.   Published online December 31, 2015
DOI: https://doi.org/10.12701/yujm.2015.32.2.102
  • 1,871 View
  • 6 Download
AbstractAbstract PDF
Secondary systemic (AA) amyloidosis is a severe complication of progressed Crohn disease (CD) characterized by the deposition of amyloid A in body organs and tissues. Various therapeutic approaches have been recommended, however there is still no effective treatment. Recently, several case reports have demonstrated the effects of anti-tumor necrosis factor-alpha therapy in patients with AA amyloidosis associated with CD. We report on a 35-year-old female patient with CD complicated by AA amyloidosis in the gastrointestinal tract and renal involvement, who was treated with infliximab. The infliximab therapy improved the gastrointestinal symptoms and decreased the serum creatinine.

JYMS : Journal of Yeungnam Medical Science