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JYMS : Journal of Yeungnam Medical Science

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Case report
Development of donepezil-induced hypokalemia following treatment of cognitive impairment
Dongryul Kim, Hye Eun Yoon, Hoon Suk Park, Seok Joon Shin, Bum Soon Choi, Byung Soo Kim, Tae Hyun Ban
Yeungnam Univ J Med. 2021;38(1):65-69.   Published online June 1, 2020
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AbstractAbstract PDF
Donepezil is a cholinesterase inhibitor used extensively to treat Alzheimer disease. The increased cholinergic activity is associated with adverse effects, therefore gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are common. Hypokalemia is a rare adverse event that occurs in less than 1% of donepezil-treated patients. Although hypokalemia of mild and moderate grade does not present serious signs and symptoms, severe hypokalemia often results in prolonged hospitalization and mortality. Herein, we report a case of hypokalemia developed after the initiation of donepezil therapy for cognitive impairment.


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JYMS : Journal of Yeungnam Medical Science