Skip Navigation
Skip to contents

JYMS : Journal of Yeungnam Medical Science

Indexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI
FREE article processing charge
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Hypercortisolism"
Filter
Filter
Article category
Keywords
Publication year
Authors
Case reports
Endocrinology, Diabetes, and Metabolism
Ruptured triple hormone-secreting adrenal cortical carcinoma with hyperaldosteronism, hypercortisolism, and elevated normetanephrine: a case report
Sin Yung Woo, Seongji Park, Kun Young Kwon, Dong-Mee Lim, Keun-Young Park, Jong-Dai Kim
J Yeungnam Med Sci. 2024;41(4):306-311.   Published online September 6, 2024
DOI: https://doi.org/10.12701/jyms.2024.00626
  • 1,474 View
  • 63 Download
AbstractAbstract PDF
We report a case of a ruptured triple hormone-secreting adrenal mass with hyperaldosteronism, hypercortisolism, and elevated normetanephrine levels, diagnosed as adrenal cortical carcinoma (ACC) by histology. A 53-year-old male patient who initially presented with abdominal pain was referred to our hospital for angiocoagulation of an adrenal mass rupture. Abdominal computed tomography revealed a heterogeneous 19×11×15 cm right adrenal mass with invasion into the right lobe of the liver, inferior vena cava, retrocaval lymph nodes, and aortocaval lymph nodes. Angiocoagulation was performed. Laboratory evaluation revealed excess cortisol via a positive 1-mg overnight dexamethasone suppression test, primary hyperaldosteronism via a positive saline infusion test, and plasma normetanephrine levels three times higher than normal. An adrenal mass biopsy was performed for pathological confirmation to commence palliative chemotherapy because surgical management was not deemed appropriate considering the extent of the tumor. Pathological examination revealed stage T4N1M1 ACC. The patient started the first cycle of adjuvant mitotane therapy along with adjuvant treatment with doxorubicin, cisplatin, and etoposide, and was discharged. Clinical cases of dual cortisol- and aldosterone-secreting ACCs or ACCs presenting as pheochromocytomas have occasionally been reported; however, both are rare. Moreover, to the best of our knowledge, a triple hormone-secreting ACC has not yet been reported. Here, we report a rare case and its management. This case report underscores the necessity of performing comprehensive clinical and biochemical hormone evaluations in patients with adrenal masses because ACC can present with multiple hormone elevations.
Endocrinology, Diabetes, and Metabolism
Cushing syndrome in pregnancy, diagnosed after delivery
Han Byul Kim, Mi Kyung Kim, El Kim, Keun Soo Ahn, Hye Soon Kim, Nam Kyung Kim
Yeungnam Univ J Med. 2021;38(1):60-64.   Published online May 22, 2020
DOI: https://doi.org/10.12701/yujm.2020.00290
  • 7,198 View
  • 122 Download
  • 3 Crossref
AbstractAbstract PDF
Cushing syndrome (CS) is rare in pregnancy, and few cases have been reported to date. Women with untreated CS rarely become pregnant because of the ovulatory dysfunction induced by hypercortisolism. It is difficult to diagnose CS in pregnancy because of its very low incidence, the overlap between the clinical signs of hypercortisolism and the physiological changes that occur during pregnancy and the changes in hypothalamus-pituitary-adrenal axis activity that occur during pregnancy and limit the value of standard diagnostic testing. However, CS in pregnancy is associated with poor maternal and fetal outcomes; therefore, its early diagnosis and treatment are important. Here, we report two patients with CS that was not diagnosed during pregnancy, in whom maternal and fetal morbidity developed because of hypercortisolism.

Citations

Citations to this article as recorded by  
  • Cushing’s disease with twin pregnancy and diabetes mellitus: a case report and literature review
    Hideyasu Asai, Ikuo Yamamori, Shigeru Hagimoto, Kyoichi Okumura, Koki Sakakibara
    Endocrine Journal.2024; 71(10): 1003.     CrossRef
  • Endogenous Cushing’s syndrome during pregnancy
    Nada Younes, Matthieu St-Jean, Isabelle Bourdeau, André Lacroix
    Reviews in Endocrine and Metabolic Disorders.2023; 24(1): 23.     CrossRef
  • Cushing Syndrome in Pregnancy: A Case Presentation and Review of Literature
    HamidReza Samimagham, Ava Ziaei, Mohammad Tamaddondar, Mitra Kazemi Jahromi
    Journal of Kermanshah University of Medical Sciences.2023;[Epub]     CrossRef

JYMS : Journal of Yeungnam Medical Science
TOP