Skip Navigation
Skip to contents

JYMS : Journal of Yeungnam Medical Science

Indexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI
FREE article processing charge
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
110 "Disease"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original articles
Endocrinology, Diabetes, and Metabolism
Association between thyroid function and 10-year cardiovascular disease risk of patients with diabetes: a cross-sectional study using KNHANES 2013–2014
Bogyeong Kim, Minjin Jeon, Yuseop Lee, Hyunji Reem, Seung Min Chung
J Yeungnam Med Sci. 2026;43:28.   Published online April 8, 2026
DOI: https://doi.org/10.12701/jyms.2026.43.28
  • 491 View
  • 31 Download
AbstractAbstract PDFSupplementary Material
Background
This study investigated the association between thyroid function and the 10-year cardiovascular disease (CVD) risk in patients with diabetes.
Methods
This retrospective cross-sectional study analyzed 246 patients with diabetes aged 30 to 79 years (weighted n=1,611,708) from the 2013 to 2014 Korea National Health and Nutrition Examination Survey. Individuals with a history of CVD, thyroid disease, or pregnancy were excluded. Thyroid function was categorized as euthyroid, hypothyroid, or hyperthyroid, based on serum thyroid-stimulating hormone (TSH) levels (reference in Koreans, 0.62–6.86 mIU/L). The 10-year CVD risk was estimated using the Predicting Risk of CVD EVENTs calculator.
Results
The mean participant age was 54.3±10.1 years, with a male-to-female ratio of 1.41:1. Although patients with hypothyroid (14.1%) and hyperthyroid (15.7%) statuses showed a higher CVD risk than those with euthyroid status (12.3%), the difference was not statistically significant (p=0.337). However, in the hypothyroid group (n=11), TSH levels showed a moderate correlation with 10-year CVD risk (r=0.603, p<0.05), although this finding should be interpreted with caution owing to the small sample size. After adjusting for diabetes- and thyroid-related variables, TSH level was independently associated with higher estimated 10-year CVD risk, particularly in patients with a glycated hemoglobin level of <7% (adjusted coefficient, 0.17; 95% confidence interval, 0.05–0.29; p<0.05).
Conclusion
Monitoring TSH levels in patients with well-controlled diabetes may provide additional information regarding the risk of CVD; however, prospective studies are needed to confirm the long-term prognostic value.
Pulmonary and Respiratory Medicine
Feasibility of app-based pulmonary telerehabilitation program for textile dyeing workers with respiratory symptoms: a quasi-experimental study
Myeong Geun Jeong, Gun Seo Jung, Kyoung Tae Kim
J Yeungnam Med Sci. 2026;43:20.   Published online March 2, 2026
DOI: https://doi.org/10.12701/jyms.2026.43.20
  • 1,447 View
  • 40 Download
AbstractAbstract PDFSupplementary Material
Background
Textile dyeing workers are at an increased risk of developing occupational respiratory diseases owing to frequent exposure to harmful chemicals, irritants, and high humidity in the workplace. Pulmonary rehabilitation is essential but associated with access and adherence challenges. This study aimed to evaluate the feasibility, effectiveness, accessibility, and safety of an app-based pulmonary telerehabilitation program for this population.
Methods
Forty-five textile dyeing workers with respiratory symptoms underwent a 4-week pulmonary telerehabilitation program consisting of daily gamified respiratory muscle training using a Bluetooth-enabled device and video-guided flexibility exercises. The program was delivered through a mobile application and adherence was monitored using an online platform. Pulmonary function tests, 6-minute walk test, hand grip strength, and St. George’s Respiratory Questionnaire (SGRQ) scores were assessed at baseline (T0) and post-intervention (T1). The adherence, adverse events, and system usability were evaluated.
Results
Improvements were observed in forced expiratory volume in 1 second (FEV1), FEV1/forced vital capacity, maximal inspiratory pressure, and maximal expiratory pressure at T1 compared to T0. The SGRQ activity scores improved after the intervention. The mean adherence rate was 95.69%; three participants had adherence rates <80% for ≥1 week each. The mean System Usability Scale score was high.
Conclusion
The program resulted in significant improvements in pulmonary function and quality of life with high adherence rates and good usability. This may be a promising approach for managing occupational respiratory diseases among textile dyeing workers. Further studies with larger sample sizes and longer follow-up periods are warranted to validate these results and assess the long-term outcomes.
Public Health, Environmental, and Occupational Health
Radiologic evaluation of subclinical cardiovascular structural changes in school cafeteria workers: a chest computed tomography study with age-matched controls
Jung Hee Hong, Jin Young Kim, Kiook Baek
J Yeungnam Med Sci. 2025;42:76.   Published online November 16, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.76
  • 971 View
  • 45 Download
AbstractAbstract PDF
Background
Chronic exposure to cooking oil fumes (COFs) is associated with adverse health outcomes. Although previous studies have focused on respiratory effects, the impact on cardiovascular structures remains unclear. This study aimed to assess the subclinical cardiovascular changes in school cafeteria workers with long-term COF exposure.
Methods
We conducted a retrospective analysis of the low-dose chest computed tomography (CT) scans of 88 school cafeteria workers and an age- and sex-matched control group of 88 individuals. The cardiothoracic ratio; ascending aortic diameter; and presence of coronary artery, aortic valve, and ascending aortic calcifications were evaluated and compared between the groups.
Results
The cafeteria worker group demonstrated a significantly greater ascending aortic diameter (31.69±3.28 mm vs. 30.64±3.21 mm, p=0.032) and cardiothoracic ratio (0.47±0.04 vs. 0.45±0.04, p=0.026) compared to controls. No significant differences were observed in the prevalence of coronary artery, aortic valve, or ascending aortic calcification between the two groups.
Conclusion
Our findings suggest that long-term occupational exposure to COFs contributes to subtle cardiovascular alterations detectable on chest CT, even in the absence of overt calcification. These results highlight the need for occupational health surveillance and longitudinal studies to evaluate the clinical implications of these changes.
Review article
Infectious Disease
Vaccine trends: a narrative review
Jacob Sangwoon Bae
J Yeungnam Med Sci. 2025;42:71.   Published online November 5, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.71
  • 1,145 View
  • 75 Download
AbstractAbstract PDF
Vaccination has played a central role in the historical and modern fight against infectious diseases. This review explores the evolution of infectious disease perception from ancient humoral theories to the modern “One Health” framework, reflecting the integration of environmental, animal, and human health. Vaccines have not only reduced morbidity and mortality but have also provided profound economic and developmental benefits across societies. Climate change, antimicrobial resistance, and the rapid emergence of new infectious threats have prompted innovations in vaccine technologies, including messenger RNA, DNA, viral vector, and nanoparticle-based platforms. These advances support personalized vaccine strategies, such as vaccinomics, and extend their application to noncommunicable diseases, including cancer and Alzheimer disease. Despite their success, vaccines face challenges including global access disparities, waning immunity, pathogen evolution, and vaccine hesitancy. Nonetheless, vaccination remains a cornerstone of global health security, with strong returns on investment and crucial roles in socioeconomic stabilization during pandemics. Future vaccine strategies must integrate technological innovation with equitable access and public trust, for instance, through global initiatives like the Coalition for Epidemic Preparedness Innovations and the World Health Organization COVID-19 Vaccines Global Access, and the establishment of regional manufacturing hubs to effectively respond to unpredictable threats like “Disease X.”
Communications
Physical therapy, Sports therapy, and Rehabilitation
The feasibility of conducting successful pulmonary rehabilitation in India
Manivel Arumugam, Senthilkumar Ramasamy, Pitchaimani Govindharaj, Mahendran Murugan
J Yeungnam Med Sci. 2025;42:40.   Published online June 28, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.40
  • 4,430 View
  • 169 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Pulmonary rehabilitation (PR) is a highly effective evidence-based treatment with multidisciplinary and comprehensive individualized interventions that reduce morbidity by improving functional capacity and managing respiratory symptoms. It can contribute to overall wellness, reduce symptoms related to respiratory conditions, and facilitate routine work and social activities. Hence, it is a vital component of integrated care for patients with chronic respiratory diseases. In India, PR faces several challenges arising from patients, society, and hospitals. Recent evidence suggests that PR has significant benefits in chronic respiratory diseases, including reduced morbidity and mortality, improved quality of life, and cost savings. Nevertheless, it has been significantly underutilized and has not received the necessary attention in India. The lack of proper utilization of PR can be attributed to several factors, including a lack of awareness and understanding among healthcare professionals regarding its advantages, insufficient referrals to PR programs, scarcity of specialized professionals trained in PR, and a general lack of awareness among patients about its benefits. This article aims to outline the obstacles to PR, identify the factors that influence its successful implementation, and propose possible solutions to overcome these barriers.

Citations

Citations to this article as recorded by  
  • Creating home-based pulmonary rehabilitation programs for patients with asthma: insights from practice
    Cahidenur Koçak, Massimiliano Polastri, Esra Pehlivan
    Journal of Yeungnam Medical Science.2025; 42: 57.     CrossRef
Original articles
Dentistry
Galectin-3 as a possible link between periodontitis and chronic kidney disease: a cross-sectional study
Sri Vidhya Marimuthu, Devi Arul, Muthukumar Santhanakrishnan, Ramprasad Elumalai, Sandhya Suresh, Sathya Selvarajan, Ravindranath Dhulipalla, Ramanarayana Boyapati
J Yeungnam Med Sci. 2025;42:22.   Published online January 20, 2025
DOI: https://doi.org/10.12701/jyms.2025.42.22
  • 3,892 View
  • 137 Download
AbstractAbstract PDF
Background
Chronic periodontitis is associated with various systemic inflammatory diseases; however, research on its association with chronic kidney disease (CKD) is relatively limited. Because both conditions share common risk factors, systemic inflammation plays a key role in the progression of these diseases. Galectin-3 (Gal-3) is a proinflammatory cytokine that plays an important role in chronic inflammatory diseases and is a potential biomarker. This study aimed to measure salivary Gal-3 levels in patients with periodontitis and CKD to better understand their association and evaluate Gal-3 as a diagnostic biomarker for these conditions.
Methods
Seventy-five patients were categorized into three groups: Group I, patients with CKD and periodontitis (n=25); Group II, patients with chronic periodontitis who were systemically healthy (n=25); and Group III, patients with CKD without chronic periodontitis (n=25). Demographic characteristics and periodontal and renal parameters were recorded for each patient. Saliva samples were collected to evaluate Gal-3 levels using an enzyme-linked immunosorbent assay.
Results
Patients with chronic periodontitis and CKD and those with chronic periodontitis alone (Groups I and II, respectively) showed significantly higher salivary Gal-3 levels than patients with CKD alone (Group III) (p<0.001). Bivariate correlation analysis indicated a strong relationship between clinical parameters and Gal-3 levels across all three groups.
Conclusion
Salivary Gal-3 level is a valuable early diagnostic marker of chronic periodontitis and CKD.
Cardiology and Cardiovascular Medicine
Complete or incomplete revascularization in patients with left main culprit lesion acute myocardial infarction with multivessel disease: a retrospective observational study
Sun Oh Kim, Hong-Ju Kim, Jong-Il Park, Kang-Un Choi, Jong-Ho Nam, Chan-Hee Lee, Jang-Won Son, Jong-Seon Park, Sung-Ho Her, Ki-Yuk Chang, Tae-Hoon Ahn, Myung-Ho Jeong, Seung-Woon Rha, Hyo-Soo Kim, Hyeon-Cheol Gwon, In-Whan Seong, Kyung-Kuk Hwang, Seung-Ho Hur, Kwang-Soo Cha, Seok-Kyu Oh, Jei-Keon Chae, Ung Kim
J Yeungnam Med Sci. 2025;42:18.   Published online December 19, 2024
DOI: https://doi.org/10.12701/jyms.2025.42.18
  • 9,790 View
  • 200 Download
AbstractAbstract PDF
Background
Complete revascularization has demonstrated better outcomes in patients with acute myocardial infarction (AMI) and multivessel disease. However, in the case of left main (LM) culprit lesion AMI with multivessel disease, there is limited evidence to suggest that complete revascularization is better.
Methods
We reviewed 16,831 patients in the Korea Acute Myocardial Infarction Registry who were treated from July 2016 to June 2020, and 399 patients were enrolled with LM culprit lesion AMI treated with percutaneous coronary intervention. We categorized the patients as those treated with complete revascularization (n=295) or incomplete revascularization (n=104). The study endpoint was major adverse cardiac and cerebrovascular events (MACCE), a composite of all-cause death, myocardial infarction, ischemia-driven revascularization, stent thrombosis, and stroke. We performed propensity score matching (PSM) and analyzed the incidence of MACCE at 1 year.
Results
After PSM, the two groups were well balanced. There was no significant difference between the two groups in MACCE at 1 year (12.1% vs. 15.2%; hazard ratio, 1.28; 95% confidence interval, 0.60–2.74; p=0.524) after PSM. The components of MACCE and major bleeding were also not significantly different.
Conclusion
There was no significant difference in clinical outcomes between the groups treated with complete or incomplete revascularization for LM culprit lesion AMI with multivessel disease.
Review article
Medical Informatics
Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review
Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang
J Yeungnam Med Sci. 2025;42:8.   Published online November 18, 2024
DOI: https://doi.org/10.12701/jyms.2024.01004
  • 26,440 View
  • 262 Download
  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDF
Digital therapeutics (DTx) are emerging as a transformative innovation in healthcare offering evidence-based digital interventions for the treatment, management, and prevention of various diseases and disorders. In Korea, DTx have gained significant attention as potential solutions to the increasing burden of chronic diseases and mental health conditions. However, the Korean DTx market faces several challenges that hinder its widespread adoption and integration into the national healthcare system. This study provides a comprehensive analysis of the current state of the DTx market in Korea, identifies the key challenges impeding its growth, and proposes strategies for overcoming these obstacles. This study utilized a literature review and market analysis approach to examine the latest research, industry reports, and regulatory documents related to DTx. The analysis focused on three primary areas: (1) the current regulatory landscape, (2) technological advancements and challenges, and (3) economic and commercial factors influencing DTx adoption in Korea. A comparative analysis of global regulatory practices was also conducted to identify best practices. The findings revealed that while Korea has made significant strides in supporting DTx development, the market remains in its early stages. The key challenges include underdeveloped regulatory frameworks, issues with data quality and security, and a lack of established reimbursement pathways. We recommend developing tailored regulatory frameworks for DTx, enhancing policy support for small and medium-sized enterprises involved in DTx development, and increasing investments in technological infrastructure. By addressing these challenges, Korea could position itself as a leader in the global DTx market, delivering innovative and effective treatments to enhance patient care and outcomes.

Citations

Citations to this article as recorded by  
  • Strategies to Increase Patients’ Adherence to Digital Therapeutics for Musculoskeletal Diseases: A Narrative Review
    Myeonghwan Bang, Jung Hyun Park
    Yonsei Medical Journal.2026; 67(3): 175.     CrossRef
  • Diving into the Regulatory Landscape of Digital Therapeutics
    Madhumitha Masilamani, Melvin George
    Therapeutic Innovation & Regulatory Science.2026; 60(3): 725.     CrossRef
  • Comparing mental health professionals’ willingness to use digital therapeutics: a cross-national survey in South Korea and Germany
    Daa Un Moon, Shinjae Park, Min-Ji Kim, Stefan Gutwinski, Felix Bermpohl, Malek Bajbouj, Hong Jin Jeon, Alva Lütt
    BMC Health Services Research.2026;[Epub]     CrossRef
  • Applying a mobile intervention for chronic insomnia in routine care: Study protocol for a multicenter randomized controlled trial
    Daa Un Moon, Jeonghun Kim, Jeyoung Hannah Sun, Yujin Lee
    Internet Interventions.2025; 41: 100848.     CrossRef
  • Digital Therapeutics for Cognitive Impairment: Exploring Innovations, Challenges, and Future Prospects
    Grace Yuange Zang, Keqin Rao, Jing Wu, Yunhan He, Yi Tang, Leiyu Shi
    Journal of Medical Internet Research.2025; 27: e73689.     CrossRef
  • Cluster-based quality analysis of mobile health applications based on health behavior theories
    Kyong Hee Park, Jeongwon Heo, Hyewon Jang, Youngju Lee, Seoyeon Kim, Hye-Ryoung Kim
    Korean Journal of Health Education and Promotion.2025; 42(3): 53.     CrossRef
  • Perceptions and Acceptance of Digital Mental Health Therapeutics Among Psychiatrists
    Dahye Jeon, Mose Hwang, Sungmin Son, Taehui Kim, Kyuho Jeong, Aeri Shim, YeonJoo Nam
    Journal of Korean Neuropsychiatric Association.2025; 64(4): 306.     CrossRef
  • Musculoskeletal Digital Therapeutics and Digital Health Rehabilitation: A Global Paradigm Shift in Orthopedic Care
    Youn Kyu Lee, Eun-Ji Yoon, Tae Hyung Kim, Jong-Ick Kim, Jong-Ho Kim
    Journal of Clinical Medicine.2025; 14(23): 8467.     CrossRef
  • Developing and Evaluating Guidelines to Prevent Overdependence on Digital Therapeutics in Children and Adolescents: Randomized Controlled Trial
    Euno Kim, Hajae Jeon, Junghan Lee, Hyangkyeong Oh, Meelim Kim, Jaeyong Shin, Eunjoo Kim
    Journal of Medical Internet Research.2025; 27: e69248.     CrossRef
Original articles
Public Health, Environmental, and Occupational Health
Factors associated with musculoskeletal pain in professional dancers, including lapse period of group practice due to the COVID-19 outbreak: repeated-measures analysis
Kiook Baek, Yu-Mi Choi, Joon Sakong
J Yeungnam Med Sci. 2024;41(3):196-206.   Published online May 17, 2024
DOI: https://doi.org/10.12701/jyms.2024.00171
  • 6,448 View
  • 60 Download
AbstractAbstract PDFSupplementary Material
Background
This study investigated the prevalence and associated factors of musculoskeletal pain among professional dancers who experienced a lapse in group practice due to coronavirus disease 2019.
Methods
General characteristics, practice time, region of musculoskeletal pain due to injury using the visual numeric scale (VNS), and causative motion were surveyed among professional dancers. Pain of VNS 0 to 3 was categorized as “no or minor,” 4 to 6 was categorized as “moderate,” and 7 to 10 was categorized as “severe.” The causal motions of musculoskeletal pain were analyzed according to body region. Factors other than motion associated with pain were also analyzed.
Results
In total, 368 participants were included. In the univariate analysis, age and practice time were positively associated with “moderate” pain. Practice time, dance experience, and postural accuracy were positively associated with “severe” pain, as was performing Korean traditional dance. In the multivariable analysis, practice time, group practice, and age were positively associated with pain of VNS 4 to 10, and practice time, group practice, and Korean traditional dance were positively associated with pain of VNS 7 to 10.
Conclusion
Among the factors related to dancer training, practice time, group practice, and dance type affect the occurrence of pain.
Nephrology
Effect of pitavastatin on erythrocyte membrane fatty acid content in patients with chronic kidney disease: two-arm parallel randomized controlled trial
Minna Kim, Seong Eun Kim, Su Mi Lee, Won Suk An
J Yeungnam Med Sci. 2024;41(3):188-195.   Published online May 8, 2024
DOI: https://doi.org/10.12701/jyms.2024.00094
  • 6,752 View
  • 121 Download
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Background
Statins reduce the risk of cardiovascular events in patients with chronic kidney disease (CKD). Although diabetes mellitus (DM) is a reported side effect of statin treatment, some studies have indicated that pitavastatin does not cause DM. The present study investigated the effect of pitavastatin on the fatty acid (FA) content of erythrocyte membranes, which affects the occurrence of DM and cardiovascular diseases. In addition, changes in adiponectin and glycated hemoglobin (HbA1c) levels were evaluated after pitavastatin treatment.
Methods
A total of 45 patients were enrolled, 28 of whom completed the study. Over 24 weeks, 16 patients received 2 mg pitavastatin and 12 patients received 10 mg atorvastatin. Dosages were adjusted after 12 weeks if additional lipid control was required. There were 10 and nine patients with DM in the pitavastatin and atorvastatin groups, respectively. Erythrocyte membrane FAs and adiponectin levels were measured using gas chromatography and enzyme-linked immunosorbent assay, respectively.
Results
In both groups, saturated FAs, palmitic acid, trans-oleic acid, total cholesterol, and low-density lipoprotein cholesterol levels were significantly lower than those at baseline. The arachidonic acid (AA) content in the erythrocyte membrane increased significantly in the pitavastatin group, but adiponectin levels were unaffected. HbA1c levels decreased in patients treated with pitavastatin. No adverse effects were associated with statin treatment.
Conclusion
Pitavastatin treatment in patients with CKD may improve glucose metabolism by altering erythrocyte membrane AA levels. In addition, pitavastatin did not adversely affect glucose control in patients with CKD and DM.

Citations

Citations to this article as recorded by  
  • The use of hypolipidemic agents in patients with hyperuricemia on the background of type 2 diabetes mellitus and atherosclerosis
    A. A. Mosina, Yu. A. Sorokina, L. V. Lovtsova, A. L. Urakov
    Meditsinskiy sovet = Medical Council.2025; (6): 265.     CrossRef
Psychiatry and Mental Health
The characteristics of elderly suicidal attempters in the emergency department in Korea: a retrospective study
Ji-Seon Jang, Wan-Seok Seo, Bon-Hoon Koo, Hey-Geum Kim, Seok-Ho Yun, So-Hey Jo, Dae-Seok Bai, Young-Gyo Kim, Eun-Jin Cheon
J Yeungnam Med Sci. 2024;41(1):30-38.   Published online December 29, 2023
DOI: https://doi.org/10.12701/jyms.2023.01004
  • 9,543 View
  • 118 Download
  • 1 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary Material
Background
Although Korea ranks first in the suicide rate of elderly individuals, there is limited research on those who attempt suicide, with preventive measures largely based on population-based studies. We compared the demographic and clinical characteristics of elderly individuals who attempted suicide with those of younger adults who visited the emergency department after suicide attempts and identified the factors associated with lethality in the former group.
Methods
Individuals who visited the emergency department after a suicide attempt from April 1, 2017, to January 31, 2020, were included. Participants were classified into two groups according to age (elderly, ≥65 years; adult, 18–64 years). Among the 779 adult patients, 123 were elderly. We conducted a chi-square test to compare the demographic and clinical features between these groups and a logistic regression analysis to identify the risk factors for lethality in the elderly group.
Results
Most elderly participants were men, with no prior psychiatric history or suicide attempts, and had a higher prevalence of underlying medical conditions and attributed their attempts to physical illnesses. Being sober and planning suicide occurred more frequently in this group. In the elderly group, factors that increased the mortality rate were biological male sex (p<0.05), being accompanied by family members (p<0.05), and poisoning as a suicide method (p<0.01).
Conclusion
Suicide attempts in elderly individuals have different characteristics from those in younger adults and are associated with physical illness. Suicides in the former group are unpredictable, deliberate, and fatal. Therefore, tailored prevention and intervention strategies addressing the characteristics of those who are elderly and attempt suicide are required.

Citations

Citations to this article as recorded by  
  • Effectiveness of the Loving Life TokTok 65+ Program for Suicide Prevention Education for the Elderly
    Jae Sang Lee, Eun Seok Kim, Kkotdawoon Han, Su Kyong Song, Young-Eun Jung
    Journal of Korean Neuropsychiatric Association.2026; 65(1): 44.     CrossRef
  • Poisoning in the elderly is increasing rapidly and is more severe than younger patients
    Geoffrey K. Isbister, Michael A. Downes, Kylie McArdle, Shane Jenkins, Caitlyn Lovett, Ingrid Berling
    Clinical Toxicology.2026; : 1.     CrossRef
  • Analysis of suicide cases in post-mortem examination files of the Department of Forensic Medicine at the Medical University of Białystok in the years 2016-2021 = Analiza samobójstw w materiale sekcyjnym Zakładu Medycyny Sądowej Uniwersytetu Medycznego w B
    Anna Francuziak, Paulina Kulasza, Kinga Kozłowska, Julia Janica, Urszula Cwalina, Anna Niemcunowicz-Janica, Michał Szeremeta
    Archives of Forensic Medicine and Criminology.2024; 74(2): 106.     CrossRef
Physical therapy, Sports Therapy, and Rehabilitation
Incidence and risk factors of deep vein thrombosis and pulmonary thromboembolism after spinal cord disease at a rehabilitation unit: a retrospective study
Yoonhee Kim, Minjae Jeong, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Du Hwan Kim
J Yeungnam Med Sci. 2023;40(Suppl):S56-S64.   Published online September 20, 2023
DOI: https://doi.org/10.12701/jyms.2023.00689
  • 7,799 View
  • 101 Download
  • 4 Web of Science
  • 5 Crossref
AbstractAbstract PDF
Background
Deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) are major complications of spinal cord disease. However, studies of their incidence in Korean patients are limited. Thus, this study investigated the incidence and risk factors of DVT and PTE in Korean patients with spinal cord disease.
Methods
We retrospectively analyzed the medical records of 271 patients with spinal cord disease who were admitted to a rehabilitation unit within 3 months of disease onset at a tertiary hospital. The presence of DVT and PTE was mainly determined using Doppler ultrasonography and chest embolism computed tomography. Risk factor analysis included variables such as sex, age, obesity, completeness of motor paralysis, neurological level of injury, cause of injury, lower extremity fracture, active cancer, and functional ambulation category (FAC) score.
Results
The incidences of DVT and PTE in the patients with spinal cord disease were both 6.3%. Risk factor analysis revealed that age of ≥65 years (p=0.031) and FAC score of ≤1 (p=0.023) were significantly associated with DVT development. Traumatic cause of injury (p=0.028) and DVT (p<0.001) were significant risk factors of PTE.
Conclusion
Patients with spinal cord disease developed DVT and PTE within 3 months of disease onset with incidence rates of 6.3% and 6.3%, respectively. Age of ≥65 years and an FAC of score ≤1 were risk factors for DVT. Traumatic cause of injury and DVT were risk factors for PTE. However, given the inconsistent results of previous studies, the risk factors for DVT and PTE remain inconclusive. Therefore, early screening for DVT and PTE should be performed in patients with acute-to-subacute spinal cord disease regardless of the presence or absence of these risk factors.

Citations

Citations to this article as recorded by  
  • Safety and efficacy of botulinum toxin in Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis: A randomized clinical trial
    Matheus Sales, Giselle Barbara De Almeida Scaldafferri, Matheus Henrique Almeida, Vítor Melo, Tatiana Dias, Paulo Canas Rodrigues, Ailton Melo, Nildo Manoel Da Silva Ribeiro
    The Journal of Spinal Cord Medicine.2026; : 1.     CrossRef
  • Assessing the Incidence and Risk Factors of Deep Vein Thrombosis in Traumatic Spinal Cord Injury Patients at Tertiary Care Hospital in India
    Sushil Chugh, Dhananjay B. Alagundagi, Shwetha Shetty Kalladka, Prakash Patil, Kurian Zachariah
    Indian Journal of Physical Medicine and Rehabilitation.2025; 35(3): 191.     CrossRef
  • Trends and Impact of Pharmacological VTE Prophylaxis Timing for Traumatic Cervical Spinal Cord Injury Across North American Trauma Centers
    Ahmad Essa, Armaan K. Malhotra, Husain Shakil, James P. Byrne, Jetan Badhiwala, Avery B. Nathens, Tej D. Azad, Eva Y. Yuan, Yingshi He, Andrew S. Jack, Francois Mathieu, Jefferson R. Wilson, Christopher D. Witiw
    Journal of Bone and Joint Surgery.2025;[Epub]     CrossRef
  • Associations of RBC counts and incidence of DVT in patients with spinal cord injury: a five year observational retrospective study
    Zhang Jinlong, Wang Cheng, He Chengqi
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures
    Yong Jiao, Xiaohong Mu
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
Gastroenterology and Hepatology
Association between total body muscle percentage and prevalence of non-alcoholic fatty liver disease in Korean adults findings from an 18-year follow-up: a prospective cohort study
Byoung Chan Ahn, Chul Yong Park, Jung Hee Hong, Ki Ook Baek
J Yeungnam Med Sci. 2023;40(Suppl):S47-S55.   Published online August 29, 2023
DOI: https://doi.org/10.12701/jyms.2023.00605
  • 5,423 View
  • 66 Download
AbstractAbstract PDFSupplementary Material
Background
This study aimed to elucidate the association between total lean muscle mass and the incidence of non-alcoholic fatty liver disease (NAFLD) in the adult Korean population.
Methods
Utilizing data derived from the 18-year prospective cohort of the Korean Genome and Epidemiology Study, NAFLD was diagnosed via the hepatic steatosis index with an established cutoff value of 36. Lean muscle mass was assessed via bioelectrical impedance analysis and subsequently divided into tertiles. A generalized mixed model with a logit link was employed for repeated measures data analysis, accounting for potential confounders.
Results
Analysis encompassed 7,794 participants yielding 49,177 measurements. The findings revealed a markedly increased incidence of NAFLD in the lower tertiles of muscle mass, specifically, tertile 1 (odds ratio [OR], 20.65; 95% confidence interval [CI], 9.66–44.11) and tertile 2 (OR, 4.57; 95% CI, 2.11–9.91), in comparison to tertile 3. Age-dependent decreases in the OR were observed within the tertile 1 group, with ORs of 10.12 at age of 40 years and 4.96 at age of 80 years. Moreover, each 1%-point increment in total muscle mass corresponded with an estimated OR of 0.87 (95% CI, 0.82–0.93) for NAFLD resolution.
Conclusions
The study demonstrates a significant association between total muscle mass and NAFLD prevalence among Korean adults. Given the potential endocrine role of muscle mass in NAFLD pathogenesis, interventions aimed at enhancing muscle mass might serve as an effective public health strategy for mitigating NAFLD prevalence.
Case report
Pathology and Forensic Medicine
Classical Hodgkin lymphoma following follicular lymphoma: a case report
Bomi Kim
J Yeungnam Med Sci. 2023;40(Suppl):S113-S122.   Published online August 17, 2023
DOI: https://doi.org/10.12701/jyms.2023.00584
  • 7,302 View
  • 179 Download
AbstractAbstract PDF
The simultaneous, composite, or sequential occurrence of follicular lymphoma (FL) and classical Hodgkin lymphoma (HL), both of which originate from germinal center B-cell, is rare. Questions have been raised with regard to the type of tests that pathologists should perform when observing the presence of a “large-cell lymphoma” following an FL and what are the most critical pathological points for diagnosis. Here, we present a case of a classical HL following an FL after administering rituximab-bendamustine (R-Benda) chemotherapy. Furthermore, we also summarized the literature and compared this case with other HLs that followed FLs. A 55-year-old woman was diagnosed with a grade 3A FL of the breast and axillary lymph node masses. She completed six R-Benda chemotherapy cycles for stage IV FL. Twenty-three months after the diagnosis, follow-up image studies showed an increase in the size and number of the lesions. Biopsies of the neck lymph node and liver were performed, and the diagnosis was classical HL. Sequential or composite FL and HL may sometimes develop from the same clone because they share the same genetic alterations, such as B-cell lymphoma (Bcl)-2 or Bcl-6 translocation. When a large-cell lymphoma is found after the treatment of FL, classical HL should be considered a pathological differential diagnosis, and histological, immunohistochemical, or molecular investigations must be considered during the diagnostic process.
Original articles
Dentistry
Evaluation of periodontal status in women with polycystic ovary syndrome versus healthy women: a cross-sectional study
Sandhya Pavankumar, Pavan Kumar Yellarthi, Sandeep JN, Ramanarayana Boyapati, Trinath Kishore Damera, Naveen Vital Kumar G
J Yeungnam Med Sci. 2023;40(Suppl):S17-S22.   Published online May 8, 2023
DOI: https://doi.org/10.12701/jyms.2023.00143
  • 8,411 View
  • 197 Download
  • 5 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
Polycystic ovary syndrome (PCOS) affects approximately 4% to 12% of females of reproductive age. Previous studies have shown an association between systemic and periodontal diseases. This study aimed to compare the prevalence of periodontal disease in women with PCOS and healthy women.
Methods
A total of 196 women aged 17 to 45 years were included in this study. Oral hygiene index-simplified (OHI-S), gingival index (GI), community periodontal index (CPI), and loss of attachment (LA) were assessed. Individuals who smoked, were pregnant, had any systemic disease (such as type 1 or type 2 diabetes mellitus, cardiovascular disease, malignancy, osteoporosis, and thyroid dysfunction), had a history of systemic antibiotic use in the past three months, or received any periodontal intervention in the past 6 months of screening were excluded. Student t-test was used to analyze the data. A p-value of <0.05 was considered statistically significant.
Results
Despite similar OHI-S scores (p=0.972) in the two groups, women with PCOS had significantly higher GI, CPI, and LA scores than healthy women (p<0.001).
Conclusion
Periodontal disease was more prevalent in women with PCOS than in healthy women. This finding may be due to the synergistic effects of PCOS and periodontitis on proinflammatory cytokines. PCOS may have an effect on periodontal disease, and vice versa. Hence, education on periodontal health and early detection and intervention for periodontal diseases is of paramount importance in patients with PCOS.

Citations

Citations to this article as recorded by  
  • A Potential Link Between Oral Microbiota and Female Reproductive Health
    Justyna Marcickiewicz, Małgorzata Jamka, Jarosław Walkowiak
    Microorganisms.2025; 13(3): 619.     CrossRef
  • The Association Between Periodontal Disease and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
    Vincenzo Bitonti, Tiziana Perri, Lorenzo Cigni, Domenico Familiari, Giuseppe Vazzana, Rocco Franco
    Dentistry Journal.2025; 13(5): 188.     CrossRef
  • Insight of the interrelationship and association mechanism between periodontitis and diabetes mellitus
    Yongqiang Yang, Xia Sun, Yucheng Yang, Yingchun Qie
    Regenerative Therapy.2024; 26: 1159.     CrossRef
Nephrology
Cortical thickness of the rostral anterior cingulate gyrus is associated with frailty in patients with end-stage renal disease undergoing hemodialysis in Korea: a cross-sectional study
Sang Hyun Jung, Jong Soo Oh, So-Young Lee, Hye Yun Jeong
J Yeungnam Med Sci. 2023;40(4):381-387.   Published online March 24, 2023
DOI: https://doi.org/10.12701/jyms.2022.00941
  • 4,865 View
  • 61 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Background
Frailty is defined as a condition of being weak and delicate, and it represents a state of high vulnerability to adverse health outcomes. Recent studies have suggested that the cingulate gyrus is associated with frailty in the elderly population. However, few imaging studies have explored the relationship between frailty and the cingulate gyrus in patients with end-stage renal disease (ESRD) undergoing hemodialysis.
Methods
Eighteen right-handed patients with ESRD undergoing hemodialysis were enrolled in the study. We used the FreeSurfer software package to estimate the cortical thickness of the regions of interest, including the rostral anterior, caudal anterior, isthmus, and posterior cingulate gyri. The Beck Depression Inventory, Beck Anxiety Inventory, and laboratory tests were also conducted.
Results
The cortical thickness of the right rostral anterior cingulate gyrus (ACG) was significantly correlated with the Fried frailty index, age, and creatinine level. Multiple regression analysis indicated that the cortical thickness of the right rostral ACG was associated with frailty after controlling for age and creatinine level.
Conclusion
Our results indicate that the cortical thickness of the rostral ACG may be associated with frailty in patients with ESRD on hemodialysis and that the rostral ACG may play a role in the frailty mechanism of this population.

Citations

Citations to this article as recorded by  
  • The impact of balance exercise on brain age and brain morphometry: insights from MRI analysis
    Varima Narula, Denise Taylor, Ruth McLaren, Rachael L. Taylor, Susan Mahon, Paul F. Smith, Shikha Chaudhary, Roger W. Winton, Justin Fernandez, Vickie Shim, Alan Wang
    Aging Clinical and Experimental Research.2026;[Epub]     CrossRef
Case report
Neurology
Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report
Chae Hun Lee, Byeong Joo Choi, Jung Hun Kim, Tae Woong Yang, Gi Jeong Kim, Ha Young Shin, Se Hoon Kim, Seung Woo Kim
J Yeungnam Med Sci. 2023;40(4):430-434.   Published online February 13, 2023
DOI: https://doi.org/10.12701/jyms.2022.00850
  • 4,341 View
  • 49 Download
AbstractAbstract PDF
Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.
Original article
Cardiology and Cardiovascular Medicine
Outcomes after repair of complete atrioventricular canal with a modified single-patch technique: a retrospective study
George Samanidis, Konstantinos Kostopanagiotou, Meletios Kanakis, Georgios Kourelis, Kyriaki Kolovou, Georgios Vagenakis, Dimitrios Bobos, Nicholas Giannopoulos
J Yeungnam Med Sci. 2023;40(2):187-192.   Published online February 1, 2023
DOI: https://doi.org/10.12701/jyms.2022.00759
  • 4,747 View
  • 79 Download
AbstractAbstract PDF
Background
This study aimed to present the short- and midterm outcomes after complete atrioventricular canal defect (CAVC) repair using a single-patch technique.
Methods
This study included 30 children who underwent surgical correction of the CAVC using a single-patch technique.
Results
The median age of the patients was 5.7 months (interquartile range [IQR], 5.0–7.5 months), and 23 patients (76.7%) had type A CAVC. Fourteen patients (46.7%) were female and 17 (56.7%) had been diagnosed with Down syndrome. The in-hospital mortality rate was 0%. No deaths were observed during a median follow-up of 4 years (IQR, 3.5–5.0 years). Patients without Down syndrome were associated with late moderate mitral regurgitation (MR) (p=0.02). Late MR less than moderate degree was observed in 96.6%, 78.5%, and 50% of patients after 2, 4, and 5 years of follow-up, respectively, while late tricuspid valve regurgitation less than moderate degree was observed in 96.7%, 85.9%, and 59.0% of patients after 2, 4, and 6 years of follow-up, respectively. After a median follow-up of 4 years, only one patient had required surgical repair of a left ventricular outflow tract obstruction, which occurred 26 months after the first operation. Multivariable logistic regression analysis adjusted for the type of CAVC, sex, Down syndrome, age, and weight revealed that the absence of Down syndrome was a risk factor for late moderate MR (MR-2) (odds ratio, 0.05; 95% confidence interval, 0.006–0.50; p=0.01).
Conclusion
A single-patch technique for CAVC surgical repair is a safe method with acceptable short- and midterm results.
Review articles
Radiology, Radiotherapy & Diagnostic Imaging
Hepatic encephalopathy on magnetic resonance imaging and its uncertain differential diagnoses: a narrative review
Chun Geun Lim, Myong Hun Hahm, Hui Joong Lee
J Yeungnam Med Sci. 2023;40(2):136-145.   Published online January 10, 2023
DOI: https://doi.org/10.12701/jyms.2022.00689
  • 18,485 View
  • 435 Download
  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Hepatic encephalopathy (HE) is a severe neuropsychiatric abnormality in patients with either acute or chronic liver failure. Typical brain magnetic resonance imaging findings of HE are bilateral basal ganglia high signal intensities due to manganese deposition in chronic liver disease and hyperintensity in T2, fluid-attenuated inversion recovery, or diffusion-weighted imaging (DWI) with hemispheric white matter changes including the corticospinal tract. Low values on apparent diffusion coefficient mapping of the affected area on DWI, indicating cytotoxic edema, can be observed in acute HE. However, neuropsychological impairment in HE ranges from mild deficits in psychomotor abilities affecting quality of life to stupor or coma with higher grades of hepatic dysfunction. In particular, the long-lasting compensatory mechanisms for the altered metabolism in chronic liver disease make HE imaging results variable. Therefore, the clinical relevance of imaging findings is uncertain and differentiating HE from other metabolic diseases can be difficult. The recent introduction of concepts such as “acute-on-chronic liver failure (ACLF),” a new clinical entity, has led to a change in the clinical view of HE. Accordingly, there is a need to establish a corresponding concept in the field of neuroimaging diagnosis. Herein, we review HE from a historical and etiological perspective to increase understanding of brain imaging and help establish an imaging approach for advanced new concepts such as ACLF. The purpose of this manuscript is to provide an understanding of HE by reviewing neuroimaging findings based on pathological and clinical concepts of HE, thereby assisting in neuroimaging interpretation.

Citations

Citations to this article as recorded by  
  • Correlation Between Brain MRI Findings and Serum Ammonia Levels in Hepatic Encephalopathy
    Muhammad Fahad Atta, Maria Irum, Sumaira Aslam, Naima Mujahid, Khawar Anwar, Shabzain Ishrat
    Pakistan Journal of Health Sciences.2026; : 14.     CrossRef
  • “Two birds talking” and “monkey face” Sign in hepatic encephalopathy
    Qian Zheng, Jifen Wang
    Acta Neurologica Belgica.2026;[Epub]     CrossRef
  • Hepatic Encephalopathy Classification via Neuro-livo Features-Based Deep Tri-path Fused Neural Network
    R. K. Shanmugha Priya, K. Suthendran
    International Journal of Computational Intelligence Systems.2025;[Epub]     CrossRef
  • Cell–cell communications in the brain of hepatic encephalopathy: The neurovascular unit
    Kyuwan Choi, Yena Cho, Yerin Chae, So Yeong Cheon
    Life Sciences.2025; 363: 123413.     CrossRef
  • A Case of Hepatic Encephalopathy With Diffuse Brainstem Signal Changes on Magnetic Resonance Imaging
    Hiromu Yurimoto, Taiki Matsubayashi, Isamu Shibata, Misako Furuki, Masato Obayashi
    Cureus.2025;[Epub]     CrossRef
  • Brain Changes in Alcohol Induced Liver Cirrhosis Patients: Insights from Quantitative Susceptibility Mapping
    Andrej Vovk, Stefan Ropele, Sebastian Stefanovic, Borut Stabuc, Dusan Suput, Marjana Turk Jerovsek, Gasper Zupan
    Biomedicines.2025; 13(12): 2937.     CrossRef
  • Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy
    Chun Geun Lim, Hui Joong Lee
    Journal of the Korean Society of Radiology.2024; 85(2): 381.     CrossRef
  • Response to “Brain Lesions in Liver Cirrhosis May Not Only Be Due to Hepatic Encephalopathy”
    Hui Joong Lee
    Journal of the Korean Society of Radiology.2024; 85(4): 827.     CrossRef
  • Altered Mental Status in the Solid-Organ Transplant Recipient
    Nicolas Weiss, Henning Pflugrad, Prem Kandiah
    Seminars in Neurology.2024; 44(06): 670.     CrossRef
  • Reversibility of structural and functional alterations of hepatic encephalopathy
    Henning Pflugrad, Ann-Katrin Hennemann
    Metabolic Brain Disease.2024;[Epub]     CrossRef
  • Rule out all differential causes before attributing cerebral bleeding to 5-aminolevulinic acid
    Josef Finsterer, Sounira Mehri
    Child's Nervous System.2023; 39(4): 847.     CrossRef
  • Minimal hepatic encephalopathy: clinical, neurophysiological, neuroimaging markers
    P. I. Kuznetsova, A. A. Raskurazhev, S. N. Morozova, I. M. Lovchev, M. S. Novruzbekov, M. M. Tanashyan
    Russian neurological journal.2023; 28(5): 21.     CrossRef
  • Prevalence of Precipitating Factors of Hepatic Encephalopathy at Nangarhar Regional Hospital
    Ameerullah Razai, Ismail Khan Safi, Said Abdul Jamil Saidi, Said Inam Saidi
    Nangarhar University International Journal of Biosciences.2023; : 34.     CrossRef
Endocrinology, Diabetes, and Metabolism
Long-term management of Graves disease: a narrative review
Hyo-Jeong Kim
J Yeungnam Med Sci. 2023;40(1):12-22.   Published online November 4, 2022
DOI: https://doi.org/10.12701/jyms.2022.00444
  • 49,976 View
  • 750 Download
  • 6 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Graves disease (GD) is the most common cause of hyperthyroidism, accounting for more than 90% of cases in Korea. Patients with GD are treated with any of the following: antithyroid drugs (ATDs), radioactive iodine (RAI) therapy, or thyroidectomy. Most patients begin treatment with ATDs, and clinical guidelines suggest that the appropriate treatment period is 12 to 18 months. While RAI treatment and surgery manage thyrotoxicosis by destroying or removing thyroid tissue, ATDs control thyrotoxicosis by inhibiting thyroid hormone synthesis and preserving the thyroid gland. Although ATDs efficiently control thyrotoxicosis symptoms, they do not correct the main etiology of GD; therefore, frequent relapses can follow. Recently, a large amount of data has been collected on long-term ATDs for GD, and low-dose methimazole (MMZ) is expected to be a good option for remission. For the long-term management of recurrent GD, it is important to induce remission by evaluating the patient’s drug response, stopping ATDs at an appropriate time, and actively switching to surgery or RAI therapy, if indicated. Continuing drug treatment for an extended time is now encouraged in patients with a high possibility of remission with low-dose MMZ. It is also important to pay attention to the quality of life of the patients. This review aimed to summarize the appropriate treatment methods and timing of treatment transition in patients who relapsed several times while receiving treatment for GD.

Citations

Citations to this article as recorded by  
  • Management of hyperthyroidism in adults in India: Consensus statement of the Indian Thyroid Society
    Shashank Joshi, Krishna Seshadri, Sujoy Ghosh, Pramila Kalra, Arun S. Menon, Himagirish K. Rao, Mini G. Pillai, Sarita Bajaj, YP Ganavi, Narendra Kotwal, Rajesh Rajput
    Thyroid Research and Practice.2026; 22(1): 1.     CrossRef
  • A 30-year-old male patient who experienced recurring weakness in bilateral upper and lower extremities: a clinical vignette
    Soo Hyun Ahn, Mathieu Boudier-Revéret, Seoyon Yang, Min Cheol Chang
    Journal of Yeungnam Medical Science.2025; 42: 27.     CrossRef
  • Outcomes of Fixed-Dose Radioactive Iodine Therapy in Hyperthyroidism and Optimization of Follow-Up After Treatment Failure With Low-Dose Antithyroid Medication
    Panita Kantikool, Naphat Buraphanawibun
    Cureus.2025;[Epub]     CrossRef
  • Hub genes and key pathways of Graves’ disease: bioinformatics analysis and validation
    Duan-rong Zhuang, Xin Hu, Hui-bin Huang
    Hormones.2025; 24(3): 605.     CrossRef
  • Tingkat Keberhasilan Terapi Radioiodin Pertama pada Pasien Graves’ Disease
    Aliya Khadijah Kemaleratu, Yuliana Rahmah Retnaningrum, Yudanti Riastiti
    Jurnal Sains dan Kesehatan.2025; 6(1): 1.     CrossRef
  • Outcome of Graves' disease and associated genetic predisposition: A systematic review of literature
    Md. Ikhsan Mokoagow, Ahmad Zufar Manthovani, Marina Epriliawati
    Next Research.2025; 2(4): 100836.     CrossRef
  • Commentary: Azathioprine as an adjuvant therapy in severe Graves’ disease: a randomized controlled open-label clinical trial
    Madhukar Mittal, Azher Rizvi
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Total Thyroidectomy – A Cost-effective Alternative to Anti-Thyroid Drugs in the Management of Grave's Disease
    Erivelto Volpi, Leonardo M. Volpi
    Clinical Thyroidology.2023; 35(5): 183.     CrossRef
  • Evaluation of the Abbott Alinity i Thyroid-Stimulating Hormone Receptor Antibody (TRAb) Chemiluminescent Microparticle Immunoassay (CMIA)
    Deborah J. W. Lee, Soon Kieng Phua, Yali Liang, Claire Chen, Tar-Choon Aw
    Diagnostics.2023; 13(16): 2707.     CrossRef
  • Mechanisms and Treatment Options for Hyperthyroid-Induced Osteoporosis: A Narrative Review
    Robert M Branstetter, Rahib K Islam, Collin A Toups, Amanda N Parra, Zachary Lee, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D Kaye
    Cureus.2023;[Epub]     CrossRef
Focused Review article
Neurology
Pain in amyotrophic lateral sclerosis: a narrative review
Soyoung Kwak
J Yeungnam Med Sci. 2022;39(3):181-189.   Published online June 8, 2022
DOI: https://doi.org/10.12701/jyms.2022.00332
  • 16,029 View
  • 223 Download
  • 19 Web of Science
  • 20 Crossref
AbstractAbstract PDF
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

Citations

Citations to this article as recorded by  
  • Long-wave infrared imaging for respiratory rate measurement in a patient with amyotrophic lateral sclerosis: A case report
    Jaeho Kim, Sungho Kim, Sreya Deb Sreshta, Uday Debnath, Yoo Jin Choo, Min Cheol Chang
    Journal of International Medical Research.2026;[Epub]     CrossRef
  • Acetyl-l-Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review
    Diego Maria Michele Fornasari
    Pain and Therapy.2026;[Epub]     CrossRef
  • Clinical parameters affecting the course of amyotrophic lateral sclerosis: a longitudinal analysis of the Greek registry for amyotrophic lateral sclerosis (ALS-GR)
    Ioannis Liampas, Vasilios K Kimiskidis, Vasiliki Zouvelou, Dimitra Veltsista, Afroditi Moscholouri, Eleftherios Triantafyllou, Ariadni Daponte, Sofia Xirou, Angeliki-Erato Sterpi, Stavroula Salakou, Vasiliki Poulidou, Marianthi Arnaoutoglou, Zisis Tsouris
    Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.2026; : 1.     CrossRef
  • Resting-State EEG Oscillations in Amyotrophic Lateral Sclerosis (ALS): Toward Mechanistic Insights and Clinical Markers
    James Chmiel, Marta Stępień-Słodkowska
    Journal of Clinical Medicine.2025; 14(2): 545.     CrossRef
  • Progressive Bulbar Palsy (PBP) or Bulbar Onset MND: “A Case Report”
    Sagar S. Bhovare, Akhataribano S. Sayyad
    Journal of Pharmacy and Bioallied Sciences.2025; 17(Suppl 1): S971.     CrossRef
  • Health-Related Quality of Life, Psychological Health, and Patient-Reported Outcomes of Amyotrophic Lateral Sclerosis Patients in China
    Dilip Dhakal, Congzhou Chen, Bo Zhang, Guanqiao Li
    Brain Sciences.2025; 15(7): 696.     CrossRef
  • Analysis of factors influencing sleep disorders in patients with amyotrophic lateral sclerosis
    Qianping Jiang, Dan Yang, Rui Jiang, Shilei Wan, Miao Wu, Dandan Xu, Jing Zhou
    Scientific Reports.2025;[Epub]     CrossRef
  • Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies
    Ramin Raoufinia, Ghazal Alyari, Amin Tadayoni nia, Mohammad Reza Abbaszadegan, Ali Mahmoudi, Sajjad Shafaeibajestan, Ehsan Saburi, Jalil Tavakol-Afshari, Mehdi Hassani, Faezeh Jamali, Shahram Salari, Amir Reza Boroumand, Hamid reza Rahimi
    Stem Cell Research & Therapy.2025;[Epub]     CrossRef
  • Greek Registry for Amyotrophic Lateral Sclerosis (ALS‐GR): An Observational Cohort of Individuals With ALS Across 11 Specialized Centers in Greece
    Ioannis Liampas, Vasilios K. Kimiskidis, Vasiliki Zouvelou, Dimitra Veltsista, Afroditi Moscholouri, Eleftherios Triantafyllou, Ariadni Daponte, Sofia Xirou, Angeliki‐Erato Sterpi, Stavroula Salakou, Vasiliki Poulidou, Marianthi Arnaoutoglou, Zisis Tsouri
    European Journal of Neurology.2025;[Epub]     CrossRef
  • Rehabilitation in Amyotrophic Lateral Sclerosis: Recommendations for Clinical Practice and Further Research
    Andreas Gratzer, Natalie Gdynia, Nadine Sasse, Rainer Beese, Cordula Winterholler, Yvonne Bauer, Carsten Schröter, Hans-Jürgen Gdynia
    Journal of Clinical Medicine.2025; 14(23): 8590.     CrossRef
  • Health-related quality of life across disease stages in patients with amyotrophic lateral sclerosis: results from a real-world survey
    Katie Stenson, T. E. Fecteau, L. O’Callaghan, P. Bryden, J. Mellor, J. Wright, L. Earl, O. Thomas, H. Iqbal, S. Barlow, S. Parvanta
    Journal of Neurology.2024; 271(5): 2390.     CrossRef
  • Amyotrophic Lateral Sclerosis and Pain: A Narrative Review from Pain Assessment to Therapy
    Vincenzo Pota, Pasquale Sansone, Sara De Sarno, Caterina Aurilio, Francesco Coppolino, Manlio Barbarisi, Francesco Barbato, Marco Fiore, Gianluigi Cosenza, Maria Beatrice Passavanti, Maria Caterina Pace, Enzo Emanuele
    Behavioural Neurology.2024;[Epub]     CrossRef
  • Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions
    Bogdan Bjelica, Maj-Britt Bartels, Jasper Hesebeck-Brinckmann, Susanne Petri
    Journal of Neurology.2024; 271(7): 3953.     CrossRef
  • Perceived Pain in People Living with Amyotrophic Lateral Sclerosis—A Scoping Review
    Debora Rosa, Laura Ingrande, Ilaria Marcomini, Andrea Poliani, Giulia Villa, Martina Sodano, Duilio Fiorenzo Manara
    Nursing Reports.2024; 14(4): 3023.     CrossRef
  • Pain in Amyotrophic Lateral Sclerosis Is Underrated
    Soyoung Kwak, Min Cheol Chang
    International journal of Pain.2024; 15(2): 51.     CrossRef
  • Likely Pathogenic Variants of Cav1.3 and Nav1.1 Encoding Genes in Amyotrophic Lateral Sclerosis Could Elucidate the Dysregulated Pain Pathways
    Zsófia Flóra Nagy, Balázs Sonkodi, Margit Pál, Péter Klivényi, Márta Széll
    Biomedicines.2023; 11(3): 933.     CrossRef
  • Palliative Care in Amyotrophic Lateral Sclerosis
    Sebastiano Mercadante, Lou'i Al-Husinat
    Journal of Pain and Symptom Management.2023; 66(4): e485.     CrossRef
  • The blind spot and challenges in pain management
    Min Cheol Chang
    Journal of Yeungnam Medical Science.2022; 39(3): 179.     CrossRef
  • Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?
    Bradley Roberts, Frances Theunissen, Francis L. Mastaglia, P. Anthony Akkari, Loren L. Flynn
    International Journal of Molecular Sciences.2022; 23(16): 9364.     CrossRef
  • Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report
    Siyang Peng, Weiqian Chang, Yukun Tian, Yajing Yang, Shaohong Li, Jinxia Ni, Wenzeng Zhu
    Medicine.2022; 101(45): e31446.     CrossRef
Case reports
Emergency and Critical Care Medicine
Prolonged oral sildenafil use-induced Mondor disease: a case report
Han Sol Chung, You Ho Mun
J Yeungnam Med Sci. 2022;39(3):262-265.   Published online May 24, 2022
DOI: https://doi.org/10.12701/jyms.2022.00220
  • 16,773 View
  • 105 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Penile Mondor disease (MD) is a palpable, painful, subcutaneous induration caused by superficial dorsal penile vein thrombosis. We report a case of penile MD that was suspected to be related to prolonged oral sildenafil use. A 46-year-old man visited our emergency department with sustained penile pain and swelling that began 7 hours after sexual intercourse. He had used oral sildenafil intermittently for 11 years and engaged in sexual intercourse the previous night after taking sildenafil. Examination revealed no evidence of intercourse-related trauma to the genital area or an increase in penile skin temperature. However, penile swelling and tenderness over the protruding dorsal penile vein were noted. A color Doppler ultrasound examination was performed immediately, which showed hyperechoic thrombosis in the right superficial dorsal penile vein that was dilated, with soft tissue swelling and no detectable flow signal in the thrombotic lesion. The patient was diagnosed as having penile MD. The patient was treated conservatively. Some reports have indicated the involvement of sildenafil in thrombogenesis. Physicians should be aware that prolonged oral sildenafil use may be associated with penile MD.

Citations

Citations to this article as recorded by  
  • Management of Penile Mondor’s disease: insights from a scoping review
    Alessio Papaveri, Angelo Cafarelli, Federico Falsetti, Luca Spinozzi, Davide Ciavarella, Enrico Sicignano, Valentina Maurizi, Michele Marchioni, Luigi Schips, Daniele Castellani, Vineet Gauhar, Carlo Giulioni
    Sexual Medicine Reviews.2026;[Epub]     CrossRef
  • Penile superficial dorsal vein thrombophlebitis following prolonged sexual activity
    Ahmed Adam Osman, Hanan HassanHirei, Abdulkadir Isse Mohamed, Shuayb Moallim Ali, Amal Naleye Ali, Abdikarim Hussein Mohamed
    Radiology Case Reports.2024; 19(12): 6161.     CrossRef
  • A case with Penile Mondor’s disease
    Hülya Cenk, Gülbahar Saraç, İrem Mantar Yanatma
    TURKDERM.2023; : 151.     CrossRef
Obstetrics, Gynecology, and Reproductive Medicine
Laparoscopic excision and repair of a cesarean scar pregnancy in a woman with uterine didelphys: a case report
Seong-Eon Park, Ji-Eun Ryu, Tae-Kyu Jang
J Yeungnam Med Sci. 2023;40(2):202-206.   Published online May 16, 2022
DOI: https://doi.org/10.12701/jyms.2022.00115
  • 5,904 View
  • 88 Download
  • 2 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Cesarean scar pregnancy (CSP) is a rare complication that occurs in less than 1% of ectopic pregnancies, and uterine didelphys is one of the rarest uterine forms. We report a successful laparoscopic excision and repair of CSP in a woman with uterine didelphys and a double vagina. A 34-year-old gravida one, para one woman with a history of low transverse cesarean section presented to our hospital with a suspected CSP. She was confirmed to have uterine didelphys with a double vagina during an infertility examination 7 years earlier. Magnetic resonance imaging showed a 2.5-cm gestational sac-like cystic lesion in the lower segment of the right uterus at the cesarean scar. We decided to perform a laparoscopic approach after informing the patient of the surgical procedure. The lower segment of the previous cesarean site was excised with monopolar diathermy to minimize bleeding. We identified the gestational sac in the lower segment of the right uterus, which was evacuated using spoon forceps. The myometrium and serosa of the uterus were sutured layer-by-layer using synthetic absorbable sutures. No remnant gestational tissue was visible on follow-up ultrasonography one month after the surgery. This laparoscopic approach to CSP in a woman with uterine didelphys is an effective and safe method of treatment. In women with uterine anomalies, it is important to confirm the exact location of the gestational sac by preoperative imaging for successful surgery.

Citations

Citations to this article as recorded by  
  • Clinical study of two reversible arterial blockade methods in the treatment of scar pregnancy under combined hysterolaparoscopy
    Wei Wei
    American Journal of Translational Research.2024; 16(11): 6770.     CrossRef
Original articles
Dentistry
Effect of nonsurgical periodontal therapy and smoking status on hematological variables related to anemia of chronic disease in chronic periodontitis patient: a case-control study
Sangita Show, Somen Bagchi, Arka Kanti Dey, Ramanarayana Boyapati, Pritish Chandra Pal, Kanikanti Siva Tejaswi
J Yeungnam Med Sci. 2022;39(3):244-249.   Published online May 16, 2022
DOI: https://doi.org/10.12701/jyms.2022.00045
  • 6,614 View
  • 105 Download
  • 1 Web of Science
AbstractAbstract PDF
Background
Chronic infectious, inflammatory, or neoplastic disorders are associated with anemia of chronic disease. Chronic inflammatory diseases such as periodontitis may contribute to masked anemia, especially in smokers. This study was aimed at verifying and comparing the efficacy of nonsurgical periodontal therapy (NSPT) for improving anemia among chronic periodontitis patients with and without the habit of smoking.
Methods
Thirty systemically healthy individuals with chronic periodontitis were divided into two groups of 15 each, smokers (group A) and nonsmokers (group B). The groups were compared based on hematological parameters such as serum erythropoietin (SE) and serum ferritin (SF) levels at baseline and 3 months after NSPT for anemia evaluation.
Results
The baseline SE levels in groups A and B were 11.84 and 15.19 mIU/mL (p=0.031), respectively; the corresponding levels at 3 months after NSPT were 13.00 and 17.74 mIU/mL (p=0.022). The baseline SF levels in groups A and B were 95.49 and 44.86 ng/mL (p=0.018), respectively; the corresponding levels at 3 months after NSPT were 77.06 and 39.05 ng/mL (p=0.009). Group B showed a significant increase and decrease in the SE and SF levels, respectively, at 3 months after NSPT (p=0.035 and p=0.039, respectively), whereas group A showed insignificant changes (p=0.253 and p=0.618, respectively).
Conclusion
NSPT led to an improvement in anemia among chronic periodontitis patients. However, the improvement is less in smokers compared to that in nonsmokers. Furthermore, SF and SE levels might serve as effective biomarkers for assessing anemia in smokers and nonsmokers with chronic periodontitis.
Gastroenterology and Hepatology
Factors associated with the prescription of probiotics in patients with inflammatory bowel disease: a cross-sectional study
Joo Kyung Kim, Jae Hee Cheon
J Yeungnam Med Sci. 2023;40(1):37-48.   Published online April 18, 2022
DOI: https://doi.org/10.12701/jyms.2022.00031
  • 9,026 View
  • 112 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDF
Background
Commensal bacteria play an important role in the pathogenesis of inflammatory bowel disease (IBD) and probiotics have been used as treatment options. We aimed to explore the current use of probiotics and factors associated with their prescription in patients with IBD.
Methods
This cross-sectional study was conducted on a single hospital-based cohort. Patients were eligible if they were ≥18 years old, visited the IBD clinic as an outpatient more than twice during the study period, and had a confirmed diagnosis of IBD. Patients were divided into two groups based on the prescription of probiotics. Clinical assessments were compared between the two groups.
Results
In total, 217 patients were enrolled in this study. In patients with Crohn disease (CD), moderate or severe abdominal pain; prior use of methotrexate (MTX), iron, thiopurines, or biologics; history of IBD-related surgery; and stool frequency were independently associated with the prescription of probiotics. In patients with ulcerative colitis (UC), moderate or severe abdominal pain, hematochezia, stool frequency, and moderate or severe physician global assessment score were independently associated with the prescription of probiotics.
Conclusion
Increased disease activity may be associated with fewer prescriptions of probiotics in patients with IBD. However, physicians prescribed probiotics to control symptoms, such as abdominal pain and increased stool frequency in patients with UC and CD, and hematochezia in patients with UC. Additionally, the use of MTX and iron, and a history of IBD-related surgeries were associated with more frequent probiotic prescriptions in patients with CD.

Citations

Citations to this article as recorded by  
  • Oral administration of nanozyme-armed probiotic Escherichia coli Nissle 1917 with ROS scavenging for inflammatory bowel disease therapy
    Tiantian Cui, Bing Li, Zhaoyang Lou, Kai Yang, Kaijin Yan, Danhong Ding, Hong Ge
    Chemical Engineering Journal.2025; 519: 164949.     CrossRef
  • The role of the fecal microbiota in inflammatory bowel disease
    Rami Khalaf, Martina Sciberras, Pierre Ellul
    European Journal of Gastroenterology & Hepatology.2024; 36(11): 1249.     CrossRef
  • Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022
    Cuilan Huang, Wujuan Hao, Xuyang Wang, Renmin Zhou, Qiong Lin
    Frontiers in Microbiology.2023;[Epub]     CrossRef
Review article
Anatomy
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review
Haneol Ko, Sang-Pil Yoon
J Yeungnam Med Sci. 2022;39(4):269-277.   Published online February 14, 2022
DOI: https://doi.org/10.12701/jyms.2021.01683
  • 15,506 View
  • 148 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDF
The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

Citations

Citations to this article as recorded by  
  • Application of Optogenetic Neuromodulation in Regulating Depression
    Jin Zhang, Xiang Peng, Man Li, Xiao-ming Zhang, Hong-chun Xiang
    Current Medical Science.2025; 45(2): 185.     CrossRef
  • 光纤传感技术发展的新趋势——生物医学领域的需求与应用(特邀)
    苑婷婷 Yuan Tingting, 张晓彤 Zhang Xiaotong, 刘银 Liu Yin, 金龙 Jin Long, 黄赟赟 Huang Yunyun, 关柏鸥 Guan Baiou, 徐致远 Xu Zhiyuan, 冯程成 Feng Chengcheng, 杨世泰 Yang Shitai, 陈意坚 Chen Yijian, 苑立波 Yuan Libo
    Acta Optica Sinica.2025; 45(9): 0900001.     CrossRef
  • γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders
    Zhong-Peng Dai, Qiang Wen, Ping Wu, Yan-Ni Zhang, Cai-Lian Fang, Meng-Yuan Dai, Hong-Liang Zhou, Huan Wang, Hao Tang, Si-Qi Zhang, Xiao-Kun Li, Jian-Song Ji, Liu-Xi Chu, Zhou-Guang Wang
    Military Medical Research.2025;[Epub]     CrossRef
  • Modulating Proteasome Function with Polyphenol Metabolites: A Promising Therapeutic Avenue for Alzheimer's Disease
    Nyerovwo Charity Okei
    European Journal of Medical and Health Research.2024; 2(2): 16.     CrossRef
  • A comprehensive review of optical fiber technologies in optogenetics and their prospective developments in future clinical therapies
    Siyu Chen, Zhuo Wang, Kun Xiao, Benzhao He, Jing Zhao, Xin Yang, Qingqing Liu, Anuj K. Sharma, Arnaldo Leal Junior, Rui Min
    Optics & Laser Technology.2024; 179: 111332.     CrossRef
  • Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders
    Salman Alfihed, Majed Majrashi, Muhammad Ansary, Naif Alshamrani, Shahad H. Albrahim, Abdulrahman Alsolami, Hala A. Alamari, Adnan Zaman, Dhaifallah Almutairi, Abdulaziz Kurdi, Mai M. Alzaydi, Thamer Tabbakh, Faisal Al-Otaibi
    Biosensors.2024; 14(7): 335.     CrossRef
  • Daily Dynamics of Resting-State Electroencephalographic Theta and Gamma Fluctuations Are Associated With Cognitive Performance in Healthy Aging
    Kenza Bennis, Francis Eustache, Fabienne Collette, Gilles Vandewalle, Thomas Hinault, Gali Weissberger
    The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.2024;[Epub]     CrossRef
  • Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
    Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
    Scientific Reports.2023;[Epub]     CrossRef
  • Light-Controlled Modulation and Analysis of Neuronal Functions
    Carlo Matera, Piotr Bregestovski
    International Journal of Molecular Sciences.2022; 23(21): 12921.     CrossRef
Original articles
Pediatrics, Perinatology, and Child Health
Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study
Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon
J Yeungnam Med Sci. 2022;39(1):46-52.   Published online August 26, 2021
DOI: https://doi.org/10.12701/yujm.2021.01221
  • 11,640 View
  • 109 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.

Citations

Citations to this article as recorded by  
  • Commentary on "Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection"
    Young Suk Shim
    Annals of Pediatric Endocrinology & Metabolism.2025; 30(5): 227.     CrossRef
  • Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
    Pattharaporn Sinthuprasith, Karn Wejaphikul, Dolrutai Puttawong, Hataitip Tang-Ngam, Naphatsorn Sanrattana, Kevalee Unachak, Prapai Dejkhamron
    Journal of Pediatric Endocrinology and Metabolism.2024; 37(6): 487.     CrossRef
  • COVID-19 infection and inactivated vaccination: Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes
    Zhen-Ran Xu, Li Xi, Jing Wu, Jin-Wen Ni, Fei-Hong Luo, Miao-Ying Zhang
    World Journal of Diabetes.2024; 15(12): 2276.     CrossRef
  • Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
    Anas Elgenidy, Ahmed K. Awad, Khaled Saad, Mostafa Atef, Hatem Helmy El-Leithy, Ahmed A. Obiedallah, Emad M. Hammad, Faisal-Alkhateeb Ahmad, Ahmad M. Ali, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher Fathy Taha
    Pediatric Research.2023; 93(5): 1149.     CrossRef
  • Comments on Rahmati et al., The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis. J Med Virol. 2022; 1‐16 (doi: 10.1002/jmv.27996)
    Joachim Rosenbauer, Anna Stahl‐Pehe, Sabrina Schlesinger, Oliver Kuß
    Journal of Medical Virology.2023;[Epub]     CrossRef
  • Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes
    Clemens Kamrath, Alexander J. Eckert, Reinhard W. Holl, Joachim Rosenbauer, Andrea Scaramuzza
    Pediatric Diabetes.2023; 2023: 1.     CrossRef
  • Difficulties in differential diagnosis of carbohydrate metabolism disorders in patients with coronavirus infection in real clinical practice. Case report
    Tatyana N. Markova, Mukhamed S. Stas, Valentina V. Chibisova, Anastasia A. Anchutina
    Consilium Medicum.2023; 25(4): 241.     CrossRef
  • Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review
    Valeria Calcaterra, Veronica Maria Tagi, Raffaella De Santis, Andrea Biuso, Silvia Taranto, Enza D’Auria, Gianvincenzo Zuccotti
    Journal of Clinical Medicine.2023; 12(16): 5248.     CrossRef
  • Glycemic control and complications of type 2 diabetes mellitus in children and adolescents during the COVID-19 outbreak
    Kyeong Eun Oh, Yu Jin Kim, Ye Rim Oh, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(4): 275.     CrossRef
  • Incidence of Diabetic Ketoacidosis Among Pediatrics With Type 1 Diabetes Prior to and During COVID-19 Pandemic: A Meta-Analysis of Observational Studies
    Osamah M. Alfayez, Kholood S. Aldmasi, Nada H. Alruwais, Nouf M. Bin Awad, Majed S. Al Yami, Omar A. Almohammed, Abdulaali R. Almutairi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Comparison of Initial Presentation of Pediatric Diabetes Before and During the Coronavirus Disease 2019 Pandemic Era
    Yoonha Lee, Minseung Kim, Kyeongeun Oh, Eungu Kang, Young-Jun Rhie, Jieun Lee, Yong Hee Hong, Young-Lim Shin, Jae Hyun Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
    Masoud Rahmati, Maryam Keshvari, Shahrzad Mirnasuri, Dong K. Yon, Seung W. Lee, Jae Il Shin, Lee Smith
    Journal of Medical Virology.2022; 94(11): 5112.     CrossRef
  • COVID-19 and diabetes: What do we know so far?
    Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian
    Experimental Biology and Medicine.2022; 247(15): 1330.     CrossRef
  • Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
    Ioanna Farakla, Theano Lagousi, Michael Miligkos, Nicolas C. Nicolaides, Ioannis-Anargyros Vasilakis, Maria Mpinou, Maria Dolianiti, Elina Katechaki, Anilia Taliou, Vasiliki Spoulou, Christina Kanaka-Gantenbein
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
Oncology and Cancer Research
Treatment decision for cancer patients with fever during the coronavirus disease 2019 (COVID-19) pandemic
In Hee Lee, Sung Ae Koh, Soo Jung Lee, Sun Ah Lee, Yoon Young Cho, Ji Yeon Lee, Jin Young Kim
Yeungnam Univ J Med. 2021;38(4):344-349.   Published online August 23, 2021
DOI: https://doi.org/10.12701/yujm.2021.01144
  • 8,494 View
  • 63 Download
AbstractAbstract PDF
Background
Cancer patients have been disproportionally affected by the coronavirus disease 2019 (COVID-19) pandemic, with high rates of severe outcomes and mortality. Fever is the most common symptom in COVID-19 patients. During the COVID-19 pandemic, physicians may have difficulty in determining the cause of fever (COVID-19, another infection, or cancer fever) in cancer patients. Furthermore, there are no specific guidelines for managing cancer patients with fever during the COVID-19 pandemic. Thus, this study evaluated the clinical characteristics and outcomes of cancer patients with fever during the COVID-19 pandemic.
Methods
This study retrospectively reviewed the medical records of 328 cancer patients with COVID-19 symptoms (fever) admitted to five hospitals in Daegu, Korea from January to October 2020. We obtained data on demographics, clinical manifestations, laboratory test results, chest computed tomography images, cancer history, cancer treatment, and outcomes of all enrolled patients from electronic medical records.
Results
The most common COVID-19-like symptoms were fever (n=256, 78%). Among 256 patients with fever, only three (1.2%) were diagnosed with COVID-19. Most patients (253, 98.8%) with fever were not diagnosed with COVID-19. The most common solid malignancies were lung cancer (65, 19.8%) and hepatobiliary cancer (61, 18.6%). Twenty patients with fever experienced a delay in receiving cancer treatment. Eighteen patients discontinued active cancer treatment because of fever. Major events during the treatment delay period included death (2.7%), cancer progression (1.5%), and major organ dysfunction (2.7%).
Conclusion
Considering that only 0.9% of patients tested for COVID-19 were positive, screening for COVID-19 in cancer patients with fever should be based on the physician’s clinical decision, and patients might not be routinely tested.
Case reports
Immunology and Allergy
Idiopathic multicentric Castleman disease presenting progressive reticular honeycomb infiltration of lung and immunoglobulin G and immunoglobulin G4 dominant hypergammaglobulinemia: a case report
Hyun-Je Kim, Young-Hoon Hong
J Yeungnam Med Sci. 2022;39(2):153-160.   Published online July 5, 2021
DOI: https://doi.org/10.12701/yujm.2021.01039
  • 8,896 View
  • 105 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Multicentric Castleman disease (MCD) is an uncommon systemic lymphoproliferative disorder that may cause multiple organ damage. Castleman disease-associated diffuse parenchymal lung disease (DPLD) has not been well studied. A 32-year-old man was referred to our hospital for progressive generalized weakness, light-headedness, and dyspnea on exertion for more than one year. Laboratory evaluations showed profound anemia, an elevated erythrocyte sedimentation rate, and an increased C-reactive protein level with polyclonal hypergammaglobulinemia. Chest radiography, computed tomography (CT), and positron emission tomography-CT scan demonstrated diffuse lung infiltration with multiple cystic lesions and multiple lymphadenopathy. In addition to these clinical laboratory findings, bone marrow, lung, and lymph node biopsies confirmed the diagnosis of idiopathic MCD (iMCD). Siltuximab, an interleukin-6 inhibitor, and glucocorticoid therapy were initiated. The patient has been tolerating the treatment well and had no disease progression or any complications in 4 years. Herein, we report this case of human herpesvirus-8-negative iMCD-associated DPLD accompanied by multiple cystic lesions, multiple lymphadenopathy, and polyclonal hypergammaglobulinemia with elevated immunoglobulin G (IgG) and IgG4 levels. We recommend a close evaluation of MCD in cases of DPLD with hypergammaglobulinemia.

Citations

Citations to this article as recorded by  
  • Striking effectiveness of siltuximab-based treatment in refractory idiopathic multicentric Castleman disease resembling IgG4-related disease
    Xing Gong, Weiwei Yan, Feng Zhang, Dongdong Zhang
    Journal of Chemotherapy.2025; : 1.     CrossRef
Pediatrics, Perinatology, and Child Health
Successful treatment with vedolizumab in an adolescent with Crohn disease who had developed active pulmonary tuberculosis while receiving infliximab
Sujin Choi, Bong Seok Choi, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2021;38(3):251-257.   Published online February 19, 2021
DOI: https://doi.org/10.12701/yujm.2020.00878
  • 8,925 View
  • 144 Download
  • 2 Crossref
AbstractAbstract PDF
Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

Citations

Citations to this article as recorded by  
  • The safety of vedolizumab in a patient with Crohn’s disease who developed anti-TNF-alpha agent associated latent tuberculosis infection reactivation: A case report
    Yuya Sugiyama, Nobuhiro Ueno, Shion Tachibana, Yu Kobayashi, Yuki Murakami, Takahiro Sasaki, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
    Medicine.2023; 102(28): e34331.     CrossRef
  • Vedolizumab Is Safe and Efficacious for the Treatment of Pediatric-Onset Inflammatory Bowel Disease Patients Who Fail a Primary Biologic Agent
    Sujin Choi, Eun Sil Kim, Yiyoung Kwon, Mi Jin Kim, Yon Ho Choe, Byung-Ho Choe, Ben Kang
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
Original article
Hematology
A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults
Abraham Kwak, Nani Jung, Ye Jee Shim, Heung Sik Kim, Hyun Ji Lim, Jae Min Lee, Mi Hwa Heo, Young Rok Do
Yeungnam Univ J Med. 2021;38(3):208-218.   Published online November 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00591
  • 12,063 View
  • 169 Download
  • 11 Crossref
AbstractAbstract PDF
Background
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.
Methods
The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated.
Results
Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1–83 years), and the median follow-up duration was 8.5 months (range, 0–204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×109/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH.
Conclusion
Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

Citations

Citations to this article as recorded by  
  • Catastrophic ENT Complications of Pediatric Infectious Mononucleosis: Recent Experience at a Tertiary Pediatric Hospital
    Lorenzo Gaini, Anna Cozzi, Gioia Piatti, Michele Gaffuri, Samantha Bosis, Paola Marchisio, Giovanna Ghidini, Giorgio Croci, Antonio Carpino, Sara Torretta
    Journal of Clinical Medicine.2026; 15(7): 2516.     CrossRef
  • Novel perspectives on the rare hemophagocytic lymphohistiocytosis: insights from a multi-center retrospective cohort
    Changkun Chen, Yanquan Liu, Xiaojun Chen, Hehui Zhang, Jianzhen Shen, Zuotao Li, Yue Yin, He Huang
    Frontiers in Medicine.2026;[Epub]     CrossRef
  • Haemophagocytic lymphohistiocytosis and abdominal compartment syndrome in acute pancreatitis
    Nishka Tapaswi, Hasib Ahmadzai, Alec J Hope, Oliver Fisher, Linda Y Zhang
    Journal of Surgical Case Reports.2025;[Epub]     CrossRef
  • Prevalence and mortality of haemophagocytic lymphohistiocytosis in dengue fever: a systematic review and meta-analysis
    Leong Tung Ong, Roovam Balasubramaniam
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2024; 118(11): 711.     CrossRef
  • Predicting relapsed/refractory disease in childhood hemophagocytic lymphohistiocytosis based on clinical features at diagnosis: A 13-year single-institute retrospective study in Thailand
    Pattranan Kusontammarat, Chane Choed-Amphai, Lalita Sathitsamitphong, Watchareewan Sontichai, Rungrote Natesirinilkul, Pimlak Charoenkwan
    Annals of Hematology.2024; 103(10): 3963.     CrossRef
  • Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report
    Li Huang, Jie Tan, Peihao Lin, Zixuan Chen, Qihua Huang, Haiyan Yao, Lihong Jiang, Baoyi Long, Youming Long
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Hemophagocytic Lymphohistiocytosis Triggered by Herpes Simplex Virus 1 and 2: A Narrative Review
    Andria Papazachariou, Petros Ioannou
    Hematology Reports.2024; 16(3): 487.     CrossRef
  • Spontaneous Resolution of Hemophagocytic Lymphohistiocytosis in a Child Infected with Epstein–Barr Virus
    Rita Alfattal, Hussain Sadeq, Abdullah Ali
    Journal of Applied Hematology.2023; 14(1): 57.     CrossRef
  • Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
    María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado
    Journal of Leukocyte Biology.2022; 112(4): 607.     CrossRef
  • Secondary Hemophagocytic Lymphohistiocytosis and Autoimmune Cytopenias: Case Description and Review of the Literature
    Bruno Fattizzo, Marta Ferraresi, Juri Giannotta, Wilma Barcellini
    Journal of Clinical Medicine.2021; 10(4): 870.     CrossRef
  • HLH-Like Syndrome and Rhabdomyolysis in an Adolescent Patient
    Lauren T. Maloney, Bronwyn Baz, Dia Hazra
    Pediatrics.2021;[Epub]     CrossRef
Case report
Hematology
Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease
Sang Min Lee, Young Tae Lim, Kyung Mi Jang, Mi Jin Gu, Jong Ho Lee, Jae Min Lee
Yeungnam Univ J Med. 2021;38(3):245-250.   Published online November 11, 2020
DOI: https://doi.org/10.12701/yujm.2020.00654
  • 10,845 View
  • 118 Download
  • 6 Crossref
AbstractAbstract PDF
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome—HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m2/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.

Citations

Citations to this article as recorded by  
  • Late recurrence of Kikuchi–Fujimoto disease nine years after initial diagnosis: a case-based review
    Arian Akhondi, Valerie Anne-Sophie Faber, Adam Hawkins, David Ray Chen
    Clinical Rheumatology.2026;[Epub]     CrossRef
  • Case Report: Two Cases of Kikuchi Disease in West Texas With Non-Self-Limited Disease
    Pitchaporn Yingchoncharoen, Nattanicha Chaisrimaneepan, Miriam Paz, Alexandra Hoffman, Kuldeep Lohano, Safaa Labib, John Pixley
    Journal of Investigative Medicine High Impact Case Reports.2025;[Epub]     CrossRef
  • Histiocytic necrotizing lymphadenitis with hemophagocytic lymphohistiocytosis in adults: A single‐center analysis of 5 cases
    Qingqing Chen, Jing Zhang, Huijun Huang, Tonglu Qiu, Ze Jin, Yu Shi, Huayuan Zhu, Lei Fan, Jianyong Li, Wenyu Shi, Yi Miao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • A young Saudi female with combined hemophagocytic lympho-histiocytosis and Kikuchi’s disease: A case report
    Kamal Al-Zahrani, Batol Gasmelseed, Hesham Waaer Shadi, Rehab Y AL-Ansari
    SAGE Open Medical Case Reports.2023;[Epub]     CrossRef
  • Cefalea y fiebre: no todo es lo que parece
    María Pilar Iranzo-Alcolea, Carmen Ariño-Palao, Grisell Starita-Fajardo, Andrés González-García, Cecilia Suárez-Carantoña
    Revista Española de Casos Clínicos en Medicina Interna.2023; 8(2): 105.     CrossRef
  • Kikuchi–Fujimoto disease: literature review and report of four cases
    V. G. Potapenko, V. V. Baykov, А. Yu. Markova, N. B. Mikhailova, A. S. Ter‑Grigoryan, Yu. А. Krivolapov
    Oncohematology.2022; 17(4): 48.     CrossRef
Focused Review article
Pulmonary and Respiratory Medicine
An update on the role of bronchoscopy in the diagnosis of pulmonary disease
June Hong Ahn
Yeungnam Univ J Med. 2020;37(4):253-261.   Published online August 28, 2020
DOI: https://doi.org/10.12701/yujm.2020.00584
  • 16,926 View
  • 295 Download
  • 19 Crossref
AbstractAbstract PDF
Bronchoscopy has evolved over the past few decades and has been used by respiratory physicians to diagnose various airway and lung diseases. With the popularization of medical check-ups and growing interest in health, early diagnosis of lung diseases is essential. With the development of endobronchial ultrasound, ultrathin bronchoscopy, and electromagnetic navigational bronchoscopy, bronchoscopy has been able to widen its scope in diagnosing pulmonary diseases. In this review, we have described the brief history, role, and complications of bronchoscopy used in diagnosing pulmonary lesions, from simple flexible bronchoscopy to bronchoscopy combined with several up-to-date technologies.

Citations

Citations to this article as recorded by  
  • Bronchoscopic manifestations and epidemiological characteristics of lymph node fistula-type tracheobronchial tuberculosis in Hunan Province, China (2019–2023)
    Li Luo, Lei Zhou, Linzi Luo, Quhua Yin, Zhibin Lu, Dan Feng, Qingqing Zeng, Yangbao Xiao, Jun Liang
    BMC Infectious Diseases.2026;[Epub]     CrossRef
  • Immune profile and routine laboratory indicator-based machine learning for prediction of lung cancer
    Yi Huang, Kaishan Jiang, Xiaochen Wang, Siyu Zou, Ziyong Sun, Shiji Wu, Bin Wang, Hongyan Hou, Feng Wang
    Computers in Biology and Medicine.2025; 190: 110111.     CrossRef
  • Endobronchial hamartomas as a rare cause of chronic cough
    Selsabil Daboussi, Asma Saidane, Abdellatif Syrine, Samira Mhamdi, Faten Gargouri, Houssem Messaoudi, Saber Hachicha, Chiraz Aichaouia, Zied Moatemri
    Respiratory Medicine Case Reports.2025; 55: 102210.     CrossRef
  • Application value of fibro-bronchoscopic cryosurgery combined with medication in the treatment of tracheobronchial tuberculosis
    Yue-Ying Zhou, Hui-Juan Li, Kai-Jia Wu, Ji-Chan Shi, Xian-Gao Jiang, Gui-Qing He, Ning Pan, Chao-Chao Qiu, Hong-Ye Ning, Zheng-Xing Wu
    BMC Surgery.2025;[Epub]     CrossRef
  • Effectiveness of Oral Prophylactic Antibiotics for Diagnostic Bronchoscopy: A Nationwide Database Study
    Tomohiro Akaba, Taisuke Jo, Jun Suzuki, Yuya Kimura, Hiroki Matsui, Kiyohide Fushimi, Etsuko Tagaya, Hideo Yasunaga
    Annals of the American Thoracic Society.2025; 22(5): 707.     CrossRef
  • Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods
    R. N. Islamov, R. A. Sharipov, M. A. Bagirov, R. K. Tukfatullin, G. V. Chitorelidze, E. V. Pavlova, R. K. Yagafarova
    Creative surgery and oncology.2025; 15(2): 160.     CrossRef
  • Flexible Bronchoscopy and Non-Small-Cell Lung Cancer Staging: A Narrative Review of Modern Techniques for Optimized Clinical Decision-Making
    Simona-Maria Roșu, Denisa Maria Mitroi, Oana Maria Catană, Viorel Biciușcă, Sorina Ionelia Stan, Beatrice Mahler, Oana-Andreea Parliteanu, Adina Andreea Mirea, Mara Amalia Bălteanu
    Journal of Clinical Medicine.2025; 14(16): 5773.     CrossRef
  • Geographic variation in bronchoscopy use across Japan: A nationwide analysis using administrative claims data
    Tomohiro Akaba, Ken Arimura, Keiko Kan-o, Miki Kubo, Mitsuko Kondo, Musashi Ueda, Osamitsu Yagi, Atsushi Kurokawa, Naoko Kawashima, Yutaro Horie, Yuno Shiota, Etsuko Tagaya
    Respiratory Investigation.2025; 63(6): 1174.     CrossRef
  • Deep-learning-assisted disposable bronchoscopy with enhanced image quality
    Ang Li, Ming Lei, Zachary Burns, George Cheng, Zhaowei Liu
    Biomedical Optics Express.2025; 16(11): 4243.     CrossRef
  • Application of fiberoptic bronchoscopy in the diagnosis and treatment of pneumonia in children
    He Zhang, De-Xing Wang, Hai-Ming Yu
    Srpski arhiv za celokupno lekarstvo.2025; 153(9-10): 504.     CrossRef
  • Disposable Versus Reusable Bronchoscopes: A Narrative Review of Cost-effectiveness, Risk of Cross-contamination and Environmental Impact
    Illaa Smesseim, Johannes M.A. Daniels, Jouke Annema, Peter I. Bonta, Dirk-Jan Slebos
    Archivos de Bronconeumología.2024; 60(4): 250.     CrossRef
  • Applications of Machine Learning in Cancer Imaging: A Review of Diagnostic Methods for Six Major Cancer Types
    Andreea Ionela Dumachi, Cătălin Buiu
    Electronics.2024; 13(23): 4697.     CrossRef
  • Flexible bronchoscopy indications and outcomes between indigenous and non‐indigenous patients in the Northern Territory of Australia
    Mohammad M. Seyedshahabedin, Timothy P. Howarth, Lin Mo, Edwina Biancardi, Subash S. Heraganahally
    Internal Medicine Journal.2023; 53(9): 1634.     CrossRef
  • Endobronchial ultrasound‐guided re‐biopsy of non–small cell lung cancer with acquired resistance after EGFR tyrosine kinase inhibitor treatment
    Kyung Soo Hong, Jinmo Cho, Jong Geol Jang, Min Hye Jang, June Hong Ahn
    Thoracic Cancer.2023; 14(4): 363.     CrossRef
  • Observational findings of transbronchial lung biopsy in patients with interstitial lung disease: a retrospective study in Aleppo University Hospital
    Fateh Kashkash, Abdullah Khorri
    Annals of Medicine & Surgery.2023; 85(2): 146.     CrossRef
  • Invasive Diagnostic Procedures from Bronchoscopy to Surgical Biopsy—Optimization of Non-Small Cell Lung Cancer Samples for Molecular Testing
    Nensi Lalić, Aleksandra Lovrenski, Miroslav Ilić, Olivera Ivanov, Marko Bojović, Ivica Lalić, Spasoje Popević, Mihailo Stjepanović, Nataša Janjić
    Medicina.2023; 59(10): 1723.     CrossRef
  • Utility of Radial Probe Endobronchial Ultrasound Guided Transbronchial Lung Biopsy in Bronchus Sign Negative Peripheral Pulmonary Lesions
    Kyung Soo Hong, Kwan Ho Lee, Jin Hong Chung, Kyeong-Cheol Shin, Hyun Jung Jin, Jong Geol Jang, June Hong Ahn
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Radial Probe Endobronchial Ultrasound Using Guide Sheath-Guided Transbronchial Lung Biopsy in Peripheral Pulmonary Lesions without Fluoroscopy
    Kyung Soo Hong, Heeyun Ahn, Kwan Ho Lee, Jin Hong Chung, Kyeong-Cheol Shin, Hyun Jung Jin, Jong Geol Jang, Seok Soo Lee, Min Hye Jang, June Hong Ahn
    Tuberculosis and Respiratory Diseases.2021; 84(4): 282.     CrossRef
  • Advances in the science and treatment of respiratory diseases
    Jin Hong Chung
    Yeungnam University Journal of Medicine.2020; 37(4): 251.     CrossRef
Case reports
Gastroenterology and Hepatology
Co-existence of relapsing polychondritis and Crohn disease treated successfully with infliximab
Hye-In Jung, Hyun Jung Kim, Ji-Min Kim, Ju Yup Lee, Kyung Sik Park, Kwang Bum Cho, Yoo Jin Lee
Yeungnam Univ J Med. 2021;38(1):70-73.   Published online June 19, 2020
DOI: https://doi.org/10.12701/yujm.2020.00304
  • 9,961 View
  • 104 Download
  • 3 Crossref
AbstractAbstract PDF
Relapsing polychondritis (RP) is a rare, progressive immune-mediated systemic inflammatory disease of unknown etiology, characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with other autoimmune diseases. However, the co-occurrence of RP and Crohn disease (CD) has rarely been reported. Herein, we present a 35-year-old woman diagnosed with RP and CD, who was refractory to initial conventional medications, including azathioprine and glucocorticoid, but who subsequently responded to infliximab (IFX). For both diseases, remission was sustained with IFX. There has been no previous report regarding the successful treatment of co-existing RP and CD with IFX.

Citations

Citations to this article as recorded by  
  • Coexistence of Relapsing Polychondritis and Crohn’s Disease: Clinical Insights from a Rare Case
    Sang Wan Chung
    Journal of Clinical Medicine.2026; 15(4): 1609.     CrossRef
  • Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review
    Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hay
    Internal Medicine.2025; 64(20): 2971.     CrossRef
  • Relapsing Polychondritis in a Patient With Auricular Chondritis and Inflammatory Bowel Disease: A Case Report With Literature Review
    David D Bickford, Thomas Ritter, Pinky Jha, Hari R Paudel
    Cureus.2022;[Epub]     CrossRef
Nephrology
Development of donepezil-induced hypokalemia following treatment of cognitive impairment
Dongryul Kim, Hye Eun Yoon, Hoon Suk Park, Seok Joon Shin, Bum Soon Choi, Byung Soo Kim, Tae Hyun Ban
Yeungnam Univ J Med. 2021;38(1):65-69.   Published online June 1, 2020
DOI: https://doi.org/10.12701/yujm.2020.00269
  • 8,950 View
  • 140 Download
  • 1 Crossref
AbstractAbstract PDF
Donepezil is a cholinesterase inhibitor used extensively to treat Alzheimer disease. The increased cholinergic activity is associated with adverse effects, therefore gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are common. Hypokalemia is a rare adverse event that occurs in less than 1% of donepezil-treated patients. Although hypokalemia of mild and moderate grade does not present serious signs and symptoms, severe hypokalemia often results in prolonged hospitalization and mortality. Herein, we report a case of hypokalemia developed after the initiation of donepezil therapy for cognitive impairment.

Citations

Citations to this article as recorded by  
  • Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
    Luminita Capatina, Elena Todirascu-Ciornea, Edoardo Marco Napoli, Giuseppe Ruberto, Lucian Hritcu, Gabriela Dumitru
    Antioxidants.2020; 9(11): 1083.     CrossRef
Pediatrics, Perinatology, and Child Health
Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in NUDT15 R139C
Jaewoan Bae, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2020;37(4):332-336.   Published online May 22, 2020
DOI: https://doi.org/10.12701/yujm.2020.00178
  • 8,487 View
  • 91 Download
  • 4 Crossref
AbstractAbstract PDF
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients who are NUDT15 poor metabolizers and consider the use of an alternative immunomodulatory therapy. We report a case of a 12-year-old Korean girl with Crohn’s disease (CD), in whom thiopurine-induced leukopenia was prevented by initiation of azathioprine (AZA) therapy at a low dose (0.5 mg/kg/day) and early detection of significant hair loss and white blood cell (WBC) count decrease at 17 days from the start of AZA treatment. The WBC count dropped from 8,970/μL to 3,370/μL in 2 weeks, and AZA treatment was stopped because of concerns of potential leukopenia in the near future. Her WBC count recovered to 5,120/μL after 3 weeks. Gene analysis later revealed that she had a homozygous mutation in NUDT15 R139C, resulting in a poor metabolizing activity of NUDT15. In situations when NUDT15 genotyping is unavailable, initiation of AZA therapy at 0.5 mg/kg/day with close observation of hair loss and WBC counts within 2 weeks may be an alternative way to prevent thiopurine-induced early leukopenia in Asian children with CD.

Citations

Citations to this article as recorded by  
  • NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy
    Isfahan Shah Lubis, Kusnandar Anggadiredja, Aluicia Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli
    Medical Sciences.2025; 13(3): 112.     CrossRef
  • Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation
    Xinmiao He, Ming Tian, Wentao Wang, Yanzhong Feng, Zhongqiu Li, Jiahui Wang, Yan Song, Jinfeng Zhang, Di Liu
    Veterinary Sciences.2023; 10(5): 307.     CrossRef
  • Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review
    Juan Gu, Yupei Lin, Yuhe Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • KASL clinical practice guidelines for management of autoimmune hepatitis 2022

    Clinical and Molecular Hepatology.2023; 29(3): 542.     CrossRef
Review article
Gastroenterology and Hepatology
Gallbladder polyps: evolving approach to the diagnosis and management
Kook Hyun Kim
Yeungnam Univ J Med. 2021;38(1):1-9.   Published online May 15, 2020
DOI: https://doi.org/10.12701/yujm.2020.00213
  • 49,560 View
  • 652 Download
  • 12 Crossref
AbstractAbstract PDF
Gallbladder (GB) polyp is a mucosal projection into the GB lumen. With increasing health awareness, GB polyps are frequently found using ultrasonography during health screening. The prevalence of GB polyps ranges between 1.3% and 9.5%. Most patients are asymptomatic and have benign characteristics. Of the nonneoplastic polyps, cholesterol polyps are most common, accounting for 60%–70% of lesions. However, a few polyps have malignant potential. Currently, the guidelines recommend laparoscopic cholecystectomy for polyps larger than 1 cm in diameter due to their malignan potential. The treatment algorithm can be influenced by the size, shape, and numbers of polyps, old age (>50 years), the presence of primary sclerosing cholangitis, and gallstones. This review summarizes the commonly recognized concepts on GB polyps from diagnosis to an algorithm of treatment.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of ultrasound-guided radiofrequency ablation versus laparoscopic cholecystectomy in gallbladder polyps: a bicentric study
    Huajiao Zhao, Gang Dong, Zheng Zhang, Yanwei Chen, Shuangshuang Zhao, Mengyuan Shang, Yun Cai, Xincai Wu, Baoding Chen
    Scientific Reports.2026;[Epub]     CrossRef
  • Predicting Neoplastic Gallbladder Polyps: The Role of Current Surgical Indications and Preoperative Images
    Ik Hyun Jo, Chang Nyol Paik, Hong Geun Ahn, Dong Do You, Jae Hyun Han, Hyun A Kim
    The Korean Journal of Gastroenterology.2025; 85(1): 52.     CrossRef
  • Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm
    Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li
    European Journal of Medical Research.2025;[Epub]     CrossRef
  • Incidental Gallbladder Polyps – A Case Report on Diagnostic Dilemmas and Management Uncertainty
    Brice Bestenheider, Florian Simon Buehlmann, Christoph F. Dietrich
    Zeitschrift für Gastroenterologie.2025; 63(10): 1046.     CrossRef
  • Danning tablets for the treatment of multiple gallbladder polyps: Study protocol of multicentre, randomised, open-labelled, controlled trial
    Tian Yang, Ming-Da Wang, Gui-Lin Xie, Xiong-Hua Wang, Liu Zheng, Li-Min Wang, Guang-Fa Xiao, Yong-Qing Yang, Chao Li, Alfred Wei Chieh Kow, Feng Shen
    iLIVER.2024; 3(4): 100127.     CrossRef
  • Endoscopic ultrasound-guided gallbladder endoscopic mucosal resection: a pilot porcine study
    Huifang Pang, Quan Man, Li Min, Zheng Zhang, Shengtao Zhu, Shuyue Yang, Yao Xu, Haijun Hou, Shutian Zhang, Peng Li
    Minimally Invasive Therapy & Allied Technologies.2023; 32(1): 24.     CrossRef
  • The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review
    Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G. Shelat
    Annals of Hepato-Biliary-Pancreatic Surgery.2023; 27(3): 241.     CrossRef
  • The gallbladder: what’s new in 2022?
    Rachel Runde, Edward D. Auyang, Raye Ng, Kaysey Llorente, Hina Arif Tiwari, Shana Elman, William M. Thompson
    Abdominal Radiology.2022; 48(1): 2.     CrossRef
  • Gallbladder polyps: diagnosis and treatment tactics (literature review)
    S. N. Perekhodov, D. V. Nikolaev, S. S. Saidov
    Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2021; 11(4): 88.     CrossRef
  • Is there a role for growth status in distinguishing gallbladder adenomas from cholesterol polyps? – A retrospective study based on 520 cholecystectomy patients
    Wenqing Bao, Anan Xu, Shubin Ni, Bo Wang, Humaira Urmi, Bin Zhao, Yongmei You, Hai Hu
    Scandinavian Journal of Gastroenterology.2021; 56(12): 1450.     CrossRef
  • Imagerie des tumeurs bénignes des voies biliaires et de la vésicule
    J.-P. Tasu, B. Bergougnoux, E. Frouin, S. Velasco, C. Aubé, N. Beydoun
    EMC - Radiologie et imagerie médicale - Abdominale - Digestive.2021; 39(4): 1.     CrossRef
  • Polyps and cancer of the biliary system (lecture for medical practitioners)
    G. V. Shavkuta
    South Russian Journal of Therapeutic Practice.2020; 1(2): 78.     CrossRef
Original articles
Obstetrics, Gynecology, and Reproductive Medicine
Clinical outcomes of hysterectomy for benign diseases in the female genital tract: 6 years’ experience in a single institute
Hyo-Shin Kim, Yu-Jin Koo, Dae-Hyung Lee
Yeungnam Univ J Med. 2020;37(4):308-313.   Published online April 24, 2020
DOI: https://doi.org/10.12701/yujm.2020.00185
  • 9,495 View
  • 202 Download
  • 2 Crossref
AbstractAbstract PDF
Background
Hysterectomy is one of the major gynecologic surgeries. Historically, several surgical procedures have been used for hysterectomy. The present study aims to evaluate the surgical trends and clinical outcomes of hysterectomy performed for benign diseases at the Yeungnam University Hospital.
Methods
We retrospectively reviewed patients who underwent a hysterectomy for benign diseases from 2013 to 2018. Data included the patients’ demographic characteristics, surgical indications, hysterectomy procedures, postoperative pathologies, and perioperative outcomes.
Results
A total of 809 patients were included. The three major indications for hysterectomy were uterine leiomyoma, pelvic organ prolapse, and adenomyosis. The most common procedure was total laparoscopic hysterectomy (TLH, 45.2%), followed by open hysterectomy (32.6%). During the study period, the rate of open hysterectomy was nearly constant (29.4%–38.1%). The mean operative time was the shortest in the single-port laparoscopic assisted vaginal hysterectomy (LAVH, 89.5 minutes), followed by vaginal hysterectomy (VH, 96.8 minutes) and TLH (105 minutes). The mean decrease in postoperative hemoglobin level was minimum in single-port LAVH (1.8 g/dL) and VH (1.8 g/dL). Conversion to open surgery or multi-port surgery occurred in five cases (0.6%). Surgical complications including wound dehiscence, organ injuries, and conditions requiring reoperation were observed in 52 cases (6.4%).
Conclusion
Minimally invasive approach was used for most hysterectomies for benign diseases, but the rate of open hysterectomy has mostly remained constant. Single-port LAVH and VH showed the most tolerable outcomes in terms of operative time and postoperative drop in hemoglobin level in selected cases.

Citations

Citations to this article as recorded by  
  • Depression and qulity of life in women of reproductive age in the context of surgical menopause
    Olga Cernetchi, Elena Vataman
    Bulletin of the Academy of Sciences of Moldova. Medical Sciences.2025; (2(82)): 18.     CrossRef
  • Analysis of Different Routes of Hysterectomy Based on a Prospective Algorithm and Their Complications in a Tertiary Care Institute
    Subrat Panda, Ananya Das, Rituparna Das, Nalini Sharma, Wansalan Shullai, Vinayak Jante, Anusuya Sharma, Kaushiki Singh, Prateeti Baruah, Ruksana Makakmayum, Imtiaz Wani
    Minimally Invasive Surgery.2022; 2022: 1.     CrossRef
Pulmonary and Respiratory Medicine
Polyunsaturated fatty acids, lung function, and health-related quality of life in patients with chronic obstructive pulmonary disease
Hyunji Choi, Taeyun Kim
Yeungnam Univ J Med. 2020;37(3):194-201.   Published online April 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00052
  • 8,153 View
  • 115 Download
  • 7 Crossref
AbstractAbstract PDF
Background
Dietary polyunsaturated fatty acids (PUFA) are thought to modify systemic inflammation. The present study aimed to evaluate the relationship between PUFA intake, lung function, and health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD).
Methods
In this study, we used the dataset of 6th Korea National Health and Nutrition Examination Survey, in which, a total of 22,948 individuals including 573 participants with a high probability of developing COPD were enrolled. Participants with missing data for the investigated variables were excluded. Linear regression analyses were used to evaluate the association between PUFA intake (omega-3 [N3], omega-6 [N6], and total) with lung function, and HRQoL. HRQoL was determined according to the European Quality of Life-5 Dimensions (EQ-5D). Subgroup analysis of older patients was performed. Age, sex, body mass index, smoking, alcohol, education, residence, total calorie intake, and predicted FEV1% were adjusted in all analyses.
Results
Although lung function was not associated with PUFA intake, EQ-5D index was remarkably associated with N3, N6, and total PUFA intake in a dose-dependent manner. This association was more pronounced in elderly COPD patients. Mean levels of N3, N6, and total PUFA intake were significantly higher in patients having better HRQoL with respect to mobility, self-care, and usual activities.
Conclusion
Our results suggest that N3, N6, and total PUFA intake are associated with HRQoL in COPD patients. This association may be attributed to mobility, self-care, and usual activities. Further longitudinal study is required to clarify this relationship.

Citations

Citations to this article as recorded by  
  • The Inflammatory Roles of n-3 and n-6 Polyunsaturated Fatty Acids in COPD: Clinical Implications and Underlying Mechanisms
    Yingqi Wang, Yidie Bao, Boya Liu, Hui Li, Hongxia Duan, Yide Wang, Jiachi Zhang, Weibing Wu, Peijun Li, Xiaodan Liu
    Journal of Inflammation Research.2026; Volume 19: 1.     CrossRef
  • Association between polyunsaturated fatty acids dietary intake and pulmonary function among American children: NHANES 2007–2012
    Mengmeng Ding, Shuyan Qie, Hanming Wang
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Association between dietary fatty acid intake and preserved ratio impaired spirometry in U.S. adults: a population-based cross-sectional study
    Xiang Liu, Wei Zeng, Wangyan Zhou, Dayang Zheng, Xu Yang, Weijun Liao
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD
    Siyu Zeng, Yanqiu Zhang, Shiran Li, Zhimin Li, Pengfei Li, Jingxian Xie, Jiao Zhang, Liling Xie, Yong Yang
    Frontiers in Immunology.2025;[Epub]     CrossRef
  • Dietary modulation of lung lipids influences inflammatory responses to inhaled ozone
    Russell Hunter, Brenna Baird, Milad Mazloumi-Bakhshayesh, Siem Goitom, Selita Lucas, Guy Herbert, David Scieszka, Edward Davis, Haiwei Gu, Yan Jin, Barry E. Bleske, Matthew J. Campen
    Journal of Lipid Research.2024; 65(9): 100630.     CrossRef
  • Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review
    Lieke E J van Iersel, Rosanne J H C G Beijers, Harry R Gosker, Annemie M W J Schols
    Nutrition Reviews.2022; 80(6): 1434.     CrossRef
  • Medium and long chain free fatty acid receptors in the pathophysiology of respiratory diseases
    O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, M. V. Antonyuk, T. A. Gvozdenko
    Bulletin Physiology and Pathology of Respiration.2021; (80): 115.     CrossRef
Case report
Gastroenterology and Hepatology
Anti-nuclear antibody-negative immunoglobulin G4-associated autoimmune hepatitis mimicking lymphoproliferative disorders
Min Kyu Kang, Jung Gil Park, Joon Hyuk Choi
Yeungnam Univ J Med. 2020;37(2):136-140.   Published online March 24, 2020
DOI: https://doi.org/10.12701/yujm.2020.00066
  • 8,068 View
  • 122 Download
  • 5 Crossref
AbstractAbstract PDF
Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) is a very rare subtype of autoimmune hepatitis and characterized by marked elevated serum IgG and hepatic infiltration of IgG4-expressing plasma cells. Pathologic confirmation of hepatic IgG4-expressing plasma cells is usually required for the final diagnosis of IgG4-associated AIH. Herein, we report the case of a 47-year-old female diagnosed with autoantibody-negative IgG4-associated AIH mimicking lymphoproliferative disorders.

Citations

Citations to this article as recorded by  
  • IgG4‐Associated Autoimmune Hepatitis: a Systematic Review
    Chun‐Hsun Liao, Hsu‐Hua Tseng, Ting‐An Shen, Tzu‐Chan Hong, Shih‐Jer Hsu, Jia‐Horng Kao, Chun‐Jen Liu
    Journal of Gastroenterology and Hepatology.2026; 41(2): 443.     CrossRef
  • Immunoglobulin G4-related Autoimmune Hepatitis Following Type 1 Autoimmune Pancreatitis: A Case Report and Literature Review
    Chiharu Toh, Shinichi Morita, Nobutaka Takeda, Fusako Yamazaki, Kunihiko Yokoyama, Masatoshi Sato, Daisuke Kumaki, Takeshi Sakai, Kazuhiro Funakoshi, Koichi Tsuneyama
    Internal Medicine.2025; 64(11): 1659.     CrossRef
  • A clinicopathological study of IgG4-related autoimmune hepatitis and IgG4-hepatopathy
    Atsushi Tanaka, Kenji Notohara, Maki Tobari, Masanori Abe, Takeji Umemura, Atsushi Takahashi, Akemi Tsutsui, Takanori Ito, Kohichi Tsuneyama, Atsushi Masamune, Ken-ichi Harada, Hiromasa Ohira, Mitsuhiro Kawano
    Journal of Gastroenterology.2025; 60(5): 632.     CrossRef
  • Hepatic Involvement of Diffuse Large B-Cell Lymphoma Mimicking Antinuclear Antibody-Negative Autoimmune Hepatitis Diagnosed by Liver Biopsy
    Euna Lee, Min-Kyu Kang, Gabin Moon, Mi-Jin Gu
    Medicina.2022; 59(1): 77.     CrossRef
  • Immunoglobulin G4 (IgG4)‐related autoimmune hepatitis and IgG4‐hepatopathy: A histopathological and clinical perspective
    Atsushi Tanaka, Kenji Notohara
    Hepatology Research.2021; 51(8): 850.     CrossRef
Review article
Public Health, Environmental, and Occupational Health
Reproductive toxic agents in work environments and related cases in Korea
Chulyong Park
Yeungnam Univ J Med. 2020;37(1):22-31.   Published online January 9, 2020
DOI: https://doi.org/10.12701/yujm.2019.00416
  • 14,615 View
  • 115 Download
  • 1 Crossref
AbstractAbstract PDF
There has been a growing concern and subsequent interest surrounding numerous reproductive toxic agents found in various working and non-working environments. Meanwhile, there have been many efforts in medical fields such as toxicology and epidemiology applying experimental studies to elucidate reproductive toxic agents’ characterization and health effects. However, there remains insufficient research data and inadequate evidence in humans. Adverse reproductive outcomes vary from transient, moderate health effects to severely detrimental consequences, such as permanent infertility or childhood cancer of one’s offspring. Furthermore, upon exposure to toxic agents, the latent period before reproductive health effects are observed is relatively short compared to other occupational diseases (e.g., occupational cancer); instant action is required once exposure to reproductive toxic agents is detected. Therefore, it is very important for workers and healthcare professionals to know about the reproductive toxic agents they are likely to be exposed to. In this review, we discuss the general epidemiology of reproductive health in Korea, and the information regarding these reproductive toxic agents.

Citations

Citations to this article as recorded by  
  • Association between Occupational Chemical Exposure and Sperm Parameters; A Narrative Review
    Soheila Pourmasumi, Reza Vazirinejad, Zahra Ahmadi, Ali Mehdipour, Alireza Nazari
    Journal of Occupational Health and Epidemiology.2023; 12(1): 50.     CrossRef
Original article
Gastroenterology and Hepatology
Comparison of small bowel findings using capsule endoscopy between Crohn’s disease and intestinal tuberculosis in Korea
Yong Gil Kim, Kyung-Jo Kim, Young-Ki Min
Yeungnam Univ J Med. 2020;37(2):98-105.   Published online November 22, 2019
DOI: https://doi.org/10.12701/yujm.2019.00374
  • 10,782 View
  • 139 Download
  • 6 Crossref
AbstractAbstract PDF
Background
Little is known about capsule endoscopy (CE) findings in patients with intestinal tuberculosis who exhibit small bowel lesions. The aim of the present study was to distinguish between Crohn’s disease (CD) and intestinal tuberculosis based on CE findings.
Methods
Findings from 55 patients, who underwent CE using PillCam SB CE (Given Imaging, Yoqneam, Israel) between February 2003 and June 2015, were retrospectively analyzed.
Results
CE revealed small bowel lesions in 35 of the 55 patients: 19 with CD and 16 with intestinal tuberculosis. The median age at diagnosis for patients with CD was 26 years and 36 years for those with intestinal tuberculosis. On CE, three parameters, ≥10 ulcers, >3 involved segments and aphthous ulcers, were more common in patients with CD than in those intestinal tuberculosis. Cobblestoning was observed in five patients with CD and in none with intestinal tuberculosis. The authors hypothesized that a diagnosis of small bowel CD could be made when the number of parameters in CD patients was higher than that for intestinal tuberculosis. The authors calculated that the diagnosis of either CD or intestinal tuberculosis would have been made in 34 of the 35 patients (97%).
Conclusion
The number of ulcers and involved segments, and the presence of aphthous ulcers, were significantly higher and more common, respectively, in patients with CD than in those with intestinal tuberculosis. Cobblestoning in the small bowel may highly favor a diagnosis of CD on CE.

Citations

Citations to this article as recorded by  
  • The Overlap Between Crohn’s Disease and Intestinal Tuberculosis: A Never-Ending Story
    Sergiu Marian Cazacu, Costin Teodor Streba, Cristian Constantin, Claudiu Marinel Ionele, Ion Rogoveanu, Alexandru Valentin Popescu, Mirela-Marinela Florescu
    Medicina.2026; 62(4): 794.     CrossRef
  • An Updated Review on Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis
    Ravi K Sharma, Alpa Singh, Saurabh Dawra
    Journal of Postgraduate Medicine, Education and Research.2025; 60(1): 18.     CrossRef
  • Deep Learning Radiomics Analysis of CT Imaging for Differentiating Between Crohn’s Disease and Intestinal Tuberculosis
    Ming Cheng, Hanyue Zhang, Wenpeng Huang, Fei Li, Jianbo Gao
    Journal of Imaging Informatics in Medicine.2024; 37(4): 1516.     CrossRef
  • Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
    Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Difficulties in the differential diagnosis of intestinal tuberculosis and Crohn‘s disease
    M. N. Reshetnikov, D. V. Plotkin, Yu. R. Zyuzya, A. A. Volkov, O. N. Zuban, E. M. Bogorodskaya
    Acta Biomedica Scientifica.2021; 6(5): 196.     CrossRef
  • Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis
    Vishal Sharma
    Expert Review of Gastroenterology & Hepatology.2020; 14(8): 647.     CrossRef
Case report
Radiology, Radiotherapy & Diagnostic Imaging
Massive cerebral venous sinus thrombosis secondary to Graves' disease
Hye-Min Son
Yeungnam Univ J Med. 2019;36(3):273-280.   Published online September 18, 2019
DOI: https://doi.org/10.12701/yujm.2019.00339
  • 9,372 View
  • 100 Download
  • 10 Crossref
AbstractAbstract PDF
Cerebral venous sinus thrombosis (CVT) is a rare cerebrovascular condition accounting for 0.5–1% of all types of strokes in the general population. Hyperthyroidism is associated with procoagulant and antifibrinolytic activity, thereby precipitating a hypercoagulable state that predisposes to CVT. We report the case of a 31-year-old Korean man with massive CVT and diagnosis of concomitant Graves’ disease at admission. Early diagnosis and prompt treatment of CVT are important to improve prognosis; therefore, CVT should be considered in the differential diagnosis in all patients with hyperthyroidism presenting with neurological symptoms.

Citations

Citations to this article as recorded by  
  • Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study
    Lifeng Zhang, Kaibei Li, Qifan Yang, Yao Lin, Caijuan Geng, Wei Huang, Wei Zeng
    European Journal of Medical Research.2024;[Epub]     CrossRef
  • Association Between Thyrotoxicosis and Cerebral Venous Thrombosis
    Margherita Paccagnella, Anna Pizzo, Veronica Calabrò, Valerio Velardi, Bruno Fabris, Stella Bernardi
    Journal of Clinical Medicine.2024; 13(21): 6547.     CrossRef
  • Hyperthyroidism-induced Cerebral Venous Thrombosis Presenting as Chronic Isolated Intracranial Hypertension
    Takumi Tashiro, Yuichi Kira, Norihisa Maeda
    Internal Medicine.2023; 62(20): 3021.     CrossRef
  • Cerebral Sinus Vein Thrombosis and Gender: A Not Entirely Casual Relationship
    Tiziana Ciarambino, Pietro Crispino, Giovanni Minervini, Mauro Giordano
    Biomedicines.2023; 11(5): 1280.     CrossRef
  • Insights Into a Hypercoagulable Case of Thyrocardiac Disease and Literature Overview
    Pin-Yi Wu, Ruchika Meel
    Annals of Internal Medicine: Clinical Cases.2023;[Epub]     CrossRef
  • Cerebral Venous Thrombosis during Thyrotoxicosis: Case Report and Literature Update
    Emanuela Maria Raho, Annibale Antonioni, Niccolò Cotta Ramusino, Dina Jubea, Daniela Gragnaniello, Paola Franceschetti, Francesco Penitenti, Andrea Daniele, Maria Chiara Zatelli, Maurizio Naccarato, Ilaria Traluci, Maura Pugliatti, Marina Padroni
    Journal of Personalized Medicine.2023; 13(11): 1557.     CrossRef
  • Unprovoked Isolated Pulmonary Embolism and Graves’ Disease in a Patient With Dyspnea: A Case Report
    Roshan Bisural, Deepak Acharya, Samaj Adhikari, Baikuntha Chaulagai, Arjun Mainali, Tutul Chowdhury, Nicole Gousy
    Cureus.2022;[Epub]     CrossRef
  • Cerebral venous sinus thrombosis caused by traumatic brain injury complicating thyroid storm: a case report and discussion
    Shurong Gong, Wenyao Hong, Jiafang Wu, Jinqing Xu, Jianxiang Zhao, Xiaoguang Zhang, Yuqing Liu, Rong-Guo Yu
    BMC Neurology.2022;[Epub]     CrossRef
  • Severe headache as a monosymptom of cerebral venous sinus thrombosis: a case report with effective utilization of the SNNOOP10 approach
    Garik Yeganyan, Hasmik Sargsyan, Mariam Manukyan, Henrik Schytz, Samson Khachatryan
    Armenian Journal of Health & Medical Sciences.2022; : 52.     CrossRef
  • Hyperthyroidism as a Precipitant Factor for Cerebral Venous Thrombosis: A Case Report
    Ahmed Elkhalifa Elawad Elhassan, Mohammed Omer Khalil Ali, Amina Bougaila, Mohammed Abdelhady, Hassan Abuzaid
    Journal of Investigative Medicine High Impact Case Reports.2020;[Epub]     CrossRef
Review articles
Psychiatry and Mental Health
Cognitive dysfunctions in individuals with diabetes mellitus
Hye-Geum Kim
Yeungnam Univ J Med. 2019;36(3):183-191.   Published online July 24, 2019
DOI: https://doi.org/10.12701/yujm.2019.00255
  • 27,638 View
  • 544 Download
  • 66 Crossref
AbstractAbstract PDF
Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated with a decrease in the speed of information processing, psychomotor efficiency, attention, mental flexibility, and visual perception. Longitudinal epidemiological studies of type 1 DM have indicated that chronic hyperglycemia and microvascular disease, rather than repeated severe hypoglycemia, are associated with the pathogenesis of DM-related cognitive dysfunction. However, severe hypoglycemic episodes may contribute to cognitive dysfunction in high-risk patients with DM. Type 2 DM has been associated with memory deficits, decreased psychomotor speed, and reduced frontal lobe/executive function. In type 2 DM, chronic hyperglycemia, long duration of DM, presence of vascular risk factors (e.g., hypertension and obesity), and microvascular and macrovascular complications are associated with the increased risk of developing cognitive dysfunction. The pathophysiology of cognitive dysfunction in individuals with DM include the following: (1) role of hyperglycemia, (2) role of vascular disease, (3) role of hypoglycemia, and (4) role of insulin resistance and amyloid. Recently, some investigators have proposed that type 3 DM is correlated to sporadic Alzheimer’s disease. The molecular and biochemical consequences of insulin and insulin-like growth factor resistance in the brain compromise neuronal survival, energy production, gene expression, plasticity, and white matter integrity. If patients claim that their performance is worsening or if they ask about the effects of DM on functioning, screening and assessment are recommended.

Citations

Citations to this article as recorded by  
  • Diurnal cortisol cycle and cognitive performance in older people with Type 2 diabetes
    Lorena Vallejo, Mariola Zapater-Fajarí, Teresa Montoliu, Vanesa Hidalgo, Alicia Salvador
    Psychoneuroendocrinology.2026; 185: 107718.     CrossRef
  • Herbal Remedy for Diabetes Mellitus: Investigation of Antidiabetic, Hepatoprotective and Antioxidant Properties of the Plant Acacia leucophloea (Roxb.) Willd
    Md Nadeem Bari, Md Rizwan Ansari, Imran Mohammad, Mohammad Anwar
    Advances in Human Biology.2026; 16(1): 185.     CrossRef
  • Dorzagliatin shows potential in preventing cognitive impairment in diabetes: evidence from Mendelian randomization analysis and animal study
    Jiangxia Ni, Ke Wang, Lingge Feng, Chuyi Wang, Changhong Li, Yelin Chen, Li Chen
    Frontiers in Endocrinology.2026;[Epub]     CrossRef
  • Assessment of Hippocampal, Prefrontal Cortical, and Striatal Dopaminergic Circuitry Underlying Altered Social Behavior in Diabetes
    Arun Parashar, Vineet Mehta, Udayabanu Malairaman, Muskan Thakur, Varsha Sharma
    Molecular Neurobiology.2026;[Epub]     CrossRef
  • Exploring shared molecular pathways and gene signatures in type 2 diabetes mellitus and Alzheimer's disease in a Pakistani cohort
    Zarish Noreen, Tanmoy Mondal, Jheannelle Johnson, Jasneet Sahota, Christopher A Loffredo, Gail Nunlee-Bland, Brent Korba, Attya Bhatti, Vijay Chandra, Somiranjan Ghosh
    Journal of Alzheimer's Disease Reports.2026;[Epub]     CrossRef
  • Prevalence and Correlation of Cognitive Decline and Physical Frailty in Adults with Diabetes
    Farwa Khaliq, Nayab John, Syed Ali Hussain, Rabia Afzal, Esha Khan, Mubin Mustafa Kiyani
    The Healer Journal of Physiotherapy and Rehabilitation Sciences.2026; 6(2): 43.     CrossRef
  • Frailty, resilience, instrumental activities of daily living, and cognitive function in older adults with type 2 diabetes: A parallel mediation analysis
    Cheng-Chen Chou, Hua-Fen Chen, Jong-Ni Lin, Chi-Wen Chen, Yuan-Mei Liao, An-Yun Yeh
    Geriatric Nursing.2026; 70: 104043.     CrossRef
  • Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
    Xueting Yu, Huimei He, Jie Wen, Xiuyuan Xu, Zhaojuan Ruan, Rui Hu, Fang Wang, Haibing Ju
    Open Medicine.2025;[Epub]     CrossRef
  • Exploring the therapeutic potentials of cuminaldehyde: a comprehensive review of biological activities, mechanisms, and novel delivery systems
    Abhik Paul, Sai Satyaprakash Mishra, Avik Maji, Ajeya Samanta, Sourin Nahar, Tapan Kumar Maity
    Phytochemistry Reviews.2025; 24(6): 5207.     CrossRef
  • Health benefits of okra (Abelmoschus esculentus) against diabetes mellitus and cognitive dysfunction: a review
    Nazir Ahmad, Kaisun Nesa Lesa, Zullies Ikawati, Nanang Fakhrudin
    Food Production, Processing and Nutrition.2025;[Epub]     CrossRef
  • Predictive value and weight of factors associated with cognitive performance in Hispanics/Latinos enrolled in the Health and Aging Brain Study: Health Disparities
    Raul Vintimilla, Darian Johnson, Douglas Taylor, James Hall, Fan Zhang, Sid O'Bryant
    Alzheimer's & Dementia: Translational Research & Clinical Interventions.2025;[Epub]     CrossRef
  • Specific Cognitive Functions Associated With Self-Care Behaviors in Older Adults With Type 2 Diabetes and Mild Cognitive Impairment
    Cheng-Chen Chou, Hua-Fen Chen, Yuan-Mei Liao, Chi-Wen Chen, Pei-Ching Liu, An-Yun Yeh
    Western Journal of Nursing Research.2025; 47(7): 605.     CrossRef
  • Effect of Trans‐Auricular Vagal Nerve Stimulation on Cognitive Functions in Diabetic Polyneuropathy Patients
    Moshera H. Darwish, Mohamed S. El‐Tamawy, Saleh M. Alhirsan, Mariam El‐Anany, Heba A. Khalifa
    Physiotherapy Research International.2025;[Epub]     CrossRef
  • Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction
    Xiaoyu Meng, Haiyang Du, Danpei Li, Yaming Guo, Peiqiong Luo, Limeng Pan, Ranran Kan, Peng Yu, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Wenjun Li, Yan Yang, Xuefeng Yu
    Journal of Diabetes.2025;[Epub]     CrossRef
  • Investigating the neuroprotective role of Synta-66 in type-2 diabetes mellitus-induced dementia in rats
    Ashi Mannan, Maneesh Mohan, Shareen Singh, Sonia Dhiman, Thakur Gurjeet Singh
    Journal of Pharmacy and Pharmacology.2025; 77(9): 1222.     CrossRef
  • The Effect of Intermittent Fasting and Vitamin Supplement on Cognitive Functions in Type 2 Diabetes Mellitus
    Radwa M. Al-sayed, Mai M. Hasan, Samia Hussein, Aya M. Mohammed, Abdallah S. Abdelazem, Eman M. Abdelghany, Yassmen M. El-sayed, Eman Abdel Raouf Mohammed
    Bratislava Medical Journal.2025; 126(9): 2157.     CrossRef
  • Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD)
    Ashi Mannan, Shareen Singh, Maneesh Mohan, Thakur Gurjeet Singh
    Metabolic Brain Disease.2025;[Epub]     CrossRef
  • Prevalence and Associated Factors of Cognitive Dysfunction Among Middle-Aged Type 2 Diabetes Mellitus Patients in South India: A Cross-Sectional Study
    Dhrubajyoti J Debnath, Siva Santosh Kumar Pentapati, Hitesh Babu Sarihaddu
    Cureus.2025;[Epub]     CrossRef
  • Interplay between physical activity, inflammation, and cognitive performance in women with type 2 diabetes: an observational study focused on IL-6 pathway mediators
    Zakieh Heidari, Mahdieh Molanouri Shamsi, Amin Kadkhodaei, Mehrdad Behmanesh, Shahnaz Shahrbanian, Sara Soudi
    Diabetology & Metabolic Syndrome.2025;[Epub]     CrossRef
  • Mitochondrial Reactive Oxygen Species Production in Vascular Dementia Following Experimental Diabetes
    Ed Wilson Santos, Subika Khatoon, Yun-Min Zheng, Yong-Xiao Wang
    Cells.2025; 14(16): 1260.     CrossRef
  • Study on the impact of diabetes on neuro-psycho-behavioral functions, Kénitra, Morocco
    Hajar Lerhlibi, Soukaina Chehab, Khalid Chakhtoura, Mostafa Slim
    Multidisciplinary Reviews.2025; 9(6): 2026277.     CrossRef
  • The impact of APOE ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects
    Rafael Lara Nohmi, Mozania Reis de Matos, Sueli Mieko Oba‐Shinjo, Bruno Fukelmann Guedes, Paula Rodrigues Sola, Miyuki Uno, Marisa Passarelli, Sonia Maria Dozzi Brucki, Michal Schnaider Beeri, Sharon Sanz Simon, Maria Lucia Correa‐Giannella, Suely Kazue N
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.2025;[Epub]     CrossRef
  • Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes
    Debashree Mazumdar, Santosh Singh
    Indian Journal of Clinical Biochemistry.2024; 39(1): 3.     CrossRef
  • Nephroprotective properties of Achillea millefolium green-formulated Au NPs in streptozotocin-induced diabetic nephropathy in mice: Introducing a novel therapeutic drug for the treatment of nephropathy
    Nana Li, Xiu Wang, Shanshan Kong
    Inorganic Chemistry Communications.2024; 161: 112103.     CrossRef
  • Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis
    Getachew Mesfin Bambo, Daniel Asmelash, Ermiyas Alemayehu, Alemu Gedefie, Tadesse Duguma, Samuel Sahile Kebede
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • A new nomogram model for the individualized prediction of mild cognitive impairment in elderly patients with type 2 diabetes mellitus
    Yuanyuan Jiang, Xueyan Liu, Huiying Gao, Jingzheng Yan, Yingjuan Cao
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Sex Differences in the Trajectories of Cognitive Decline and Affected Cognitive Domains Among Older Adults With Controlled and Uncontrolled Glycemia
    Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre, Jay Magaziner
    The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2024;[Epub]     CrossRef
  • The PI3K/Akt signaling axis and type 2 diabetes mellitus (T2DM): From mechanistic insights into possible therapeutic targets
    Rana Taheri, Yazdan Mokhtari, Amir‐Mohammad Yousefi, Davood Bashash
    Cell Biology International.2024; 48(8): 1049.     CrossRef
  • The Role of Insulin Deficiency in Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
    Yu. V. Bykov
    Fundamental and Clinical Medicine.2024; 9(2): 94.     CrossRef
  • Prevalence of Candida albicans Infection Among Diabetic Foot Ulcer Patients in Al-Yarmouk Teaching Hospital
    Fatin Ali Al-Chalabi, Rabab Majead Abed, Mohsen Hashim Risan, Younus Desher Jabr
    Medical Journal of Babylon.2024; 21(Suppl 1): S137.     CrossRef
  • Daphnetin modulates GLP-1R to alleviate cognitive dysfunction in diabetes: implications for inflammation and oxidative stress
    Feng Liang, Xinyi Tian, Lining Ding
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Metabolic kinetics and muscle and brain health markers in older adults, and the role of age and presence of chronic morbidities: A large cross-sectional cohort study
    Minchae C. Kang, Nicolaas E.P. Deutz, Sarah K. Kirschner, Mariëlle P.K.J. Engelen
    Clinical Nutrition.2024; 43(12): 36.     CrossRef
  • Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis
    Nimantha Karunathilaka, Christina Parker, Peter A. Lazzarini, Pamela Chen, Chloe Katsanos, Margaret MacAndrew, Kathleen Finlayson
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats
    Teresa Ponce-Lopez, José Antonio González Álvarez Tostado, Fernando Dias, Keren Happuck Montiel Maltez
    Biomolecules.2023; 13(9): 1289.     CrossRef
  • Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications
    Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
    Critical Reviews in Food Science and Nutrition.2023; 63(28): 9163.     CrossRef
  • Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus
    Ericka Patricia da Silva, Geórgia da Silva Feltran, Sérgio Alexandre Alcântara dos Santos, Rodrigo Cardoso de Oliveira, Rahyza I.F. Assis, Luis Antônio Justulin Junior, Denise Carleto Andia, Willian F. Zambuzzi, Alexandra Latini, Rodrigo A. Foganholi da S
    Brain Research.2023; 1803: 148234.     CrossRef
  • Research Progress on Lipocalin-2 in Diabetic Encephalopathy
    Wenjie Zhang, Shihong Chen, Xianghua Zhuang
    Neuroscience.2023; 515: 74.     CrossRef
  • The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins
    Clement G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B. Tchounwou
    International Journal of Molecular Sciences.2023; 24(10): 9085.     CrossRef
  • Gender differences in cognitive function and its associated factors among older adults with type 2 diabetes
    Hua-Fen Chen, Ju Ying Jiang, Mei-Hsiu Chen, Rong Lin, Seng Wei Ooi Jerence, Chin-Huan Chang, Cheng-Chen Chou
    Geriatric Nursing.2023; 52: 165.     CrossRef
  • Exploring the Potential of Antidiabetic Agents as Therapeutic Approaches for Alzheimer's and Parkinson's Diseases: A Comprehensive Review
    Mahima Koshatwar, Sourya Acharya, Roshan Prasad, Tejaswee Lohakare, Mayur Wanjari, Avinash B Taksande
    Cureus.2023;[Epub]     CrossRef
  • Isolation and characterization of bacteria from diabetic foot ulcer: amputation, antibiotic resistance and mortality rate
    Muamar M. A. Shaheen, Sewar Al Dahab, Maryiam Abu Fada, Rawand Idieis
    International Journal of Diabetes in Developing Countries.2022; 42(3): 529.     CrossRef
  • Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease
    Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash
    Journal of Biochemical and Molecular Toxicology.2022;[Epub]     CrossRef
  • Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission
    Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbel
    Saudi Journal of Biological Sciences.2022; 29(4): 2738.     CrossRef
  • Diabetes Mellitus-Related Neurobehavioral Deficits in Mice Are Associated With Oligodendrocyte Precursor Cell Dysfunction
    Li-Ping Wang, Jieli Geng, Chang Liu, Yuyang Wang, Zhijun Zhang, Guo-Yuan Yang
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • Single-Cell Sequencing Analysis of the db/db Mouse Hippocampus Reveals Cell-Type-Specific Insights Into the Pathobiology of Diabetes-Associated Cognitive Dysfunction
    Shizhan Ma, Wenkai Bi, Xueying Liu, Shangbin Li, Yaxin Qiu, Chengcheng Huang, Renjun Lv, Qingqing Yin
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Impact of time in range during hospitalization on clinical outcomes in diabetic patients with toe amputation: a propensity score matching analysis
    Su Li, Ze-Xin Huang, Dong-hao Lou, Ye-Yong Jiang, Sheng Zhao
    BMC Surgery.2022;[Epub]     CrossRef
  • Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach
    Lin Lin, Jindi Zhang, Yutong Liu, Xinyu Hao, Jing Shen, Yang Yu, Huashuai Xu, Fengyu Cong, Huanjie Li, Jianlin Wu
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Does diabetes affect the risk of involvement in a motor vehicle crash?
    Jamie Dow, Lucie Boucher, David Carr, Judith L. Charlton, Linda Hill, Sjaan Koppel, Roy Lilley, Richard Marotolli, Desmond O'Neill, Mark Rapoport, Christine Roy, Neil Swirsky, Vincent Woo, Emmanuelle Gagné, Claude Giroux, Tamara Rader
    Journal of Transport & Health.2022; 27: 101509.     CrossRef
  • No Effects of Acute Psychosocial Stress on Working Memory in Older People With Type 2 Diabetes
    Lorena Vallejo, Mariola Zapater-Fajarí, Teresa Montoliu, Sara Puig-Perez, Juan Nacher, Vanesa Hidalgo, Alicia Salvador
    Frontiers in Psychology.2021;[Epub]     CrossRef
  • Neurovascular coupling alterations in type 2 diabetes: a 5-year longitudinal MRI study
    Yang Zhang, Xiaolu Zhang, Guangyang Ma, Wen Qin, Jiayang Yang, Jiahui Lin, Quan Zhang
    BMJ Open Diabetes Research & Care.2021; 9(1): e001433.     CrossRef
  • Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes rats
    Ali Heidarianpour, Fereshteh Mohammadi, Maryam Keshvari, Naser Mirazi
    Biomedicine & Pharmacotherapy.2021; 135: 111230.     CrossRef
  • The Link Between Nutrition and Alzheimer’s Disease: From Prevention to Treatment
    Laís Bhering Martins, Ana Letícia Malheiros Silveira, Antonio Lúcio Teixeira
    Neurodegenerative Disease Management.2021; 11(2): 155.     CrossRef
  • Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
    Rasha Elbialy Elsharkawy, Ghada Saed Abdel Azim, Marwa Abdellah Osman, Hend Maghraby Maghraby, Rehab Abdelfattah Mohamed, Eman Mahmoud Abdelsalam, Eman Elshohat Ebrahem, Nora Mohamed Ahmed Seliem
    Neuropsychiatric Disease and Treatment.2021; Volume 17: 627.     CrossRef
  • SLC40A1 Mediates Ferroptosis and Cognitive Dysfunction in Type 1 Diabetes
    Lijun Hao, Jun Mi, Liping Song, Yinnan Guo, Yanli Li, Yiru Yin, Ce Zhang
    Neuroscience.2021; 463: 216.     CrossRef
  • Relationship between peripheral neuropathy and cognitive performance in the elderly population
    Yu-Jen Lin, Tung-Wei Kao, Wei-Liang Chen
    Medicine.2021; 100(20): e26071.     CrossRef
  • The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore
    See Ann Soo, Kok Pin Ng, Fennie Wong, Seyed Ehsan Saffari, Chathuri Yatawara, Zahinoor Ismail, Nagaendran Kandiah
    Journal of Alzheimer's Disease.2021; 82(1): 411.     CrossRef
  • Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders
    Qian Chen, Ting Cao, NaNa Li, Cuirong Zeng, Shuangyang Zhang, Xiangxin Wu, Bikui Zhang, Hualin Cai
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Mitochondrial remodelling—a vicious cycle in diabetic complications
    Bhoomika Sherkhane, Gundu Chayanika, Anika Sood, Dharmendra Kumar Khatri, Shashi Bala Singh
    Molecular Biology Reports.2021; 48(5): 4721.     CrossRef
  • The Association between the Binding Processes of Working Memory and Vascular Risk Profile in Adults
    Eirini Bika, Despina Moraitou, Elvira Masoura, George Kolios, Georgia Papantoniou, Maria Sofologi, Vasileios Papaliagkas, Georgios Ntritsos
    Brain Sciences.2021; 11(9): 1140.     CrossRef
  • The effect of cordycepin on brain oxidative stress and protein expression in streptozotocin-induced diabetic mice
    Krittika SRISUKSAI, Kongphop PARUNYAKUL, Narumon PHAONAKROP, Sittiruk ROYTAKUL, Wirasak FUNGFUANG
    Journal of Veterinary Medical Science.2021; 83(9): 1425.     CrossRef
  • The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
    Jianbo Yu, Xufeng Liao, Yanzi Zhong, Yongqiang Wu, Xinsheng Lai, Huifeng Jiao, Min Yan, Yu Zhang, Chaolin Ma, Shunqi Wang
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Impact of diabetes on the accuracy and speed of accessing information from episodic and working memory
    Selene Cansino, Frine Torres-Trejo, Cinthya Estrada-Manilla, Eira Castellanos-Domínguez, Ana Zamora-Olivares, Silvia Ruiz Velasco, Jim Grange
    Cogent Psychology.2021;[Epub]     CrossRef
  • Ингибиторы натрий-глюкозного котранспортера способны положительно влиять на состояние головного мозга
    Олег Леонидович Колесников , Алла Алексеевна Колесникова , Юлия Олеговна Тарабрина
    Естественные и Технические Науки.2021; (№11): 149.     CrossRef
  • Melatonin: new insights on its therapeutic properties in diabetic complications
    Mohammad Hossein Pourhanifeh, Azam Hosseinzadeh, Ehsan Dehdashtian, Karim Hemati, Saeed Mehrzadi
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Diabetic encephalopathy causes the imbalance of neural activities between hippocampal glutamatergic neurons and GABAergic neurons in mice
    Chun Wang, Juan Li, Shidi Zhao, Li Huang
    Brain Research.2020; 1742: 146863.     CrossRef
  • Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
    Gabriela Dumitrita Stanciu, Veronica Bild, Daniela Carmen Ababei, Razvan Nicolae Rusu, Alina Cobzaru, Luminita Paduraru, Delia Bulea
    Journal of Clinical Medicine.2020; 9(6): 1713.     CrossRef
Pathology and Forensic Medicine
Pathological interpretation of connective tissue disease-associated lung diseases
Kun Young Kwon
Yeungnam Univ J Med. 2019;36(1):8-15.   Published online January 15, 2019
DOI: https://doi.org/10.12701/yujm.2019.00101
  • 14,066 View
  • 218 Download
  • 2 Crossref
AbstractAbstract PDF
Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations. Histopathological findings of diverse morphological changes can be present in CTD-LDs airway lesions (chronic bronchitis/bronchiolitis, follicular bronchiolitis, etc.), interstitial lung diseases (nonspecific interstitial pneumonia/fibrosis, usual interstitial pneumonia, lymphocytic interstitial pneumonia, diffuse alveolar damage, and organizing pneumonia), pleural changes (acute fibrinous or chronic fibrous pleuritis), and vascular changes (vasculitis, capillaritis, pulmonary hemorrhage, etc.). CTD patients can be exposed to various infectious diseases when taking immunosuppressive drugs. Histopathological patterns of CTD-LDs are generally nonspecific, and other diseases that can cause similar lesions in the lungs must be considered before the diagnosis of CTD-LDs. A multidisciplinary team involving pathologists, clinicians, and radiologists can adequately make a proper diagnosis of CTD-LDs.

Citations

Citations to this article as recorded by  
  • Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role
    Stefano Lucà, Francesca Pagliuca, Fabio Perrotta, Andrea Ronchi, Domenica Francesca Mariniello, Giovanni Natale, Andrea Bianco, Alfonso Fiorelli, Marina Accardo, Renato Franco
    International Journal of Molecular Sciences.2024; 25(7): 3618.     CrossRef
  • Acute fibrinous and organizing pneumonia: two case reports and literature review
    Haihong Chen, Yukun Kuang, Xinyan Huang, Ziyin Ye, Yangli Liu, Canmao Xie, Ke-Jing Tang
    Diagnostic Pathology.2021;[Epub]     CrossRef
Case Report
Ophthalmology
Ocular manifestations in a patient with de novo Fabry disease
You Hyun Lee, Kyu Young Shim, Sung Bae Park, Yu Cheol Kim
Yeungnam Univ J Med. 2018;35(2):232-235.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.232
  • 7,956 View
  • 89 Download
  • 1 Crossref
AbstractAbstract PDF
Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

Citations

Citations to this article as recorded by  
  • Implications of Corneal Refractive Surgery in Patients with Fabry Disease
    Majid Moshirfar, Nour Bundogji, Alyson N. Tukan, Yasmyne C. Ronquillo
    Ophthalmology and Therapy.2022; 11(3): 925.     CrossRef
Review article
Public Health, Environmental, and Occupational Health
Implementation of a care coordination system for chronic diseases
Jung Jeung Lee, Sang Geun Bae
Yeungnam Univ J Med. 2019;36(1):1-7.   Published online December 20, 2018
DOI: https://doi.org/10.12701/yujm.2019.00073
  • 12,456 View
  • 190 Download
  • 6 Crossref
AbstractAbstract PDF
The number of people with chronic diseases has been increasing steadily but the indicators for the management of chronic diseases have not improved significantly. To improve the existing chronic disease management system, a new policy will be introduced, which includes the establishment of care plans for hypertension and diabetes patients by primary care physicians and the provision of care coordination services based on these plans. Care coordination refers to a series of activities to assist patients and their families and it has been known to be effective in reducing medical costs and avoiding the unnecessary use of the hospital system by individuals. To offer well-coordinated and high-quality care services, it is necessary to develop a service quality assurance plan, track and manage patients, provide patient support, agree on patient referral and transition, and develop an effective information system. Local governance should be established for chronic disease management, and long-term plans and continuous quality improvement are necessary.

Citations

Citations to this article as recorded by  
  • Coordination of care in health systems for users with diabetes and hypertension: a scoping review
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Coordenação do cuidado nos sistemas de saúde a usuários com diabetes e hipertensão: uma revisão de escopo
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Coordinación del cuidado en los sistemas de salud para usuarios con diabetes e hipertensión: una revisión de alcance
    Virgílio Luiz Marques de Macedo, Naira Pereira de Sousa, Ana Cristina dos Santos, Walterlânia Santos, Marina Morato Stival, Tânia Cristina Morais Santa Barbara Rehem
    Revista Latino-Americana de Enfermagem.2025;[Epub]     CrossRef
  • Personalized, interdisciplinary patient pathway for cross-sector care of multimorbid patients (eliPfad trial): study protocol for a randomized controlled trial
    Christoph Heinrich Lindemann, Volker Burst, Linus Alexander Völker, Sebastian Brähler, Dusan Simic, Ingrid Becker, Martin Hellmich, Clarissa Kurscheid, Nadine Scholten, Ruben Krauspe, Kerstin Leibel, Stephanie Stock, Paul Thomas Brinkkoetter
    Trials.2024;[Epub]     CrossRef
  • Evaluation of the Implementation of Integrated Primary Care for Patients with Type 2 Diabetes and Hypertension in Belgium, Cambodia, and Slovenia
    Nataša Stojnić, Monika Martens, Edwin Wouters, Savina Chham, Josefien van Olmen, Katrien Danhieux, Nina Ružić Gorenjec, Ir Por, Antonija Poplas-Susič, Zalika Klemenc-Ketiš
    International Journal of Integrated Care.2024;[Epub]     CrossRef
  • Trends in the Quality of Primary Care and Acute Care in Korea From 2008 to 2020: A Cross-sectional Study
    Yeong Geun Gwon, Seung Jin Han, Kyoung Hoon Kim
    Journal of Preventive Medicine and Public Health.2023; 56(3): 248.     CrossRef
Case Reports
Pathology and Forensic Medicine
Mammary Paget’s disease without underlying malignancy of the breast
Nuri Jang, Suhwan Kang, Young Kyung Bae
Yeungnam Univ J Med. 2018;35(1):99-103.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.99
  • 9,225 View
  • 52 Download
  • 5 Crossref
AbstractAbstract PDF
Mammary Paget’s disease (MPD) is usually accompanied by underlying breast malignancy; however, a few cases have been reported as only skin lesions without any evidence of malignancy of the breast on imaging tests and microscopic examination of surgical specimen. Here, we describe a 47-year-old woman who visited our hospital who had an eczematous lesion on right nipple and areola for over 10 years. The lesion was diagnosed as Paget’s disease by punch biopsy; however, imaging studies demonstrated no breast malignancy or lymph node metastasis. The patient underwent surgery of on the nipple and areola including underlying breast tissue. No underlying malignancy was found upon microscopic examination, except for Paget’s disease. Immunohistochemical stains revealed that the tumor cells were positive for cytokeratin 7, and negativity for p63, cytokeratin 5/6, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. We report a case of MPD without underlying malignancy. To the best of our knowledge, this is the third case reported in Korea.

Citations

Citations to this article as recorded by  
  • Isolated Extensive Paget’s Disease Without Underlying Breast Carcinoma
    Shivani Moudgil, Cherry Bansal, Gurupriya Anand, Gomty Mahajan
    Indian Journal of Surgery.2025;[Epub]     CrossRef
  • ‘Eczematous’ dermatitis of the nipple: clinical and histopathological differential diagnosis of Paget disease
    Hatice B. Zengin, Puay Hoon Tan, Regina Liu, Bruce R. Smoller
    Pathology.2024; 56(3): 300.     CrossRef
  • An unusual case of longstanding mammary Paget disease presenting with reticulated skin changes
    S. K. Dhariwal, E. Rytina, J. C. Sterling
    Clinical and Experimental Dermatology.2021; 46(4): 748.     CrossRef
  • Histopathological patterns of skin adnexal tumours in Ibadan, South-West Nigeria
    OmoladeO Adegoke, MustaphaAkanji Ajani
    Hamdan Medical Journal.2021; 14(4): 168.     CrossRef
  • Clinicopathological characteristics of mammary Paget’s disease: A single‐center 25‐year experience in Korea
    Young J. Kim, Keon H. Lee, Woo J. Lee, Chong H. Won, Sung E. Chang, Jee H. Choi, Mi W. Lee
    The Breast Journal.2020; 26(4): 806.     CrossRef
Emergency and Critical Care Medicine
Ultrasonographic findings in Fitz-Hugh-Curtis syndrome: a thickened or three-layer hepatic capsule
You Ho Moon, Jung ho Kim, Won joon Jeong, Sin-Youl Park
Yeungnam Univ J Med. 2018;35(1):127-129.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.127
  • 9,463 View
  • 72 Download
  • 1 Crossref
AbstractAbstract PDF
Fitz-Hugh-Curtis syndrome (FHCS) is characterized by inflammation of the perihepatic capsules associated with the pelvic inflammatory disease (PID). FHCS is not a serious disease, but if not treated properly, it can result in increased medical costs, prolonged treatment, and dissatisfaction with treatment. However, early recognition of FHCS in the emergency department can be difficult because its symptoms or physical findings may mimic many other diseases. Although contrast-enhanced computed tomography (CECT) is the useful imaging modality for recognition of FHCS, it is available only when a high suspicion is established. We performed point-of-care ultrasonography in an 18-year-old woman who had a sharp right upper quadrant (RUQ) abdominal pain without PID symptoms and found a thickened or three-layer hepatic capsule. These findings coincided with areas showing increased hepatic capsular enhancement in the arterial phase of CECT. These results show that if the thickened or three-layer hepatic capsule without evidence of a common cause of RUQ pain is observed on ultrasonography in women of childbearing age with RUQ abdominal pain, the physician can consider the possibility of FHCS.

Citations

Citations to this article as recorded by  
  • Analysis of Misdiagnosis of FHCS Syndrome as Cholecystitis and Literature Review
    旭旗 申
    Advances in Clinical Medicine.2022; 12(06): 5608.     CrossRef
Review Article
Nuclear Medicine
Beta-amyloid imaging in dementia
Kyung Ah Chun
Yeungnam Univ J Med. 2018;35(1):1-6.   Published online June 30, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.1.1
  • 12,695 View
  • 144 Download
  • 13 Crossref
AbstractAbstract PDF
Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the Aβ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as 11C-labeled Pittsburgh Compound B or 18F-labeled tracers, such as 18F-florbetaben, 18F-florbetapir, and 18F-flutemetamol, which bind to Aβ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of Aβ throughout the brain in living subjects. Aβ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.

Citations

Citations to this article as recorded by  
  • Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
    Shadaan Ahmad, Lubna Ahmad, Mohammad Adil, Ritu Sharma, Saara khan, Nazeer Hasan, Mohd. Aqil
    Drug Delivery and Translational Research.2026; 16(3): 825.     CrossRef
  • The role of neuroimaging in Alzheimer’s disease: implications for the diagnosis, monitoring disease progression, and treatment
    Julius Mulumba, Rui Duan, Bo Luo, Jiang Wu, Muhammad Sulaiman, Feng Wang, Yong Yang
    Exploration of Neuroscience.2025;[Epub]     CrossRef
  • Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
    Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
    Neurobiology of Aging.2024; 133: 67.     CrossRef
  • Current status of PET tracers for the early diagnosis of Alzheimer's disease
    Yuying Li, Tianqing Liu, Qi Zeng, Mengchao Cui
    TrAC Trends in Analytical Chemistry.2024; 172: 117546.     CrossRef
  • Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits
    Saurabh Kumar Jha, Vinod Kumar Nelson, Punna Rao Suryadevara, Siva Prasad Panda, Chitikela P. Pullaiah, Mohana Vamsi Nuli, Mehnaz Kamal, Mohd Imran, Saijyothi Ausali, Mosleh Mohammad Abomughaid, Rashi Srivastava, Rahul Deka, Pingal Pritam, Neha Gupta, Har
    Ageing Research Reviews.2024; 100: 102386.     CrossRef
  • A Study on the Inhibition of AChE Activity by Ethanolic Extract of Tibet Wild Gymnadenia crassinervis and Its Protective and Reparative Effects on Aβ25−35‐Induced Cell Injury
    Hexingzi Cheng, Anping Li, Pei Yang, Zhengchang Zhong, Hemei Liu, Liangshi Zhang, Qifeng Mo, Christophe Hano
    Journal of Food Biochemistry.2024;[Epub]     CrossRef
  • Fluorine-18-Labeled Diaryl-azines as Improved β-Amyloid Imaging Tracers: From Bench to First-in-Human Studies
    Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
    Journal of Medicinal Chemistry.2023; 66(7): 4603.     CrossRef
  • Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
    Qianling Chen, Xuebing Chen, Luyao Xu, Rui Zhang, Zhigang Li, Xia Yue, Dongfang Qiao
    Forensic Science, Medicine and Pathology.2022; 18(4): 530.     CrossRef
  • Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease
    Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun
    European Journal of Medicinal Chemistry.2022; 244: 114806.     CrossRef
  • Tubulin modifying enzymes as target for the treatment of tau-related diseases
    Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem van der Laan
    Pharmacology & Therapeutics.2021; 218: 107681.     CrossRef
  • Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring
    Wieke M. van Oostveen, Elizabeth C. M. de Lange
    International Journal of Molecular Sciences.2021; 22(4): 2110.     CrossRef
  • Imaging Techniques as an Aid in the Early Detection of Cardiac Amyloidosis
    M.F. Santarelli, M. Scipioni, D. Genovesi, A. Giorgetti, P. Marzullo, L. Landini
    Current Pharmaceutical Design.2021; 27(16): 1878.     CrossRef
  • Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis
    Hong Yu, Bo Yuan, Qiubo Chu, Chunyue Wang, Hui Bi
    International Journal of Molecular Medicine.2019;[Epub]     CrossRef
Case Report
Cardiology and Cardiovascular Medicine
Acute upper limb ischemia in a patient with newly diagnosed paroxysmal atrial fibrillation
Dong Shin Kim, Seunghwan Kim, Hyang Ki Min, Chiwoo Song, Young Bin Kim, Sae Jong Kim, Ji Young Park, Sung Kee Ryu, Jae Woong Choi
Yeungnam Univ J Med. 2017;34(2):242-246.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.242
  • 5,523 View
  • 43 Download
AbstractAbstract PDF
Acute limb ischemia (ALI) due to an embolism is associated with high mortality rate and poor prognosis, and early diagnosis with prompt revascularization is required to reduce the risk of limb amputation or even death. The etiologies of ALI are diverse, and it includes an embolism from the heart and thrombotic occlusion of the atherosclerotic native vessels, stents, or grafts. An uncommon cause of ALI is acute arterial thromboembolism, and atrial fibrillation (AF) is the single most important risk factors for systemic thromboembolism. It is important to correctly identify the source of ALI for secondary prevention, as it depends on the underlying cause. Percutaneous transluminal angioplasty (PTA) has been proven to be a safe and effective treatment for focal atherosclerotic and thrombotic occlusive diseases of the aorta and its major extremity branches. Herein, we report on a 77-year-old female patient with acute upper limb ischemia, treated by PTA using a catheter-guided thrombectomy. He was newly diagnosed with paroxysmal AF (PAF) while evaluation the cause of his acute arterial thromboembolism. We recommend that cardiologists always consider PAF as a possible diagnosis even in patients without any history of AF under ALI because it is possible to develop thromboembolism in clinical practice.
Original Article
Anatomy
Developing a new index to assess varicella outbreak
Kiwook Yang, Incheol Seo
Yeungnam Univ J Med. 2017;34(2):222-230.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.222
  • 3,667 View
  • 19 Download
AbstractAbstract PDF
BACKGROUND
Varicella is the most common infectious disease reported despite the high vaccination rate. Interventions that target humans are particularly effective for varicella because humans are its only natural host. On the other hand, the existing national varicella surveillance systems lack the information to identify an outbreak. Therefore, a new index to assess varicella outbreaks was developed. METHODS: The residential addresses of 2,718 varicella cases reported in Daegu in 2016 were converted to geographic coordinates and the distances between new varicella case and previous cases within 21 days were calculated from the date analyzed. Two cases were considered to be adjacent if the distance between them was less than 1 km. Finally, a proximity index was introduced by dividing the number of adjacent cases by the number of new cases on the date analyzed. RESULTS: First, time-series charts and scatter plots were used to verify that the proximity index reflected the spatial closeness of the different varicella cases. The proximity index is helpful in identifying outbreaks from a list of single varicella cases. In addition, in this study, a new epidemic characteristic of varicella based on the proximity index was shown. CONCLUSION: The proximity index introduced in this study can be used to determine the likelihood of an outbreak from a single case of varicella, and it can be embedded in a web-based national varicella surveillance system that is currently in operation.
Review
Surgery
Surgical treatment of perianal fistula in Crohn's disease
Sohyun Kim
Yeungnam Univ J Med. 2017;34(2):169-173.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.169
  • 3,360 View
  • 16 Download
AbstractAbstract PDF
Perianal Crohn's disease is a major problem that impair quality of life. This article reviews the current surgical treatment of Crohn's perianal fistula. Fistulotomy and loose seton are commonly used surgical methods for treatment of perianal Crohn's disease. Mucosal advancement flap and fibrin glue are used in this treatment, despite a lake of controlled trials. Fecal diversion is disturbingly high in complicated complex perianal fistula in Crohn's disease. Ligation of intersphincteric fistula and autologous or allogenic stem cells are new surgical procedures for treatment of Crohn's disease that need further studies. Treatment success might be improved by multimodal treatment and new surgical and medical treatment options.
Case Reports
Cardiology and Cardiovascular Medicine
Severe chest pain with mid-ventricular obstruction in a patient with hyperthyroidism
Jong Ho Nam, Jang Won Son, Geu Ru Hong
Yeungnam Univ J Med. 2017;34(1):128-131.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.128
  • 3,219 View
  • 9 Download
AbstractAbstract PDF
Mid-ventricular obstruction (MVO) rarely occurs in patients without hypertrophic cardiomyopathy. Increased cardiac contractility may play an important role in causing MVO. We experienced a case of severe chest pain and MVO in a 50-year-old female patient. She had hypertension, diabetes, stroke and peripheral artery disease. Her blood pressure was very high (222/122 mmHg) with severe fluctuation. The transthoracic echocardiography revealed MVO accompanied by hyper-dynamic left ventricular systolic function. We regarded her chest pain and MVO as secondary findings related to other diseases. Coronary angiography and several tests for uncontrolled hypertension were performed, and those evaluations revealed that she had coronary artery disease and hyperthyroidism. We considered that the increase in the myocardial oxygen demand in response to the increase in cardiac contractility and workload associated with hyperthyroidism aggravated her symptoms and MVO. She was treated with methimazole and beta blockers and her symptoms dramatically improved.
Cardiology and Cardiovascular Medicine
Acute myocardial infarction with a giant left main aneurysm in atypical Kawasaki disease
Min Wook Kim, Hyun Soo Kim, Myung Dong Lee, Hyun Sook Jung, Seong Bo Yoon, Young Woo Kim
Yeungnam Univ J Med. 2017;34(1):106-110.   Published online June 30, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.1.106
  • 3,514 View
  • 9 Download
AbstractAbstract PDF
Kawasaki disease (KD) is an acute vasculitis of small and medium sized arteries. Even many years after onset, aneurysms and stenosis in coronary arteries may lead to an acute myocardial infarction, which is described as atypical or missed KD in childhood. KD is an underlying disease of young adults with acute myocardial infarction. We report on a rare case involving a total occlusion in the proximal left anterior descending coronary artery combined with a giant left main aneurysm in a young adult patient with acute myocardial infarction ascribed to antecedent KD that is undefined but almost certain.
Nephrology
Rapidly resolved IgG4-related retroperitoneal fibrosis after steroid pulse therapy.
Soomin Jeung, Hyosang Kim, Yuri Seo, Hee Young Yoon, Nah Kyum Lee, Shinhee Park, Bomi Seo, Su Yeon Park, Su Kil Park
Yeungnam Univ J Med. 2016;33(1):40-43.   Published online June 30, 2016
DOI: https://doi.org/10.12701/yujm.2016.33.1.40
  • 3,006 View
  • 14 Download
AbstractAbstract PDF
Retroperitoneal fibrosis (RF) is a disorder characterized by the presence of a retroperitoneal mass and concurrent systemic inflammation. Some cases of RF are recognized as belonging to the spectrum of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoids are highly effective for treatment of retroperitoneal fibrosis, although the optimal dose and duration of therapy have not been established. An initial dose of prednisone (40-60 mg) daily is usually administered with a tapering scheme. We report on a 55-year-old man diagnosed with IgG4-related RF and successfully treated with a 3-day course of daily 250 mg (4 mg/kg) intravenous methylprednisolone, which resulted in the prompt resolution of urinary obstruction and systemic symptoms.
Oncology and Cancer Research
Pumpless extracorporeal interventional lung assist for bronchiolitis obliterans after allogenic peripheral blood stem cell transplantation for acute lymphocytic leukemia.
Yeon Hee Park, Chae Uk Chung, Jae Woo Choi, Sang Ok Jung, Sung Soo Jung, Jeong Eun Lee, Ju Ock Kim, Jae Young Moon
Yeungnam Univ J Med. 2015;32(2):98-101.   Published online December 31, 2015
DOI: https://doi.org/10.12701/yujm.2015.32.2.98
  • 3,140 View
  • 5 Download
AbstractAbstract PDF
Bronchiolitis obliterans (BO), which is associated with graft-versus-host disease after allogenic hematopoietic stem cell transplantation, is a major obstacle to survival after bone marrow transplantation due to its gradual progress, eventually leading to respiratory failure. Pumpless extracorporeal interventional lung assist (iLA) is effective in treatment of reversible hypercapnic respiratory failure. In this paper, we present a 23-year-old female patient who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia. After 6 months, she complained of shortness of breath and was diagnosed with BO. Five months later, she developed an upper respiratory tract infection that worsened her BO and caused life-threatening hypercapnia. Since mechanical ventilation failed to eliminate CO2 effectively, iLA was applied as rescue therapy. Her hypercapnia and respiratory acidosis showed significant improvement within a few hours, and she was successfully weaned off iLA after 12 days. This is the first case report of iLA application for temporarily aggravated hypercapnia of PBSCT-associated BO followed by successful weaning. This rescue therapy should be considered in ventilator-refractory reversible hypercapnia in BO patients.
Original Article
Pediatrics, Perinatology, and Child Health
QT dispersion in children with Kawasaki disease.
Bo Kyung Song, Kyoung Sung, Min Jung Cho, Hyoung Doo Lee
Yeungnam Univ J Med. 2014;31(2):94-98.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.94
  • 2,697 View
  • 7 Download
AbstractAbstract PDF
BACKGROUND
We analyzed the changes in QT dispersion (QTd) in children with Kawasaki disease (KD), and determined the presence of repolarization abnormality in these children even in the absence of coronary artery abnormalities. METHODS: Ninety-one children with KD and 20 healthy controls were enrolled in this retrospective study. Serial echocardiographic and electrocardiographic (ECG) measurements in the beginning of treatment, 2nd month and 6th month after the diagnosis were compared. Fifty-one of 91 children had at least 2 serial ECG data. The number of patients who had 3 consecutive ECG data was 23. RESULTS: Among the 67 KD patients with no coronary artery changes, the consecutive mean QTd values were 41.86 ms, 37.84 ms, and 25.47 ms, respectively (26 ms for controls). In the analysis of changes among KD patients without coronary artery abnormalities, QTd showed a significant decrease with time (p=0.01). Especially, the 1st month and the 6th month QTd values were significantly different (p=0.028). The mean QTd values in KD patients with coronary artery changes were significantly higher than those in KD patients with no coronary artery changes at each time (1st, 2nd, and 6th month exam). CONCLUSION: QTd is significantly increased in children during the early stage of KD. Repolarization abnormality may exist during the acute stage of KD, regardless of the echocardiographic changes.
Case Reports
Endocrinology, Diabetes, and Metabolism
Delayed presentation of aggravation of thyrotoxicosis after radioactive iodine therapy at Graves disease.
Ji Hyun Lee, Hyun Jin Na, Jin Woo Park, Cheol Ho Lee, Hyun Jeong Han, Tae Ho Kim, Se Hwa Kim
Yeungnam Univ J Med. 2014;31(2):148-151.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.148
  • 3,221 View
  • 10 Download
AbstractAbstract PDF
Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, <0.08 microIU/L thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.
Nephrology
Spontaneous abdominal intramuscular hematoma in a non-dialysis chronic kidney disease patient under cilostazol therapy.
Seonghui Kang, Hyung Min Yu, Ha Young Na, Young Kyung Ko, Se Woong Kwon, Chae Ho Lim, Sun Woong Kim, Young Il Jo
Yeungnam Univ J Med. 2014;31(2):139-143.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.139
  • 3,295 View
  • 7 Download
AbstractAbstract PDF
Spontaneous intramuscular hematoma of the abdominal wall is a rare condition characterized by acute abdominal pain. It is often misdiagnosed as a surgical condition. It used to be associated with risk factors such as coughing, pregnancy, and anticoagulant therapy. Most cases of abdominal wall hematomas were rectus sheath hematomas caused by the rupture of either the superior or inferior epigastric artery, but spontaneous internal oblique hematoma was extremely rare. In this report, we present a case of spontaneous internal oblique hematoma in a 69-year-old man with non-dialysis chronic kidney disease who was taking cilostazol. The patient complained of abrupt abdominal pain with a painful palpable lateral abdominal mass while sleeping. The abdominal computed tomography showed an 8 cm-sized mass in the patient's left internal oblique muscle. The administration of cilostazol was immediately stopped, and the intramuscular hematoma of the lateral oblique muscle disappeared with conservative management.
Nephrology
Autoimmune thyroiditis with minimal change disease presenting acute kidney injury.
Ji Su Kim, Chi Young Park, Suk Pyo Shin, Yeong Min Lim, Eun Jung Ko, Hyung Jong Kim
Yeungnam Univ J Med. 2014;31(2):127-130.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.127
  • 3,054 View
  • 4 Download
AbstractAbstract PDF
Autoimmune thyroiditis is the most common cause of hypothyroidism in the world. It is characterized clinically by gradual thyroid failure, goiter formation, or both, because of the autoimmune-mediated destruction of the thyroid gland. Renal involvement presenting proteinuria in autoimmune thyroiditis is not uncommon, occurring in 10% to 30% of the cases. Glomerulonephropathy associated with autoimmune thyroiditis, however, is a rare disease. Most reports of autoimmune thyroiditis with glomerulonephropathy have demonstrated a mixed pathological morphology and have been predominantly associated with membranous glomerulopathy. The case of minimal-change disease associated with thyroiditis presenting acute kidney injury is a rare disease that has not been reported in South Korea. Reported herein is the case of a 16-year-old man diagnosed with Hashimoto's thyroiditis, with minimal-change disease presenting acute kidney injury. He revealed hypothyroidism, proteinuria, and impaired renal function. Renal biopsy showed minimal-change disease and minimal tubular atrophy. The patient was treated with thyroid hormone, and his renal function and proteinuria improved. Therefore, for patients with autoimmune thyroiditis presenting unexplained proteinuria, glomerulonephropathy should be ruled out. Conversely, for patients with glomerulonephropathy and persistent proteinuria despite proper treatment, thyroid function and antibody tests should be performed.
Cardiology and Cardiovascular Medicine
Coronary artery vasospasm after atrial septal defect surgery.
Jin Won Yoon, Young Soo Lee, Dong Keun Kim, Young Hoon Choi, Dong Ju Kim, Jae Jin Lee, Hyo Seung Ahn, Wook Hyun Cho
Yeungnam Univ J Med. 2014;31(2):122-126.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.122
  • 2,625 View
  • 3 Download
AbstractAbstract PDF
Coronary vasospasm is one of the fatal complications that may occur in patients undergoing open heart surgery. To date, however, there are not many cases in this series and no definite pathophysiology has been documented. We experienced a case of coronary artery vasospasm after atrial septal defect (ASD) surgery and then successfully treated it with both transbrachial intra-aortic balloon pump and percutaneous cardiopulmonary support. Only several hours after ASD surgery, the patient exhibited the cardiovascular collapse, the ST-segment elevation, followed by ventricular fibrillation and normal coronary angiography findings. It is important to make a differential diagnosis of coronary artery vasospasm in patients presenting with ST-segment elevation who had no notable coronary artery diseases. This case indicates that clinicians should be aware of the possibility that the coronary artery vasospasm may also occur in patients undergoing ASD surgery.
Endocrinology, Diabetes, and Metabolism
Columnar variant of papillary carcinoma in the thyroglossal duct cyst with progression to lung metastasis.
Yujung Yun, Hye Jung Park, Young Ki Lee, Yongin Cho, Beoduel Kang, Hyun Ju Kim, Jung Hee Lee, Moo Nyun Jin, Dong Yeob Shin
Yeungnam Univ J Med. 2014;31(2):103-108.   Published online December 31, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.2.103
  • 2,960 View
  • 6 Download
AbstractAbstract PDF
Thyroglossal duct cyst (TGDC) carcinoma generally shows a favorable prognosis. If metastasis is present latently, it may not threaten the patient's life immediately. It has been shown, however, that larger than 1 cm papillary carcinoma (PC), level VI metastasis to the lymph node (LN), which is the nearest to the thyroid, independently predicts a worse prognosis. In the case presented herein, a 61-year-old female patient was diagnosed with an about 3 cm PC in the TGDC, particularly the columnar variant subtype, one of the aggressive variants. She had occult papillary thyroid microcarcinoma, but no LN metastasis. Even though she underwent the Sistrunk procedure and total thyroidectomy with central compartment neck dissection followed by high-dose radioactive iodine remnant ablation, however, the cancer cells spread to level IV neck LN, and finally to the lung. Therefore, when a patient is diagnosed with an aggressive histologic variant of PC in the TGDC, even without LN metastasis, the invasive surgical approach and close postoperative surveillance are necessary, with consideration of the risk of disease progression. Therefore, if it is possible to stratify the risk for patients, higher-risk patients can be offered a more invasive therapeutic approach.
Dermatology
Fast-growing multiple symmetric lipomatosis.
Jin Hwa Choi, Byung Su Kim, Seung Hyun Sohng, Hyo Jin Lee, Dong Hoon Shin, Jong Soo Choi, Young Kyung Bae
Yeungnam Univ J Med. 2014;31(1):48-51.   Published online June 30, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.1.48
  • 2,351 View
  • 3 Download
AbstractAbstract PDF
Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetrical massive fatty deposits on the face, neck, shoulders, and upper trunk. We report a 74-year-old man who complained of painless subcutaneous nodules on his posterior neck that developed 3 weeks earlier. In a week, variably-sized similar lesions developed on both his shoulders and upper extremities. At the time of his hospital visit, several firm nodules as big as a walnut to a child's fist and with the normal-skin-hue were observed on his posterior neck, both shoulders, upper extremities, and trunk. The histological examination of his upper left arm revealed more mature adipocytes without encapsulation in the subcutaneous tissue. MSL was generally known to occur slowly over months or years. However, this is an unusual case that showed a fast-growing nature.
Review
Differential diagnosis of peripheral vertigo
Differential diagnosis of peripheral vertigo.
Chang Hoon Bae
Yeungnam Univ J Med. 2014;31(1):1-8.   Published online June 30, 2014
DOI: https://doi.org/10.12701/yujm.2014.31.1.1
  • 7,931 View
  • 178 Download
  • 3 Crossref
AbstractAbstract PDF
Dizziness can be classified mainly into 4 types: vertigo, disequilibrium, presyncope, and lightheadedness. Among these types, vertigo is a sensation of movement or motion due to various causes. The main causes of peripheral vertigo are benign paroxysmal positional vertigo (BPPV), acute vestibular neuritis (AVN), and Meniere's disease. BPPV is one of the most common causes of peripheral vertigo. It is characterized by brief episodes of mild to intense vertigo, which are triggered by specific changes in the position of the head. BPPV is diagnosed from the characteristic symptoms and by observing the nystagmus such as in the Dix-Hallpike test. BPPV is treated with several canalith repositioning procedures. AVN is the second most common cause of peripheral vertigo. Its key symptom is the acute onset of sustained rotatory vertigo without hearing loss. It is treated with symptomatic therapy with antihistamines, anticholinergic agents, antidopaminergic agents, and gamma-aminobutyric acid-enhancing agents that are used for symptoms of acute vertigo. Meniere's disease is characterized by episodic vertigo, fluctuating hearing loss, and tinnitus. It is traditionally relieved with life-style modification, a low-salt diet, and prescription of diuretics. However, diagnosis and treatment of the peripheral vertigo can be difficult without knowledge of BPPV, AVN, and Meniere's disease. This article provides information on the differential diagnosis of peripheral vertigo in BPPV, AVN, and Meniere's disease.

Citations

Citations to this article as recorded by  
  • The Effect of Banhabaekchulcheonma-tang on Benign Paroxysmal Positional Vertigo: A Systematic Review Using the CNKI Database
    Gi-hyeon Gwon, Seo-hye Oh, Eun-soo Park, Mi-hyeon Kim, Seung-hyo Hong, Geum-ju Song, Eun-young Park
    The Journal of Internal Korean Medicine.2021; 42(4): 572.     CrossRef
  • Korean Medicine Interventions for Benign Paroxysmal Positional Vertigo: A Systematic Review of Clinical Studies Published in Korea
    Jun-su Jung, Sung-heon Jung, Min-joo Kim, Jang-kyung Park, Kwang-ho Bae, Kyung-hwan Kong, Ho-yeon Ko
    The Journal of Internal Korean Medicine.2017; 38(4): 479.     CrossRef
  • Clinical significance of saccade test, smooth pursuit test, and optokinetic nystagmus test in nystagmography
    Yoon Seok Choi, Hyung Gyun Na, Si Youn Song, Yong Dae Kim, Chang Hoon Bae
    Yeungnam University Journal of Medicine.2017; 34(1): 29.     CrossRef
Case Reports
Rheumatology
A Case of Pseudolymphomatous IgG4-Related Disease Involving the Maxilla.
Min Jung Kim, Seung Il Bae, Hoon Tae Kim, Young Hoon Hong, Hyun Je Kim, Choong Ki Lee, Mi Jin Gu
Yeungnam Univ J Med. 2013;30(2):128-131.   Published online December 31, 2013
DOI: https://doi.org/10.12701/yujm.2013.30.2.128
  • 3,108 View
  • 11 Download
AbstractAbstract PDF
Immunoglobulin G4 (IgG4)-related disease is an inflammatory condition characterized by IgG4 positive plasma cell infiltration. It can affect any organ in the body and mainly involves the pancreas, liver, biliary tracts, orbits, salivary glands and lymph nodes. It can manifest as an inflammatory pseudotumor. Pseudolymphoma as an inflammatory pseudotumor is a group of benign tumors that exhibit histological and clinical features suggestive of malignant lymphoma. Studies on IgG4-related disease are rarely reported, and no case of the disease that involved the maxillary bone and adjacent soft tissue, except for the skin, has been reported. Therefore, we report herein a case of pseudolymphomatous IgG4-related disease that involved the maxilla, with a literature review.
Cardiology and Cardiovascular Medicine
A Case of von Hippel-Lindau Disease with Aortic Valve Insufficiency.
Sang Hyeon Kang, In Chul Park, Duk Song Cho, Hye Jung Lee, Ho Jin Lee, Dong Hyun Lee
Yeungnam Univ J Med. 2013;30(2):101-104.   Published online December 31, 2013
DOI: https://doi.org/10.12701/yujm.2013.30.2.101
  • 2,510 View
  • 4 Download
AbstractAbstract PDF
Von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary disorder caused by a germline mutation of the VHL gene. It is a multi-systemic disorder that is predisposed to benign or malignant tumors of visceral organs such as hemangioblastoma of the central nervous system, renal cell carcinoma, retinal angioma and pheochromocytoma. We report herein a case of VHL disease that initially manifested with aortic valve insufficiency.
Endocrinology, Diabetes, and Metabolism
A Case of Pancytopenia with Hyperthyroidism.
Tae Hoon Kim, Ji Sung Yoon, Byung Sam Park, Dong Won Lee, Jae Ho Cho, Jun Sung Moon, Eui Hyun Kim, Kyu Chang Won, Hyoung Woo Lee
Yeungnam Univ J Med. 2013;30(1):47-50.   Published online June 30, 2013
DOI: https://doi.org/10.12701/yujm.2013.30.1.47
  • 3,695 View
  • 30 Download
  • 4 Crossref
AbstractAbstract PDF
There has been an increase in the number of reports of atypical manifestations of Graves' disease (GD), such as jaundice, anemia, thrombocytopenia and leukopenia. Pancytopenia also rarely occurs in GD. In this paper, a case of pancytopenia with GD that was successfully treated with an anti-thyroid drug is reported. In this case, a 69-year-old woman showed pancytopenia with a normal peripheral blood smear, bone marrow aspiration smear and bone marrow biopsy. Her thyroid function test and thyroid scintigraphy confirmed her hyperthyroid status. Her laboratory abnormality and clinical condition improved after she was treated with an anti-thyroid drug. This is a rare case of pancytopenia associated with GD.

Citations

Citations to this article as recorded by  
  • Rare Autoimmune Pancytopenia Due to Graves Disease
    Ally W Wang, Geeti Mahajan, Aaron Etra, Shira R Saul
    JCEM Case Reports.2025;[Epub]     CrossRef
  • Therapeutic plasma exchange for Graves’ disease in pregnancy
    Matthew Lumchee, Mimi Yue, Josephine Laurie, Adam Morton
    Obstetric Medicine.2023; 16(2): 126.     CrossRef
  • Non-myeloproliferative Pancytopenia: A Rare Presentation of Thyrotoxicosis
    Izzathunnisa Rahmathullah, Maheswaran Umakanth, Suranga Singhapathirane
    Cureus.2023;[Epub]     CrossRef
  • Atypical Complications of Graves’ Disease: A Case Report and Literature Review
    Khaled Ahmed Baagar, Mashhood Ahmed Siddique, Shaimaa Ahmed Arroub, Ahmed Hamdi Ebrahim, Amin Ahmed Jayyousi
    Case Reports in Endocrinology.2017; 2017: 1.     CrossRef
Pediatrics, Perinatology, and Child Health
A Case of Hemolytic Disease of a Newborn by an Anti-Di(a) Antibody Treated with Intravenous Immunoglobulin.
Chang Eon Lee, Su Jin Park, Won Duck Kim
Yeungnam Univ J Med. 2013;30(1):21-24.   Published online June 30, 2013
DOI: https://doi.org/10.12701/yujm.2013.30.1.21
  • 3,365 View
  • 6 Download
AbstractAbstract PDF
Hemolytic disease in a newborn that causes early jaundice is common. It is often due to the Rh (D) and ABO incompatibility, but rarely due to unexpected antibodies. Among these unexpected antibodies, the anti-Di(a) antibody rarely occurs. The anti-Di(a) antibody was observed in the serum and red-cell eluate of an infant, and in the serum of his mother. The frequency of the appearance of the Di(a) antigen in the Korean population is estimated to be 6.4-14.5%. This paper reports a case of hemolytic disease in a newborn associated with the anti-Di(a) antibody. A full-term male infant was transferred to the authors' hospital due to hyperbilirubinemia the day after his birth. The laboratory data indicated a hemoglobin value of 11.6 g/dL, a reticulocyte count of 10.6%, a total bilirubin count of 14.4 mg/dL, a direct bilirubin count of 0.6 mg/dL, and a positive result in the direct Coombs' test. Due to the identification of an irregular antibody from the maternal serum, an anti-Di(a) antibody was detected, which was also found in the eluate made from the infant's blood. The infant had been treated with phototherapy and intravenous immunoglobulin since the second day after his birth and was discharged due to an improved condition without exchange transfusion. Therefore, in cases of iso-immune hemolytic disease in a newborn within 24 hours from birth who had a negative result in an antibody screening test, the conduct of an anti-Di(a) antibody identification test is recommended due to the suspicion of an anti-Di(a) antigen, followed by early administration of intravenous immunoglobulin.
Cardiology and Cardiovascular Medicine
Superior Vena Cava Syndrome Without Thrombosis Found in Behcet's Disease.
Hyun Soo Kim, Hyung Jun Kim, Ki Hwan Hur, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang
Yeungnam Univ J Med. 2012;29(1):38-41.   Published online June 30, 2012
DOI: https://doi.org/10.12701/yujm.2012.29.1.38
  • 3,047 View
  • 4 Download
  • 1 Crossref
AbstractAbstract PDF
Behcet's disease is a rare multisystemic disorder whose main pathological defectis vasculitis, and superior vena cava (SVC) syndrome without thrombosis is a very rare manifestation of the disease. These authors encountered a case of SVC syndrome without thrombosis caused by Behcet's disease. A 33-year-old man visited the hospital for aggravated dyspnea without any related medical and familial history. He had a three-day history of abrupt swelling of the face, neck, and right arm. He suffered from recurrent oral ulcer, and there were acneiform nodules on his face as well as redness and swelling at the site of the intravenous injection. On the multi-detected computed tomography (CT) chest angiograms (chest angio MDCT), the SVC narrowed without thrombosis. Venogram was carried out, and percutaneous transluminal balloon angioplasty of the SVC stenotic site was performed. The following day, the swelling was found to have subsided. The details of the case are reported herein.

Citations

Citations to this article as recorded by  
  • Recurrent onycholysis in a patient with Behcet's disease
    Hyeon Seok Kim, Dong Seok Lee, Seung Hwan Lee, Woo Hyuk Kwon, Yun Jeong Kim
    Yeungnam University Journal of Medicine.2016; 33(1): 56.     CrossRef
Endocrinology, Diabetes, and Metabolism
A Case of Rifampin-Induced Recurrent Adrenal Insufficiency During the Treatment of Pulmonary Tuberculosis in a Patient with Addison's Disease.
Jong Sik Kang, Gwang Beom Ko, Jae June Lee, Minsoo Kim, Sung Jin Jeon, Gwang Hyeon Choi, Sun Mok Kim, Woo Je Lee
Yeungnam Univ J Med. 2012;29(1):19-23.   Published online June 30, 2012
DOI: https://doi.org/10.12701/yujm.2012.29.1.19
  • 3,745 View
  • 33 Download
AbstractAbstract PDF
Adrenal insufficiency during the treatment of pulmonary tuberculosis is a troublesome condition and can at times be lifethreatening if untreated. Rifampin is one of the most widely prescribed anti-tuberculosis agents. Furthermore, rifampin has been known to be capable of affecting the metabolism of various medications, including glucocorticoids. In this paper, a case of recurrent adrenal insufficiency induced by rifampin during the treatment of pulmonary tuberculosis is reported. The patient was a 63-year-old man who was diagnosed with Addison's disease 17 years earlier and had been undergoing glucocorticoid replacement therapy. Five months before, the patient manifested pulmonary tuberculosis and was immediately given anti-tuberculosis medication that included rifampin. After one week of medication, general weakness and hyponatremia occurred. Despite the increased dose of the glucocorticoid medication, the adrenal insufficiency recurred many times. Since the substitution of levofloxacin for rifampin, the episodes of adrenal insufficiency have not recurred so far.
Nephrology
Two Cases of Severe Pancytopenia Associated with Low-Dose Methotrexate Therapy in Patients with Chronic Kidney Disease and Rheumatoid Arthritis.
Hong Ik Kim, Woo Hyun Lee, Jang Seok Oh, Hyo Rim Hong, In Hee Lee
Yeungnam Univ J Med. 2011;28(1):60-69.   Published online June 30, 2011
DOI: https://doi.org/10.12701/yujm.2011.28.1.60
  • 2,493 View
  • 7 Download
AbstractAbstract PDF
Due to its efficacy and tolerability, low dose oral methotrexate(MTX) therapy has been widely used for treatment of rheumatoid arthritis(RA). However, it can rarely cause serious, life-threatening hematologic toxicities, such as pancytopenia. We report here on two patients with chronic kidney disease(CKD), who developed severe pancytopenia after 5 years (cumulative dose 1,240mg) and 4 years(cumulative dose 1,320mg) of low dose MTX therapy for treatment of RA, respectively. Both patients presented with renal insufficiency, hypoalbuminemia, concurrent use of nonsteroidal anti-inflammatory drugs, and elevated mean corpuscular volume of red blood cells(RBCs), all of which are known as risk factors of MTX-induced pancytopenia. Despite receiving treatment, which included RBC and platelet transfusions, antibiotic therapy, granulocyte colony stimulating factor, and leucovorin rescue, one patient died of sepsis. Based on our case study, prompt investigation of risk factors associated with MTX toxicity is required for all patients receiving MTX therapy. MTX treatment, even at a low dose, should be discontinued in patients with advanced CKD.
Reumatology
A Case of Systemic Lupus Erythematosus Misdiagnosed as Adult-onset Still's Disease.
Myung Jin Oh, Hyun Je Kim, Han Sol Lee, Ji An Hur, Young Hoon Hong, Choong Ki Lee
Yeungnam Univ J Med. 2010;27(1):78-84.   Published online June 30, 2010
DOI: https://doi.org/10.12701/yujm.2010.27.1.78
  • 3,728 View
  • 57 Download
AbstractAbstract PDF
Adult-onset Still's disease (AOSD) is an inflammatory disorder that's characterized by daily, spiking high fever, arthritis and an evanescent, salmon-pink rash. AOSD is diagnosed purely on the basis of the typical clinical features of the illness. The symptoms commonly include swelling of the lymph nodes, enlargement of the spleen and liver, and a sore throat. AOSD is difficult to differentiate from systemic lupus erythematosus (SLE) due to the similar clinical manifestations. We report here on a case of a 16-year-old female patient with autism and epilepsy and who complained of daily spiking fever for 20 days. The patient had maculopapular skin rashes on the face and whole body and lymphadenopathy. The liver function tests were elevated mildly. The initial rheumatoid factor (RF) and antinuclear antibody (ANA) tests were negative. We diagnosed her as having adult-onset Still's disease according to the criteria of Yamaguchi. We successfully treated her with oral prednisolone. But her antinuclear antibody test was changed to positive after discharge. So we finally diagnosed her as having SLE.
Anesthesiology and Pain Medicine
Anesthetic Management of a Patient with Alexander's Disease: Case Report.
Bum Soo Kim, Dae Lim Jee, Sun Ok Song
Yeungnam Univ J Med. 2010;27(1):47-51.   Published online June 30, 2010
DOI: https://doi.org/10.12701/yujm.2010.27.1.47
  • 2,591 View
  • 64 Download
AbstractAbstract PDF
We present here the case of a 13-year-old male patient with Alexander's disease who underwent surgical correction of a femur fracture. Alexander's disease is a rare and fatal disorder that affects the white matter in the brain and it causes developmental delay, psychomotor regression, spasticity, megaloencephaly and seizure. The patient had the possibility of a seizure attack during the perioperative period. We discuss the anesthetic management of a patient with Alexander's disease and we review the relevant literature.
Anesthesiology and Pain Medicine
Anesthetic Management of a Patient with Kimura's Disease.
Eun Ji Choi, Sang Jin Park
Yeungnam Univ J Med. 2009;26(1):38-43.   Published online June 30, 2009
DOI: https://doi.org/10.12701/yujm.2009.26.1.38
  • 2,682 View
  • 9 Download
AbstractAbstract PDF
Kimura's disease is an idiopathic chronic condition, associated with a high-titer of IgE and peripheral eosinophilia. It frequently presents as a solitary or multiple lesions in the head and neck area. During the perioperative period, anesthesiologists should understand the anatomical structures of the patient who has Kimura's disease involvement of the head and neck, especially the airway. It is important to pay attention to the occurrence of signs and symptoms of acute allergic reactions related to a high-titer of IgE and eosinophilia. We report our experience with anesthetic management in an 18-year-old patient with multiple neck masses due to Kimura's disease.
Review
Nuclear Medicine
Clinical Application of Cardiac Hybrid Imaging in Coronary Artery Disease.
Ihn Ho Cho, Eun Jung Kong
Yeungnam Univ J Med. 2009;26(1):15-23.   Published online June 30, 2009
DOI: https://doi.org/10.12701/yujm.2009.26.1.15
  • 2,349 View
  • 4 Download
AbstractAbstract PDF
Constant technological developments in coronary artery disease have contributed to the assessment of both the presence of coronary stenosis and its hemodynamic consequences. Hence, noninvasive imaging helps guide therapeutic decisions by providing complementary information on coronary morphology and on myocardial perfusion and metabolism. This can be done using single photon emission computed tomography(SPECT) or positron emission tomography(PET) and multidetector CT(MDCT). Advances in image-processing software and the advent of SPECT/CT and PET/CT have paved the way for the combination of image datasets from different modalities, giving rise to hybrid imaging. Three dimensional cardiac hybrid imaging helped to confirm hemodynamic significance in many lesions, add new lesions such as left main coronay artery disease, exclude equivocal defects, correct the corresponding arteries to their allocated defects and identify culprit segment. Cardiac hybrid imaging avoids the mental integration of functional and morphologic images and facilitates a comprehensive interpretation of coronary lesions and their pathophysiologic adequacy by three dimensional display of fused images, and allows the best evaluation of myocardial territories and the coronary-artery branches that serve each territory. This integration of functional and morphological information were feasible to intuitively convincing and might facilitate developmnt of a comprehensive non-invasive assessment of coronary artery disease.
Case Report
Pediatrics, Perinatology, and Child Health
Pediatric Crohn's Disease presenting as Severe Constipation and Abdominal Distension.
Myong Soon Sung, Seok Jeong Kang, Kwang Hae Choi
Yeungnam Univ J Med. 2008;25(2):139-144.   Published online December 31, 2008
DOI: https://doi.org/10.12701/yujm.2008.25.2.139
  • 3,050 View
  • 10 Download
  • 1 Crossref
AbstractAbstract PDF
Crohn's disease is a chronic inflammatory bowel disease that mainly affects children and young adults. Its cause remains unknown. The incidence of pediatric Crohn's disease is increasing, so it is important for clinicians to be aware of the presentation of this disease in the pediatric population. The majority of patients complain of abdominal pain (72%), with only 25% presenting with the 'classical triad' of abdominal pain, weight loss, and diarrhea. Many children with Crohn's disease present in a 'non-classical' manner, with vague complaints such as lethargy or anorexia, which may be associated with only mild abdominal discomfort. Other symptoms include fever, nausea, vomiting, growth retardation, malnutrition, delayed puberty, psychiatric symptoms, arthropathy, and erythema nodosum. Severe constipation and abdominal distension are uncommon symptoms at diagnosis. We report a case of pediatric Crohn's disease, which was diagnosed after the patient presented with severe constipation and abdominal distension.

Citations

Citations to this article as recorded by  
  • Type 1 Dolichocolon as a Potential Anatomic Co-morbidity in Children with Perianal Crohn’s Disease
    Richard Kellermayer, Réka G. Szigeti, Marla Sammer, Adam M. Vogel, Harland S. Winter
    Digestive Diseases and Sciences.2026;[Epub]     CrossRef
Original Articles
Dentistry
Oral Condition in Cardiovascular Disease Patients
Sung-Pyo Hong, Eun-Young Park, Hee-Kyung Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S598-605.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S598
  • 2,617 View
  • 9 Download
  • 1 Crossref
AbstractAbstract PDF
The main purpose of this study was to provide primary informations for developing dental health program which must be necessary for cardiovascular disease patients. To conduct this study we analyses the oral health condition of cardiovascular disease patients through oral examination (DMFT index, periodontal index, oral hygiene status) and evaluate oral health behavior through questionnaires survey April 2006 to June 2006. For patients group, we select 50 cardiovascular disease patients who have hypertension, hyperlipidemia, atherosclerosis or myocardial infarction by taking the health examination for the local insured which National Health Insurance Corporation carried out at Sungju area in Gyeongsangbuk-do. And for the controls, we select 50 persons who have normal healthy condition and match the age and sex to patients group. This study showed that DMFT mean values in cardiovascular disease patients were significantly higher than that in controls (p<0.05). Decay teeth index and Filling teeth index did not differ statistically between two groups but the mean Missing teeth index was significantly higher in cardiovascular disease patients than that in controls (p<0.05). PI (Periodontal Index) mean values were significantly higher in cardiovascular disease patients than in the controls(p<0.01). In the cardiovascular disease patients, the M component of the DMFT index was found to be higher as compared to the controls. Cardiovascular disease patients lose their teeth mainly due to periodontal disease, which is supported by the increased PI mean values.

Citations

Citations to this article as recorded by  
  • A study on the general health status related hypertension and oral health status of rural elder
    Hyun-Ja Jeong, Ae-Hwa Jaung, Hye-Jin Kim
    Journal of the Korea Academia-Industrial cooperation Society.2011; 12(11): 4852.     CrossRef
Gastroenterology and Hepatology
Does Ulcerative Proctitis Progress to Extensive Colitis Depending on Treatment?
Youn Sun Park, Byung Ik Jang, Tae Nyeun Kim
Yeungnam Univ J Med. 2007;24(2 Suppl):S384-390.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S384
  • 2,473 View
  • 9 Download
AbstractAbstract PDF
Background
:The incidence of Ulcerative colitis (UC) in Korea are low compared with those of Western countries, but have been increasing rapidly during the past decades. Clinical characteristics of UC in Asian population are not well recognized. Therefore we investigated the clinical course of UC in Korea. Material and Methods:We retrospectively analyzed 211 UC patients first diagnosed and long term follow up colonoscopic examined at Yeungnam University Medical Center between 1989 and 2006. We reviewed extension of lesion by follow up endoscopic finding and symptom depend on treatment.
Results
:The male to female ratio was 1 : 1.1 and the median age at diagnosis was 46.0 years (range, 17-83 years). At diagnosis, proctitis was noted in 70 patients (33.2%), proctosigmoiditis in 40 (19%), left-sided colitis in 22 (10.4%), extensive colitis in 79 (37.4%). Further extension in the colon was most frequently observed in patients with proctitis (22.8%). In the patients initially diagnosed with proctitis, 28.6% of the patients were not taking any kind of medication for UC and 54 patients (77%, treatment group 34 patients, untreatment group 20) had not progressed during the observation period (56 months, range 2-193 months). The maximal extent of the disease was not affected by treatment (P = 0.99).
Conclusion
:The initial extent of the disease in Korean UC patients was similar to that found in other Western studies. In the present study, most of limited UC(proctitis, proctosigmoiditis, 77-82%) did not progress to extensive colitis regardless of treatments, but large scale multicenter analysis was needed.
Thoracic and Cardiovascular Surgery
Comparison of Postoperative Results after Pneumonectomy between Lung Cancer and Infectious Lung Disease Groups
Jang Hoon Lee, Jung Cheul Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S304-309.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S304
  • 1,753 View
  • 2 Download
AbstractAbstract PDF
Background
:Pneumonectomy has been known with higher rate of morbidity and mortality. Thereby, we evaluated patients who received pneumonectomy for lung cancer and infectious lung disease related to postoperative morbidity and mortality. Materials and methods:The retrospective study was undertaken in 55 patients who had undergone pneumonectomy at Yeungnam University Hospital from January 1996 to December 2004. We devided into two groups, lung cancer group (group A, n=40) and infectious lung disease group (group B, n=15) and then compared and analyzed.
Results
:The mean age was higher in group A and there was statistical significance (60.8 9.4 vs 45.7 12.1, p<0.001). With preoperative pulmonary function test, FEV1, FVC were higher in group A and there were statistical significane (p<0.001, p=0.006). With preoperative lung perfusion scan, the perfusion ratio of affected lung and postoperative predicted FEV1 were higher in group A and there were statistical significance (p<0.001, p=0.007). According to MRC dyspnea scale, change of respiratory difficulty of group A had statistical significance (p<0.001). There were a total 20 postoperative complications (36.4%) of which arrhythmia 7, postoperative bleeding 5, empyema and/or bronchopleural fistula 3, pneumonia 2, adult respiratory distress syndrome 1, vocal cord palsy 1. The postoperative complication rate was no difference between two groups (37.5% vs 33.3%) but arrhythmia developed in group A only. There were 3 postoperative mortalities, all in group A.
Conclusion
:Preoperative pulmonary function test and postoperative predicted FEV1 were lower in group B, however, postoperative complication rate was no difference between two groups and mortality developed in group A only. Because of lesser resected lung volume and well adopted in long term diseased period, there was lesser hemodynamic change in infectious lung disease. So postoperative mortality not developed in infectious lung disease group due to arrhythmia and respiratory failure.
Review Articles
Radiology, Radiotherapy & Diagnostic Imaging
Ultrasonography of the Scrotum
Bok Hwan Park, Jae Ho Cho
Yeungnam Univ J Med. 2007;24(2 Suppl):S24-35.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S24
  • 2,039 View
  • 4 Download
AbstractAbstract PDF
Ultrasonography is an important imaging tool in the evaluation of the scrotal structures and various scrotal disorders because of excellent anatomic resolution, easy and speedy applicability, and safety with no inonizing radiation. Furthermore, a blood flow information can be obtained by the use of color Doppler ultrasonography and spectral waveform analysis. It plays a primary role in the detection, characterization, and localization of scrotal masses and fluid collections. Knowledge of characteristic imaging findings enables appropriate, expeditious evaluation of various scrotal disorders. The objective of this article is to familiarize the reader with the ultrasonographic features of various scrotal disorders.
Gastroenterology and Hepatology
Clinical Update: Inflammatory Bowel Disease
Byung Ik Jang
Yeungnam Univ J Med. 2007;24(2 Suppl):S221-233.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S221
  • 2,548 View
  • 3 Download
  • 1 Crossref
AbstractAbstract PDF
Inflammatory bowel disease(IBD) which is well known as Crohn’s disease and ulcerative colitis is a chronic disorder that repeats improvement and exacerbation. The possible causes of the disease are environmental factors, genetic factors and immune deficiency resulted from bacterial infection. Recently, IL-23 is proved to be a main cytokine which has a central role in Crohn’s disease. The diagnosis of IBD is made by clinical manifestation, serologic test, endoscopic finding and histologic finding. The mainstay of remission and maintenance therapy of ulcerative colitis is 5-aminosalicylate(5-ASA). Steroid can be used in severe or refractory case and nowadays, budesonide shows a good effect with minimal side effects. In cases of steroid dependent, we can use the immunomodulators such as azathioprine, cyclosporin and 6-thioguanine. The cytokine associated with inflammation of IBD has been emphasized and the treatment which targets the cytokine such as tumor necrosis factor is tried. Infliximab and adalimumab block tumor necrosis factors-a and they are proved the efficacy by many clinical trial. Leukocytapheresis(LCAP) is tried in ulcerative colitis since 1980 in Japan. When we treat IBD patients, we need to consider all the things such as safety, side effects and economy of the patients. We expect that the development of new biologic agent which is more cost effective and more effect with more convinience.

Citations

Citations to this article as recorded by  
  • Inflammatory Bowel Disease and Cytokine
    Eun Young Choi, Kwang Keun Cho, In Soon Choi
    Journal of Life Science.2013; 23(3): 448.     CrossRef
Radiology, Radiotherapy & Diagnostic Imaging
Radiological Diagnosis of Adrenal Diseases
Jae Ho Cho
Yeungnam Univ J Med. 2007;24(2 Suppl):S170-185.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S170
  • 2,041 View
  • 2 Download
AbstractAbstract PDF
Adrenal glands are relatively small than other upper abdominal solid organs but they are affected by complex physiologic and neoplastic processes. In the past, normal adrenal gland and small adrenal masses are difficult to examine because adrenal gland is small and located deeply in the abdominal cavity. However, by the recent remarkable advance of the MR and CT machines and imaging techniques detection of normal adrenal gland and detection and differential diagnosis of various adrenal lesions are possible. And so radiology is playing a critical role in not only the detection of adrenal abnormalities but in characterizing them as benign or malignant. In the diagnosis of adrenal lesions, various imaging modalities are used including, ultrasonography, CT, MR imaging and nuclear medicine imaging. Ultrasonography plays a role as a screening imaging modality. CT is the imaging modality of choice for both detection and characterization of adrenal masses. MR imaging is a problem solving modality in cases of inconclusive or insufficient on CT. The purpose of this article is to give an overview of adrenal diseases and their imaging appearances and describe the current concepts of differentiating a benign from a malignant adrenal mass.
Neurology
Diagnosis and Treatment of Parkinson's Disease Dementia : An Update
Mee Young Park
Yeungnam Univ J Med. 2007;24(2 Suppl):S159-169.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S159
  • 2,584 View
  • 18 Download
AbstractAbstract PDF
Dementia in the Parkinson’s disease has been increasingly recognized especially in old age. And akinetic-rigid symptoms or cognitive impairment at onset of Parkinson’s disease (PD) are also high risk factors for dementia. However, there have been no gold standard guideline in order to identify the Parkinson’s disease dementia (PDD). Recently, the Movement Disorder Society developed a new diagnostic criteria for PDD in December 2007. I introduce a new PDD diagnostic criteria proposal with a review of treatment strategy of PDD. After the sensitivity and specificity of these criteria ascertained, a revision may be need. But they promising clinical and prospective research baselines in the future.
Microbiology
Platelet Activating Factor-Acetylhydrolase
Tae-Yoon Lee
Yeungnam Univ J Med. 2007;24(2 Suppl):S142-151.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S142
  • 1,928 View
  • 5 Download
AbstractAbstract PDF
Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.
Review
Surgery
Hirschsprung's Disease.
Nam Hyuk Lee
Yeungnam Univ J Med. 2007;24(1):11-23.   Published online June 30, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.1.11
  • 2,553 View
  • 5 Download
AbstractAbstract PDF
Hirschsprung's disease is one of the most common causes of intestinal obstruction in neonates and infants. The underlying pathology of this disease is the absence of the ganglion cells in both the myenteric (Auerbach's) plexus and the submucosal (Meissner's) plexus. Since Hirschsprung's report in 1886, there have been thousands of papers on Hirschsprung's disease but the cause of the absence of the ganglion cells has not been identified. Hirschsprung's disease can be successfully treated with the Swenson, the Duhamel, and the Soave operations even though the pathogenesis is unknown. With the recent progress of molecular biology and genetics, a more detailed approach to the pathogenesis of Hirschsprung's disease can be undertaken. In addition, there have been recent developments in the surgical approach. In this review, recent advances in surgery for Hirschsprung's disease are presented.
Case Report
Cardiology and Cardiovascular Medicine
A Case of Glycogen Storage Disease with Hypertrophic Cardiomyopathy.
Dong Hee Kim, Sang Wook Kang, Won Jong Park, Kyoung Ae Jang, Joon Hyuk Choi, Woong Kim, Sang Hee LEE, Geu Ru Hong
Yeungnam Univ J Med. 2006;23(2):252-257.   Published online December 31, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.2.252
  • 2,551 View
  • 5 Download
AbstractAbstract PDF
Glycogen storage diseases are a heterogeneous group of metabolic disorder affecting multiple organ system: liver, skeletal muscle, heart and brain. Clinical features include: short status, hepatomegaly, hypoglycemia, dyslipidemia and rare involvement of the myocardium except in the case of type III, glycogen storage diseases with hypertrophic cardiomyopathy in adult, which is extremely rare. We treated a case of hypertrophic cardiomyopathy with hepatomegaly that was unknown etiology. The patient was diagnosed as having glycogen storage disease. This 46-year old women was transferred with dyspnea on exertion and abnormal LFTs. She was diagnosed with hypertrophic cardiomyopathy by echocardiography but there was no specific cause for hypertrophic cardiomyopathy. A liver biopsy was performed. The result showed glycogen storage disease possible type III, IV or IX. In conclusion, patients with hypertrophic cardiomyopathy of unknown etiology and abnormal LFTs should be evaluated for glycogen storage disease.
Original Article
Gastroenterology and Hepatology
The Usefulness of Capsule Endoscopy in Diagnosis of Small Bowel Diseases.
Jong Ryul Eun, Byung Ik Jang
Yeungnam Univ J Med. 2006;23(1):45-51.   Published online June 30, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.1.45
  • 2,414 View
  • 1 Download
AbstractAbstract PDF
BACKGROUND
This study was conducted to evaluate the usefulness of capsule endoscopy (CE) for the diagnosis of small bowel diseases. MATERILAS AND METHODS: We reviewed the medical records of 66 patients (mean age: 52.1 years, male/female: 39/27), who underwent CE at Yeungnam University Hospital from August 2003 to March 2006. RESULTS: Suspicious gastrointestinal (GI) bleeding presenting as anemia or history of gross bleeding was the most common reason to perform CE (71.2%). Other indications included GI symptoms (21.2%) such as abdominal pain/discomfort, nausea, diarrhea, and others (7.6%). In studies performed for GI bleeding (n=47), ulcer/erosion was the most common finding (n=22, 46.8%) followed by tumor (n=5, 10.6%), angiodysplasia (n=3, 6.4%), polyp (n=3, 6.4%), active bleeding (n=1, 2.1 %), ulcer with stenosis (n=1, 2.1%), and normal findings (n=12, 25.5%). Of these, a bleeding focus was detected in 32 cases (68.1%) undergoing CE studies. Among 14 patients with GI symptoms, only two patients had typical findings related with symptoms. Surgical resection was performed in five cases with tumor. Of these, four were diagnosed as gastrointestinal stromal tumor and the other one was a lymphangioma. There were no complications associated with the CE procedure. CONCLUSION: Capsule endoscopy is a safe, noninvasive diagnostic tool for small bowel diseases and may be useful for the diagnosis of small bowel hemorrhage including obscure bleeding. However, further studies are needed to confirm its utility for abdominal symptoms other than hemorrhage because of the low diagnostic yield.
Case Reports
Gastroenterology and Hepatology
Colon Cancer in Behcet's Disease.
Ji Eun Lee, Jang Won Sohn, Kyu Hyung Lee, Youn Sun Park, Kook Hyun Kim, Jae Won Choi, Jong Ryul Eun, Byung Ik Jang, Tae Nyeun Kim
Yeungnam Univ J Med. 2006;23(1):124-130.   Published online June 30, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.1.124
  • 3,340 View
  • 8 Download
  • 2 Crossref
AbstractAbstract PDF
Behcet's disease has rarely been reported in association with malignant diseases. In most cases the autoimmune nature of the disease itself or immunosuppressive drug use has been blamed for malignant transformation. Solid tumors in addition to lymphoid and hematological malignancies are also seen during the course of Behcet's disease. We present here a case of colon cancer in a 40-year-old man with Behcet's disease. A near total colectomy was performed and postoperative chemotherapy and radiotherapy was administered to treat visceral peritoneal invasion. Recurrent evidence was not found. We present the clinical details of this rare case of colon cancer with Behcet's disease.

Citations

Citations to this article as recorded by  
  • Cancer colique au cours de la maladie de Behçet
    S. Bouomrani, H. Baïli, K. Souid, I. Kilani, M. Beji
    Journal Africain d'Hépato-Gastroentérologie.2016; 10(1): 1.     CrossRef
  • Morbidity of Solid Cancer in Behçet's Disease: Analysis of 11 Cases in a Series of 506 Patients
    So Young Na, Jaeyoung Shin, Eun-So Lee
    Yonsei Medical Journal.2013; 54(4): 895.     CrossRef
Neurology
A Family of Dentatorubropallidoluysian Atrophy.
Ji Yoon Chung, Mee Young Park, Jun Lee, Jun Pil Yoon, Hyun Jung Park
Yeungnam Univ J Med. 2006;23(1):118-123.   Published online June 30, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.1.118
  • 2,190 View
  • 4 Download
AbstractAbstract PDF
Dentatorubropallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder usually inherited in an autosomal dominant pattern. DRPLA has been shown to be associated with expansion of an unstable cytosine-adenine-guanine (CAG) trinucleotide repeat in a gene on chromosome 12p. We evaluated a family with DRPLA that affected three members; A 35-year-old female presented with seven year history of gait ataxia, dysarthria and mild cognitive impairment. The MRI of the brain revealed diffuse cerebellar atrophy with an incidental lipoma in the midbrain. Her 30-year-old brother presented with progressive cerebellar ataxia that developed at the age of 20. Her grandmother and mother were reported to have developed ataxia during the late period of their life, and died at the age of 60 and 55, respectively. The demonstration of an expanded CAG repeat in the gene for DRPLA was used to confirm the diagnosis.
Review
Pulmonary and Respiratory Medicine
Nutritional Management in Patients with Chronic Obstructive Pulmonary Disease.
Kwan Ho Lee
Yeungnam Univ J Med. 2004;21(2):133-142.   Published online December 31, 2004
DOI: https://doi.org/10.12701/yujm.2004.21.2.133
  • 3,495 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
Chronic obstructive pulmonary disease (COPD) is characterized by a not entirely reversible limitation in the airflow. An airflow limitation is progressive and associated with an abnormal inflammatory response of the lung to gases and harmful particles. In COPD, the weight loss is commonly observed and there is a negative impact on the respiratory as well as skeletal muscle function. The pathophysiological mechanisms that result in weight loss in COPD are not fully understood. However, the mechanisms of weight loss in COPD may be the result of an increased energy expenditure unbalanced by an adequate dietary intake. The commonly occurring weight loss and muscle wasting in COPD patients adversely affect the respiratory and peripheral muscle function, the exercise capacity, the health status, and even the survival rates. Therefore, it is very valuable to include management strategies that the increase energy balance in order to increase the weight and fat free mass. A Better understanding of the molecular and cellular pathological mechanisms of COPD can improve the many new directions for both the basic and clinical investigations. The Nutritional supply is an important components of a multidisciplinary pulmonary rehabilitation program. Future studies combining an exercise program, the role of anabolic steroids, nutritional individualization, a more targeted nutritional therapy, and the development of new drugs including anti-cytokines is needed for the effective management of COPD.

Citations

Citations to this article as recorded by  
  • Nutrient intake and dietary quality of Korean adults according to chronic obstructive pulmonary disease (COPD): Based on the 2012~2014 Korea National Health and Nutrition Examination Survey
    Bo Mi Kang, Hae Ryun Park, Young Mi Lee, Kyung Hee Song
    Journal of Nutrition and Health.2017; 50(6): 585.     CrossRef
Case Report
Neurology
Neuro-Behcet's Disease Presented with Cerebral Venous Sinus Thrombosis: A Case Report.
Yun Kyung Lee, Mee Young Park, Seung Hyun Lee, Sung Gyun Joo, Yong Kook Cho
Yeungnam Univ J Med. 2004;21(1):96-100.   Published online June 30, 2004
DOI: https://doi.org/10.12701/yujm.2004.21.1.96
  • 3,198 View
  • 3 Download
AbstractAbstract PDF
Behcet's disease is a chronic, relapsing multisystem disorder, that may develop into variable neurological manifestations. They include vascular and parenchymal involvement. Vascular involvement is dominated by cerebral venous sinus thrombosis marked by benign intracranial hypertension. Cerebral venous sinus thrombosis can present with all the classical criteria for idiopathic intracranial hypertension, including normal brain CT findings with normal CSF content. But brain MRI is a useful diagnostic method in this situation to confirm the presence of cerebral venous sinus thrombosis. We experienced a case of raised intracranial pressure in a 21-year-old man, caused by cerebral venous sinus thrombosis. We disclosed his symptoms and signs thus fulfilling the diagnostic criteria for Behcet's disease.
Original Articles
Social and Family Medicine
The Relationship Between Adiposity and Risk factors for Cadiovascular Disease at Normal Body Weight Male.
Woo Sung Kwon, Jun Su Kim, Jin Wook Chae, Keun Mi Lee, Seung Pil Jung, Yong Moon
Yeungnam Univ J Med. 2003;20(1):62-70.   Published online June 30, 2003
DOI: https://doi.org/10.12701/yujm.2003.20.1.62
  • 2,242 View
  • 6 Download
AbstractAbstract PDF
BACKGROUND
Most of all studies about the relation between the health risk and obesity are based on the European and American data. The purpose of this study is to examine the relation between adiposity and risk factors for cardio vacular disease (CVD) in normal weight individuals. MATERIALS AND METHODS: Normal weight subjects with a body mass index (BMI) between 18.5 and 23 kg/m2 (76 subjects) and overweight subjects with a BMI between 23 and 25 kg/m2 (53 subjects) were retained for this study. Normal weight subjects were divided into three group of each adiposity variable, then three group and the overweight group were evaluated for the presence of CVD risk factors and analyze the correlation coefficients between adiposity variables and risk factors controlled for age in normal weight, overweight groups. Using logistic regression analysis, the odds ratio (OR) for the prevalence of risk factors for each group of adiposity variables and the overweight group was estimated relative to the first group in normal weight subjects. RESULTS: Systolic BP, diastolic BP, LDL cholestrol, HDL cholesterol, triglycerides in normal weight subjects were significantly correlated with all adiposity variables (P<0.01). Third group (3.7 for %fat and 4.7 for fat mass)of adiposity variables in the normal weight group and the overweight group (6.6 for %fat and 11.5 for fat mass) tended to have higher ORs compared to first group for risk factor variables. CONCLUSION: Normal weight subjects with elevated adiposity had higher prevalence of risk factors than normal weights subjects with less adiposity. Measuring of adiposity added additional information of cardiovascular disease risk factors in normal weight subjects.
Dentistry
Clinical Evaluation about the Immediate Implant Replacement after Tooth Extraction.
Eun Young Yang, Sang Deuk Chun, Jae Hwan Rho, Seung Eun Lee, Jae Chul Song, Byung Rho Chin
Yeungnam Univ J Med. 2003;20(1):45-52.   Published online June 30, 2003
DOI: https://doi.org/10.12701/yujm.2003.20.1.45
  • 2,537 View
  • 1 Download
AbstractAbstract PDF
BACKGROUND
Immediate implant placement has become an acceptable treatment for the edentulous area. The advantages of the immediate implant placement include considerable decrease in time from tooth extraction to placement of the finial prosthesis, fewer surgical procedures, and better acceptance of the overall treatment plans. But the success is dependent on the quantity and quality of the extraction socket. The purpose of this study is to evaluate the success of the immediate implant placement. MATERIALS AND METHODS: Twenty-one sites in 16 patients were selected for the evaluation of the immediate implant placement. All of the cases were followed using clinical and radiographic examinations. Criteria of success were the absence of peri-implant radiolucency, mobility, and persistent pain or sign of infection. RESULTS: Of the 21 implants, 13 implants have been succeeded. Of the 13 implants, 10 implants were replaced for the periodontal disease and 3 implants were replaced for the trauma. CONCLUSION: The criteria of the success in immediate implant placement are as follows. 1) Implants placed into fresh extraction sockets have a high rate of survival. 2) Implant should be placed as close as possible to the alveolar crest. 3) Implant placed into available bone beyond the apex have a high success rate.
Review
Pediatrics, Perinatology, and Child Health
Kawasaki Disease.
Young Hwan Lee
Yeungnam Univ J Med. 2000;17(2):99-107.   Published online December 31, 2000
DOI: https://doi.org/10.12701/yujm.2000.17.2.99
  • 2,910 View
  • 13 Download
  • 1 Crossref
AbstractAbstract PDF
Kawasaki disease, an acute febrile illness which primarily affects in children under the age of six, was first described by Tomisaku Kawasaki in 1967. It has been reported that Kawasaki disease is probable driven by abnormalities of the immune system after an infectious insult, but this has not been confirmed. It mainly affects small and medium-sized arteries, particularly the coronary arteries. Deaths may occur at any time with cardiovascular complications. The early recognition and treatment with follow-up evaluation for the coronary arterial lesion is very important in a case of Kawasaki disease.

Citations

Citations to this article as recorded by  
  • Risk factors for the occurrence and persistence of coronary aneurysms in Kawasaki disease
    Soo-kyeong Jeon, Geena Kim, Hoon Ko, Joung-Hee Byun, Hyoung Doo Lee
    Korean Journal of Pediatrics.2019; 62(4): 138.     CrossRef
Original Article
Pediatrics, Perinatology, and Child Health
Statistical analysis of patients referred to pediatric cardiologic clinic for diagosis of heart disease.
Kwang Hae Choi, Young Hwan Lee
Yeungnam Univ J Med. 2000;17(1):49-54.   Published online June 30, 2000
DOI: https://doi.org/10.12701/yujm.2000.17.1.49
  • 2,825 View
  • 5 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Echocardiography is rapidly established itself as the primary diagnostic technique for investigation of children with heart disease, and referrals are increasing to the pediatric cardiology clinic for investigation. However, because there is a lack of analysis data on the patients referred to pediatric cardiology clinics, we have proceeded to compare and analyze their characteristics to provide basic data base. METHODS: From Oct. 1, 1998 to Jul. 10, 1999, total 443 cases referred to the pediatric cardiology clinic of Yeungnam University Hospital were studied retrospectively by medical records, chest X-ray, EKG and echocardiography, etc. RESULTS: The results were as follows. 1. The proportion of male was 61.0%(261 cases) and that of female was 39.0%(167 cases). The ratio of male to female was 1.6:1. The proportion infants less than 1 year-old was 62.6%(268 cases) of all patients. 2. Cardiac murmur was present in 248 cases(57.9%), which was the most common case of referral to the pediatric cardiology clinic. The impression at referral was more congenital heart disease(70.6%) than acquired heart disease(17.8%) and arrhythmia(11.6%). 3. The final diagnosis was as follows : congenital heart disease was present in 212 cases(49.5%), acquired heart disease, 59 cases(13.9%); arrhythmia, 13 cases(3.0%); normal heart, 144 cases(33.6%). CONCLUSION: Among the patients referred to pediatric cardiology clinic, 33.6%(144 cases) had normal hearts and why these patient were referred may be possibly due to more dependence on echocardiography than on auscultation instruction. Threfore, clinical and auscultatory skill should be emphasized to minimize dependence on expensive echocardiography for evaluation of pediatric heart disease.

Citations

Citations to this article as recorded by  
  • Evaluation and diagnostic approach for heart murmurs in children
    Hee Joung Choi
    Journal of the Korean Medical Association.2020; 63(7): 398.     CrossRef
Case Report
Rheumatology
Two Cases of Systemic Lupus Erythematosus with Cerebrovascular Involvement.
Bong Jun Kim, Eun Young Lee, Young Hoon Hong, Ki Do Park, Young Doo Song, Choong Ki Lee, Young Ran Shim
Yeungnam Univ J Med. 1998;15(2):371-380.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.371
  • 2,391 View
  • 4 Download
AbstractAbstract PDF
Systemic lupus erythematosus(SLE) is an autoimmune disease which may affect many different organs and disclose various clinical manifestations. Recently central nervous system(CNS) involvement has been recognized as an increasingly significant contributor to morbidity and mortality of SLE. The clinical manifestations of CNS-lupus are highly variable and range from mild cognitive dysfunction, movement disorder, headache, psychosis to life-threatening stroke and coma. Among the neuropsychiatric disorders encountered in patients with SLE, cerebrovascular disease has been a relatively rare complication. The diagnosis and management of CNS-lupus is difficult because of the lack of useful diagnostic methods. If, cerebrovascular involvement is suspected, then aggressive treatment such as high dose steroid, immunosuppressive therapy, plasma exchange, may be required to reduce high mortality rate. We experienced 2 cases cerebrovascular disease occurring in SLE patients which presented with various neuropsychiatric manifestations. They were diagnosed as CNS-lupus by neuropsychiatric symptoms, brain MRI, and EEG, and showed good response to high dose steroid pulse therapy.
Original Articles
Neurology
MRI Findings of Neuro-Behcet' Disease.
Han Won Jang, Woo Mok Byun, Kil Ho Cho, Mi Soo Hwang
Yeungnam Univ J Med. 1998;15(2):306-315.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.306
  • 2,978 View
  • 52 Download
AbstractAbstract PDF
MR findings in nine patients(three female, six male) with neuroBehcet's disease were retrospectively analyzed. NeuroBehcet's disease was diagnosed on the basis of typical clinical symptoms. Involved site, pattern, signal intensity, and contrast enhancement pattern on MRI were evaluated. In addition, follow up MR imaging was performed in four patients. The midbrain(7/9), internal capsule(7/9), pons(6/9), thalamus(6/9), basal ganglia(5/9), middle cerebella peduncle(4/9), medulla oblongata(2/9), and subcortical white matter(2/9) are involved on MRI. The size of lesions were 1cm to 3cm and their margin was ill-defined and patchy. Inhomogeneous high signal intensity on the T2-weighted images and low signal intensity on T1-weighted images was seen respectvely. In four of nine cases, there was focal enhancement. On follow up MR imaging, improvement or recurrance of the lesions was found. Also in two cases of follow up cases there was artophy in brainstem and/or middle cerebellar peduncles. In conclusion, MR imaging with systemic clinical symptoms is useful for diagnosing neuro-Behcet's disease.
Gastroenterology and Hepatology
Effect of alpha-Interferon 2b on Chronic Hepatitis B Patients with High Serum ALT.
Heon Ju Lee, Young Doo Song
Yeungnam Univ J Med. 1998;15(2):237-245.   Published online December 31, 1998
DOI: https://doi.org/10.12701/yujm.1998.15.2.237
  • 2,393 View
  • 2 Download
AbstractAbstract PDF
No abstract available.
Pulmonary and Respiratory Medicine
The Clinical Study of Clarithromycin for the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Ki Beom Kim, Chang Jin Shin, Hak Jun Lee, Jin Hong Chung, Kwan Ho Lee, Hyun Woo Lee
Yeungnam Univ J Med. 1997;14(1):94-100.   Published online June 30, 1997
DOI: https://doi.org/10.12701/yujm.1997.14.1.94
  • 2,676 View
  • 29 Download
AbstractAbstract PDF
To evaluate the efficacy and safety of clarithromycin in acute exacerbation of chronic obstructive pulmonary disease, we administered clarithromycin(250mg) twice in a day in 30 patients with acute exacerbation of chronic obstructive pulmonary disease from September to November in 1996. Twenty eight eases of 30 patients were cured(93.4%) and 2 cases(6.7%) show clinical improvement. Three cases were improved within 3 days of treatment and 24 cases were improved between 5 days and 12 days of treatment. There were no significant side effects. These results suggest that clarithromycin will be effective as a first line therapy in patients with acute exacerbation of chronic obstructive pulmonary disease.

JYMS : Journal of Yeungnam Medical Science
TOP