Sarcopenia is a condition in which muscle mass and strength are decreased and muscle function is impaired. It is an indicator of frailty and loss of independence in older adults. It is also associated with increased physical disability, which increases the risk of falls. As a multifactorial disease, sarcopenia is caused by a combination of factors including aging, hormonal changes, nutritional deficiencies, and physical inactivity. Understanding the underlying pathophysiology of sarcopenia and identifying its different causes is critical to developing effective prevention and treatment strategies. This review summarizes the pathophysiology, consequences, diagnostic methods, and multidisciplinary approaches to sarcopenia.
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Underlying Mechanisms of Osteoporosis in the Context of Multimorbidity: Clinical Challenges and Management Strategies Alberto Castagna, Carmelo Pujia, Elisa Mazza, Samantha Maurotti, Yvelise Ferro, Valeria Rizzo, Martina Formica, Rosy Conforto, Caterina Mercuri, Angela Sciacqua, Carmine Gazzaruso, Arturo Pujia, Tiziana Montalcini Nutrients.2026; 18(2): 262. CrossRef
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