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JYMS : Journal of Yeungnam Medical Science

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Byung Cheol Choi 1 Article
The Effects of Dimethly Sulfoxide and Sodium thiosulfate for the Prevention of Tissue Necrosis due to Extravasation of Mitomycin-C.
Sang Hyun Woo, Byung Cheol Choi, Ki Hyung Kim, Jung Hyun Seul, Tae Eun Jung
Yeungnam Univ J Med. 1996;13(2):243-250.   Published online December 31, 1996
DOI: https://doi.org/10.12701/yujm.1996.13.2.243
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Extravasation of toxic chemotherapeutic 'agents cause severe skin ulceration and necrosis which often need secondary surgical intervention. Still, there were not established antidote agent in case of extravasation with mitomycin-c. Dimethyl sulfoxide is known as an effective chemical scavenger of toxic hydroxyl free radical and sodium thiosulfate also was demonstrated significant protector from mitomycin-c induced ulceration by a few experimental studies. Author investigated necrotic area of mitomycin-c injected site and compare to the effectiveness of topical treatment with dimethyl sulfoxide and intradermal injection of sodium thiosulfate according to starting times, forty five mice were divided into 3 groups. Control group(n=5) had no treatment after subcutaneous injection of mitomycin-c. Experimental group I and 11 were 20 mice treated dimethyl sulfoxide and sodium.

JYMS : Journal of Yeungnam Medical Science