Journal of Yeungnam Medical Science

Jong Soo Choi

22 Articles

Clear cell acanthoma on areola.: Byeong Su Kim, Yeon Woong Kim, Jin Hwa Choi, Seung Hyun Sohng, Dong Hoon Shin, Jong Soo Choi; Yeungnam Univ J Med. 2015;32(2):111-113. Published online December 31, 2015; DOI: https://doi.org/10.12701/yujm.2015.32.2.111

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Abstract PDF: Clear cell acanthoma (CCA) is an asymptomatic benign lesion of unknown origin that typically appears as a brownish, dome-shaped papule on the leg. It has an unusual clinical feature in that it appears as chronic eczema, Bowen disease, or Paget disease on the areola. Its histopathologic findings are well-demarcated psoriasiform acanthosis with pale keratinocytes (clear cells) that are rich in intracellular glycogen, which stain positively with Periodic acid-Shiff. We report herein on a young female patient with CCA on the areolar areas.

Fast-growing multiple symmetric lipomatosis.: Jin Hwa Choi, Byung Su Kim, Seung Hyun Sohng, Hyo Jin Lee, Dong Hoon Shin, Jong Soo Choi, Young Kyung Bae; Yeungnam Univ J Med. 2014;31(1):48-51. Published online June 30, 2014; DOI: https://doi.org/10.12701/yujm.2014.31.1.48

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Abstract PDF: Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetrical massive fatty deposits on the face, neck, shoulders, and upper trunk. We report a 74-year-old man who complained of painless subcutaneous nodules on his posterior neck that developed 3 weeks earlier. In a week, variably-sized similar lesions developed on both his shoulders and upper extremities. At the time of his hospital visit, several firm nodules as big as a walnut to a child's fist and with the normal-skin-hue were observed on his posterior neck, both shoulders, upper extremities, and trunk. The histological examination of his upper left arm revealed more mature adipocytes without encapsulation in the subcutaneous tissue. MSL was generally known to occur slowly over months or years. However, this is an unusual case that showed a fast-growing nature.

A Case of Giant Pyogenic Granuloma on the Palm.: Jeung Young Park, Young Sik Kim, Mi Hye Kim, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 2010;27(1):85-90. Published online June 30, 2010; DOI: https://doi.org/10.12701/yujm.2010.27.1.85

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Abstract PDF: Pyogenic granuloma is one of the common benign vascular tumors of infants and children and it can also occur in adults. There are 25 reports of patients with pyogenic granuloma in the Korean medical literature. In three reports, giant pyogenic granuloma developed over 2 cm in size (1.3 x 0.7 cm, 1.2 x 0.8 cm and 1.1 x 0.7 cm, respectively). There have been no reports in the Korean medical literature of pyogenic granuloma over 2 cm in size. Herein, we report on a giant pyogenic granuloma on the palm of a 72-year old female. The lesion was of an unusually large size of 2.8 x 2.5 x 1.3 cm and we excised it by performing electrosurgery.

A Case of Verruca Plana Looked Like Vitiligo: Seok Ki Moon, Mi Hye Kim, Chan Woo Kim, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S742-745. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S742

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Abstract PDF: Verruca plana is caused by human papillomavirus. Clinical features are 2- to 4-mm slightly elevated, flat topped, smooth papules that may be hyperpigmented. They are generally multiple and are grouped on the face and hand dorsum. Children and young adults are primarily affected. We report a case of verruca plana with vitiligo like lesions in a 6-year-old female patient. She had been treated with topical imiquimod cream and the lesions were getting better.

A Case of Facial Lichen Striatus: Mi Hye Kim, Chan Woo Kim, Seok Ki Moon, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S746-748. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S746

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Abstract PDF: Lichen striatus is a inflammatory disorder characterized by distinctive linear distribution of papules. The lesion presents commonly on the extremities and facial involvement has been reported as being less frequent. Only four cases have been reported in the Korean literatures. A 3-year-old patient presented with linear erythematous papules on the nose. Histopathologically, the lesion showed spongiosis in the epidermis and lymphocytic infiltration around the hair follicles and eccrine glands in the dermis. We report a case of lichen striatus with facial involvement.

Two Cases of Alopecia Totalis treated with Diphenylcyclopropenone (DPCP) Immunotherapy.: Seok Ki Moon, Young Min Shin, Chan Woo Kim, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 2006;23(2):232-239. Published online December 31, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.2.232

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Abstract PDF: Treatments for alopecia areata include topical corticosteroid treatment, corticosteroid intralesional injection, systemic corticosteroid treatment, PUVA(psoralen-UVA) and topical immunotherapy. The therapeutic effects are variable. Alopecia totalis is hard to treat completely. Topical immunotherapy with dinitrochlorobenzene (DNCB), squaric acid dibutyl ester (SADBE) or diphenylcyclopropenone (diphencyprone, DPCP) represents the most accepted therapeutic modality for the treatment of extensive alopecia areata. We report two cases of alopecia totalis treated with DPCP. After DPCP treatment, total scalp hair was completely recovered.

A Case of Coexistent Lichen Sclerosus et Atrophicus and Morphea.: Jin Woo Park, Woo Jin Kim, Ki Baek Jeong, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim, Young Ran Shim; Yeungnam Univ J Med. 2003;20(1):99-103. Published online June 30, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.1.99

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Abstract PDF: Cases of coexistent lichen sclerosus et artrophicus and morphea have been reported. It is controversial that both diseases are single disease-spectrum or entirely separated. We encounterd a forty five year old female with a hypopigmented firm plaque on the left neck. Its histologic feature showed compact orthokeratosis, follicular plugging, atrophy of the stratum malpighii with vacuolar alteration of basal layer, and homogenization of the collagen in the upper dermis (lichen sclerosus et atrophicus). Increased thick collagen bundles were seen in the lower dermis (morphea).

A Case of Solitary Glomus Tumor.: Hae Ook Cho, Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1996;13(1):152-157. Published online June 30, 1996; DOI: https://doi.org/10.12701/yujm.1996.13.1.152

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Abstract PDF: We report a case of subungual solitary glomus tumor in a 28-year-old female, who has suffered from pain and tenderness of the left 4th finger tip for about 5 years. Simple surgical excision was performed for removal of the tumor mass and for the relief of the subjective symptoms. No recurrence has been observed for 5 months following excision of the tumor.

A Case of Lichenoid Drug Eruption Caused by Antituberculosis Drug.: Soo Keoung Lee, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1995;12(2):405-411. Published online December 31, 1995; DOI: https://doi.org/10.12701/yujm.1995.12.2.405

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Abstract PDF: Lichenoid drug eruption is lichenoid skin eruptions caused by certain drugs and compounds, and can be identical or similiar to lichen planus. A 75-year-old woman who had taken antituberculosis medication(INH, ethambutol, rifampin) for 4 months developed pruritic generalized erythematous papular eruptions on the trunk and extremities, alopecia and nail dystropy. Histopathologic findings were hyperkeratosis, hypergranulosis, hyc rophic degenaration of basal layer, band like lymphohistiocytic infiltration in the upper dermis and perivascular lymphohistiocytic infiltration in the deep dermis. She was treated with systemic corticosteroid, and then skin lesion were slightly improved. After termination of antituberculosis medication, skin lesions were markedly improved with residual hyperpigmentation. Alopecia and nail dystrophy were also improved.

Antimycotic susceptibility testing of trichophyton rubrum by microculture method.: Moo Woong Lee, Jong Chul Kim, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1992;9(2):396-406. Published online December 31, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.2.396

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Abstract PDF: Various susceptibility tests have been used to determine minimal inhibition concentration (MIC) of dermatophytes. They have limitations to apply practically because they need long time to determine MiC. Authors examined MIC of T. rubrum to ketoconazole and itraconazole using 96- well microplate and 24-well macroplate by method of Granade and Artis and tried to check the possibility of this method on clinical application. Nine strains of T. rubrum from patients with dermatophytosis were used. Evaluations of the factors affecting MIC were also tried. The results as follows. 1. Effect of inoculation density on determination time and MIC: Determination of MIC were possible in 4th days after inoculation at higher inoculation density (aborbance 2.0, 1.0) compared to 6th days at lower inoculation density (absorbance 0.5, 0.25). 2. Effect of incubation temperature on MIC: When incubating at 37℃, MIC were below 0.006-0.04µg/ml to ketoconazole and below 0.006-0.04µg/ml to itraconazole while at 25℃ 0.08-5.68µ8/ml to ketoconazole and 0.006-0.71µg/ml to itraconazole. Significant reduction of MIC was observed at 37℃ compared to 25℃. 3. Effect of container size on determination time and MIC: When incubating in 96–well microplate and 24-well macroplate, determination of MIC was possible in 4th to 6th days after inoculation in broth-containig 96-well microplate compared to 8th to 12th days in broth-containing 24-well macroplate. But no difference in MIC was observed between different container size. 4. Effect of media on MIC: When using broth as media, MIC were below 0.006-5.68µg/ml to ketoconazole, below 0.006-0.36µg/ml to itraconazole in broth-containg 24-well macroplate. When using agar as media, MIC were below 0.006-5.68 µg/ml to ketoconazole, below 0.006-5.68 µg/ ml to itraconazole in agar-containing 24-well macroplate. 5. These findings confirm that determination of MIC of dermatophtes by method of Granade and Artis is fast and simple technique for antifungal susceptibility test.

Four cases of cutaneous tuberculosis.: Moo Woong Lee, Tae Hun Kwak, Jong Soo Choi, Ki Hong Kim, Mi Jin Kim; Yeungnam Univ J Med. 1992;9(1):181-188. Published online June 30, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.1.181

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Abstract PDF: The incidence of the cutaneous tuberculosis has shown a steady decline over the past decades. This parallels the decreasing incidence of pulmonary tuberculosis. We experienced 5 cases of cutaneous tuberculosis from January 1990 to February 1991. We present herein 4 cases of cutaneous tuberculosis. They were 3 cases of vulgaris and 1 case of tuberculosis verrucosa cutis. Mantoux tests were done except one case and were reactive in all cases. Culture for Mycobacterium tuberculosis were done but Mycobacterium tuberculosis were not cultivated in the all cases. Histopathological findings showed tuberculoid granulomas in the dermis except one case and no acid fast bacilli were demonstrated on AFB stains.

A case of piroxicam-induced photosensitive dermatitis.: Ki Hong Kim, Jong Cheul Kim, Yong Myo Park, Dong Hoon Shin, Jong Soo Choi; Yeungnam Univ J Med. 1991;8(1):215-219. Published online June 30, 1991; DOI: https://doi.org/10.12701/yujm.1991.8.1.215

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Abstract PDF: We report a case of piroxicam-induced photosensitive dermatitis in a 54-year-old female. She had taken oral piroxicam and was exposed to the sunlight on her way home for a few minutes. Several hours after the sun-exposure she developed well-defined, confluent, erythematous plaques and numerous vesicobullae with pruritus and prickling sensation on the sun-exposed areas. A phototest was done on her first visit. The minimal erythemogenic dose (2 J/cm²) of ultraviolet (UV) A was markedly decreased whereas that of UVB was within a normal limit. Visible light irradiation for 30 minutes did not cause skin lesions. Six months after the initial skin lesions, a photopatch test with 1% and 10% piroxicam solution followed by UVA (10 J/cm²) irradiation showed positive responses on both concentrations.

A Case of Sporotrichosis misdiagnosed as Lupus Vulgaris.: Ki Hong Kim, Dong Hoon Shin, Yong Myo Park, Jong Cheul Kim, Jong Soo Choi; Yeungnam Univ J Med. 1990;7(1):191-195. Published online June 30, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.1.191

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Abstract PDF: A case of sporotrichosis misdiagnosed as lupus vulgaris was presented. A 56-year-old woman had been to pea sized, nontender pustules and a hypertrophic-scar-like nodule on the right thigh. She denied any trauma before the lesions developed. Histopathologic findings from the lesion showed tuberculosis-like granulomatous changes. And she was diagnosed as lupus vulgaris. She also had pulmonary tuberculosis and had been treated with antituberculous drugs for 1 year. But skin lesions was not cleared. We suspected the lesions as one of deep mycoses and could confirm sporotrichosis by mycologic studies. They showed characteristic gross colonies and microscopic findings of Sporothrix schenckii..

A Case of Extramammary Paget's Disease.: Yong Myo Park, Dong Hoon Shin, Jong Soo Choi; Yeungnam Univ J Med. 1989;6(2):265-269. Published online December 31, 1989; DOI: https://doi.org/10.12701/yujm.1989.6.2.265

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Abstract PDF: Extramammary paget's disease is uncommon intraepithelial carcinoma of the skin and frequently associated with a subjacent or a regionally proximate carcinoma. We have experienced a case of extramammary Paget's disease affecting 71 year-old man. The patient has been suffered from a well demarcated, and slowly growing erythematous plaque on the left suprapubic area of 3 years. A biopsy specimen reveals infiltration of typical Paget's cells within the epidermis and the adnexa. We review the literature briefly.

Comparison of KOH Positivity According to Sites of the Ring-shaped Dermatophytotic Skin Lesion.: Dong Hoon Shin, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1988;5(2):53-58. Published online December 31, 1988; DOI: https://doi.org/10.12701/yujm.1988.5.2.53

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Abstract PDF: KOH examination is a simple, rapid and diagnostic procedure to confirm dermatophytic infections. It is important to select a proper examination site of the lesion. To determinate the proper examination site of the lesion, mycologic studies were done with multiple specimens collected from the center, margin and out of margin of the ring-shaped dermatophytic skin lesion on the 58 patients. The results were as follows. Positive rate of KOH wet smear was 94.8% at the center and 100% at the margin of the lesions, 22.4% at the 1 cm and 5.2% at the 2 cm out of the lesions. The more hyphae were found in the lesion, the more hyphae were found out of the lesion. Culture was done on the Sabouraud's glucose agar from the highest KOH positive area and the positive culture was 48 strains (82.8%) of 58 patients. These findings suggested that the ring-shaped active margin was the best site to examine mycologic studies.

Three Cases of Kaposi's Varicelliform Eruption.: Hyun Sug Kim, Kae Yong Hwang, Jong Soo Choi, Ki Hong Kim; Yeungnam Univ J Med. 1987;4(2):205-210. Published online December 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.2.205

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Abstract PDF: Kaposi's varicelliform eruption is a more or less generalized infection of the skin, and sometimes of internal organs, with herpes simplex, vaccinia or Coxsackie virus A 16; it appears in people who have atopic dermatitis or some other skin diseases. There is a predilection for infants and children, but no age-group is exempt. We reported 3 cases of Kaposi's varicelliform eruption with atopic dermatitis. They had characteristic multiple umbilicated vesicles on the sites that atopic dermatitis had been involved. A 14-year-old boy and a 2-month-old infant had fever. A 17-year-old boy had wide-spread vesicles. All three patients showed multinucleated giant cells on Tzanck test, that suggests herpes simplex virus origin. They were treated with acyclovir. Within 1 to 2 days after the initiation of the therapy, new lesions had ceased to develop. Most of the lesions were cleared in 7 days without complication.

Study of the Experimental Dermatophyte Infection in Animals.: Jong Soo Choi, Kae Yong Hwang, Ki Hong Kim, Sung Kwang Kim, Jae Kyu Chung, Soon Bong Suh; Yeungnam Univ J Med. 1987;4(1):81-87. Published online August 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.1.81

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Abstract PDF: Experimental dermatophyte infections are essential for studying dermatophytosis. Induction of standard infections depends on control of three factors-spore dose, scarification, and species of the experimental animals. The authors evaluated the three factors in the experimental infection models, which were inoculated with quantitated spore solution of N.gypsea “+” and A. benhomiae “+” in rabbit, guinea pig, rat, and mouse. The results were as follows. 1. Infection was correlated with concentration of inoculums. 2. In traumatization method, abrasion with knife was the most effective for inoculation, followed by pricking, epilation, and shaving of hair in decreasing order. 3. Rabbit and guinea pig were more susceptible to dermatophyte infection rather than the rat and mouse. However, the mouse was not infected at all. 4. Guinea pig was the proper animal model for experimental dermatophytosis in susceptibility, degree of clinical response, and duration of the infection. 5. A.benhamiae “+” showed more severe inflammation and shorter course the N.gypsea “+”.

Study of Relationship between Histologic Findings and Variation of Number of Mast cell in Psoriasis.: Byung Chun Mun, Jong Soo Choi, Ki Hong Kim, Tae Sook Lee; Yeungnam Univ J Med. 1987;4(1):49-57. Published online August 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.1.49

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Abstract PDF: To evaluate whether mast cells are involved in developing pathologic feature of psoriasis, 60 biopsy specimens of patients with psoriasis were analyzed. They had not been treated for at least 1 week before skin biopsy. Histological findings in early and fully developed lesions and numbers of mast cells in their dermal papillae were investigated. The results were as follows: 1. In epidermal changes of psoriatic lesions, parakeratosis and acanthosis revealed different findings between early lesions and fully developed lesions. While early lesions revealed mounds of parakeratosis and mild to moderate acanthosis, fully developed lesions revealed confluent parakeratosis and moderate to severe acanthosis. In dermal changes of psoriatic lesions, papillomatosis revealed different findings between early developed lesions and fully developed lesions. While early lesions revealed normal to moderate papillomatosis, fully developed lesions revealed moderate to severe papillomatosis. 2. Degree of acanthosis is related to the degree of papillomatosis. The more increase in the degree of acanthosis, papillomatosis, and parakeratosis, mast cell numbers in dermal papillae were more increased. 3. Mast cell numbers in dermal papillae were more increased in fully developed lesions than early lesions. 4. These findings suggest that mast cell may play an active role in developing pathologic finding of psoriasis.

Two Cases of Allergic Contact Dermatitis to Betadine(R).: Kae Yong Hwang, Byung Chun Mun, Jong Soo Choi, Ki Hong Kim, Jong Chul Ahn; Yeungnam Univ J Med. 1986;3(1):387-393. Published online December 31, 1986; DOI: https://doi.org/10.12701/yujm.1986.3.1.387

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Abstract PDF

Antiseptics are substances that kill or prevent the growth of microorganisms when applied to living tissue. They must be effective against microorganisms but must also retain their activity in presence of body fluids without being harmful locally or systemically. Among many antiseptics, Betadine(R) has been widely used because of its low toxicity and high germicidal efficacy. We reported 2 cases of allergic contact dermatitis to Betadine(R) in surgical patients. They had eczematous eruption along the Betadine(R) applying sites. Path tests Betadine(R) confirmed the diagnosis.

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A Case of Metastatic Carcinoma of the Skin.: Byung Chun Mun, Kae Yong Hwang, Jong Soo Choi, Won Hee Choi, Tae Sook Lee; Yeungnam Univ J Med. 1986;3(1):357-360. Published online December 31, 1986; DOI: https://doi.org/10.12701/yujm.1986.3.1.357

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Abstract PDF: We report a case of metastatic carcinoma of the skin in 62-year-old male who showed multiple nodules on the anterior chest, scalp, face and left axilla for 2 months duration. He suffered from lower abdominal discomfortness for 6 months. Histopathologic findings revealed atypical cell nests and some tubular or glandular formation in the dermis and subcutaneous fat tissue. Material in the lumen showed diastase resistant and PAS positive, and alcian blue positive at pH 2.4, but negative pH 0.4. So it represented sialomucin. We did not find primary site of malignant tumor. In view of clinical and histopathological findings, it was considered to be originated from the large intestine.

Cutaneous Manifestations Associated with Liver Diseases.: Young Sup Cho, Jong Soo Choi, Ki Hong Kim, Heon Ju Lee; Yeungnam Univ J Med. 1985;2(1):167-174. Published online December 31, 1985; DOI: https://doi.org/10.12701/yujm.1985.2.1.167

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It has been well recognized that the various cutaneous manifestations associated with liver diseases. A clinical study was made of 255 patients (AVH84, LC70, HC41, CAH26, CPH23, AH11) with the liver diseases at Yeungnam University Hospital during the periods from May to November, 1985. The authors classified the cutaneous manifestations into 7 groups according to pathogenesis, and compared them with other reports. The results were as follows: 1. In 255 patients with various liver diseases, 161 patients (63%) showed the various cutaneous manifestations. 2. The various cataneous manifestations were jaundice and/or pruritus (43.1%), vascular changes (39.6%), allergic manifestations (10.6%), nail changes (5.1%), hormone-induced changes (4.3%), pigmentary changes (3.5%) and others (2.4%) in that order. 3. Cutaneous manifestations were associated most frequently with liver cirrhosis (1.6 groups) and the least with chronic active hepatitis (0.7 group). 4. Allergic manifestations were seen mainly in patients with acute viral hepatitis. Three patients showed the serum sickness-like prodrome. 5. The other cutaneous manifestations were seen mainly in patients with chronic liver diseases.

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A Case of Toxic Epidermal Necrolysis.: Jong Soo Choi; Yeungnam Univ J Med. 1984;1(1):185-190. Published online December 31, 1984; DOI: https://doi.org/10.12701/yujm.1984.1.1.185

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Abstract PDF: Toxic epidermal necrolysis is a reactive erythema of nonstaphylococcal origin characterized by a scalded appearance of the skin. The TEN is widely regarded as a variant of severe erythema multiforme because of its acute course, its freguent common cause, its freguent overlap with Stevens-Johnson disease, and its histologic identity. I present a case of TEN with severe mucosal involvement resembled Stevens-Johnson disease.

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