Journal of Yeungnam Medical Science

Case report

Endocrinology, Diabetes, and Metabolism
Interleukin-6-producing paraganglioma as a rare cause of systemic inflammatory response syndrome: a case report: Yin Young Lee, Seung Min Chung; J Yeungnam Med Sci. 2023;40(4):435-441. Published online March 7, 2023; DOI: https://doi.org/10.12701/jyms.2022.00766

4,906 View
87 Download
1 Web of Science
2 Crossref

Pheochromocytomas and paragangliomas (PPGLs) may secrete hormones or bioactive neuropeptides such as interleukin-6 (IL-6), which can mask the clinical manifestations of catecholamine hypersecretion. We report the case of a patient with delayed diagnosis of paraganglioma due to the development of IL-6-mediated systemic inflammatory response syndrome (SIRS). A 58-year-old woman presented with dyspnea and flank pain accompanied by SIRS and acute cardiac, kidney, and liver injuries. A left paravertebral mass was incidentally observed on abdominal computed tomography (CT). Biochemical tests revealed increased 24-hour urinary metanephrine (2.12 mg/day), plasma norepinephrine (1,588 pg/mL), plasma normetanephrine (2.27 nmol/L), and IL-6 (16.5 pg/mL) levels. 18F-fluorodeoxyglucose (FDG) positron emission tomography/CT showed increased uptake of FDG in the left paravertebral mass without metastases. The patient was finally diagnosed with functional paraganglioma crisis. The precipitating factor was unclear, but phendimetrazine tartrate, a norepinephrine-dopamine release drug that the patient regularly took, might have stimulated the paraganglioma. The patient’s body temperature and blood pressure were well controlled after alpha-blocker administration, and the retroperitoneal mass was surgically resected successfully. After surgery, the patient’s inflammatory, cardiac, renal, and hepatic biomarkers and catecholamine levels improved. In conclusion, our report emphasizes the importance of IL-6-producing PPGLs in the differential diagnosis of SIRS.

Citations

Citations to this article as recorded by

PHEOCHROMOCYTOMA AND PARAGANGLIOMA: CLINICAL PICTURE, DIAGNOSIS, TREATMENT, FOLLOW-UP AND PROGNOSIS - A LITERATURE REVIEW
Dominika Żyła, Kornelia Rojek, Andrzej Zuzak, Katarzyna Zych, Sylwia Koziej, Adam Jakubas, Mateusz Korga, Milena Krawczyk
International Journal of Innovative Technologies in Social Science.2025;[Epub] CrossRef
Screening and treatment of endocrine hypertension focusing on adrenal gland disorders: a narrative review
Seung Min Chung
Journal of Yeungnam Medical Science.2024; 41(4): 269. CrossRef

Review

Microbiology
The Cytokines: An Overview.: Hee Sun Kim; Yeungnam Univ J Med. 2010;27(1):1-7. Published online June 30, 2010; DOI: https://doi.org/10.12701/yujm.2010.27.1.1

3,178 View
50 Download
3 Crossref

Abstract PDF

Having an understanding of the properties of cytokines is essential for the immunologist, the researcher and the medical practitioner who need to understand immunologic diseases and immunological therapeutic approaches. Cytokines are redundant in their actions on target cells and promiscuous in their receptor reactions. (ED note: That is some cool use of English!) Moreover, many cells concomitantly produce several cytokines that have overlapping actions. Here this review provides conceptual framework to understand the intriguing aspects of the cytokine system.

Citations

Citations to this article as recorded by

Antioxidant and immune-enhancing effects of Fuyu persimmons and Hachiya persimmons
Nayoung Kim, Mijoo Choi, Jaeeun Jung, Gwanghwan Ahn, Eunju Park
Journal of Nutrition and Health.2025; 58(1): 28. CrossRef
Modulatory Effects of Herbal Medicines Extracts on Cytokine Release in Immune Response of RAW 264.7 and TK-1
Su-kyoung Bae, Se-hee Cho, Tae-kyu Ahn, Jee-in Kim, Bong-hyun Kim, Jae-hwan Lim
The Journal of Internal Korean Medicine.2018; 39(6): 1244. CrossRef
Anti-inflammatory Effect of Angelicae acutilobae Radix Water Extract on LPS-stimulated Mouse Macrophages
Hyo-Sang Han
The Korea Journal of Herbology.2013; 28(6): 129. CrossRef

Original Articles

Obstetrics, Gynecology, and Reproductive Medicine
Clinical Significance of Interleukin-6 Concentration of Cervical Discharge in Pregnant Women with Preterm Labor and Preterm Rupture of Membrane: Seong Woong Kim, Sung Chul Park, Sung Ho Lee, Doo Jin Lee; Yeungnam Univ J Med. 2007;24(2 Suppl):S505-518. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S505

1,835 View
1 Download

Abstract PDF: Background
：This study is conducted to determine the clinical efficacy of measurement of IL-6 concentration in cervical discharge as a biochemical predictor of preterm labor and PROM. Materials and Methods：Twenty-two pregnant women with preterm labor and 28 women with preterm rupture of membrane(PROM) between 20-36 gestational weeks were selected as study group, and 26 normal pregnant women were selected as control group. In both groups, following routine antenatal laboratory tests, concentration of interleukin-6(IL-6) in cervical discharge and amniotic fluid(in case of preterm labor and PROM) were estimated, and maternal C-reactive protein(CRP) level and WBC count were checked also. To compare the microbiological environment of both groups, Gram stain and culture of cervical smear were undertaken.
Results
：There were no significant differences in maternal age, gravity, parity, gestational age at sampling, and prior preterm delivery, but there were significant differences in initial cervical dilation, effacement, cervicovaginal pH, and preterm delivery in each groups. The average IL-6 level of cervical discharge in women with preterm labor and PROM were significantly higher than control group (p＜0.01). The distribution of women with preterm labor and PROM were significantly different from control group, when 186.7 pg/mL was selected as cutoff value(p＜0.01). There was strong positive correlation between IL-6 concentration in cervical discharge and amniotic fluid IL-6 concentration (r=0.865, p＜0.05). There was no significant difference in CRP in each groups. Maternal WBC count of PROM group at admission was higher than that of preterm labor and control group, but was not statistically significant (p=0.062). Gram (-) rods was detected frequently in women with preterm labor and PROM than control group (p＜0.05). The distribution of microorganisms in cervical discharge in women with preterm labor and PROM were different from control group. Conlusion：The results of this study suggested that cervical IL-6 concentration could be used as an indicator detecting the high risk pregnant women who might develop preterm labor and PROM, and could be accepted as a noninvasive diagnostic marker of intrauterine infection.

Pulmonary and Respiratory Medicine
Effect of on Aerosolized Vitamin E Pretreatment on Interleukin-1 Induced Acute Lung Injury in Rats: Jin Hong Chung, Kyeong-Cheol Shin; Yeungnam Univ J Med. 2007;24(2 Suppl):S365-372. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S365

1,831 View
2 Download

Abstract PDF: Background
：Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Reactive oxygen species, as well as elastase released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether aerosolized vitamin E can attenuate acute lung injury induced by IL-1 in rats. Materials and Methods：We intratracheally instilled either saline or IL-1 with and without pretreatment with aerosolized vitamin E in rats. After 5 hours of intratracheal instillation, lung lavage neutrophils, lung lavage protein concentration, lung myeloperoxidase(MPO) activity and lung wet weight to dry weight ratio(WW/DW) were measured in rat.
Results
：In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage protein concentration, lung MPO activity and WW/DW were higher. Pretreatment with aerosolized vitamin E decreased lung lavage neutrophils, lung MPO activity and WW/DW in rats given IL-1 intratracheally.
Conclusion
：These results suggest that direct pulmonary supplement of vitamin E decreases lung inflammation and leak in rats given IL-1 intratracheally.

Microbiology
Upregulation of IP-10(CXCL10) mRNA Expression by Interleukin-18.: Hyo Young Kim, Hee Sun Kim; Yeungnam Univ J Med. 2007;24(1):67-78. Published online June 30, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.1.67

2,292 View
7 Download

Abstract PDF: BACKGROUND
Interleukin-18 (IL-18) is one of the principal inducers of interferon-gamma (IFN-gamma) in lymphocytes. MATERIALS AND METHODS: The effect of IL-18 on the expression of chemokine IP-10(CXCL10) mRNA in C57BL/6 mouse peritoneal macrophages was studied by using Northern blot analysis, enzyme linked immunosobent assay and electrophoretic mobility shift assay. RESULTS: IL-18 was determined to exert no direct effect on the expression of IP-10(CXCL10) mRNA. However, IL-18 pretreatment was determined to play a cooperative role in the synergistic induction of LPS-induced IP-10(CXCL10) mRNA expression. The effect associated with IL-18 pretreatment with regard to the synergistic induction of LPS-induced IP-10 (CXCL10) mRNA expression was detected after 16 hr of IL-18 pretreatment, administered prior to LPS stimulation. The pattern of NF-kB binding activity during IL-18 pretreatment with LPS stimulation was found to coincide with the expression of IP-10(CXCL10) mRNA. CONCLUSION: Although IL-18 alone exerts no direct effect on the expression of chemokine IP-10(CXCL10), a definite period of IL-18 pretreatment induces the synergistic expression of LPS-induced IP-10(CXCL10) mRNA. NF-kB activation is a component of this synergistic effect of IL-18 pretreatment. These results provide useful information, which may facilitate the elucidation of the action mechanisms underlying IL-18 effect on the expression of IP-10(CXCL10) mRNA.

Review

Rheumatology
Identification of Interleukin 1-Responsive Genes in Human Chondrosarcoma SW1354 cells by cDNA Microarray Technology.: Jun Ha Jeon, Yong Wook Jung, Dae Young Yun, Hyun Do Kim, Chang Mo Kwon, Young Hoon Hong, Jae Ryong Kim, Choong Ki Lee; Yeungnam Univ J Med. 2007;24(1):24-40. Published online June 30, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.1.24

2,271 View
5 Download

Abstract PDF: BACKGROUND
Accumulating evidence shows that interleukin(IL)-1 plays a critical role in inflammation and connective tissue destruction observed in both osteoarthritis and rheumatoid arthritis. IL-1 induces gene expression related to cytokines, chemokines and matrix metalloproteinases by activation of many different transcription factors. MATERIALS AND METHODS: The chondrosarcoma cell line, SW1353, is known to be a valuable in vitro system for investigating catabolic gene regulation by IL-1beta in chondrocytic cells. To explore and analyze the changes in gene expression by IL-1 responsible for arthritis, SW1353 was treated with IL-1 for 1, 6 and 24 h and then total RNAs were purified for each time. The changes in gene expression were analyzed with 17k human cDNA microarrays and validated by semi-quantitative RT-PCR. RESULTS: Greater than a two-fold change was observed in 1,200 genes including metallothioneins, matrix metalloproteinases, extracellular matrix proteins, antioxidant proteins, cytoskeleton proteins, cell cycle regulatory proteins, proteins for cell growth and apoptosis, signaling proteins and transcription factors. These changes appeared to be correlate with the pathophysiological changes observed in early osteoarthritis. CONCLUSION: cDNA microarray analysis revealed a marked variability in gene expression, and provided insight into the overall molecular changes. The result of this study provide initial information for further studies to identify therapeutic targets in osteoarthritis pathogenesis.

Original Articles

Pulmonary and Respiratory Medicine
Effect of Neutrophil Elastase inhibitor, ICI 200,355, on Interleukin-1 Induced acute lung injury in rats.: Jin Hong Chung, Yeung Chul Mun, Hye Jung Park, Kyeong Cheol Shin, Kwan Ho Lee; Yeungnam Univ J Med. 2002;19(1):55-62. Published online June 30, 2002; DOI: https://doi.org/10.12701/yujm.2002.19.1.55

2,511 View
0 Download

Abstract PDF: BACKGROUND
Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether ICI 200,355, a synthetic elastase inhibitor, can attenuate acute lung injury induced by IL-1 in rats. MATERIALS AND METHODS: We intratracheally instilled either saline or IL-1 with and without treatment of ICI 200,355 in rats. Lung lavage neutrophils, lung lavage cytokine-induced neutrophil chemoattractant(CINC) concentration, lung lavage protein concentration, lung myeloperoxidase(MPO) activity and lung leak index were measured at 5 hours of intratracheal treatment. RESULTS: In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage CINC concentration, lung lavage protein concentration, lung MPO activity and lung leak index were higher. Intratracheal ICI 200,355 administration decreased lung lavage neutrophils, lung MPO activity and lung leak index, respectively, but did not decreased lung lavage CINC concentration. CONCLUSION: These results suggest that ICI 200,355 decreases lung inflammation and leak without decreasing lung lavage CINC concentration in rats given IL-1 intratracheally.

Immunology and Allergy
The effect of interleukin-10 on KC gene expression in mouse peritoneal macrophages.: Hee Sun Kim; Yeungnam Univ J Med. 1998;15(1):47-54. Published online June 30, 1998; DOI: https://doi.org/10.12701/yujm.1998.15.1.47

2,061 View
1 Download

Abstract PDF: Interleukin-10(IL-10) inhibits production of a wide range of cytokines in various cell types and transcriptionally inhibits lipopolysaccharide(LPS)-induced expression of proinflammatory mediators. Cytokine expression by macrophages is an important aspect to ochestrate inflammatory responses. As an approach to identify mechanistic targets of IL-10, it was examined the time course for expression of KC(murine homologue of Gro) gene in murine peritoneal macrophages stimulated with LPS with or without IL-10. The effect of IL-10 on LPS induced KC mRNA expression was delayed and only seen after 1 hour treatment. Pretreatment with IL-10 did not eliminate the delayed inhibitory response nor increase the magnitude of suppression. These effects did not depend upon time of IL-10 treatment but the time of LPS treatment. LPS-induced KC mRNA expression by inhibitoy action of IL-10 was not controlled at the level of transcription. The result indicates that IL-10 acts late in the process of KC gene expression and that the prominant site of action may be mRNA stability or translation.

First
Prev
Page of 1
Next
Last

Search