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J Yeungnam Med Sci > Volume 33(1); 2016 > Article
Yeungnam University Journal of Medicine 2016;33(1):1-7.
DOI:    Published online June 30, 2016.
Diverse clinical manifestations caused by varicella-zoster virus reactivation.
Hosun Park
Department of Microbiology, College of Medicine, Yeungnam University, Daegu, Korea.
The two distinctive clinical features of varicella-zoster virus (VZV) are varicella (chickenpox) by primary infection and zoster (singles) by the reactivation of latent infection. In addition to the two typical clinical symptoms mentioned above, diverse clinical manifestations have been reported as a result of VZV reactivation, including chronic radicular pain without rash, visual loss, facial palsy, dysphagia, sore throat, odynophagia, otalgia, hearing loss, dizziness, headache, hemiplegia, etc. Most of these symptoms are derived from neuropathy and vasculopathy of affected nerves and arteries. Diagnosis of VZV disease can be difficult if there is no appearance of a skin rash during development of atypical symptoms. In addition to natural infection, vaccination and anti-viral agent treatment have influenced the changes of epidemics and clinical presentations of varicella and zoster. In this article, diverse clinical manifestations caused by VZV reactivation, particular without skin rash, are reviewed.
Key Words: Varicella-zoster virus, Herpes zoster, Zoster sine herpete, Cranial neuropathy, Vasculopathy
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