Journal of Yeungnam Medical Science

Gi Beom Kim

2 Articles

Current perspectives in stem cell therapies for osteoarthritis of the knee: Gi Beom Kim, Oog-Jin Shon; Yeungnam Univ J Med. 2020;37(3):149-158. Published online April 13, 2020; DOI: https://doi.org/10.12701/yujm.2020.00157

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Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.

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Scaffold-Free Cartilage Construct from Infrapatellar Fat Pad Stem Cells for Cartilage Restoration
Orada Sriwatananukulkit, Tulyapruek Tawonsawatruk, Kasem Rattanapinyopituk, Ticomporn Luangwattanawilai, Narongrit Srikaew, Ruedee Hemstapat
Tissue Engineering Part A.2022; 28(5-6): 199. CrossRef
Autologous Protein Solution Effect on Chondrogenic Differentiation of Mesenchymal Stem Cells from Adipose Tissue and Bone Marrow in an Osteoarthritic Environment
Stefania Pagani, Francesca Veronesi, Gianluca Giavaresi, Giuseppe Filardo, Tiziana Papio, Iacopo Romandini, Milena Fini
CARTILAGE.2021; 13(2_suppl): 225S. CrossRef
Mesenchymal Stem Cell-Derived Exosomes and Their Therapeutic Potential for Osteoarthritis
Gi Beom Kim, Oog-Jin Shon, Min-Soo Seo, Young Choi, Wook Tae Park, Gun Woo Lee
Biology.2021; 10(4): 285. CrossRef
Molecular basis for new approaches to therapy of osteoarthritis (part I)
E. V. Chetina, G. A. Markova, A. M. Lila
Modern Rheumatology Journal.2021; 15(4): 7. CrossRef
The therapeutic potential of mesenchymal stem cells in treating osteoporosis
Tianning Chen, Tieyi Yang, Weiwei Zhang, Jin Shao
Biological Research.2021;[Epub] CrossRef
The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease
Robert A. Culibrk, Mariah S. Hahn
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef

Spinal Fusion Based on Ex Vivo Gene Therapy Using Recombinant Human BMP Adenoviruses.: Gi Beom Kim, Jae Ryong Kim, Myun Hwan Ahn, Jae Sung Seo; Yeungnam Univ J Med. 2007;24(2):262-274. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.262

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Abstract PDF: PURPOSE: Bone morphogenetic proteins (BMPs) play an important role in the formation of cartilage and bone, as well as regulating the growth of chondroblasts and osteoblasts. In this study, we investigated whether recombinant human BMP adenoviruses are available for ex vivo gene therapy, using human fibroblasts and human bone marrow stromal cells in an animal spinal fusion model. MATERIALS AND METHODS: Human fibroblasts and human bone marrow stromal cells were transduced with recombinant BMP-2 adenovirus (AdBMP-2) or recombinant BMP-7 adenovirus (AdBMP-7), referred to as AdBMP-7/BMSC, AdBMP-2/BMSC, AdBMP-7/HuFb, and AdBMP-2/HuFb. We showed that each cell secreted active BMPs by alkaline phosphatase staining. Since AdBMP-2 or AdBMP-7 tranducing cells were injected into the paravertebral muscle of athymic nude mice, at 4 weeks and 7 weeks, we confirmed that new bone formation occurred by induction of spinal fusion on radiographs and histochemical staining. RESULTS: In the region where the AdBMP-7/BMSC was injected, new bone formation was observed in all cases and spinal fusion was induced in two of these. AdBMP-2/BMSC induced bone formation and spinal fusion occurred among one of five. However, in the region where AdBMP/HuFb was injected, neither bone formation nor spinal fusion was observed. CONCLUSION: The osteoinductivity of AdBMP-7 was superior to that of AdBMP-2. In addition, the human bone marrow stromal cells were more efficient than the human fibroblasts for bone formation and spinal fusion. Therefore, the results of this study suggest that AdBMP-7/ BMSC would be the most useful approach to ex vivo gene therapy for an animal spinal fusion model.

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