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JYMS : Journal of Yeungnam Medical Science

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Ji Hoon Jang 1 Article
The role of microRNAs in cell death pathways
Ji Hoon Jang, Tae-Jin Lee
Yeungnam Univ J Med. 2021;38(2):107-117.   Published online January 13, 2021
DOI: https://doi.org/10.12701/yujm.2020.00836
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  • 11 Crossref
AbstractAbstract PDF
MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

Citations

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JYMS : Journal of Yeungnam Medical Science