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JYMS : Journal of Yeungnam Medical Science

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Hyeong Chan Shin 2 Articles
High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis
Hyeong Chan Shin
Yeungnam Univ J Med. 2021;38(2):169-174.   Published online March 5, 2021
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  • 90 Download
  • 4 Crossref
AbstractAbstract PDF
Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland, but primary thyroid MEC has rarely been reported and usually has a good prognosis. Herein, I report a case of thyroidal MEC with a poor prognosis in an 82-year-old woman with an anterior neck mass. Ultrasonography and computed tomography revealed a thyroid mass. The patient initially underwent fine-needle aspiration, was diagnosed with malignancy, and underwent a right lobectomy. On gross examination, a 4.0×3.6×2.6 cm-sized ill-defined, unencapsulated, and infiltrative tan to whitish mass with necrosis was identified. Microscopically, epidermoid tumor cell nests or solid sheets were identified. Mucous cells that were positive for periodic acid–Schiff and mucicarmine stains were also identified within epidermoid cell nests. Frequent mitosis and necrosis were observed. Immunohistochemical staining for p40 and p63 was positive, and that for thyroid transcription factor-1 and PAX8 was focally positive. According to the Armed Forces Institute of Pathology grading system for salivary gland MEC, the current case was classified as high-grade MEC. After surgery, the patient suffered from dyspnea due to a remnant neck mass that compressed and obstructed the trachea; therefore, the patient refused further treatment. Thyroidal MECs are considered low-grade with a favorable prognosis, but there are several reported cases of thyroidal MEC with poor prognosis. The current case is a rare presentation of high-grade thyroidal MEC with a poor prognosis.


Citations to this article as recorded by  
  • Primary mucoepidermoid carcinoma of the thyroid with concomitant MAML2 gene rearrangement and BRAF V600E mutation – A case report
    Frederica Loghides, Brigid Aherne
    Oral Oncology Reports.2024; 9: 100154.     CrossRef
  • Mucoepidermoid carcinoma of the pancreas: A case report and literature review
    Huan Zhang, Shuyan Wang, Chunnian Wang
    Medicine.2024; 103(4): e36993.     CrossRef
  • Primary Thyroid Mucoepidermoid Carcinoma (MEC) Is Clinically, Prognostically, and Molecularly Different from Sclerosing MEC with Eosinophilia: A Multicenter and Integrated Study
    Hieu Trong Le, Truong P. X. Nguyen, Mitsuyoshi Hirokawa, Ryohei Katoh, Norisato Mitsutake, Michiko Matsuse, Ayaka Sako, Tetsuo Kondo, Nilesh Vasan, Young Mi Kim, Ying Liu, Lewis Hassell, Kennichi Kakudo, Huy Gia Vuong
    Endocrine Pathology.2023; 34(1): 100.     CrossRef
  • Overview of the 2022 WHO Classification of Thyroid Neoplasms
    Zubair W. Baloch, Sylvia L. Asa, Justine A. Barletta, Ronald A. Ghossein, C. Christofer Juhlin, Chan Kwon Jung, Virginia A. LiVolsi, Mauro G. Papotti, Manuel Sobrinho-Simões, Giovanni Tallini, Ozgur Mete
    Endocrine Pathology.2022; 33(1): 27.     CrossRef
A Case of Gastric Lipoma with Upper Gastrointestinal Bleeding.
Min Geun Gu, Kook Hyun Kim, Byung Sam Park, Sung Yun Jung, Yo Han Jeong, Dong Won Lee, Hyeong Chan Shin, Mi Jin Gu
Yeungnam Univ J Med. 2013;30(2):132-135.   Published online December 31, 2013
  • 1,732 View
  • 4 Download
AbstractAbstract PDF
Gastric lipoma is a typical benign submucosal tumor that is usually asymptomatic and is generally detected incidentally when performing gastroscopy. However, depending on its size and location, an atypical gastrointestinal lipoma can cause abdominal pain, diarrhea, constipation, intestinal obstruction, intussuception and life-threatening gastrointestinal bleeding. We report herein a case of gastric lipoma with bleeding in a 43-year-old man. The gastroscopy showed a 4x4 cm ulcero-fungating submucosal mass at the anterior wall of the gastric antrum. Laparoscopic gastric wedge resection was performed and the lesion was diagnosed as gastric lipoma.

JYMS : Journal of Yeungnam Medical Science