Journal of Yeungnam Medical Science

Review article

Current perspectives in stem cell therapies for osteoarthritis of the knee: Gi Beom Kim, Oog-Jin Shon; Yeungnam Univ J Med. 2020;37(3):149-158. Published online April 13, 2020; DOI: https://doi.org/10.12701/yujm.2020.00157

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Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.

Citations

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Stem Cells and Development.2024; 33(7-8): 168. CrossRef
Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial
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Osteoarthritis and Cartilage Open.2024; 6(3): 100500. CrossRef
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Journal of Orthopaedic Surgery and Research.2023;[Epub] CrossRef
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CARTILAGE.2021; 13(2_suppl): 225S. CrossRef
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Review

Adult Mesenchymal Stem Cells for Cell Therapy in Clinical Application.: In Hwan Song; Yeungnam Univ J Med. 2009;26(1):1-14. Published online June 30, 2009; DOI: https://doi.org/10.12701/yujm.2009.26.1.1

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Abstract PDF

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

Citations

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Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior
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Biomedicines.2022; 10(5): 1151. CrossRef
Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice
Kyong Jin Jung, Gun Woo Lee, Chul Hyun Park, Tae Jin Lee, Joo Young Kim, Eon Gi Sung, Seong Yong Kim, Byung Ik Jang, In Hwan Song
Gut and Liver.2020; 14(1): 100. CrossRef
Human adipose-derived stem cells attenuate inflammatory bowel disease in IL-10 knockout mice
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Tissue and Cell.2015; 47(1): 86. CrossRef

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