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JYMS : Journal of Yeungnam Medical Science

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Original article
Galectin-3 as a possible link between periodontitis and chronic kidney disease: a cross-sectional study
Sri Vidhya Marimuthu, Devi Arul, Muthukumar Santhanakrishnan, Ramprasad Elumalai, Sandhya Suresh, Sathya Selvarajan, Ravindranath Dhulipalla, Ramanarayana Boyapati
J Yeungnam Med Sci. 2025;42:22.   Published online January 20, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.22    [Epub ahead of print]
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  • 54 Download
AbstractAbstract PDF
Background
Chronic periodontitis is associated with various systemic inflammatory diseases; however, research on its association with chronic kidney disease (CKD) is relatively limited. Because both conditions share common risk factors, systemic inflammation plays a key role in the progression of these diseases. Galectin-3 (Gal-3) is a proinflammatory cytokine that plays an important role in chronic inflammatory diseases and is a potential biomarker. This study aimed to measure salivary Gal-3 levels in patients with periodontitis and CKD to better understand their association and evaluate Gal-3 as a diagnostic biomarker for these conditions.
Methods
Seventy-five patients were categorized into three groups: Group I, patients with CKD and periodontitis (n=25); Group II, patients with chronic periodontitis who were systemically healthy (n=25); and Group III, patients with CKD without chronic periodontitis (n=25). Demographic characteristics and periodontal and renal parameters were recorded for each patient. Saliva samples were collected to evaluate Gal-3 levels using an enzyme-linked immunosorbent assay.
Results
Patients with chronic periodontitis and CKD and those with chronic periodontitis alone (Groups I and II, respectively) showed significantly higher salivary Gal-3 levels than patients with CKD alone (Group III) (p<0.001). Bivariate correlation analysis indicated a strong relationship between clinical parameters and Gal-3 levels across all three groups.
Conclusion
Salivary Gal-3 level is a valuable early diagnostic marker of chronic periodontitis and CKD.
Review articles
Recent updates on classification and unsolved issues of diverticular disease: a narrative review
Kyeong Ok Kim
J Yeungnam Med Sci. 2024;41(4):252-260.   Published online August 30, 2024
DOI: https://doi.org/10.12701/jyms.2024.00542
  • 2,481 View
  • 130 Download
AbstractAbstract PDF
Recently, a paradigm shift has occurred in the classification of diverticular disease and the understanding of its pathogenesis. Diverticular disease is now defined as a variety of clinically significant conditions such as diverticulitis, diverticular bleeding, symptomatic uncomplicated diverticular disease, and segmental colitis associated with diverticulosis. Low-grade inflammation, visceral hypersensitivity, abnormal intestinal motility, and genetic factors have emerged as the key contributors to the pathogenesis of diverticular disease. Routine antibiotic use is no longer recommended for all cases of diverticulitis, and simple recurrence is not an indication for surgical treatment. Early colonoscopy with proper preparation is recommended for the treatment of diverticular bleeding, although recent studies have not shown significant efficacy in preventing recurrence. The roles of dietary fiber, nonabsorbable antibiotics, 5-aminosalicylates, and probiotics in the prevention of diverticular disease are controversial and require further investigation.
Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
Hyun Uk Chung, Jun Hyuk Son
J Yeungnam Med Sci. 2022;39(1):3-11.   Published online September 15, 2021
DOI: https://doi.org/10.12701/yujm.2021.01263
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  • 171 Download
  • 8 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML.

Citations

Citations to this article as recorded by  
  • Unusual Pediatric Red Eye
    Carson W. Ercanbrack, Jamal O. Azhari, David B. Warner, Maher Abulfaraj, Abdelrahman M. Elhusseiny
    The Journal of Pediatrics.2024; 267: 113924.     CrossRef
  • The Possible Role of Pathogens and Chronic Immune Stimulation in the Development of Diffuse Large B-Cell Lymphoma
    Lajos Gergely, Miklos Udvardy, Arpad Illes
    Biomedicines.2024; 12(3): 648.     CrossRef
  • Deep learning-based intratumoral and peritumoral features for differentiating ocular adnexal lymphoma and idiopathic orbital inflammation
    Huachen Zhang, Li Xu, Lijuan Yang, Zhiming Su, Haobei Kang, Xiaoyang Xie, Xuelei He, Hui Zhang, Qiufang Zhang, Xin Cao, Xiaowei He, Tao Zhang, Fengjun Zhao
    European Radiology.2024;[Epub]     CrossRef
  • Radiomics analysis of T1WI and T2WI magnetic resonance images to differentiate between IgG4-related ophthalmic disease and orbital MALT lymphoma
    Yuchao Shao, Yuqing Chen, Sainan Chen, Ruili Wei
    BMC Ophthalmology.2023;[Epub]     CrossRef
  • Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO)
    Mohammad Javed Ali
    Progress in Retinal and Eye Research.2023; 96: 101193.     CrossRef
  • The Biology of Ocular Adnexal Marginal Zone Lymphomas
    Patricia Johansson, Anja Eckstein, Ralf Küppers
    Cancers.2022; 14(5): 1264.     CrossRef
  • One Case of Conjunctival MALT Lymphoma and Literature Review
    旭霞 李
    Advances in Clinical Medicine.2022; 12(08): 7586.     CrossRef
Review Article
Clinical Update: Inflammatory Bowel Disease
Byung Ik Jang
Yeungnam Univ J Med. 2007;24(2 Suppl):S221-233.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S221
  • 1,689 View
  • 3 Download
  • 1 Crossref
AbstractAbstract PDF
Inflammatory bowel disease(IBD) which is well known as Crohn’s disease and ulcerative colitis is a chronic disorder that repeats improvement and exacerbation. The possible causes of the disease are environmental factors, genetic factors and immune deficiency resulted from bacterial infection. Recently, IL-23 is proved to be a main cytokine which has a central role in Crohn’s disease. The diagnosis of IBD is made by clinical manifestation, serologic test, endoscopic finding and histologic finding. The mainstay of remission and maintenance therapy of ulcerative colitis is 5-aminosalicylate(5-ASA). Steroid can be used in severe or refractory case and nowadays, budesonide shows a good effect with minimal side effects. In cases of steroid dependent, we can use the immunomodulators such as azathioprine, cyclosporin and 6-thioguanine. The cytokine associated with inflammation of IBD has been emphasized and the treatment which targets the cytokine such as tumor necrosis factor is tried. Infliximab and adalimumab block tumor necrosis factors-a and they are proved the efficacy by many clinical trial. Leukocytapheresis(LCAP) is tried in ulcerative colitis since 1980 in Japan. When we treat IBD patients, we need to consider all the things such as safety, side effects and economy of the patients. We expect that the development of new biologic agent which is more cost effective and more effect with more convinience.

Citations

Citations to this article as recorded by  
  • Inflammatory Bowel Disease and Cytokine
    Eun Young Choi, Kwang Keun Cho, In Soon Choi
    Journal of Life Science.2013; 23(3): 448.     CrossRef
Review
Hirschsprung's Disease.
Nam Hyuk Lee
Yeungnam Univ J Med. 2007;24(1):11-23.   Published online June 30, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.1.11
  • 1,822 View
  • 5 Download
AbstractAbstract PDF
Hirschsprung's disease is one of the most common causes of intestinal obstruction in neonates and infants. The underlying pathology of this disease is the absence of the ganglion cells in both the myenteric (Auerbach's) plexus and the submucosal (Meissner's) plexus. Since Hirschsprung's report in 1886, there have been thousands of papers on Hirschsprung's disease but the cause of the absence of the ganglion cells has not been identified. Hirschsprung's disease can be successfully treated with the Swenson, the Duhamel, and the Soave operations even though the pathogenesis is unknown. With the recent progress of molecular biology and genetics, a more detailed approach to the pathogenesis of Hirschsprung's disease can be undertaken. In addition, there have been recent developments in the surgical approach. In this review, recent advances in surgery for Hirschsprung's disease are presented.

JYMS : Journal of Yeungnam Medical Science
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