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JYMS : Journal of Yeungnam Medical Science

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Jong Ryeol Eun 3 Articles
Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology
In Cheol Yoon, Jong Ryeol Eun
Yeungnam Univ J Med. 2019;36(2):67-77.   Published online April 11, 2019
DOI: https://doi.org/10.12701/yujm.2019.00171
  • 9,346 View
  • 200 Download
  • 5 Crossref
AbstractAbstract PDF
The paradigm of chronic liver diseases has been shifting. Although hepatitis B and C viral infections are still the main causes of liver cirrhosis and hepatocellular carcinoma (HCC), the introduction of effective antiviral drugs may control or cure them in the near future. In contrast, the burden of nonalcoholic fatty liver disease (NAFLD) has been increasing for decades, and 25 to 30% of the general population in Korea is estimated to have NAFLD. Over 10% of NAFLD patients may have nonalcoholic steatohepatitis (NASH), a severe form of NAFLD. NASH can progress to cirrhosis and HCC. NASH is currently the second leading cause to be placed on the liver transplantation list in the United States. NAFLD is associated with obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. The pathophysiology is complex and associated with lipotoxicity, inflammatory cytokines, apoptosis, and insulin resistance. The only proven effective treatment is weight reduction by diet and exercise. However, this may not be effective for advanced fibrosis or cirrhosis. Therefore, effective drugs are urgently needed for treating these conditions. Unfortunately, no drugs have been approved for the treatment of NASH. Many pharmaceutical companies are trying to develop new drugs for the treatment of NASH. Some of them are in phase 2 or 3 clinical trials. Here, pharmacologic therapies in clinical trials, as well as the basic principles of drug therapy, will be reviewed, focusing on pathophysiology.

Citations

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  • Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
    Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer
    Antioxidants.2024; 13(4): 485.     CrossRef
  • Effect of Lactobacillus rhamnosus hsryfm 1301 Fermented Milk on Lipid Metabolism Disorders in High-Fat-Diet Rats
    Hengxian Qu, Lina Zong, Jian Sang, Yunchao Wa, Dawei Chen, Yujun Huang, Xia Chen, Ruixia Gu
    Nutrients.2022; 14(22): 4850.     CrossRef
  • Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease
    Yuanqiang Ma, Gyurim Lee, Su-Young Heo, Yoon-Seok Roh
    Antioxidants.2021; 11(1): 91.     CrossRef
  • Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis
    Suna Kılınç, Tuna Demirbaş, Enver Atay, Ömer Ceran, Zeynep Atay
    Obesity Research & Clinical Practice.2020; 14(2): 136.     CrossRef
  • Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides
    L. Kořínková, V. Pražienková, L. Černá, A. Karnošová, B. Železná, J. Kuneš, Lenka Maletínská
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
Massive bleeding from a rectal Dieulafoy lesion in a patient with alcoholic cirrhosis
Young Hoon Choi, Jong Ryeol Eun, Jae Ho Han, Hyun Lim, Jung A Shin, Gun Hwa Lee, Seung Hee Lee
Yeungnam Univ J Med. 2017;34(1):88-90.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.88
  • 1,987 View
  • 9 Download
AbstractAbstract PDF
Although Dieulafoy lesion can occur in any part of the gastrointestinal tract, its occurrence in the rectum is rare. Rectal Dieulafoy lesions have been associated with advanced age, renal failure, burns, liver transplantation and cirrhosis. Here, we report on a case of massive bleeding from a rectal Dieulafoy lesion after lung decortication surgery in a 57-year-old male patient with alcoholic cirrhosis. Although rare, a rectal Dieulafoy lesion should be included in the differential diagnosis of massive lower gastrointestinal bleeding in a patient with cirrhosis.
Cellular origin of liver cancer stem cells.
Jong Ryeol Eun
Yeungnam Univ J Med. 2015;32(1):1-7.   Published online June 30, 2015
DOI: https://doi.org/10.12701/yujm.2015.32.1.1
  • 2,053 View
  • 26 Download
AbstractAbstract PDF
Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.

JYMS : Journal of Yeungnam Medical Science