Journal of Yeungnam Medical Science

Original article

Dentistry
Incidence and severity of medication-related osteonecrosis of the jaw in patients with osteoporosis using data from a Korean nationwide sample cohort in 2002 to 2019: a retrospective study: Su-Youn Ko, Tae-Yoon Hwang, Kiwook Baek, Chulyong Park; J Yeungnam Med Sci. 2024;41(1):39-44. Published online January 3, 2024; DOI: https://doi.org/10.12701/jyms.2023.01116

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Background
Medication-related osteonecrosis of the jaw (MRONJ) is a significant concern, particularly among patients taking bisphosphonates (BPs), denosumab, and selective estrogen receptor modulators (SERMs) for osteoporosis. Despite the known risks, large-scale cohort studies examining the incidence and severity of MRONJ are lacking. We aimed to ascertain the incidence and risk of MRONJ among these patients, whom we stratified by age groups, medication types, and duration of use.
Methods
We utilized data from the National Health Insurance Service’s sample cohort database, focusing on patients aged 40 years and above diagnosed with osteoporosis. The patients were divided into three groups: those prescribed BPs only, those prescribed SERMs only, and those prescribed both.
Results
The overall incidence rate of MRONJ was 0.17%. A significantly higher incidence rate was observed among those taking osteoporosis medications, particularly among females with a relative risk of 4.99 (95% confidence interval, 3.21–7.74). The SERM group also had an incidence rate comparable to that of the BP group. Severity was assessed based on the invasiveness of the treatment methods, with 71.3% undergoing invasive treatment in the medication group.
Conclusion
This study provides valuable insights into the incidence and severity of MRONJ among a large cohort of patients with osteoporosis. It underscores the need for comprehensive guidance on MRONJ risks across different medication groups and sets the stage for future research focusing on specific populations and treatment outcomes.

Citations

Citations to this article as recorded by

Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosis
Akira Taguchi, Daisuke Inoue, Jin-Woo Kim, Keskanya Subbalekha, Wai Sin Chan, Hee Dong Chae, Chung-Hwan Chen, Ching-Lung Cheung, Eddie Siu Lun Chow, Yoon-Sok Chung, Linsey Gani, Muhammad Kamil bin Hassan, Unnop Jaisamrarn, Chakorn Vorakulpipat, Nutchada S
Osteoporosis and Sarcopenia.2026; 12(1): 1. CrossRef
Comparison of Bacterial Adhesion on Two Different Suture Materials After Tooth Extraction in Women Receiving Antiresorptive Therapy: An Exploratory Clinical Study with Prospective Data Collection
Anna Mölzer, Jesika Kotorri, Lotta Gath, Jakob Fehlhofer, Marco Rainer Kesting, Christian Bogdan, Roman G. Gerlach, Mayte Buchbender
Journal of Clinical Medicine.2026; 15(7): 2737. CrossRef
Medication-related osteonecrosis of the jaw in patients with cancer using zoledronic acid and denosumab: Single-center retrospective study
Motohiko Sano, Mai Amano, Miki Yamada, Yosuke Iijima, Shunsuke Hino, Hiroshi Sakagami, Norio Horie, Takahiro Kaneko
Journal of Oncology Pharmacy Practice.2025;[Epub] CrossRef
Incidence of medication-related osteonecrosis of the jaw and associated antiresorptive drugs in adult Finnish population
Miika Kujanpää, Ville Vuollo, Antti Tiisanoja, Marja-Liisa Laitala, György K. Sándor, Saujanya Karki
Scientific Reports.2025;[Epub] CrossRef
Effects of antiresorptives and Co-medications on 3D gingival cell Co-cultures
Heidi Maria Ekholm-Kerppola, Eliisa Löyttyniemi, Tero Soukka, Jaana Rautava
Human & Experimental Toxicology.2025;[Epub] CrossRef
Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force
Jin-Woo Kim, Sung-Hye Kong, Jae-Young Kim, Mi Kyung Kwak, Jun-Young Kim, Ji-Hyeon Oh, Hyung-Youl Park, BeomTaek Kim, Young-Kyun Lee, Jeong Joon Han, Moon-Young Kim, Yong Jun Choi, Yong-Dae Kwon, Kwang-Sup Song, Beom-Jun Kim, Sun-Jong Kim, Seung-Hoon Baek,
Endocrinology and Metabolism.2025; 40(6): 787. CrossRef
Medication-related osteonecrosis of the jaw: an evidence-based 2025 position statement from a Korean multidisciplinary task force
Jin-Woo Kim, Sung-Hye Kong, Jae-Young Kim, Mi Kyung Kwak, Jun-Young Kim, Ji-Hyeon Oh, Hyung-Youl Park, BeomTaek Kim, Young-Kyun Lee, Jeong Joon Han, Moon-Young Kim, Yong Jun Choi, Yong-Dae Kwon, Kwang-Sup Song, Beom-Jun Kim, Sun-Jong Kim, Seung-Hoon Baek,
Journal of the Korean Association of Oral and Maxillofacial Surgeons.2025; 51(6): 333. CrossRef

Review article

Public Health, Environmental, and Occupational Health
Reproductive toxic agents in work environments and related cases in Korea: Chulyong Park; Yeungnam Univ J Med. 2020;37(1):22-31. Published online January 9, 2020; DOI: https://doi.org/10.12701/yujm.2019.00416

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Abstract PDF

There has been a growing concern and subsequent interest surrounding numerous reproductive toxic agents found in various working and non-working environments. Meanwhile, there have been many efforts in medical fields such as toxicology and epidemiology applying experimental studies to elucidate reproductive toxic agents’ characterization and health effects. However, there remains insufficient research data and inadequate evidence in humans. Adverse reproductive outcomes vary from transient, moderate health effects to severely detrimental consequences, such as permanent infertility or childhood cancer of one’s offspring. Furthermore, upon exposure to toxic agents, the latent period before reproductive health effects are observed is relatively short compared to other occupational diseases (e.g., occupational cancer); instant action is required once exposure to reproductive toxic agents is detected. Therefore, it is very important for workers and healthcare professionals to know about the reproductive toxic agents they are likely to be exposed to. In this review, we discuss the general epidemiology of reproductive health in Korea, and the information regarding these reproductive toxic agents.

Citations

Citations to this article as recorded by

Association between Occupational Chemical Exposure and Sperm Parameters; A Narrative Review
Soheila Pourmasumi, Reza Vazirinejad, Zahra Ahmadi, Ali Mehdipour, Alireza Nazari
Journal of Occupational Health and Epidemiology.2023; 12(1): 50. CrossRef

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