The term histiocytic medullary reticulosis first was introduced by Scott and Robb-Smith. It is a clinicopathologic syndrome characterized by wasting, fever, lymphadenopathy, hepatosplenomegaly, pancytopenia, and is often accompanied by jaundice, purpura. Cardinal pathologic feature are systemized proliferation of atypical, neoplastic, erythrophagocytic D. We are here reporting one case which considered compatible for HMR, with a few elementary reviewed literatures.