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J Yeungnam Med Sci > Volume 24(2 Suppl); 2007 > Article
Yeungnam University Journal of Medicine 2007;24(2 Suppl):S142-151.
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S142    Published online December 31, 2007.
Platelet Activating Factor-Acetylhydrolase
Tae-Yoon Lee
Departments of Microbiology, College of Medicine, Yeungnam University, Daegu, Korea
혈소판 활성화 인자 분해효소
이태윤
영남대학교 의과대학 미생물학교실
Correspondence:  Tae-Yoon Lee, Tel: (053) 620-4362, Fax: (053) 653-6628, 
Email: doxr7p@med.yu.ac.kr
Abstract
Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.
Key Words: Platelet activating factor, Platelet activating factor-acetylhydrolase, disease, recombinant, treatment
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