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JYMS : Journal of Yeungnam Medical Science

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Seung Woo Lee 1 Article
Apathy syndrome in a patient previously treated with selective serotonin reuptake inhibitors for depression
Hye-Geum Kim, Bon-Hoon Koo, Seung Woo Lee, Eun-Jin Cheon
Yeungnam Univ J Med. 2019;36(3):249-253.   Published online March 15, 2019
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AbstractAbstract PDF
There is considerable overlap in the clinical presentations of apathy and depression. However, differential diagnosis between apathy and other psychiatric conditions, including depression and dementia, is important. In this report, we present the case of a 67-year-old woman with a history of receiving selective serotonin reuptake inhibitor (SSRI) treatment for depression. Differential diagnosis between treatment-resistant depression and SSRI-induced apathy syndrome was required. The symptoms of her apathy syndrome were relieved after the discontinuation of SSRIs and the addition of olanzapine, methylphenidate, and modafinil. Furthermore, we briefly review related literature in this article.


Citations to this article as recorded by  
  • Apathy associated with antidepressant drugs: a systematic review
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    Acta Neuropsychiatrica.2023; 35(4): 189.     CrossRef
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    Muhammad Youshay Jawad, Maurish Fatima, Umer Hassan, Zaofashan Zaheer, Muhammad Ayyan, Muhammad Ehsan, Muhmmad Huzaifa Ahmed Khan, Ahsan Qadeer, Abdul Rehman Gull, Muhammad Talha Asif, Mujeeb U. Shad
    Human Psychopharmacology: Clinical and Experimental.2023;[Epub]     CrossRef
  • Investigation of the efficiency of various antidepressant replacement regimens in the development of SSRI-induced apathy syndrome
    V. E. Medvedev, R. A. Kardashyan, V. I. Frolova, A. M. Burno, S. V. Nekrasova, V. I. Salyntsev
    Neurology, Neuropsychiatry, Psychosomatics.2020; 12(2): 48.     CrossRef

JYMS : Journal of Yeungnam Medical Science