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JYMS : Journal of Yeungnam Medical Science

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Review article
Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review
Haneol Ko, Sang-Pil Yoon
J Yeungnam Med Sci. 2022;39(4):269-277.   Published online February 14, 2022
DOI: https://doi.org/10.12701/jyms.2021.01683
  • 5,787 View
  • 123 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDF
The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

Citations

Citations to this article as recorded by  
  • Modulating Proteasome Function with Polyphenol Metabolites: A Promising Therapeutic Avenue for Alzheimer's Disease
    Nyerovwo Charity Okei
    European Journal of Medical and Health Research.2024; 2(2): 16.     CrossRef
  • A comprehensive review of optical fiber technologies in optogenetics and their prospective developments in future clinical therapies
    Siyu Chen, Zhuo Wang, Kun Xiao, Benzhao He, Jing Zhao, Xin Yang, Qingqing Liu, Anuj K. Sharma, Arnaldo Leal Junior, Rui Min
    Optics & Laser Technology.2024; 179: 111332.     CrossRef
  • Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
    Chengzhang Li, Zhenrong Li, Sihan Xu, Sanwei Jiang, Zhenli Ye, Bin Yu, Shixiang Gong, Junmei Li, Qilin Hu, Bingyan Feng, Mengmeng Wang, Chengbiao Lu
    Scientific Reports.2023;[Epub]     CrossRef
  • Light-Controlled Modulation and Analysis of Neuronal Functions
    Carlo Matera, Piotr Bregestovski
    International Journal of Molecular Sciences.2022; 23(21): 12921.     CrossRef
Case report
Development of donepezil-induced hypokalemia following treatment of cognitive impairment
Dongryul Kim, Hye Eun Yoon, Hoon Suk Park, Seok Joon Shin, Bum Soon Choi, Byung Soo Kim, Tae Hyun Ban
Yeungnam Univ J Med. 2021;38(1):65-69.   Published online June 1, 2020
DOI: https://doi.org/10.12701/yujm.2020.00269
  • 6,084 View
  • 134 Download
  • 1 Crossref
AbstractAbstract PDF
Donepezil is a cholinesterase inhibitor used extensively to treat Alzheimer disease. The increased cholinergic activity is associated with adverse effects, therefore gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are common. Hypokalemia is a rare adverse event that occurs in less than 1% of donepezil-treated patients. Although hypokalemia of mild and moderate grade does not present serious signs and symptoms, severe hypokalemia often results in prolonged hospitalization and mortality. Herein, we report a case of hypokalemia developed after the initiation of donepezil therapy for cognitive impairment.

Citations

Citations to this article as recorded by  
  • Thymus vulgaris Essential Oil Protects Zebrafish against Cognitive Dysfunction by Regulating Cholinergic and Antioxidants Systems
    Luminita Capatina, Elena Todirascu-Ciornea, Edoardo Marco Napoli, Giuseppe Ruberto, Lucian Hritcu, Gabriela Dumitru
    Antioxidants.2020; 9(11): 1083.     CrossRef

JYMS : Journal of Yeungnam Medical Science