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JYMS : Journal of Yeungnam Medical Science

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Hyun-Hwa Cha 3 Articles
Analysis of single nucleotide polymorphisms associated with the vitamin D pathway in the placentas of women with gestational diabetes mellitus: a laboratory study
Mi Ju Kim, Hyun Mi Kim, Hyun-Hwa Cha, Won Joon Seong
J Yeungnam Med Sci. 2023;40(Suppl):S9-S16.   Published online May 8, 2023
DOI: https://doi.org/10.12701/jyms.2023.00150
  • 1,234 View
  • 55 Download
AbstractAbstract PDF
Background
The aim of this study was to analyze the single nucleotide polymorphisms (SNPs) of genes known to be involved in vitamin D metabolism in the placenta using the placental tissue of mothers diagnosed with gestational diabetes mellitus (GDM) to determine whether the SNPs and occurrence of GDM are related.
Methods
We enrolled 80 women of the same gestational age, 40 with and 40 without GDM. The placenta was obtained from each woman after delivery and SNP genotyping was performed on seven SNPs in the CYP27B1 (rs10877012), CYP24A1 (rs2248359, rs6013897, and rs2209314), and GC (rs2282679, rs16847024, and rs3733359) genes. Maternal serum 25-hydroxyvitamin D levels were measured during the first trimester of pregnancy and before delivery.
Results
At the time of delivery, vitamin D levels were lower (21.05±12.05 mg/dL vs. 31.31±20.72 mg/dL, p=0.012) and the frequency of vitamin D deficiency was higher (60.7% vs. 32.5%, p=0.040) in the GDM group. In women with GDM, the G allele of rs10877012 was more common (86.3% vs. 65.0%, p=0.002). The rs10877012 GG genotype was more common in the GDM group (72.5% vs. 42.5%, p=0.007) and the rs10877012 TT genotype was more common in the control group (12.5% vs. 0%, p=0.007).
Conclusion
Mothers with GDM have lower serum concentrations of vitamin D before delivery than healthy controls and vitamin D deficiency is common. A polymorphism in CYP27B1 (rs10877012), is considered to be a cause of GDM pathogenesis.
The diagnosis of an imperforate anus in female fetuses
Hyun Mi Kim, Hyun-Hwa Cha, Jong In Kim, Won Joon Seong, Sook-Hyun Park, Mi Ju Kim
Yeungnam Univ J Med. 2021;38(3):240-244.   Published online October 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00507
  • 8,868 View
  • 190 Download
  • 5 Crossref
AbstractAbstract PDF
Imperforate anus is an anomaly caused by a defect in the development of the hindgut during early pregnancy. It is a relatively common congenital malformation and is more common in males. Although there are cases of a solitary imperforate anus, the condition is more commonly found as a part of a wider spectrum of other congenital anomalies. Although urgent reconstructive anorectal surgery is not necessary, immediate evaluation is important and urgent decompressive surgery may be required. Moreover, as there are often other anomalies that can affect management, prenatal diagnosis can help in optimizing perinatal care and prepare parents through prenatal counseling. In the past, imperforate anus was diagnosed by prenatal ultrasonography based on indirect signs such as bowel dilatation or intraluminal calcified meconium. Currently, it is diagnosed by directly checking the perineum with prenatal ultrasonography. Despite advances in ultrasound technology, accurate prenatal diagnosis is impossible in most cases and imperforate anus is detected after birth. Here, we present two cases of imperforate anus in female fetuses that were not diagnosed prenatally.

Citations

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    Cunera M.C. de Beaufort, Joep P.M. Derikx, Simon G.F. Robben, Rick R. van Rijn, Ramon R. Gorter, L.W. Ernest van Heurn
    Journal of Pediatric Surgery Case Reports.2023; 89: 102564.     CrossRef
  • Radiology findings of Down syndrome: a literature review
    Jacobus Jeno Wibisono, Carissa Faustina, Maria Georgina Wibisono, Jeanne Leman, Ratna Sutanto
    Chinese Journal of Academic Radiology.2023; 6(4): 133.     CrossRef
  • Аноректальні аномалії розвитку
    Ольга Антонюк, Василь Пикалюк, Олександр Слободян, Альона Романюк, Людмила Шварц
    Notes in Current Biology.2023;[Epub]     CrossRef
  • Anorectoplasty and external sphincteroplasty via inverted V-shaped incision on the perineum for the treatment of imperforate anus with rectal fistula to navicular fossa: Report of 26 cases
    Da Ma, Yi Wang, Ying-Song Liu
    Asian Journal of Surgery.2022; 45(6): 1313.     CrossRef
  • Challenges in prenatal diagnosis of foetal anorectal malformation and hydrocolpos – Case report
    Muhammad Alamsyah Aziz, Fatima Zahra, Cut ZB Razianti, Nuniek Kharismawati, Tjut Sutjighassani, Nadia Larastri Almira, Kevin Dominique Tjandraprawira
    Annals of Medicine & Surgery.2022;[Epub]     CrossRef
Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count
Hyun-Hwa Cha, Jong Mi Kim, Hyun Mi Kim, Mi Ju Kim, Gun Oh Chong, Won Joon Seong
Yeungnam Univ J Med. 2021;38(1):34-38.   Published online June 18, 2020
DOI: https://doi.org/10.12701/yujm.2020.00234
  • 5,610 View
  • 103 Download
  • 4 Crossref
AbstractAbstract PDF
Background
We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes.
Methods
We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test.
Results
The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r=−0.126, p=0.016).
Conclusion
We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes.

Citations

Citations to this article as recorded by  
  • Relationship between Platelet-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Spontaneous Preterm Birth: A Systematic Review and Meta-analysis
    Liang Peng, Baodi Cao, Fangpeng Hou, Baolin Xu, Hong Zhou, Luyi Liang, Yu Jiang, Xiaohui Wang, Jingjian Zhou, Lingzhang Meng
    Journal of Immunology Research.2023; 2023: 1.     CrossRef
  • High Apoptotic Index in Amniotic Membrane of Pregnant Women is A Risk Factor for Preterm Labor
    Anak Agung Gede Putra Wiradnyana, Anak Agung Ngurah Jaya Kusuma, Anak Agung Ngurah Anantasika, I Made Darmayasa, Ryan Saktika Mulyana, Gde Bagus Rizky Kornia
    European Journal of Medical and Health Sciences.2023; 5(3): 79.     CrossRef
  • Evaluation of Complete Blood Cell Count Parameters in the Diagnosis of Threatened Preterm Labor and Premature Rupture of Membranes
    Jule Eriç Horasanlı, Elifsena Canan Alp, Ramazan Bülbül
    Dubai Medical Journal.2022; 5(3): 157.     CrossRef
  • The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis
    Sina Vakili, Parham Torabinavid, Reza Tabrizi, Alireza Shojazadeh, Nasrin Asadi, Kamran Hessami, Oleh Andrukhov
    Mediators of Inflammation.2021; 2021: 1.     CrossRef

JYMS : Journal of Yeungnam Medical Science