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Case reports
Successful treatment with vedolizumab in an adolescent with Crohn disease who had developed active pulmonary tuberculosis while receiving infliximab
Sujin Choi, Bong Seok Choi, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2021;38(3):251-257.   Published online February 19, 2021
DOI: https://doi.org/10.12701/yujm.2020.00878
Funded: National Research Foundation of Korea, Ministry of Science and ICT
  • 4,998 View
  • 131 Download
  • 2 Crossref
AbstractAbstract PDF
Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

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  • The safety of vedolizumab in a patient with Crohn’s disease who developed anti-TNF-alpha agent associated latent tuberculosis infection reactivation: A case report
    Yuya Sugiyama, Nobuhiro Ueno, Shion Tachibana, Yu Kobayashi, Yuki Murakami, Takahiro Sasaki, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
    Medicine.2023; 102(28): e34331.     CrossRef
  • Vedolizumab Is Safe and Efficacious for the Treatment of Pediatric-Onset Inflammatory Bowel Disease Patients Who Fail a Primary Biologic Agent
    Sujin Choi, Eun Sil Kim, Yiyoung Kwon, Mi Jin Kim, Yon Ho Choe, Byung-Ho Choe, Ben Kang
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease
Sang Min Lee, Young Tae Lim, Kyung Mi Jang, Mi Jin Gu, Jong Ho Lee, Jae Min Lee
Yeungnam Univ J Med. 2021;38(3):245-250.   Published online November 11, 2020
DOI: https://doi.org/10.12701/yujm.2020.00654
Funded: Yeungnam University
  • 5,890 View
  • 105 Download
  • 4 Crossref
AbstractAbstract PDF
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome—HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m2/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.

Citations

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  • Histiocytic necrotizing lymphadenitis with hemophagocytic lymphohistiocytosis in adults: A single‐center analysis of 5 cases
    Qingqing Chen, Jing Zhang, Huijun Huang, Tonglu Qiu, Ze Jin, Yu Shi, Huayuan Zhu, Lei Fan, Jianyong Li, Wenyu Shi, Yi Miao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • A young Saudi female with combined hemophagocytic lympho-histiocytosis and Kikuchi’s disease: A case report
    Kamal Al-Zahrani, Batol Gasmelseed, Hesham Waaer Shadi, Rehab Y AL-Ansari
    SAGE Open Medical Case Reports.2023; 11: 2050313X2311543.     CrossRef
  • Cefalea y fiebre: no todo es lo que parece
    María Pilar Iranzo-Alcolea, Carmen Ariño-Palao, Grisell Starita-Fajardo, Andrés González-García, Cecilia Suárez-Carantoña
    Revista Española de Casos Clínicos en Medicina Interna.2023; 8(2): 105.     CrossRef
  • Kikuchi–Fujimoto disease: literature review and report of four cases
    V. G. Potapenko, V. V. Baykov, А. Yu. Markova, N. B. Mikhailova, A. S. Ter‑Grigoryan, Yu. А. Krivolapov
    Oncohematology.2022; 17(4): 48.     CrossRef
Original articles
Significance of albumin to globulin ratio as a predictor of febrile urinary tract infection after ureteroscopic lithotripsy
Seung Yun Yi, Dong Jin Park, Kyungchan Min, Jae-Wook Chung, Yun-Sok Ha, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo
Yeungnam Univ J Med. 2021;38(3):225-230.   Published online April 20, 2021
DOI: https://doi.org/10.12701/yujm.2021.00955
Funded: National Research Foundation of Korea, Ministry of Science and ICT
  • 4,212 View
  • 61 Download
  • 3 Crossref
AbstractAbstract PDF
Background
We aimed to analyze the effectiveness of albumin to globulin ratio (AGR) in predicting postoperative febrile urinary tract infection (fUTI) after ureteroscopic lithotripsy (URS) and retrograde intrarenal surgery (RIRS).
Methods
From January 2013 to May 2018, 332 patients underwent URS and RIRS. The rate of postoperative fUTI and risk factors for postoperative fUTI were analyzed using logistic regression. Patients were divided into postoperative fUTI and non-postoperative fUTI (non-fUTI) groups. AGR with other demographic and perioperative data were compared between the two groups to predict the development of fUTI after URS.
Results
Of the 332 patients, postoperative fUTI occurred in 41 (12.3%). Preoperative pyuria, microscopic hematuria, diabetes mellitus, hypoalbuminemia, and hyperglobulinemia were more prevalent in the fUTI group. Patients in the fUTI group had larger stone size, lower preoperative AGR, longer operation time, and longer preoperative antibiotic coverage period. In a multivariable logistic analysis, preoperative pyuria, AGR, and stone size were independently correlated with postoperative fUTI (p<0.001, p=0.008, and p=0.041, respectively). Receiver operating curve analysis showed that the cutoff value of AGR that could predict a high risk of fUTI after URS was 1.437 (sensitivity, 77.3%; specificity, 76.9%), while the cutoff value of stone size was 8.5 mm (sensitivity, 55.3%; specificity, 44.7%).
Conclusion
This study demonstrated that preoperative pyuria, AGR, and stone size can serve as prognostic factors for predicting fUTI after URS.

Citations

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  • An analysis of bacteriuria rates after endourological procedures
    Nethravathy Billava Seenappa, Maneesh Sinha, Thyagaraj Krishna Prasad, Venkatesh Krishnamoorthy
    International Journal of Urological Nursing.2023; 17(1): 45.     CrossRef
  • Nutritional and Inflammatory Indices and the Risk of Surgical Site Infection After Fragility Hip Fractures: Can Routine Blood Test Point to Patients at Risk?
    Tal Frenkel Rutenberg, Rana Gabarin, Vitali Kilimnik, Efrat Daglan, Moti Iflah, Shani Zach, Shai Shemesh
    Surgical Infections.2023; 24(7): 645.     CrossRef
  • Prognostic value of albumin-to-globulin ratio in COVID-19 patients: A systematic review and meta-analysis
    Juan R. Ulloque-Badaracco, Melany D. Mosquera-Rojas, Enrique A. Hernandez-Bustamante, Esteban A. Alarcón-Braga, Percy Herrera-Añazco, Vicente A. Benites-Zapata
    Heliyon.2022; 8(5): e09457.     CrossRef
Personal experience with microvascular decompression and partial sensory rhizotomy for trigeminal neuralgia
Jung Hwan Lee, Jae Meen Lee, Chang Hwa Choi
Yeungnam Univ J Med. 2021;38(3):202-207.   Published online November 23, 2020
DOI: https://doi.org/10.12701/yujm.2020.00745
Funded: Pusan National University
  • 7,138 View
  • 118 Download
  • 4 Crossref
AbstractAbstract PDF
Background
Trigeminal neuralgia (TN) is a severe, paroxysmal pain in the distribution of the fifth cranial nerve. Microvascular decompression (MVD) is the most widely used surgical treatment for TN. We undertook this study to analyze the effects of and complications of MVD and to refine the surgical procedure for treating TN.
Methods
A total of 88 patients underwent for TN underwent surgery at our hospital. Among them, 77 patients underwent MVD alone, and 11 underwent partial sensory rhizotomy (PSR) with or without MVD. The medical records of these patients were retrospectively analyzed for patient characteristics, clinical results, offending vessels, and complications if any.
Results
The mean follow-up duration was 43.2 months (range, 3–216 months). The most common site of pain was V2+V3 territory (n=27), followed by V2 (n=25) and V3 (n=23). The most common offending vessels were the superior cerebellar artery and anterior inferior cerebellar artery in that order. The overall rate of postoperative complications was 46.1%; however, most complications were transient. There were two cases of permanent partial hearing disturbance. In the MVD alone group, the cure rate was 67.5%, and the improvement rate was 26.0%. Among 11 patients who underwent PSR with or without MVD, the cure rate was 50.0%, and the improvement rate was 30.0%.
Conclusion
The clinical results of MVD were satisfactory. Although the outcomes of PSR were not as favorable as those of pure MVD in this study, PSR can be considered in cases where there is no significant vascular compressive lesion or uncertainty of the causative vessel at the surgery.

Citations

Citations to this article as recorded by  
  • Progress in Surgical Treatment of Trigeminal Neuralgia
    滨 何
    Advances in Clinical Medicine.2023; 13(02): 2313.     CrossRef
  • How Far Has Radiofrequency Thermocoagulation Come Along as a Treatment Procedure in Treating Trigeminal Neuralgia Patients?
    Stephen D Howard, Varun Soti
    Cureus.2023;[Epub]     CrossRef
  • Historical aspects of the problem of treatment of trigeminal neuralgia and the role of neurosurgical methods in its solution (literature review)
    A. N. Zhurkin, A. V. Semenov, V. A. Sorokovikov, N. V. Bartul
    Acta Biomedica Scientifica.2021; 6(4): 123.     CrossRef
  • Trigeminal Neuralgia: Current Approaches and Emerging Interventions
    Risheng Xu, Michael E Xie, Christopher M Jackson
    Journal of Pain Research.2021; Volume 14: 3437.     CrossRef
Case report
Delayed treatment-free response after romiplostim discontinuation in pediatric chronic immune thrombocytopenia
Hyun Ji Lim, Young Tae Lim, Jeong Ok Hah, Jae Min Lee
Yeungnam Univ J Med. 2021;38(2):165-168.   Published online August 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00493
Funded: Yeungnam University
  • 5,065 View
  • 136 Download
  • 3 Crossref
AbstractAbstract PDF
We report the case of a 16-month-old patient with chronic immune thrombocytopenia (ITP) patient who experienced delayed treatment-free response (TFR) after romiplostim treatment. He received intravenous immunoglobulin every month to maintain a platelet count above 20,000/μL for 2 years. Thereafter, he received rituximab and cyclosporine as second-line therapy, with no response, followed by romiplostim. After 4 weeks of treatment, the platelet count was maintained above 50,000/μL. Following 7 months of treatment, he discontinued romiplostim, and the platelet count decreased. His platelet counts remained above 50,000/μL, without any bleeding symptoms, 2 years after romiplostim discontinuation. This is the first report of TFR after romiplostim treatment in pediatric chronic ITP.

Citations

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  • A cost–utility analysis of thrombopoietin receptor agonists for treating pediatric immune thrombocytopenia purpura after failure of first‐line therapies
    Huimin Du, Jiamin Wang, Joel Livingston, Ziyad Alrajhi, Melanie Kirby‐Allen, Brian Chan, Rebecca Hancock‐Howard, Peter C. Coyte
    Pediatric Blood & Cancer.2023;[Epub]     CrossRef
  • Generic romiplostim for children with persistent or chronic immune thrombocytopenia: Experience from a tertiary care centre in North India
    Chandana Mareddy, Manas Kalra, Anupam Sachdeva
    British Journal of Haematology.2022; 197(5): 618.     CrossRef
  • Tapering of the thrombopoietin receptor agonist in paediatric patients with chronic immune thrombocytopenia: Is it possible?
    María Solsona, Rubén Berrueco, Elena Sebastián, Áurea Cervera, Ana Sastre, Itziar Astigarraga, Bienvenida Argilés, María Ángeles Dasí, José Luís Dapena, Emilio Monteagudo
    British Journal of Clinical Pharmacology.2022; 88(9): 4220.     CrossRef
Original articles
Analysis of the risk factors of acute kidney injury after total hip or knee replacement surgery
Yoo Jin Lee, Bong Soo Park, Sihyung Park, Jin Han Park, Il Hwan Kim, Junghae Ko, Yang Wook Kim
Yeungnam Univ J Med. 2021;38(2):136-141.   Published online October 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00542
Funded: Inje University Haeundae Paik Hospital, Inje University
  • 5,739 View
  • 97 Download
  • 2 Crossref
AbstractAbstract PDF
Background
Postoperative acute kidney injury (AKI), which increases the risk of postoperative morbidity and mortality, poses a major concern to surgeons. We conducted this study to analyze the risk factors associated with the occurrence of AKI after orthopedic surgery.
Methods
This was a retrospective study that included 351 patients who underwent total hip or knee replacement surgery at Inje University Haeundae Paik Hospital between January 2012 and December 2016.
Results
AKI occurred in 13 (3.7%) of the 351 patients. The patients’ preoperative estimated glomerular filtration rate (eGFR) was 66.66±34.02 mL/min/1.73 m2 in the AKI group and 78.07±21.23 mL/min/1.73 m2 in the non-AKI group. The hemoglobin levels were 11.21±1.65 g/dL in the AKI group and 12.39±1.52 g/dL in the non-AKI group. Hemoglobin level was related to increased risk of AKI (odds ratio [OR], 0.13; 95% confidence interval [CI], 0.02–0.68; p=0.016). Administration of crystalloid or colloid fluid alone and the perioperative amount of fluid did not show any significant relationship with AKI. Further analysis of the changes in eGFR was performed using a cutoff value of 7.54. The changes in eGFR were significantly related to decreased risk of AKI (OR, 0.74; 95% CI, 0.61–0.89; p=0.002).
Conclusion
Renal function should be monitored closely after orthopedic surgery if patients have chronic kidney disease and low hemoglobin level. Predicting the likelihood of AKI occurrence, early treatment of high-risk patients, and monitoring perioperative laboratory test results, including eGFR, will help improve patient prognosis.

Citations

Citations to this article as recorded by  
  • Supplemental oxygen is associated with increased complications and readmission following total shoulder arthroplasty
    Nikhil Vallabhaneni, Alexander S. Guareschi, Josef K. Eichinger, Richard J. Friedman
    Seminars in Arthroplasty: JSES.2023; 33(3): 512.     CrossRef
  • Acute kidney injury after primary total hip replacement
    M. L. Lebed, M. G. Kirpichenko, E. V. Novikova, T. G. Lebed, A. V. Mankov
    Acta Biomedica Scientifica.2023; 8(5): 125.     CrossRef
The relationship between disability and clinical outcomes in maintenance dialysis patients
Seok Hui Kang, Jun Young Do, Jun Chul Kim
Yeungnam Univ J Med. 2021;38(2):127-135.   Published online October 15, 2020
DOI: https://doi.org/10.12701/yujm.2020.00346
Funded: National Research Foundation of Korea, Ministry of Science and ICT, Ministry of Science, ICT and Future Planning
  • 5,070 View
  • 72 Download
  • 2 Crossref
AbstractAbstract PDF
Background
Dialysis patients are prone to having disabilities. We aimed to evaluate the association between disability and various clinical outcomes in Korean dialysis patients.
Methods
This study consisted of 1,615 dialysis patients from 27 centers. We evaluated disability by using four questions on the activities of daily living (ADLs) concerning whether help was needed for feeding, dressing/undressing, getting in/out of bed, or taking a bath/shower. We divided the patients into three groups: no disability (Non-D, none of the four ADL domains required help; n=1,312), mild disability (Mild-D, one ADL domain required some/full help; n=163), or moderate to severe disability (MS-D, two or more ADL domains required some/full help; n=140). We evaluated falls, frailty, health-related quality of life (HRQoL), mortality, and hospitalization.
Results
The numbers of participants with a fall during the last 1 year were 199 (15.2%), 42 (25.8%), and 44 (31.4%) in the Non-D, Mild-D, and MS-D groups, respectively (p<0.001). The numbers of participants with frailty in the Non-D, Mild-D, and MS-D groups were 381 (29.0%), 84 (51.5%), and 93 (66.4%), respectively (p<0.001). In both univariate and multivariate analyses, the physical component scale and mental component scale scores decreased as the grade of disability increased (p<0.001 for both scores). Hospitalization-free survival rate at 500 days was 64.2%, 56.7%, and 51.1% in the Non-D, Mild-D, and MS-D, respectively (p=0.001 for trend). Patient survival rate at 500 days was 95.3%, 89.5%, and 92.3% in the Non-D, Mild-D, and MS-D, respectively (p=0.005 for trend).
Conclusion
Disability was associated with falls, frailty, HRQoL scales, and survival trends in Korean dialysis patients.

Citations

Citations to this article as recorded by  
  • The predictive role of hope and social relational quality in disability acceptance among Iranian patients under hemodialysis
    Nilofar Pasyar, Mostafa Jowkar, Masoume Rambod
    BMC Nephrology.2023;[Epub]     CrossRef
  • Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
A study on evaluator factors affecting physician-patient interaction scores in clinical performance examinations: a single medical school experience
Young Soon Park, Kyung Hee Chun, Kyeong Soo Lee, Young Hwan Lee
Yeungnam Univ J Med. 2021;38(2):118-126.   Published online August 6, 2020
DOI: https://doi.org/10.12701/yujm.2020.00423
Funded: Yeungnam University Medical Center
  • 5,113 View
  • 107 Download
AbstractAbstract PDF
Background
This study is an analysis of evaluator factors affecting physician-patient interaction (PPI) scores in clinical performance examination (CPX). The purpose of this study was to investigate possible ways to increase the reliability of the CPX evaluation.
Methods
The six-item Yeungnam University Scale (YUS), four-item analytic global rating scale (AGRS), and one-item holistic rating scale (HRS) were used to evaluate student performance in PPI. A total of 72 fourth-year students from Yeungnam University College of Medicine in Korea participated in the evaluation with 32 faculty and 16 standardized patient (SP) raters. The study then examined the differences in scores between types of scale, raters (SP vs. faculty), faculty specialty, evaluation experience, and level of fatigue as time passes.
Results
There were significant differences between faculty and SP scores in all three scales and a significant correlation among raters’ scores. Scores given by raters on items related to their specialty were lower than those given by raters on items out of their specialty. On the YUS and AGRS, there were significant differences based on the faculty’s evaluation experience; scores by raters who had three to ten previous evaluation experiences were lower than others’ scores. There were also significant differences among SP raters on all scales. The correlation between the YUS and AGRS/HRS declined significantly according to the length of evaluation time.
Conclusion
In CPX, PPI score reliability was found to be significantly affected by the evaluator factors as well as the type of scale.
Review articles
The role of microRNAs in cell death pathways
Ji Hoon Jang, Tae-Jin Lee
Yeungnam Univ J Med. 2021;38(2):107-117.   Published online January 13, 2021
DOI: https://doi.org/10.12701/yujm.2020.00836
Funded: National Research Foundation of Korea, Ministry of Education
  • 9,677 View
  • 208 Download
  • 12 Crossref
AbstractAbstract PDF
MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

Citations

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  • MicroRNAs (miRNAs) role in hypertension: pathogenesis and promising therapeutics
    Nour Shaheen, Ahmed Shaheen, Rehab Adel Diab, Mariam Tarek Desouki
    Annals of Medicine & Surgery.2024; 86(1): 319.     CrossRef
  • Psychosocial Stress and MicroRNA Expression Profiles in Myometrial Tissue of Women Undergoing Surgical Treatment for Uterine Fibroids
    Christian K. Dye, Haotian Wu, Brianna VanNoy, Stephanie Calluori, Cherie Q. Marfori, Andrea A. Baccarelli, Ami R. Zota
    Reproductive Sciences.2024;[Epub]     CrossRef
  • The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy
    Hendrik Setia Budi, Laith A. Younus, Methaq Hadi Lafta, Sameena Parveen, Hawraa Jabbar Mohammad, Zahraa Haleem Al-qaim, Mohammed Abed Jawad, Rosario Mireya Romero Parra, Yasser Fakri Mustafa, Firas Rahi Alhachami, Sajad Karampoor, Rasoul Mirzaei
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review
    Marianna Makowska, Beata Smolarz, Hanna Romanowicz
    International Journal of Molecular Sciences.2023; 24(4): 3521.     CrossRef
  • The regulatory role of microRNAs in common eye diseases: A brief review
    Javier A. Benavides-Aguilar, Jonathan I. Morales-Rodríguez, Héctor Ambriz-González, Luis M. Ruiz-Manriquez, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy, Sujay Paul
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay
    Csaba Horvath, Izabela Jarabicova, Branislav Kura, Barbora Kalocayova, Eva Faurobert, Sean M. Davidson, Adriana Adameova
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119534.     CrossRef
  • Does exercise influence skeletal muscle by modulating mitochondrial functions via regulating MicroRNAs? A systematic review
    Yu-Feng Long, Simon Kwoon-Ho Chow, Can Cui, Ronald Man Yeung Wong, Ning Zhang, Ling Qin, Sheung-Wai Law, Wing-Hoi Cheung
    Ageing Research Reviews.2023; 91: 102048.     CrossRef
  • Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies
    Komal Imran, Muhammad Javed Iqbal, Rameesha Abid, Muhammad Mushtaq Ahmad, Daniela Calina, Javad Sharifi-Rad, William C. Cho
    Cell Communication and Signaling.2023;[Epub]     CrossRef
  • Vitamin D and microRNAs: Role in the pathogenesis and prognosis of breast cancer (Review)
    Luca Falzone, Giuseppe Gattuso, Saverio Candido, Alessandro Tomaselli, Simone Fagone, Demetrios Spandidos, Massimo Libra
    International Journal of Epigenetics.2023;[Epub]     CrossRef
  • The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury
    Leonid N. Maslov, Sergey V. Popov, Natalia V. Naryzhnaya, Alexandr V. Mukhomedzyanov, Boris K. Kurbatov, Ivan A. Derkachev, Alla A. Boshchenko, Igor Khaliulin, N. Rajendra Prasad, Nirmal Singh, Alexei Degterev, Evgenia A. Tomilova, Ekaterina V. Sapozhenko
    Apoptosis.2022; 27(9-10): 697.     CrossRef
  • Interleukin-10 Protects against Ureteral Obstruction-Induced Kidney Fibrosis by Suppressing Endoplasmic Reticulum Stress and Apoptosis
    Kyongjin Jung, Taejin Lee, Jooyoung Kim, Eongi Sung, Inhwan Song
    International Journal of Molecular Sciences.2022; 23(18): 10702.     CrossRef
  • Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke
    Sima Abbasi-Habashi, Glen C. Jickling, Ian R. Winship
    Frontiers in Neurology.2021;[Epub]     CrossRef
Can antioxidants be effective therapeutics for type 2 diabetes?
Soyoung Park, So-Young Park
Yeungnam Univ J Med. 2021;38(2):83-94.   Published online October 8, 2020
DOI: https://doi.org/10.12701/yujm.2020.00563
Funded: National Research Foundation of Korea
  • 10,015 View
  • 210 Download
  • 10 Crossref
AbstractAbstract PDF
The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

Citations

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  • Effect of substitution of wheat flour with chickpea flour on their physico-chemical characteristics
    Jiwan S. Sidhu, Tasleem Zafar, Abdulwahab Almusallam, Muslim Ali, Amani Al-Othman
    Arab Gulf Journal of Scientific Research.2023;[Epub]     CrossRef
  • The consumption of date palm fruits as a source of bioactive compounds in patients with type 2 diabetes: a cross sectional study
    M.Q. Al-Mssallem
    Acta Horticulturae.2023; (1371): 381.     CrossRef
  • Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
    Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi
    Biogerontology.2023; 24(5): 609.     CrossRef
  • Development and Characterization of Oxidatively Responsive Thiol–Ene Networks for Bone Graft Applications
    Tyler Touchet, Samuel Briggs, Lance Graul, Duncan J. Maitland
    ACS Applied Bio Materials.2022; 5(6): 2633.     CrossRef
  • Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
    Seung Min Chung, Jun Sung Moon, Min Cheol Chang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome
    Sahar Mazloomi, Nasrin Sheikh, Marzieh Sanoee Farimani, Shamim Pilehvari, Raffaele Pezzani
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
    Mayadah Bashir Shehadeh, Ghadeer A. R. Y. Suaifan, Ala’ Mustafa Abu-Odeh
    Molecules.2021; 26(14): 4333.     CrossRef
  • An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults
    Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis
    Applied Sciences.2021; 11(17): 7818.     CrossRef
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    Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu
    Journal of Inflammation Research.2021; Volume 14: 6749.     CrossRef
  • Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice
    Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
    Redox Biology.2020; : 101823.     CrossRef
Case report
Transpedal lymphatic embolization for lymphorrhea at the graft harvest site after coronary artery bypass grafting
Jung Guen Cha, Sang Yub Lee, Jihoon Hong, Hun Kyu Ryeom, Gab Chul Kim, Young Woo Do
Yeungnam Univ J Med. 2021;38(1):74-77.   Published online July 20, 2020
DOI: https://doi.org/10.12701/yujm.2020.00297
Funded: National Research Foundation of Korea, Ministry of Education, Science and Technology
  • 4,428 View
  • 64 Download
  • 3 Crossref
AbstractAbstract PDF
Lymphorrhea is a rare but potentially severe complication that occurs after various surgical procedures. Untreated lymphorrhea may lead to wound dehiscence, infection, and prolonged hospital stay. Currently, there is no standard effective treatment. Early management usually includes leg elevation, drainage, and pressure dressing. However, these methods are associated with prolonged recovery and high recurrence rates. We report a case of lymphorrhea from a calf wound after endoscopic great saphenous vein (GSV) harvesting for coronary artery bypass grafting (CABG). The patient presented with intractable oozing from the postoperative wound on the right calf. Lymphorrhea perGsisted for 6 weeks despite negative-pressure wound therapy with a long-acting somatostatin. We performed unilateral pedal lymphangiography that confirmed wound lymphorrhea, followed by glue embolization. No recurrence was observed after 8 months of follow-up. This case report demonstrates the successful use of lymphangiography with glue embolization in the control of lymphorrhea after GSV harvesting for CABG.

Citations

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  • Supermicrosurgical lymphatic venous anastomosis for intractable lymphocele after great saphenous vein harvesting graft
    Hirofumi Imai, Shuhei Yoshida, Toshiro Mese, Solji Roh, Isao Koshima
    Journal of Vascular Surgery Cases, Innovations and Techniques.2022; 8(1): 45.     CrossRef
  • Update February 2021
    Francine Blei
    Lymphatic Research and Biology.2021; 19(1): 96.     CrossRef
  • Lymphatic complications after harvesting venous conduits in coronary artery bypass grafting surgery
    D. V. Manvelyan, Yu. Y. Vechersky, V. V. Zatolokin, M. S. Kuznetsov, B. N. Kozlov
    The Siberian Journal of Clinical and Experimental Medicine.2021; 36(3): 27.     CrossRef
Review article
Updates on the treatment of adhesive capsulitis with hydraulic distension
Jang Hyuk Cho
Yeungnam Univ J Med. 2021;38(1):19-26.   Published online August 31, 2020
DOI: https://doi.org/10.12701/yujm.2020.00535
Funded: Ministry of Health and Welfare
  • 8,745 View
  • 228 Download
  • 10 Crossref
AbstractAbstract PDF
Adhesive capsulitis of the shoulder joint is a common disease characterized by pain at the insertional area of the deltoid muscle and decreased range of motion. The pathophysiological process involves fibrous inflammation of the capsule and intraarticular adhesion of synovial folds leading to capsular thickening and contracture. Regarding the multidirectional limitation of motion, a limitation in external rotation is especially prominent, which is related to not only global fibrosis but also to a localized tightness of the anterior capsule. Ultrasound and magnetic resonance imaging studies can be applied to rule out other structural lesions in the diagnosis of adhesive capsulitis. Hydraulic distension of the shoulder joint capsule provides pain relief and an immediate improvement in range of motion by directly expanding the capsule along with the infusion of steroids. However, the optimal technique for hydraulic distension is still a matter of controversy, with regards to the infusion volume and rupture of the capsule. By monitoring the real-time pressure-volume profile during hydraulic distension, the largest possible fluid volume can be infused without rupturing the capsule. The improvement in clinical outcomes is shown to be greater in capsule-preserved hydraulic distension than in capsule-ruptured distension. Moreover, repeated distension is possible, which provides additional clinical improvement. Capsule-preserved hydraulic distension with maximal volume is suggested to be an efficacious treatment option for persistent adhesive capsulitis.

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  • A prospective, randomized, blinded study on the efficacy of using corticosteroids in hydrodilatation as a treatment for adhesive capsulitis of the shoulder
    Joan Tomàs Gebellí-Jové, Antonio Buñuel-Viñau, Marta Canela-Capdevila, Jordi Camps, Fàtima Sabench, Petrea Iftimie-Iftimie
    Shoulder & Elbow.2024;[Epub]     CrossRef
  • Frozen Shoulder: Diagnosis and Management
    Sean R. Wise, Paul Seales, Alex P. Houser, Chase B. Weber
    Current Sports Medicine Reports.2023; 22(9): 307.     CrossRef
  • Rotator Interval vs Posterior Approach Ultrasound-guided Corticosteroid Injections in Primary Frozen Shoulder: A Meta-analysis of Randomized Controlled Trials
    Francisco Javier Arrambide-Garza, Juventino Tadeo Guerrero-Zertuche, Neri Alejandro Alvarez-Villalobos, Alejandro Quiroga-Garza, Abraham Espinosa-Uribe, Felix Vilchez-Cavazos, Yolanda Salinas-Alvarez, Juan Antonio Rivera-Perez, Rodrigo Enrique Elizondo-Om
    Archives of Physical Medicine and Rehabilitation.2023;[Epub]     CrossRef
  • Ultrasound-guided hydrodilatation of glenohumeral joint combined with acupotomy for treatment of frozen shoulder
    Huajun Xu, Yingchun Zhang, Caishan Wang
    Journal of Back and Musculoskeletal Rehabilitation.2022; 35(5): 1153.     CrossRef
  • Impact of capsular preservation on patient-reported outcomes and complication rates in total hip arthroplasty using the direct anterior approach
    Vincent A. Stadelmann, Hannes A. Rüdiger, Selina Nauer, Michael Leunig
    The Bone & Joint Journal.2022; 104-B(7): 826.     CrossRef
  • Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience
    Yung-Chieh Chen, Shu-Huei Shen, Hong-Jen Chiou, Yung-Liang Wan
    Life.2022; 12(9): 1293.     CrossRef
  • Role of Platelet-Rich Plasma in the Treatment of Adhesive Capsulitis: A Prospective Cohort Study
    Syed Imran Haider, Muhammad Zarak Awais, Muhammad Tahir Iqbal
    Cureus.2022;[Epub]     CrossRef
  • Musculoskeletal complications in patients with diabetes mellitus
    Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
    The Korean Journal of Internal Medicine.2022; 37(6): 1099.     CrossRef
  • Comparison of the spread pattern of medial-to-lateral and lateral-to-medial rotator interval injections: A cadaveric study
    Benjamin J. Kozlowski, John Tran, Philip W.H. Peng, Anne M.R. Agur, Nimish Mittal
    Interventional Pain Medicine.2022; 1(4): 100164.     CrossRef
  • Updates on Intra-articular Corticosteroid Injection for the Treatment of Adhesive Capsulitis
    Ju Heon Oh, In Ho Jung, Eun Woo Park, Jang Hyuk Cho
    Keimyung Medical Journal.2022; 41(2): 51.     CrossRef
Case report
Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in NUDT15 R139C
Jaewoan Bae, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2020;37(4):332-336.   Published online May 22, 2020
DOI: https://doi.org/10.12701/yujm.2020.00178
Funded: National Research Foundation of Korea, Ministry of Science and ICT
  • 5,079 View
  • 86 Download
  • 3 Crossref
AbstractAbstract PDF
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients who are NUDT15 poor metabolizers and consider the use of an alternative immunomodulatory therapy. We report a case of a 12-year-old Korean girl with Crohn’s disease (CD), in whom thiopurine-induced leukopenia was prevented by initiation of azathioprine (AZA) therapy at a low dose (0.5 mg/kg/day) and early detection of significant hair loss and white blood cell (WBC) count decrease at 17 days from the start of AZA treatment. The WBC count dropped from 8,970/μL to 3,370/μL in 2 weeks, and AZA treatment was stopped because of concerns of potential leukopenia in the near future. Her WBC count recovered to 5,120/μL after 3 weeks. Gene analysis later revealed that she had a homozygous mutation in NUDT15 R139C, resulting in a poor metabolizing activity of NUDT15. In situations when NUDT15 genotyping is unavailable, initiation of AZA therapy at 0.5 mg/kg/day with close observation of hair loss and WBC counts within 2 weeks may be an alternative way to prevent thiopurine-induced early leukopenia in Asian children with CD.

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  • Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation
    Xinmiao He, Ming Tian, Wentao Wang, Yanzhong Feng, Zhongqiu Li, Jiahui Wang, Yan Song, Jinfeng Zhang, Di Liu
    Veterinary Sciences.2023; 10(5): 307.     CrossRef
  • Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review
    Juan Gu, Yupei Lin, Yuhe Wang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • KASL clinical practice guidelines for management of autoimmune hepatitis 2022

    Clinical and Molecular Hepatology.2023; 29(3): 542.     CrossRef
Review article
Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis
Suji Kim, Jae Hyang Lim, Chang-Hoon Woo
Yeungnam Univ J Med. 2020;37(4):269-276.   Published online July 22, 2020
DOI: https://doi.org/10.12701/yujm.2020.00458
Funded: National Research Foundation of Korea, Ministry of Science, ICT and Future Planning, Ministry of Education
  • 8,731 View
  • 242 Download
  • 4 Crossref
AbstractAbstract PDF
Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the role of kinase signaling cascades in the regulation of either TGF--dependent or other signaling pathways, including Rho-associated coiled-coil kinase, c-jun N-terminal kinase, extracellular signal-regulated kinase 5, and p90 ribosomal S6 kinase pathways, and potential therapeutic targets in IPF.

Citations

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  • Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis
    Hongbo Ma, Shengming Liu, Shanrui Li, Yong Xia
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Vitamin D3 alleviates pulmonary fibrosis by regulating the MAPK pathway via targeting PSAT1 expression in vivo and in vitro
    Wenxiang Zhu, Qi Ding, Lu Wang, Gonghao Xu, Yirui Diao, Sihao Qu, Sheng Chen, Yuanyuan Shi
    International Immunopharmacology.2021; 101: 108212.     CrossRef
  • Advances in the science and treatment of respiratory diseases
    Jin Hong Chung
    Yeungnam University Journal of Medicine.2020; 37(4): 251.     CrossRef
  • Effects of Pirfenidone and Nintedanib on Markers of Systemic Oxidative Stress and Inflammation in Patients with Idiopathic Pulmonary Fibrosis: A Preliminary Report
    Alessandro G. Fois, Elisabetta Sotgiu, Valentina Scano, Silvia Negri, Sabrina Mellino, Elisabetta Zinellu, Pietro Pirina, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Angelo Zinellu
    Antioxidants.2020; 9(11): 1064.     CrossRef
Case report
Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia
Min Kyu Kang, Hee Jung Kwon, Min Cheol Kim
Yeungnam Univ J Med. 2020;37(3):246-249.   Published online April 10, 2020
DOI: https://doi.org/10.12701/yujm.2020.00094
Funded: Yeungnam University
  • 4,656 View
  • 100 Download
AbstractAbstract PDF
Synchronous gastric cancer and adenomatous colorectal polyp in patients with Klebsiella pneumoniae-induced pyogenic liver abscess (KP-PLA) and bacteremia is a rare presentation. A 58-year-old man with a 6-month history of diabetes mellitus (DM) presented with febrile sensation and dull abdominal pain in the right upper quadrant of the abdomen. Subsequent to laboratory test results and abdominal computed tomography findings, KP-PLA with bacteremia was diagnosed. After intravenous antibiotic administration, his symptoms improved, and upper endoscopy and colonoscopy were performed to evaluate the cause of KP-PLA. Biopsy specimens of the prepyloric anterior wall revealed a moderately differentiated adenocarcinoma. Endoscopic mucosal resection of the colon revealed high-grade dysplasia. Early gastric cancer (EGC) and adenomatous colorectal polyps with high-grade dysplasia concomitant with KP-PLA and bacteremia were diagnosed in our patient who had DM. Intravenous antibiotic treatment for KP-PLA, subtotal gastrectomy for EGC, and colonoscopic mucosal resection for the colon polyp were performed. After 25 days of hospitalization, subtotal gastrectomy with adjacent lymph node dissection was performed. Follow-up ultrasound imaging showed resolution of the abscess 5 weeks post-antibiotic treatment, as well as no tumor metastasis. Upper gastrointestinal endoscopy and colonoscopy should be performed to evaluate gastric cancer in patients with PLA or bacteremia, accompanied with DM or an immunocompromised condition.

JYMS : Journal of Yeungnam Medical Science