Journal of Yeungnam Medical Science

Original article

Pulmonary and Respiratory Medicine
Performance of the BD MAX MDR-TB assay in a clinical setting and its impact on the clinical course of patients with pulmonary tuberculosis: a retrospective before-after study: Sung Jun Ko, Kui Hyun Yoon, Sang Hee Lee; J Yeungnam Med Sci. 2024;41(2):113-119. Published online April 5, 2024; DOI: https://doi.org/10.12701/jyms.2024.00024

5,732 View
110 Download
6 Web of Science
7 Crossref

Background
Missing isoniazid (INH) resistance during tuberculosis (TB) diagnosis can worsen the outcomes of INH-resistant TB. The BD MAX MDR-TB assay (BD MAX) facilitates the rapid detection of TB and INH and rifampin (RIF) resistance; however, data related to its performance in clinical setting remain limited. Moreover, its effect on treatment outcomes has not yet been studied.
Methods
We compared the performance of BD MAX for the detection of INH/RIF resistances to that of the line probe assay (LPA) in patients with pulmonary TB (PTB), using the results of a phenotypic drug sensitivity test as a reference standard. The treatment outcomes of patients who used BD MAX were compared with those of patients who did not.
Results
Of the 83 patients included in the study, the BD MAX was used for an initial PTB diagnosis in 39 patients. The sensitivity of BD MAX for detecting PTB was 79.5%. The sensitivity and specificity of BD MAX for INH resistance were both 100%, whereas these were 50.0% and 95.8%, respectively, for RIF resistance. The sensitivity and specificity of BD MAX were comparable to those of LPA. The BD MAX group had a shorter time interval from specimen request to the initiation of anti-TB drugs (2.0 days vs. 5.5 days, p=0.001).
Conclusion
BD MAX showed comparable performance to conventional tests for detecting PTB and INH/RIF resistances. The implementation of BD MAX as a diagnostic tool for PTB resulted in a shorter turnaround time for the initiation of PTB treatment.

Citations

Citations to this article as recorded by

Diagnostic accuracy of the BD MAX MDR-TB assay on sputum and tongue swabs for Mycobacterium tuberculosis complex detection in adults under investigation for TB in South Africa
Anura David, Lyndel Singh, Manuel Pedro da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, Violet Molepo, Wendy Stevens, Lesley Erica Scott, Ana Cabrera
Microbiology Spectrum.2026;[Epub] CrossRef
Comparison of BD MAX and GeneXpert for rapid detection of tuberculosis and rifampin–isoniazid resistance
Chun-Li Lee, Xiang-Jun Chen, Yun-Shan Lu, Yu-Cheng Lin, Tai-Fen Lee, Chin-Chung Shu, Yu-Tsung Huang
Journal of Microbiology, Immunology and Infection.2026;[Epub] CrossRef
A cartridge-based assay for improved detection of multidrug-resistant Mycobacterium tuberculosis directly from sputum
Paulami Rudra, Heta Parmar, Naranjargal Daivaa, Claire Tran, Anshika Narang, Simranjit Singh, Dhara Somaiya, Robert Reiss, Shawn Ward, Adam Penn-Nicholson, Margaretha De Vos, Derek T. Armstrong, April L. Borkman, Jerrold Ellner, Susan E. Dorman, Soyeon Ki
Journal of Clinical Microbiology.2026;[Epub] CrossRef
Diagnostic Accuracy of BD MAX MDR-TB Assay Performed on Bronchoscopy Specimens in Patients with Suspected Pulmonary Tuberculosis
Sung Jun Ko, Kui Hyun Yoon
Tuberculosis and Respiratory Diseases.2025; 88(1): 150. CrossRef
The Usefulness of the BD MAX MDR-TB Molecular Test in the Rapid Diagnosis of Multidrug-Resistant Tuberculosis
Tomasz Bogiel, Edyta Dolska, Małgorzata Zimna, Kornelia Nakonowska, Dorota Krawiecka, Renata Żebracka, Maciej Pochowski, Agnieszka Krawczyk
Pathogens.2025; 14(6): 602. CrossRef
Comparative Analysis of 2 Diagnostic Devices for Detection of Mycobacterium tuberculosis and Drug Resistance in Almaty, Kazakhstan, to Determine the Optimal Diagnostic for Local Needs
Juliana G E Bartels, Nurlan Takenov, Lyailya Chingissova, Anar Rakisheva, Ainur Eleusizova, Venera Bismilda, Lyazzat Yeraliyeva, Yanis Ben Amor
Open Forum Infectious Diseases.2025;[Epub] CrossRef
Evaluating Tuberculosis Screening Tools: A Decade-Long Network Meta-Analysis of Sensitivity and Specificity with Bibliometric Insights
Diana Chusna Mufida, Muhammad Farhan Hibatulloh, Muhammad Yusuf Fadhil, Deva Fitra Firdausa Anwar, Cinday Kinanti Pramusinta, Zaskia Nafisa Salma, Annisa Eka Shabrina Salsabil, Aqilla Sakanti Chandrarini
Journal of Global Infectious Diseases.2025; 17(4): 176. CrossRef

First
Prev
Page of 1
Next
Last

Search