Journal of Yeungnam Medical Science

Focused Review articles

Physical therapy, Sports Therapy, and Rehabilitation
The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review: Aung Chan Thu; J Yeungnam Med Sci. 2022;39(3):206-215. Published online June 8, 2022; DOI: https://doi.org/10.12701/jyms.2022.00290

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Musculoskeletal pain is the most common pain reported by patients. Platelet-rich plasma (PRP) is widely used to treat musculoskeletal pain. However, the efficacy of PRP to treat this pain remains controversial. This review highlights the application of PRP in the treatment of musculoskeletal pain. PRP treatment appears to reduce pain and improve function in patients with musculoskeletal pain. However, there are limitations to the currently published studies. These limitations include the PRP preparation methods, type of activators, types of pathology to be treated, methods and times of administration, and association of PRP with other treatments.

Citations

Citations to this article as recorded by

Platelet-rich plasma versus hyaluronic acid injection following arthrocentesis for temporomandibular joint disorders under sedation: a comparative clinical study
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Oral and Maxillofacial Surgery.2026;[Epub] CrossRef
Treating external anal sphincter injury with platelet-rich plasma to resolve post-partum fecal incontinence caused by birthing trauma: A case report
Imran J Siddiqui, Jessica Probst, Sanjay Mahadevan, Roosevelt J Desronvilles, Kyle J Dineen
Journal of Case Reports and Images in Obstetrics and Gynecology.2025; 11(1): 22. CrossRef
Comparative efficacy of platelet rich plasma, hyaluronic acid, and corticosteroid injections in adhesive capsulitis management: A meta‐analysis
Robert Valencia, Gowtham Anche, Vivian Cao, Dexter Chen, Vince Song, Akash Dontamsetty, Mikhail Volokitin
PM&R.2025; 17(9): 1097. CrossRef
Platelet-Rich Plasma for Treating Chronic Noncancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials
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Pain and Therapy.2025; 14(4): 1169. CrossRef
A Prospective and Comparative Study of the Effectiveness of Intra-articular Injection of Platelet-rich Plasma versus Hyaluronic Acid for Osteoarthritis of Knee Joint
Vivek Mittal, Karuna Shankar Dinkar, Rajat Kapoor, Pranjal Gupta, Sumit Kumar Gupta, Amit Agarwal
Journal of Orthopedics, Traumatology and Rehabilitation.2025; 17(1): 15. CrossRef
Platelet-rich Plasma for the Management of Burn Wound: A Meta-Analysis
He Yi, Ruijue Li, Cuixian Li
The International Journal of Lower Extremity Wounds.2025;[Epub] CrossRef
Recent advances in platelet-rich plasma therapy for osteoarthritis: mechanisms and clinical efficacy
Liang Cai, Jiali Chen, Qiong Yuan, Weihua Zhuang, Gang Wang, Xuemei Xu, Yongchao Yao, Wenchuang (Walter) Hu
Journal of Materials Chemistry B.2025; 13(30): 9001. CrossRef
Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries
Mingdong Liu, Jiaxin Ding, Yanbo Peng, Jialin Fang, Man Zhao, Wenyuan Zhang, Haotian Chen, Jian Zhang, Haisheng Peng, Qun Wang
International Journal of Pharmaceutics: X.2025; 10: 100372. CrossRef
Autologous platelet-rich plasma therapy in complex treatment of musculoskeletal disorders: a review
Radik Z. Nurlygayanov, Lira T. Gilmutdinovna, Julia A. Bogdanova, Bulat R. Gilmutdinov, Dinara R. Nurlygaianova
Bulletin of Rehabilitation Medicine.2025; 24(5): 94. CrossRef
Platelet-rich plasma in peripheral nerve injury repair: a comprehensive review of mechanisms, clinical applications, and therapeutic potential
Kai Shang, Yang Liu, Abdul Qadeer
Experimental Biology and Medicine.2025;[Epub] CrossRef
Platelet-Rich Plasma for Musculoskeletal Disorders: A Critical Review of Therapeutic Evidence and Clinical Utility
Mohamed Merza Khalil AlRayes
International Journal of Physical Therapy Research & Practice.2025; 4(8): 346. CrossRef
Effectiveness of Arthrocentesis versus Platelet-Rich Plasma Injections in TMJ Disorders: A Clinical Study
Amit Rao, Mrinal M. Gawali, Sahana B Holla, D Shanmugapriyan, KM Paijas, Sajni Rai
Journal of Pharmacy and Bioallied Sciences.2025;[Epub] CrossRef
Evaluation of the Effect of Platelet-rich Plasma in Trigeminal Neuralgia Pain – An Interventional Prospective Single-centric Follow-up Study
Rajmala Jaiswal, Devyani Verma
Indian Journal of Pain.2025; 39(3): 131. CrossRef
Injections of Platelet-Rich Plasma: An Emerging Novel Biological Cure for Low Back Pain?
Adarsh Jayasoorya , Nitin Samal, Gajanan Pisulkar, Kaustav Datta, Kevin Kawde
Cureus.2024;[Epub] CrossRef
Platelet-Rich Plasma in the Management of Temporomandibular Joint Pain in Young Adults With Temporomandibular Disorder
Santosh Kumar Mathpati, Gourav Jain, Vijay Mishra, Atul K Singh, Rahul Mishra, Bipin K Yadav
Cureus.2024;[Epub] CrossRef
Potentials and impact of platelet-rich plasma (PRP) on the regenerative properties of muscle tissue
V. H. Dzhyvak, I. M. Klishch, O. I. Khlibovska, S. S. Levenets
Biopolymers and Cell.2024; 40(1): 3. CrossRef
Cytoprotective Effect of Growth Factors Derived From Platelets on Corticosteroid-Treated Primary Anterior Cruciate Ligament-Derived Stromal Cells and Chondrocytes
Vijay Sharma, Ulka Sakhalkar, Pratiksha Nadkarni, Rashmi Mishal, Dinesh Parandhaman, Kirti Vichare, Anjalina Francis, Mudit Khanna, Mohit Kukreja, Anuka Sharma
Cureus.2024;[Epub] CrossRef
Image Guided Minimally Invasive Internal Fixation Pilon Fracture with Distraction Arthroplasty
Gordon Slater
Journal of Clinical Medical Research.2024; : 1. CrossRef
Platelet-rich plasma for de Quervain’s tenosynovitis: A systematic review and meta-analysis
Nucki Nursjamsi Hidajat, Raden Moechammad Satrio Nugroho Magetsari, Gregorius Steven, Jethro Budiman, Gregorius Thomas Prasetiyo
World Journal of Orthopedics.2024; 15(9): 858. CrossRef
Platelet-Rich Plasma Therapy for Rotator Cuff Injuries: A Comprehensive Review of Current Evidence and Future Directions
Vinit Rathod, Sandeep Shrivastav, Milind R Gharpinde
Cureus.2024;[Epub] CrossRef
Efficacy of Intra-articular Super-dose Platelet-Rich Plasma Injection in Improving Pain in a Middle-Aged Sedentary Female With Meniscal Tear: A Case Report
Sneha Thirugnana Sambandam, Dobson Dominic, Praveen Ravi, Ashirwad Jadhav
Cureus.2024;[Epub] CrossRef
The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review
Miguel Ortega-Castillo, Abel Gomez-Caceres, Ivan Medina-Porqueres
Applied Sciences.2024; 14(22): 10442. CrossRef
Efficacy of Ultrasound-Guided Platelet-Rich Plasma (PRP) Injection in Patients with Sacroiliac Joint Pain: A Single-Arm, Before and After, Open-Label Clinical Trial
Maliheh Khosromanesh, Sogol Alikarami, Ebrahim Espahbodi, Reza Atef Yekta, Koorosh Kamali, Hossein Majedi
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Injectable Lyophilized Chitosan-Thrombin-Platelet-Rich Plasma (CS-FIIa-PRP) Implant to Promote Tissue Regeneration: In Vitro and Ex Vivo Solidification Properties
Fiona Milano, Anik Chevrier, Gregory De Crescenzo, Marc Lavertu
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Systematic Review of Platelet-Rich Plasma for Low Back Pain
Edilson Silva Machado, Fabiano Pasqualotto Soares, Ernani Vianna de Abreu, Taís Amara da Costa de Souza, Robert Meves, Hans Grohs, Mary A. Ambach, Annu Navani, Renato Bevillaqua de Castro, Daniel Humberto Pozza, José Manuel Peixoto Caldas
Biomedicines.2023; 11(9): 2404. CrossRef
Restraint stress-associated gastrointestinal injury and implications from the Evans blue-fed restraint stress mouse model
Der-Shan Sun, Te-Sheng Lien, Hsin-Hou Chang
Tzu Chi Medical Journal.2023;[Epub] CrossRef
Potential Mechanism of Platelet-rich Plasma Treatment on Testicular Problems Related to Diabetes Mellitus
Rista Dwi Hermilasari, Dicky Moch Rizal, Yohanes Widodo Wirohadidjojo
Prague Medical Report.2023; 124(4): 344. CrossRef
The blind spot and challenges in pain management
Min Cheol Chang
Journal of Yeungnam Medical Science.2022; 39(3): 179. CrossRef

Anesthesiology and Pain Medicine
The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review: Donghwi Park, Min Cheol Chang; J Yeungnam Med Sci. 2022;39(3):200-205. Published online April 7, 2022; DOI: https://doi.org/10.12701/jyms.2022.00101

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236 Download
42 Web of Science
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Abstract PDF

Pain from nervous or musculoskeletal disorders is one of the most common complaints in clinical practice. Corticosteroids have a high pain-reducing effect, and their injection is generally used to control various types of pain. However, they have various adverse effects including flushing, hyperglycemia, allergic reactions, menstrual changes, immunosuppression, and adrenal suppression. Pulsed radiofrequency (PRF) is known to have a pain-reducing effect similar to that of corticosteroid injection, with nearly no major side effects. Therefore, it has been widely used to treat various types of pain, such as neuropathic, joint, discogenic, and muscle pain. In the current review, we outlined the pain-reducing mechanisms of PRF by reviewing previous studies. When PRF was first introduced, it was supposed to reduce pain by long-term depression of pain signaling from the peripheral nerve to the central nervous system. In addition, deactivation of microglia at the level of the spinal dorsal horn, reduction of proinflammatory cytokines, increased endogenous opioid precursor messenger ribonucleic acid, enhancement of noradrenergic and serotonergic descending pain inhibitory pathways, suppression of excitation of C-afferent fibers, and microscopic damage of nociceptive C- and A-delta fibers have been found to contribute to pain reduction after PRF application. However, the pain-reducing mechanism of PRF has not been clearly and definitely elucidated. Further studies are warranted to clarify the pain-reducing mechanism of PRF.

Citations

Citations to this article as recorded by

Pulsed radiofrequency therapy ameliorates steroid-induced osteonecrosis of the femoral head by promoting nerve growth factor production
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Cytotechnology.2026;[Epub] CrossRef
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Pediatric Neurology.2026; 176: 41. CrossRef
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Journal of Clinical Medicine.2026; 15(2): 708. CrossRef
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Kia Lor, Eva Kubrova, Ryan S. D’Souza, Chelsey Hoffmann, Dylan Banks, Max Yucheng Jin, Larry J. Prokop, Yeng F. Her
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Spinal Injections: A Narrative Review from a Surgeon’s Perspective
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Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological Ca2+ Influx, Cytosolic ATP Level, Δψm, and pERK Compared to 4 Hz: An Insight on the Safety of Pulsed Radiofrequency in Pain Management
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Journal of Pain Research.2023; Volume 16: 3643. CrossRef
Summary of the 48th KORSIS Symposium in 2023
Min Cheol Chang
International journal of Pain.2023; 14(2): 96. CrossRef
The blind spot and challenges in pain management
Min Cheol Chang
Journal of Yeungnam Medical Science.2022; 39(3): 179. CrossRef
Use of QR Codes for Promoting a Home-Based Therapeutic Exercise in Patients with Lumbar Disc Herniation and Lumbar Spinal Stenosis: A Prospective Randomized Study
Min Cheol Chang, Donghwi Park, Yoo Jin Choo
Journal of Pain Research.2022; Volume 15: 4065. CrossRef

Review Article

Anesthesiology and Pain Medicine
Ketamine : Refocused Role of Ketamine in Pain Management: Sun Ok Song; Yeungnam Univ J Med. 2007;24(2 Suppl):S108-117. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S108

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Abstract PDF: Ketamine has used as a dissociative anesthetics from 40 years ago. Its mechanism of action is an antagonism of the N-methyl-D-aspartate (NMDA) receptors, which has an important role into the central sensitization during pain states. The role of ketamine, in lower sub-anesthetic doses, has recently gained increasing interest in pain management. There are considerable numbers of trials to use ketamine in acute or chronic pain states. Recently, Hocking et al. summarized their recent reviews of the evidence concerning ketamine’s clinical use on PAIN: Clinical Updates. In this review, the author introduce their summery with personal experience. Based on their summary, the primary role of ketamine in such subanesthetic doses is as an ‘anti-hyperalgesic’, ‘anti-allodynic’ or ‘tolerance-protective’ agent rather than as a primarily ‘analgesic’. However, to support the evidence-based clinical guideline using a ketamine in pain management, there will be needed numerous high-quality studies that access both immediate and long-term outcomes.

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