Journal of Yeungnam Medical Science

Review article

Octacalcium phosphate, a promising bone substitute material: a narrative review: Jooseong Kim, Sukyoung Kim, Inhwan Song; J Yeungnam Med Sci. 2024;41(1):4-12. Published online May 9, 2023; DOI: https://doi.org/10.12701/jyms.2023.00010

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Biomaterials have been used to supplement and restore function and structure by replacing or restoring parts of damaged tissues and organs. In ancient times, the medical use of biomaterials was limited owing to infection during surgery and poor surgical techniques. However, in modern times, the medical applications of biomaterials are diversifying owing to great developments in material science and medical technology. In this paper, we introduce biomaterials, focusing on calcium phosphate ceramics, including octacalcium phosphate, which has recently attracted attention as a bone graft material.

Citations

Citations to this article as recorded by

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 1—Effect of Solution Concentration and Deposition Kinetics
Bríd Murphy, Mick A. Morris, Jhonattan Baez
Nanomaterials.2023; 13(18): 2577. CrossRef

Original article

Mineralization-inducing potentials of calcium silicate-based pulp capping materials in human dental pulp cells: Sohee Kang; Yeungnam Univ J Med. 2020;37(3):217-225. Published online May 22, 2020; DOI: https://doi.org/10.12701/yujm.2020.00248

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Abstract PDF

Background
To provide a long-term bacterial seal through the formation of reparative dentin bridge, calcium silicate-based pulp capping materials have been used at sites of pulpal exposure. The aim of this study was to evaluate the mineralization-inducing potentials of calcium silicate-based pulp capping materials (ProRoot MTA [PR], Biodentine [BD], and TheraCal LC [TC]) in human dental pulp cells (HDPCs).
Methods
Specimens of test materials were placed in deionized water for various incubation times to measure the pH variation and the concentration of calcium released. The morphology of HDPCs cultured on the specimens was examined using a confocal laser scanning microscope (CLSM). Alizarin red S staining and alkaline phosphatase assays were used to evaluate mineralization-inducing potentials of the capping materials.
Results
BD showed the highest calcium release in all test periods, followed by PR and TC. (p<0.05). All experimental groups showed high alkalinity after 1 day, except at 14 days. BD showed the highest cell viability compared with PR and TC after 1 and 3 days, while TC showed the lowest value (p<0.05). The CLSM analysis showed that cells were well adhered and expressed actin filaments for all pulp capping materials. Mineralization by PR and BD groups was higher than that by TC group based on alizarin red S staining. BD showed significantly higher alkaline phosphatase activity than PR and TC, while TC showed the lowest value (p<0.05).
Conclusion
Within the limitations of the in vitro study, BD had higher mineralization-inducing potential than PR and TC.

Citations

Citations to this article as recorded by

Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study
Mahmoud M. Bakr, Mohamed Shamel, Shereen N. Raafat, Robert M. Love, Mahmoud M. Al‐Ankily
Clinical and Experimental Dental Research.2024;[Epub] CrossRef
Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts
Gabriel Kato, Rita Araújo, Cláudia Rodrigues, Pedro Sousa Gomes, Liliana Grenho, Maria Helena Fernandes
Journal of Functional Biomaterials.2023; 14(6): 314. CrossRef
Evaluation of the chemical, physical, and biological properties of a newly developed bioceramic cement derived from cockle shells: an in vitro study
Monthip Wannakajeepiboon, Chankhrit Sathorn, Chatvadee Kornsuthisopon, Busayarat Santiwong, Thanakorn Wasanapiarnpong, Pairoj Linsuwanont
BMC Oral Health.2023;[Epub] CrossRef
Cytotoxicity of dental self-curing resin for a temporary crown: an in vitro study
Jae-wan Ko, Joon Sakong, Sohee Kang
Journal of Yeungnam Medical Science.2023; 40(Suppl): S1. CrossRef
Ion release, biocompatibility, and bioactivity of resin-modified calcium hydroxide cavity liners
Nastaran Taghvaei, Mehrsima Ghavami-Lahiji, Mehdi Evazalipour, Reza Tayefeh Davalloo, Ehsan Zamani
BMC Oral Health.2023;[Epub] CrossRef
Morphogenesis of Osteoid Structures during Cultivation of Mesenchymal Stromal Cells on Fibrillary Collagen in the Presence of Silicoaluminophosphate
A. A. Gaidash, M. I. Blinova, S. A. Aleksandrova, Yu. A. Nashchekina, V. K. Krutko, O. N. Musskaya, K. V. Skrotskaya, A. V. Nashchekin, N. A. Mikhailova, A. I. Kulak
Cell and Tissue Biology.2022; 16(1): 52. CrossRef
Present status and future directions: Hydraulic materials for endodontic use
Josette Camilleri, Amre Atmeh, Xin Li, Nastaran Meschi
International Endodontic Journal.2022; 55(S3): 710. CrossRef
The scientific management of deep carious lesions in vital teeth using contemporary materials—a narrative review
M. Al-Ali, J. Camilleri
Frontiers in Dental Medicine.2022;[Epub] CrossRef

Case Report

Amlodipine intoxication complicated by acute kidney injury and rhabdomyolysis.: In Hee Lee, Gun Woo Kang; Yeungnam Univ J Med. 2015;32(1):17-21. Published online June 30, 2015; DOI: https://doi.org/10.12701/yujm.2015.32.1.17

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Abstract PDF: Amlodipine, a calcium channel blocker of the dihydropyridine group, is commonly used in management of hypertension, angina, and myocardial infarction. Amlodipine overdose, characterized by severe hypotension, arrythmias, and pulmonary edema, has seldom been reported in Korean literature. We report on a fatal case of amlodipine intoxication with complications including rhabdomyolysis and oliguric acute kidney injury. A 70-year-old woman with a medical history of hypertension was presented at the author's hospital 6 hours after ingestion of 50 amlodipine (norvasc) tablets (total dosage 250 mg) in an attempted suicide. Her laboratory tests showed a serum creatinine level of 2.5 mg/dL, with elevated serum creatine phosphokinase and myoglobin. The patient was initially treated with fluids, alkali, calcium gluconate, glucagon, and vasopressors without a hemodynamic effect. High-dose insulin therapy was also started with a bolus injection of regular insulin (RI), followed by continuous infusion of RI and 50% dextrose with water. Despite intensive treatment including insulin therapy, inotropics, mechanical ventilation, and continuous venovenous hemodiafiltration, the patient died of refractory shock and cardiac arrest with no signs of renal recovery 116 hours after her hospital admission.

Review

Use of Magnesium in Anesthesiology and Pain Medicine.: Chae Rim Seong, Dae Lim Jee; Yeungnam Univ J Med. 2009;26(2):93-101. Published online December 31, 2009; DOI: https://doi.org/10.12701/yujm.2009.26.2.93

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Abstract PDF: The use of magnesium sulphate has recently increased in anesthesiology and pain medicine. The roles of magnesium sulphate are as an analgesic adjuvant, a vasodilator, a calcium channel blocker and reducing the anesthetic requirement. These effect are primarily based on the regulation of calcium influx into the cell and antagonism of the N-methyl-D-aspartate receptor. We discuss here the clinical effects of magnesium sulphate on anesthesiology and pain medicine.

Original Article

Effect of diazepam on the oxytocin induced contraction of the isolated rat uterus.: Yoon Kee Park, Sung Ho Lee, Oh Cheol Kwon, Jeoung Hee Ha, Kwang Youn Lee, Won Joon Kim; Yeungnam Univ J Med. 1992;9(2):359-381. Published online December 31, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.2.359

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Abstract PDF: This study was designed to investigate the effect of diazepam on the spontaneous contraction and oxytocin induced contraction of the isolated rat uterus. Female rat (Sprague-Dawley) pretreated with oophorectomy and 4 days administration of estrogen. Weighing about 200 g, was sacrificed by cervical dislocation, and the uteruses were isolated. A longitudinal muscle strip was placed in temperature controlled (37℃) muscle chamber containing Locke's solution and myographied isometrically. Diazepam inhibited the spontaneous contraction and oxytocin induced contraction of the isolated rat uterus in a concentration-dependent manner. GABA, muscimol, a GABA A receptor agonist, bicuculline, a competitive GABA A receptor antagonist, picrotoxin, a non competitive GABA A receptor antagonist, baclofen, a GABA B receptor agonist, and delta-aminovaleric acid, a GABA B receptor antagonist, did not affect on the spontaneous and oxytocin induced contraction of the isolated rat uterus. The inhibitory actions of diazepam on the spontaneous and oxytocin induced contraction were not affected by all the GABA receptor agonists and antagonists, but exceptionally potentiated by bicuculline. This potentiation-effect by bicuculline was not antagonized by muscumol. In normal calcium PSS, addition of calcium restored the spontaneous contraction preinhibited by diazepam and recovered the contractile of oxtrocin preinhibited by diazepam. A23187, a calcium inophore, enhanced the restoration of both the spontaneous and oxytocin induced contraction by addition of calcium. In calcium-free PSS, diazepam suppressed the restoration of spontaneous motility by addition of calcium but allowed the recovery of spontaneous motility to a considerable extent. Diazepam could not inhibit some development of contractility by oxytocin in calcium-free PSS, but inhibited the increase in contractility by subsequent addition of calcium. These results suggest that the inhibitory action of diazepam on the rat uterine motility does not depend on or related to GABA receptors and that diazepam inhibits the extracellular calcium influx to suppress the spontaneous and oxytocin induced contractilities.

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