Journal of Yeungnam Medical Science

Original Articles

Comparison of Three Third-generation Anti-HCV Enzyme Immunoassay Tests.: Hee Soon Cho, Jin Young Moon, Chae Hoon Lee, Kyung Dong Kim; Yeungnam Univ J Med. 1998;15(1):143-150. Published online June 30, 1998; DOI: https://doi.org/10.12701/yujm.1998.15.1.143

Abstract PDF: The aim of this study was to evaluate domestic enzyme immunoassay(EIA) kit ?LG HCD 3.0?(LG) for the detection of antibody to hepatitis C virus(anti-HCV) in comparision with Axsym HCV version 3.0(Axsym), Cobas Core anti-HCV EIA(Cobas). Cobas kit shows better clear distinction between positive and negative by signal/cutoff ratio(S/C), but it also reveal relatively high false positive rate. The concordance rate of test results between LG and Axsym was 96.2%, between LG and Cobas was 95.5%, and total agreement between three EIA kit was 93.9%. LG were relative poor distinction between positive and negative results, but it could be applied clinically as a screening tool for hepatitis C in general population. The S/C of one false negative result by LG was 0.91, and false positive were less than 4.0, therefore we concluded it is necessary to confirm by immunoblotting assay when S/C were between 0.8 and 4.0.

Intrafamilial transmission of HCV: comparison with HBV.: Heon Ju Lee; Yeungnam Univ J Med. 1992;9(2):407-415. Published online December 31, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.2.407

Abstract PDF: Among 85 patients with anti-HCV positive chronic liver disease, only 21.2% have past history of blood transfusion and over half the cases, they do not have any suspicious risk factors for HCV infection. 3 of 85 families show anti-HCV positive family members. On the other hand, 40 of 60 patients with HBsAg positive chronic liver disease show HBsAg positive family members. In Korea, HBV is transmitted mainly through vertical and intrafamilial infection but HCV disease might be rather horizontal and sporadic than vertical. To define the evident source of infection in sporadic hepatitis C, first of all, simple test with high sensitivity and specificity for diagnosis of HCV infection would be needed.

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