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JYMS : Journal of Yeungnam Medical Science

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Original article
Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study
Jun Seop Kim, Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Change Jeong, Seong Il Seo, Hyun Moo Lee, Seong Soo Jeon
J Yeungnam Med Sci. 2023;40(4):412-418.   Published online June 28, 2023
DOI: https://doi.org/10.12701/jyms.2023.00234
  • 1,464 View
  • 38 Download
AbstractAbstract PDF
Background
The aim of this study was to evaluate the risk factors for prostate-specific antigen (PSA) persistence in pathological stage T3aN0 prostate cancer (PCa) after robot-assisted laparoscopic radical prostatectomy (RALP).
Methods
A retrospective study was performed on 326 patients with pT3aN0 PCa who underwent RALP between March 2020 and February 2022. PSA persistence was defined as nadir PSA of >0.1 ng/mL after RALP, and the risk factors for PSA persistence were evaluated using logistic regression analysis.
Results
Among 326 patients, 61 (18.71%) had PSA persistence and 265 (81.29%) had PSA of <0.1 ng/mL after RALP (successful radical prostatectomy [RP] group). In the PSA persistence group, 51 patients (83.61%) received adjuvant treatment. Biochemical recurrence occurred in 27 patients (10.19%) in the successful RP group during the mean follow-up period of 15.22 months. Multivariate analysis showed that the risk factors for PSA persistence were large prostate volume (hazard ratio [HR], 1.017; 95% confidence interval [CI], 1.002–1.036; p=0.046), lymphovascular invasion (LVI) (HR, 2.605; 95% CI, 1.022–6.643; p=0.045), and surgical margin involvement (HR, 2.220; 95% CI, 1.110–4.438; p=0.024).
Conclusion
Adjuvant treatment may be needed for improved prognosis in patients with pT3aN0 PCa after RALP with a large prostate size, LVI, or surgical margin involvement.
Review article
Octacalcium phosphate, a promising bone substitute material: a narrative review
Jooseong Kim, Sukyoung Kim, Inhwan Song
J Yeungnam Med Sci. 2024;41(1):4-12.   Published online May 9, 2023
DOI: https://doi.org/10.12701/jyms.2023.00010
  • 2,700 View
  • 156 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Biomaterials have been used to supplement and restore function and structure by replacing or restoring parts of damaged tissues and organs. In ancient times, the medical use of biomaterials was limited owing to infection during surgery and poor surgical techniques. However, in modern times, the medical applications of biomaterials are diversifying owing to great developments in material science and medical technology. In this paper, we introduce biomaterials, focusing on calcium phosphate ceramics, including octacalcium phosphate, which has recently attracted attention as a bone graft material.

Citations

Citations to this article as recorded by  
  • Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 1—Effect of Solution Concentration and Deposition Kinetics
    Bríd Murphy, Mick A. Morris, Jhonattan Baez
    Nanomaterials.2023; 13(18): 2577.     CrossRef
Review
Adult Mesenchymal Stem Cells for Cell Therapy in Clinical Application.
In Hwan Song
Yeungnam Univ J Med. 2009;26(1):1-14.   Published online June 30, 2009
DOI: https://doi.org/10.12701/yujm.2009.26.1.1
  • 1,929 View
  • 11 Download
  • 3 Crossref
AbstractAbstract PDF
Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

Citations

Citations to this article as recorded by  
  • Application of Bio-Active Elastin-like Polypeptide on Regulation of Human Mesenchymal Stem Cell Behavior
    Vijaya Sarangthem, Harshita Sharma, Mohini Mendiratta, Ranjit Kumar Sahoo, Rang-Woon Park, Lalit Kumar, Thoudam Debraj Singh, Sujata Mohanty
    Biomedicines.2022; 10(5): 1151.     CrossRef
  • Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice
    Kyong Jin Jung, Gun Woo Lee, Chul Hyun Park, Tae Jin Lee, Joo Young Kim, Eon Gi Sung, Seong Yong Kim, Byung Ik Jang, In Hwan Song
    Gut and Liver.2020; 14(1): 100.     CrossRef
  • Human adipose-derived stem cells attenuate inflammatory bowel disease in IL-10 knockout mice
    Woo Yeun Jung, Joo Hwan Kang, Kyung Gon Kim, Hee Snn Kim, Byung Ik Jang, Yong Hoon Park, In-Hwan Song
    Tissue and Cell.2015; 47(1): 86.     CrossRef
Original Articles
Isolation of Endothelial Cells and Smooth Muscle Cells from Rat Aort.
Young Eun Yun, In Hwan Song, Eon Ki Sung, Joo Young Kim
Yeungnam Univ J Med. 2006;23(2):182-192.   Published online December 31, 2006
DOI: https://doi.org/10.12701/yujm.2006.23.2.182
  • 1,719 View
  • 11 Download
AbstractAbstract PDF
BACKGROUND
Atherosclerosis has emerged as the leading cause of death in developed countries. At present, human umbilical vein endothelial cells (HUVEC) are most commonly used for the investigation of Endothelial cells (EC). However, HUVEC are not found in arteries but only in veins. Currently there are many reports on methods used to isolate EC;, most of these methods require special equipment to remove contaminating smooth muscle cells (SMC). MATERIALS AND METHODS: The method described here may be used to isolate not only ECs but also SMCs;,the approach presented here did not require special equipment. Rat aorta was treated with 2 mg/ml of type II collagenase solution for 45 minutes. The isolated cells from the aorta were incubated in medium G for a week;, only ECs could be separated. After the collagenase treatment, the rest of aorta was cut lengthwise, and left undisturbed to obtain SMCs in the culture dish for 10 days. To verify the purity of the isolated cells, we performed immunofluorescence and evaluated the results with transmission electron microscopy analysis. RESULTS: The immunofluorescence study demonstrated specific expression of CD31 and alpha-smooth muscle actin in the isolated ECs and SMCs, respectively. Cultured ECs and SMCs showed their own fine structure characteristics. CONCLUSION: These results suggest that this method for isolating ECs and SMCs may be especially useful for the study of atherosclerosis.
Bone Formation by rhBMP-7 Transduced HEK 293 Cells in Nude Mouse.
Su Yon Jeong, Won Tae Chang, Yon Sil Chang, Myun Hwan Ahn, Jae Ryong Kim, In Hwan Song
Yeungnam Univ J Med. 2003;20(2):142-151.   Published online December 31, 2003
DOI: https://doi.org/10.12701/yujm.2003.20.2.142
  • 1,627 View
  • 4 Download
AbstractAbstract PDF
To induce bone formation at ectopic site by tissue engineering and gene therapy, we transplanted collagen sponges containing rhBMP-7 transduced HEK 293 cells in the hypodermis of nude mice. Bone formation was investigated by histological and electron microscopic method at 3, 6, and 9 weeks after transplantation. At 9 weeks after transplantation, eosinophilic bony tissue was observed in the implanted collagen sponge and was confirmed as bone tissue by Von Kossa stain. In the transmission electron microscopic observation, the cells in newly formed bone tissue had eccentrically located nucleus and well developed rough endoplasmic reticulum (rER). Therefore, the cells were evaluated as osteoblasts. Those results suggest that it is possible to form a bone tissue in the ectopic site by transplantation of rhBMP-7 transduced HEK 293 cells. This will be contributed to push more advanced gene therapy for bone formation. However, the HEK 293 cell is unable to apply to the clinical gene therapy. Therefore it is worth to find more compatible cells for clinical application. In addition, collagen sponge is considered as an excellent scaffold and/or carrier for gene therapy and a good biomaterial for tissue engineering.
Distribution patterns of cytoskelectal proteins in cardiac endothelial cells : Investigation using monoclonal antibodies.
Han Chul Kim, In Hwan Song, Yung Chang Lee
Yeungnam Univ J Med. 1990;7(2):27-37.   Published online December 31, 1990
DOI: https://doi.org/10.12701/yujm.1990.7.2.27
  • 1,286 View
  • 1 Download
AbstractAbstract PDF
To investigate the changing patterns of microfilament and microtubule arrangement and influence of myocardial cells and colchicines to microfilament and microtubule formation in cardiac endothelial cells the authors carried out indirect immunofluorescence stain for actin and tubulin with supernatant monoclonal antibodies. Secondary antibodies were IgG FITC conjugate. The results were summarized as follows. Fiberform reactions were stronger in the cells with many processes and spread cytoplasm and they became weaker after the endothelial cells formed monolayer. In the endothelial cells cocultured with myocardial cells the fiberform of the microtubule became less visible compared to control group but fiberform of the microtubule maintained strong intensity as endothelial cells formed monolayer. In the group treated with colchicines, there were no visible differences in microfilaments compared to control group but fiberform of microtubule revealed weaker intensity after colchicines treatment. The intensity of microtubule fiberform returned to control level after 2 days.
Transition of Marker Enzymes of Rat Hepatocyte Organelles in Culture.
In Hwan Song, Joo Yung Kim, Eon Ki Sung, Yung Chang Lee
Yeungnam Univ J Med. 1989;6(2):133-140.   Published online December 31, 1989
DOI: https://doi.org/10.12701/yujm.1989.6.2.133
  • 1,544 View
  • 1 Download
AbstractAbstract PDF
To investigate recovery, growth, and activity of hepatocyte in primary culture after cell separation, the authors followed up the marker enzyme activities of golgi complex, mitochondria and biologic membrane. Thiamine pyrophosphatase, the marker enzyme of golgi complex, activity approached the level of long term culture at 4th day. Succinate dehydrogenase, the marker enzyme of mitochondria, activity decreased with time, then it maintained constant level after 4th day. Alkaline phosphatase, the marker enzyme of biological membrane, activity increased from 3rd day, and after 5th day it showed strong reaction. These data suggested that hepatocytes were stabilized and recovered normal activity 4 day after cell separation. But the main secretory function was speculated to be reduced in culture.

JYMS : Journal of Yeungnam Medical Science