Journal of Yeungnam Medical Science

Case report

Endocrinology, Diabetes, and Metabolism
A 32-year-old man with plexiform schwannoma of the thyroid gland: a case report: Il Rae Park, Min Chong Kim, Seung Min Chung, Si Youn Song; J Yeungnam Med Sci. 2024;41(4):312-317. Published online September 10, 2024; DOI: https://doi.org/10.12701/jyms.2024.00556

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Plexiform schwannomas representing a rare subset, comprise 5% of all schwannomas. However, their occurrence in the thyroid gland is exceptionally rare. A 32-year-old male presented with an incidentally discovered, asymptomatic thyroid mass. Imaging revealed an approximately 5 cm heterogeneous solid mass on the right thyroid lobe extending to the upper mediastinum and directly invading the upper trachea. Under the suspicion of thyroid malignancy, the patient underwent right thyroidectomy. Histological examination confirmed a plexiform schwannoma with S100-positive spindle cells. Currently, the patient is undergoing outpatient follow-up, with no reported complications. To our knowledge, this is the first documented case of plexiform schwannoma of the thyroid gland within the English literature. This case highlights the diverse and unpredictable clinical manifestations of thyroid masses, emphasizing the importance of a multidisciplinary approach for diagnosing and managing rare entities, such as thyroid gland schwannomas.

Citations

Citations to this article as recorded by

Plexiform Schwannoma Over the Anterior Chest Wall: A Clinicopathological Review
Debojyoti Sasmal, Saswata Barenya, Hinglaj Saha, Pankaj Kumar Halder
Amrita Journal of Medicine.2025; 21(2): 95. CrossRef

Case Reports

Gastroenterology and Hepatology
Giant esophageal schwannoma.: Min Jae Kim, Joon Cheol Song, Il Kim, Jin Tak Yun, Young Woo Kim, Young Choi, Yeon Ho Joo, Chang Hyun Kang; Yeungnam Univ J Med. 2016;33(1):21-24. Published online June 30, 2016; DOI: https://doi.org/10.12701/yujm.2016.33.1.21

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Abstract PDF: Esophageal schwannoma is a very rare submucosal tumor. We report successful management of esophageal schwannoma in a 41-year-old man who complained of progressively worsening dysphagia. A huge submucosal tumor was found via endoscopy and a chest computed tomography scan. Esophagectomy was performed with no post-operative complications. Post-operative immunohistochemistry staining showed a positive result for S-100 and negative results for c-kit and CD34. The post-operative mild dysphagia persisted, and the follow-up endoscopic findings revealed anastomosis site stenosis. Approximately 2 months later, we performed endoscopic balloon dilatation. We report herein a case of esophageal schwannoma with reviews.

Gastroenterology and Hepatology
Solitary schwannoma of the ascending colon.: Myeong Su Chu, Hyun Mo Kang, Hyeong Ju Sun, Dong Min Kim, Hyong Jong Kwak; Yeungnam Univ J Med. 2016;33(1):37-39. Published online June 30, 2016; DOI: https://doi.org/10.12701/yujm.2016.33.1.37

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Abstract PDF: Schwannomas are uncommon neoplasms arising from Schwann cells of the neural sheath. Gastrointestinal schwannomas are rare, accounting for 1% of all malignant gastrointestinal tumors. Colonoscopic biopsy with immunohistochemical (IHC) staining is useful for confirming this tumor. We report on a patient with schwannoma arising from the ascending colon, which was detected by colonoscopy and endoscopic submucosal dissection was attempted. A 41-year-old man presented with abdominal discomfort. The patient was diagnosed with a subepithelial tumor on colonoscopy. He underwent endoscopic submucosal dissection. Histopathology and IHC staining confirmed that the colonic lesion was a benign schwannoma. However, the resection margin was positive. Therefore, laparoscopic ileocolectomy was performed.

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